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Hydrogen-bonded cytosine-endowed supramolecular polymeric nanogels: Highly efficient cancer cell targeting and enhanced therapeutic efficacy

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Journal of Colloid and Interface science 2024年 665卷 329-344页

作者： Fan, Wen-Lu Huang, Shan-You Yang, Xiu-Jing Bintang Ilhami, Fasih Chen, Jem-Kun Cheng, Chih-Chia Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Advanced Membrane Materials Research Center National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Natural Science Faculty of Mathematics and Natural Science Universitas Negeri Surabaya Surabaya60231 Indonesia Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan

We demonstrate that cytosine moieties within physically cross-linked supramolecular polymers not only manipulate drug delivery and release, but also confer specific targeting of cancer cells to effectively enhance the safety and efficacy of chemotherapy—and thus hold significant potential as a new perspective for development of drug delivery systems. Herein, we successfully developed physically cross-linked supramolecular polymers (PECH-PEG-Cy) comprised of hydrogen-bonding cytosine pendant groups, hydrophilic poly(ethylene glycol) side chains, and a hydrophobic poly(epichlorohydrin) main chain. The polymers spontaneously self-assemble into a reversibly hydrogen-bonded network structure induced by cytosine and directly form spherical nanogels in aqueous solution. Nanogels with a high hydrogen-bond network density (i.e., a higher content of cytosine moieties) exhibit outstanding long-term structural stability in cell culture substrates containing serum, whereas nanogels with a relatively low hydrogen-bond network density cannot preserve their structural integrity. The nanogels also exhibit numerous unique physicochemical characteristics in aqueous solution, such as a desirable spherical size, high biocompatibility with normal and cancer cells, excellent drug encapsulation capacity, and controlled pH-responsive drug release properties. More importantly, in vitro experiments conclusively indicate the drug-loaded PECH-PEG-Cy nanogels can selectively induce cancer cell-specific apoptosis and cell death via cytosine receptor-mediated endocytosis, without significantly harming normal cells. In contrast, control drug-loaded PECH-PEG nanogels, which lack cytosine moieties in their structure, can only induce cell death in cancer cells through non-specific pathways, which significantly inhibits the induction of apoptosis. This work clearly demonstrates that the cytosine moieties in PECH-PEG-Cy nanogels confer selective affinity for the surface of cancer cells, which enhances t

关键词： Nanogels

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Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

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National science Review 2024年第1期11卷 161-173页

作者： Feng Xue Fei Li Ke-ming Zhang Lufeng Ding Yang Wang Xingtao Zhao Fang Xu Danke Zhang Mingzhai Sun Pak-Ming Lau Qingyuan Zhu Pengcheng Zhou Guo-Qiang Bi Department of Precision Machinery and Precision Instruments University of Science and Technology of China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Faculty of Life and Health Sciences Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China Institute of Semiconductors Chinese Academy of Sciences Department of Modern Life Sciences and Biotecnology Xiongan Institute of Innovation Xiongan New Area Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Suzhou Institute for Advanced Research University of Science and Technology of China Institute of Artiflcial Intelligence Hefei Comprehensive National Science Center

To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals. However, implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the ***, we present TINIscope, a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design. With its compact and lightweight design of 0.43 g, TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in ***-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions. Moreover, we explored potential multi-modal experimental designs by integrating additional modules for optogenetics, electrical stimulation or local field potential recordings. Overall, TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors.

关键词： miniature microscope multiple sites calcium imaging multimodal integration hippocampus

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Elemental decoration design with metastable cellular substructures for additively manufactured high-strength and high-corrosion resistant austenitic stainless steel

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Corrosion Communications 2024年第1期13卷 17-26页

作者： Decheng Kong Xin He Kunjie Dai Xiaoqing Ni Liang Zhang Li Wang Chaofang Dong Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and Technology University of Science and Technology Beijing Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming School of Materials Science and Engineering Shanghai Jiao Tong University Research and Application Center of Additive Manufacturing Materials Shanghai Research Institute of Materials Co.Ltd.

