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Structure and genome editing activity of the novel CRISPR-Cas12o1 effector

细胞研究（英文版） 2025年第2期35卷 145-148页

作者： Zhiqiang Duan Xi Zhang Jun-Tao Zhang Xingkun Ji Ruiheng Liu Ying Chen Shanshan Li Nannan Jia Huizhi Gao Yu Xin Ning Jia Jian-Kang Zhu Institute of Advanced Biotechnology and School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina Department of Biochemistry School of MedicineSouthern University of Science and TechnologyShenzhenGuangdongChina Bellagen Biotechnology Co.Ltd. JinanShandongChina Department of Biochemistry School of MedicineSouthern University of Science and TechnologyShenzhenGuangdongChina Shenzhen Key Laboratory of Cell Microenvironment Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchSouthern University of Science and TechnologyShenzhenGuangdongChina Key University Laboratory of Metabolism and Health of Guangdong Institute for Biological Electron MicroscopySouthern University of Science and TechnologyShenzhenGuangdongChina Institute of Advanced Biotechnology and School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina Center for Advanced Bioindustry Technologies Chinese Academy of Agricultural SciencesBeijingChina

Dear Editor, Class 2 type V CRISPR-Cas12 effectors exhibit tremendous diversity,utilizing either single crRNAs or dual RNA guides to target double-stranded DNA(dsDNA),single-stranded DNA(ssDNA)or *** dsDNA targets,Cas12 recognizes different PAM sequences and generates sticky ends on the target dsDNA.1 This characteristic enhances the efficiency of homology-directed repair2 and causes less off-target effects compared to SpCas9.3 Recent studies have identified a series of Cas12 nucleases,ranging from Cas12a to Cas12n,1,4 thereby greatly expanding the gene editing ***,among the reported Cas12 proteins,the compact ones typically show limited gene editing efficiency and associate with long non-coding RNA guides or dual RNA(crRNA and tracrRNA)guides,which may compensate for the absence of certain Cas12 domains and enhance endonuclease activity and editing efficiency.

关键词： structure activity genome novel crispr-cas12o1 editing effector

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p38-MAPK and CDK5,signaling pathways in neuroinflammation:a potential therapeutic intervention in Alzheimer's disease?

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Neural Regeneration research 2024年第8期19卷 1649-1650页

作者： Vlad Ionut Viorel Ylenia Pastorello Nosherwan Bajwa Mark Slevin George Emil Palade University of Medicine PharmacyScience and TechnologyTârgu MuresRomania Department of Anatomy and Embryology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu MuresRomania DIAKO Hospital FlensburgGermany Center for Advanced Medical and Pharmaceutical Research(CCAMF) George Emil Palade University of MedicinePharmacyScience and TechnologyTârgu MuresRomania Manchester Metropolitan University ManchesterUK

Alzheimer’s disease(AD),the most common type of dementia,affects millions of people worldwide,putting a significant strain on healthcare infrastructure and societal *** is characte rized by the build-up of amyloid-be... 详细信息

关键词： Alzheimer Aβ tau

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In situ Simulation of Thermal Reality

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research 2024年第2期2023卷 685-690页

作者： Peng Jin Jinrong Liu Fubao Yang Fabio Marchesoni Jian-Hua Jiang Jiping Huang Department of Physics State Key Laboratory of Surface Physicsand Key Laboratory of Micro and Nano Photonic Structures(MOE)Fudan UniversityShanghai 200438China Center for Phononics and Thermal Energy Science Shanghai Key Laboratory of Special Artificial Microstructure Materials and TechnologySchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics University of CamerinoCamerino 62032Italy Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China

Simulated reality encompasses virtual,augmented,and mixed realities梕ach characterized by different degrees of truthfulness in the visual perception:"all false","coexistence of true and false,"and"difficult distinction between true and false,"*** all these technologies,however,the temperature rendering of virtual objects is still an unsolved ***,the lack of thermal tactile functions substantially reduces the quality of the user's real-experience *** address this challenge,we propose theoretically and realize experimentally a technological platform for the in situ simulation of thermal *** this purpose,we design a thermal metadevice consisting of a reconfigurable array of radiating units,capable of generating the thermal image of any virtual object,and thus rendering it in situ together with its thermal *** is a substantial technological advance,which opens up new possibilities for simulated reality and its applications to human activities.

关键词： false rendering signature

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A Dual-Defense Self-balancing Framework Against Bilateral Model Attacks in Federated Learning 24th

A Dual-Defense Self-balancing Framework Against Bilateral Mo...

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24th International Conference on Algorithms and Architectures for Parallel Processing, ICA3PP 2024

作者： Wu, Xiang Yao, Aiting Pal, Shantanu Jiang, Frank Li, Xuejun Xu, Jia Dong, Chengzu Chen, Xuefei Zhang, Xiuyi Liu, Xiao Anhui Provincial International Joint Research Center for Advanced Technology in Medical Imaging School of Computer Science and Technology Anhui University Anhui China Deakin University Melbourne Australia School of Data Science Lingnan University Hong Kong

ISBN: (纸本)9789819615247

With the rapid expansion of Artificial Intelligence (AI) services, smart devices generate a large amount of user data at the edge network, which urgently needs to be protected while effectively extracting information. Federated learning (FL) is an important technology for handling dispersed data and strict privacy requirements in this context. However, the security threats caused by model inversion attacks and poisoning attacks can affect the mutual trust between the client and server. Yet, for these two types of attacks, the existing defense mechanisms are contradictory in terms of whether the model parameters are publicly disclosed. In addition, the data distribution of the clients is imbalanced which will increase the bias of model, reducing its practicality. To address this issue, this study proposes a dual defense self-balanced federated learning (DDSFL) framework, aiming to introduce a novel lightweight defense mechanism during the model parameter aggregation stage, combating these two types of attacks simultaneously by applying differential privacy and adjusting learning rates. In addition, this method also integrates a middleware-based reordering algorithm to enhance the robustness of the framework. Experimental results show that DDSFL effectively improves the ability to resist imbalanced data, forged data, and malicious behavior, significantly enhancing the generalization performance and security of the FL system. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Federated learning

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Latest progress on fully non-fused electron acceptors for high-performance organic solar cells

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Chinese Chemical Letters 2023年第8期34卷 76-81页

作者： Jianhong Gao Xiaodong Zhu Hanyi Bao Jibao Feng Xiang Gao Zhitian Liu Ziyi Ge Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials Hubei Key Laboratory of Plasma Chemistry and Advanced MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Benefitting from the development of non-fullerene acceptors(NFAs),remarkable advances have been achieved with the power conversion efficiency(PCE)exceeding 19%over the last few ***,the major achievement comes from fused ring electron acceptors(FREAs)with complex structures,leading to high ***,it is urgent to design new materials to resolve the cost issues concerning basic commercial requirements of organic solar ***,great progress has been made in fully non-fused ring electron acceptors(NFREAs)with only single-aromatic ring in the electron-donating core,which might achieve a fine balance between the efficiency and cost,thus accelerating the commercial application of organic solar ***,this article summarizes the recent advances of fully NFREAs with efficiency over 10%,which may provide a guidance for developing the cost-effective solar cells.

关键词： Organic solar cells Fully non-fused electron acceptors Noncovalent interaction Power conversion efficiency Over 10%

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Noise-robust latent vector reconstruction in ptychography using deep generative models

Noise-robust latent vector reconstruction in ptychography us...

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Computational Optical Sensing and Imaging, COSI 2024 - Part of Optica Imaging Congress

作者： Seifert, Jacob Shao, Yifeng Mosk, Allard P. Advanced Research Center for Nanolithography Science Park 106 Amsterdam1098 XG Netherlands Nanophotonics Debye Institute for Nanomaterials Science Center for Extreme Matter and Emergent Phenomena Utrecht University P.O. Box 80000 Utrecht3508 TA Netherlands Imaging Physics Department Applied Science Faculty Delft University of Technology Netherlands

We introduce a novel approach for ptychographic reconstruction, integrating a pre-trained autoencoder within a reconstruction framework based on automatic differentiation. This enables noise-robust imaging and insight... 详细信息

关键词： Signal reconstruction

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Optimal Design of Wireless Power Transmission Systems Using Antenna Arrays

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ZTE Communications 2022年第2期20卷 19-27页

作者： SUN Shuyi WEN Geyi Research Center of Applied Electromagnetics Nanjing University of In-formation Science and TechnologyNanjing 210044China

Three design methods for wireless power transmission(WPT)systems using antenna arrays have been *** three methods,corresponding to three common application scenarios of WPT systems,are based on the method of maximum power transmission efficiency(MMPTE)between two antenna *** are unconstrained MMPTE,weighted MMPTE,and constrained *** demonstrate the optimal design process with the three methods,a WPT system operating at 2.45 GHz is designed,simulated,and fabricated,in which the transmitting(Tx)array,consisting of 36 microstrip patch elements,is configured as a square and the receiving(Rx)array,consisting of 5 patch elements,is configured as an L *** power transmission efficiency(PTE)is then maximized for the three application scenarios,which yields the maximum possible PTEs and the optimized distributions of excitations for both Tx and Rx *** feeding networks are then built based on the optimized distributions of *** and experiments reveal that the unconstrained MMPTE,which corresponds to the application scenario where no radiation pattern shaping is involved,yields the highest *** next highest PTE belongs to the weighted MMPTE,where the power levels at all the receiving elements are imposed to be *** constrained MMPTE has the lowest PTE,corresponding to the scenario in which the radiated power pattern is assumed to be flat along with the Rx array.