Multi-level chemical-structural heterogeneities extensively exist in additively manufactured(AM) metals due to the intrinsic layer-by-layer non-equilibrium solidification process. Strategies designed with particular metastable substructures aiming at advanced performances are significant for AM counterparts. In this work, Si and Mo additions are conducted based on the regulations of dislocation cell substructures and stacking fault energies for stainless steel(SS) 316L fabricated by laser powder bed fusion(PBF-LB). Their load-bearing performance and corrosion behavior are characterized. Results show that additional Mo segregation at cellular boundaries contributes a stronger strengthening effect than Si, which periodically hinders dislocation slip during deformation. Addition of Si triggers deformation twinning at an early stage due to decreased stacking fault energy, and subsequent dynamic Hall-Petch effects improve strain-hardening capability and plasticity for PBF-LB SS 316L + Si. Meanwhile, addition of Mo enhances pitting corrosion resistance of PBF-LB 316L + Mo SS in chloride-containing solutions, especially the pitting re-passivation, which is opposite in the Si addition case due to the increased quantiy of undesired Si/Mn-rich oxides. Underlying deformation and corrosion mechanisms for Mo/Si-added PBF-LB SSs are discussed. Our work is anticipated to motivate the alloy design concept based on particular metastable substructures for advanced AM alloys.

关键词： Dislocation cell Elemental segregation Laser powder bed fusion Austenitic stainless steel Alloy design Corrosion resistance

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Composition Dependencies of Positive Electrode Properties and Local Structures of Li1+xNbxFe1–2xO2 with a Disordered Rocksalt Structure

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Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy 2025年 72卷 S1259-S1263页

作者： Kitamura, Naoto Kure, Ryusuke Ishibashi, Chiaki Idemoto, Yasushi Department of Pure and Applied Chemistry Faculty of Science and Technology Tokyo University of Science 2641 Yamazaki Noda Chiba278-8510 Japan Research Group for Advanced Energy Conversion Research Institute for Science and Technology Tokyo University of Science 2641 Yamazaki Noda Chiba278-8510 Japan

In this study, Li1+xNbxFe1–2xO2 (x = 0.05~0.25) with the disordered rocksalt structure were synthesized and the electrode properties and atomic arrangement were investigated. The local structures were examined by X-ray total scattering measurements and reverse Monte Carlo modeling using the data. It is found that the lattice parameter increases with increasing the Li (Nb) content, but the M−O distance in the first coordination shell decreases due to the contribution of the Nb−O correlation. This structural change could increase the space for lithium-ion diffusion. On the other hand, Nb with high valence tends to be localized around Li, suggesting that Nb inhibits ion diffusion during charge and discharge processes. Based on these results, it is necessary to consider not only the size of the constituent cations but also their valence to design new materials. © 2025 Japan Society of Powder and Powder Metallurgy.

关键词： Niobium compounds

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Low cycle fatigue characteristics and life prediction of 316LN austenitic stainless steel

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Progress in Natural science:Materials International 2024年第6期34卷 1194-1206页

作者： Kailun Ding Zhengxin Tang Xikou He Xitao Wang Jinshan He Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Research Institute of Special Steels Central Iron and Steel Research Institute Co.Ltd Shandong Provincial Key Laboratory for High Strength Lightweight Metallic Materials Advanced Materials Institute Qilu University of Technology (Shandong Academy of Science)

An investigation was conducted on the low cycle fatigue behavior, fatigue life, and fatigue fracture mechanism of forged 316LN stainless steel at 330°C, under varying strain amplitudes. The results indicate that the cyclic softening degree of 316LN austenitic stainless steel increases proportionally with the strain amplitude. This increase can be attributed to variations in the arrangement and development process of the dislocation ***, it was observed that both back stress and friction stress augment as the total strain amplitude increases. This phenomenon is primarily caused by enhanced interactions between dislocations and precipitated phases, as well as dislocations themselves. The hysteresis loop area exhibits an increase in direct correlation with the total strain amplitude. Moreover, a smaller strain amplitude corresponds to reduced plastic strain energy and increased fatigue life. In engineering applications, the simplicity and universality of a model, along with easily obtainable parameters, are crucial considerations. To evaluate the fatigue life of 316LN austenitic stainless steel,four models were employed: Coffin-Manson fatigue life model, energy life model, three-parameter power model,and three-parameter power life correction model. The predicted data from the three-parameter power life correction model fell within the acceptable error range of 1.2, demonstrating a strong alignment with the experimental values. Consequently, it can be concluded that the three-parameter power life correction model exhibits remarkable accuracy in predicting low cycle fatigue(LCF) behavior, thereby facilitating the safety assessment of component lifespan. The fatigue fracture surface exhibits distinct features of fatigue striations, with a noticeable decrease in the interval between these striations as the total strain amplitude increases.

关键词： 316LN austenitic stainless steel Low cycle fatigue Fatigue life Cyclic hardening and softening Fatigue striation

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In-situ composite microstructure formation of immiscible alloy solidified in space

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National science Review 2023年第2期10卷 88-90页

作者： Jiuzhou Zhao Hao Sun Lili Zhang Hongxiang Jiang Linjie Yang Jie He Shi-changxu Innovation Center for Advanced Materials Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China

About one-third of alloys show a phase diagram with a miscibility gap in the liquid *** solidifications of these alloys proceed with a liquid-liquid decomposition and have great potential in the development of high-performance in-situ particulate composites,and composites with a core/shell ***,these alloys generally show a phase segregated microstructure when solidified on the *** the 1960s,

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Non-Hermitian Physics in Mesoscopic Electron Transport Through Coupled Quantum Dots

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Chinese Physics Letters 2025年第4期42卷 114-124页

作者： Yiyang Li Jincheng Lu Chen Wang Jian-Hua Jiang School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou215006China Key Laboratory of Intelligent Optoelectronic Devices and Chips of Jiangsu Higher Education Institutions School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou215009China Advanced Technology Research Institute of Taihu Photon Center School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China Department of Physics Zhejiang Normal UniversityJinhua321004China School of Biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou215123China School of Physical Sciences University of Science and Technology of ChinaHefei 230026China

We investigate electron mesoscopic transport in a three-terminal setup with coupled quantum dots and a magnetic *** mapping the original transport problem into a non-Hermitian Hamiltonian form,we study the interplay between the coherent couplings between quantum dots,the magnetic flux,and the dissipation due to the tunnel coupling with the reservoirs.

关键词： quantum dots magnetic fluxby electron mesoscopic transport non hermitian physics magnetic fluxand coherent couplings transport problem tunnel coupling

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Thermal-force control ability under variation of electromagnetic stick structure parameters in RPECT

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Journal of Iron and Steel research International 2024年第1期31卷 224-236页

作者： Ting-song Yang Wen-quan Sun Feng-shan Du An-rui He Quan Yang National Engineering Research Center of Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Institute of Engineering and Technology University of Science and Technology BeijingBeijing100083China College of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina

Thermal-force driving of roll profile electromagnetic control technology(RPECT),which can be used to adjust the roll profile,can be affected by the sequential temperature rise between the electromagnetic stick(ES)and electromagnetic control *** to the limited space of ES and induction coil,the cross-sectional area of induction coil can be inevitably affected by changing the size of the ES induction zone,which can further change the energy input under the same electromagnetic parameters,the temperature rising effect and the bulging *** investigate this phenomenon,the effects of the radius of the induction zone on the thermal-force contribution ratio,the heating ability of ES and the temperature distribution were analyzed through an electromagnetic-thermal-structural finite element *** ensure that the results are applicable to RPECT,the thermal energy conversion ability and thermal-force roll crown control ability under different lengths of the induction zone were *** was found that whether the current density regulation mode or the current frequency regulation mode is adopted,the cases with 20 or 25 mm radius of the induction zone have the great thermal energy conversion ability and the good thermal-force roll crown control *** reasonable adjustment of the length of the induction zone can reduce the radius required for the maximum energy efficiency *** with the results of the simulation analysis,the optimization of ES based on the control ability maximization requirement is achieved,which provides the base for the design and configuration of ES in RPECT.