关键词： wireless power transmission system antenna arrays antenna pattern synthesis feeding network

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Optical neural networks:progress and challenges

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Light(science & Applications) 2024年第11期13卷 2511-2535页

作者： Tingzhao Fu Jianfa Zhang Run Sun Yuyao Huang Wei Xu Sigang Yang Zhihong Zhu Hongwei Chen College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangshaChina Hunan Provincial Key Laboratory of Novel Nano-Optoelectronic Information Materials and Devices National University of Defense TechnologyChangshaChina Nanhu Laser Laboratory National University of Defense TechnologyChangshaChina Department of Electronic Engineering Tsinghua UniversityBeijingChina Beijing National Research Center for Information Science and Technology(BNRist) BeijingChina

Artificial intelligence has prevailed in all trades and professions due to the assistance of big data resources,advanced algorithms,and high-performance electronic ***,conventional computing hardware is inefficient at implementing complex tasks,in large part because the memory and processor in its computing architecture are separated,performing insufficiently in computing speed and energy *** recent years,optical neural networks(ONNs)have made a range of research progress in optical computing due to advantages such as subnanosecond latency,low heat dissipation,and high *** are in prospect to provide support regarding computing speed and energy consumption for the further development of artificial intelligence with a novel computing ***,we first introduce the design method and principle of ONNs based on various optical ***,we successively review the non-integrated ONNs consisting of volume optical components and the integrated ONNs composed of on-chip ***,we summarize and discuss the computational density,nonlinearity,scalability,and practical applications of ONNs,and comment on the challenges and perspectives of the ONNs in the future development trends.

关键词： networks neural hardware

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Advancing knowledge of plasma spraying coatings for Li||Sb-Sn liquid metal batteries by X-ray micro-CT

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Chinese Chemical Letters 2023年第7期34卷 308-312页

作者： Kaixuan Cui Ping Li Wang Zhao Chunrong Liu Qi Wan Shengwei Li Xuanhui Qu Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBejing 100084China Institute of Science and Technology China Three Gorges CorporationBeijing 100038China School of Materials Science and Engineering Southwest University of Science and TechnologyMianyang 621010China Shanxi Beike Qiantong Energy Storage Science and Technology Research Institute Co. Ltd.Gaoping 048400China

The performance of Li||Sb-Sn liquid metal batteries(LMBs) is hindered by the corrosion of the Sb-Sn cathode on its current collector. Herein, a uniform, dense, and low-oxidized W coating was prepared by plasma spraying, which can effectively resist the corrosion of the cathode and improve the cycle stability of the Li||Sb-Sn LMBs. For the first time, micro-CT nondestructive inspection is applied in the field of LMBs. The corrosion micromorphology and composition evolution of the SS304 matrix and Sb-Sn cathode with or without the plasma-sprayed W coating is obtained without disassembling the battery, which proves that the W coating can effectively protect the SS304 matrix. Our autonomous new LMB device for nondestructive inspection is universal and can be applied to different LMBs systems for advancing knowledge of corrosion mechanism and protection. This work guarantees the ability to directly visualize the inner critical positions in three dimensions and fills the knowledge gap in the field of LMB detection technology.

关键词： Liquid metal batteries Sb-Sn corrosion Plasma-sprayed W coating SS304 matrix Micro-CT nondestructive inspection

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Mapping the Behavioral Signatures of Shank3b Mice in Both Sexes

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Neuroscience Bulletin 2024年第9期40卷 1299-1314页

作者： Jingjing Liu Jialin Ye Chunyuan Ji Wenting Ren Youwei He Fuqiang Xu Feng Wang NMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal Products Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Shenzhen Key Laboratory of Viral Vectors for Biomedicine Translational Research Center for the Nervous SystemShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Key Laboratory of Quality Control Technology for Virus-Based Therapeutics Guangdong Provincial Medical Products AdministrationShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Shenzhen Key Lab of Translational Research for Brain Diseases Translational Research Center for the Nervous SystemShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China University of Chinese Academy of Sciences Beijing100049China

Autism spectrum disorders(ASD)are characterized by social and repetitive *** the ASD mouse model with Shank3b mutations is widely used in ASD research,the behavioral phenotype of this model has not been fully ***,a 3D-motion capture system and linear discriminant analysis were used to comprehensively record and analyze the behavioral patterns of male and female Shank3b mutant *** was found that both sexes replicated the core and accompanied symptoms of ASD,with significant sex ***,Shank3b heterozygous knockout mice exhibited distinct autistic behaviors,that were significantly different from those those observed in the wild type and homozygous knockout *** findings provide evidence for the inclusion of both sexes and experimental approaches to efficiently characterize heterozygous transgenic models,which are more clinically relevant in autistic studies.

关键词： Autism Shank3b Spontaneous behavior 3D animal motion-capture system Computational ethology Sex differences

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