关键词： Roll profile electromagnetic control technology Electromagnetic stick Electromagnetic control roll Induction area Thermal-force driving

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CO2-Responsive Water-Soluble Conjugated Polymers as a Multifunctional Fluorescent Probe for Bioimaging Applications

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Biomacromolecules 2024年第2期25卷 997-1008页

作者： Hsiao, Yu-Nong Ilhami, Fasih Bintang Cheng, Chih-Chia Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Advanced Membrane Materials Research Center National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Natural Science Faculty of Mathematics and Natural Science Universitas Negeri Surabaya Surabaya60231 Indonesia

We describe important progress in the synthesis and development of gas-responsive water-soluble conjugated polymers (WSCPs) with potential as multifunctional fluorescent materials for biomedical imaging and probes. A water-soluble WSCP (I-PT) composed of a hydrophobic fluorescent polythiophene backbone and a hydrophilic imidazole side chain was successfully prepared through a facile and efficient two-step synthetic route. Owing to the repulsive force between the hydrophilic and hydrophobic segments and the highly sensitive carbon dioxide (CO2)- and nitrogen (N2)-responsive imidazole groups in its structure, I-PT can spontaneously self-assemble into spherical-like nanoparticles in an aqueous environment, and thus exhibits unique light absorption and fluorescence properties as well as rapid responsiveness to CO2 and N2. In addition, its structure, optical absorption/fluorescence behavior, and surface potential can be quickly turned on and off through alternating cycles of CO2 and N2 bubbling and exhibit controllable cyclic switching stability, thereby allowing effective manipulation of its hierarchical structure and chemical-physical characteristics. More importantly, a series of in vitro cell experiments confirmed that, compared to the significant cytotoxicity of pristine and N2-treated I-PT nanoparticles, CO2-treated I-PT nanoparticles exhibit extremely low cytotoxicity in normal and cancer cells and undergo greatly accelerated cellular uptake, resulting in a significant increase in the intensity and stability of their fluorescence signal in the intracellular environment. Overall, this newly discovered CO2/N2-responsive system provides new insights to effectively enhance the biocompatibility, cellular internalization, and intracellular fluorescence characteristics of WSCPs and holds great potential for biomedical imaging/sensing applications. © 2023 American Chemical Society.

关键词： Light absorption

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Oxygen fugacity-mediated carbonate reactions with siliceous fluids in shallow subduction zones

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Geoscience Frontiers 2025年第1期16卷 275-286页

作者： Fengxia Sun Jun Hu Weibin Gui Ao Deng Penghui Sun Fahui Xiong Jin Liu Institute of Earthquake Forecasting The China Earthquake AdministrationBeijing 100036China Center for High Pressure Science State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China Center for High Pressure Science and Technology Advanced Research Beijing 100193China Center for Advanced Research on the Mantle(CARMA) Key Laboratory of Deep-Earth Dynamics of Ministry of Land and ResourcesInstitute of GeologyChinese Academy of Geological SciencesBeijing 100037China

Sediments are one of the main carbon sinks in subduction zones,with CaCO_(3)and SiO_(2)being the main components in *** chemical stability plays a significant role in the form of carbon in the Earth’s *** we report the reactions of CaCO_(3)with SiO_(2)in hydrated sediments at 0.8-2.0 GPa,400-500℃and redox-buffered conditions relevant to shallow subduction *** results show that the reaction CaCO_(3)+SiO_(2)=CaSiO_(3)+C+O_(2)(fluid)occurs under CoCoO and IW buffered conditions to generate wollastonite(CaSiO_(3))and carbonaceous material(CM).Moreover,wollastonite is formed by the dissolution-crystallization process,which may be significantly affected by oxygen fugacity,leading to distinct crystallization habits(Yui,1966,Schott et al.,2012).Anhydrous experiments indicate that the reaction proceeds only in the presence of H2O within the pressure and temperature(P-T)range of this *** reaction occurs more rapidly with aragonite-structured than calcite-structured CaCO_(3).Further,the experiment buffered with natural olivine at 1.0 GPa and 400℃proves that the above reaction can occur during serpentinization processes in shallow subduction *** importantly,nanoscale CM may be generated under relatively reducing conditions,exhibiting Raman characteristics of *** results provide new insights into how deep carbon is distributed in the Earth’s interior.

关键词： Subduction zone Sediments Carbonate stability Fugacity Graphite Wollastonite

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