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Exosome regulation of immune response mechanism:Pros and cons in immunotherapy

Bioactive Materials 2024年第2期32卷 124-146页

作者： Julien Milon Essola Mengjie Zhang Haiyin Yang Fangzhou Li Bozhang Xia Jacques François Mavoungou Abid Hussain Yuanyu Huang School of Life Science Advanced Research Institute of Multidisciplinary ScienceSchool of Medical TechnologyKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing100081China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaNo.11First North RoadZhongguancunBeijing100190PR China University of Chinese Academy of Sciences.Beijing 100049 PR China Rigerna Therapeutics Co.Ltd. China Universite Internationale de Libreville Libreville20411Gabon Central and West African Virus Epidemiology Libreville2263Gabon Departement de phytotechnologies Institut National Superieur d’Agronomie et de BiotechnologieUniversite des Sciences et Techniques de MasukuFranceville901Gabon Institut de Recherches Agronomiques et Forestiers Centre National de la Recherche Scientifique et du developpement TechnologiqueLibreville16182Gabon

Due to its multiple features,including the ability to orchestrate remote communication between different tissues,the exosomes are the extracellular vesicles arousing the highest interest in the scientific *** size,established as an average of 30-150 nm,allows them to be easily uptaken by most *** to the type of cells-derived exosomes,they may carry specific biomolecular cargoes used to reprogram the cells they are interacting *** certain circumstances,exosomes stimulate the immune response by facilitating or amplifying the release of foreign antigens-killing cells,inflammatory factors,or antibodies(immune activation).Meanwhile,in other cases,they are efficiently used by malignant elements such as cancer cells to mislead the immune recognition mechanism,carrying and transferring their cancerous cargoes to distant healthy cells,thus contributing to antigenic invasion(immune suppression).Exosome dichotomic patterns upon immune system regulation present broad advantages in *** perfect comprehension,from its early biogenesis to its specific interaction with recipient cells,will promote a significant enhancement of immunotherapy employing molecular biology,nanomedicine,and nanotechnology.

关键词： Exosome Immune activation Immune suppression Tumor cells RNAs

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Aligning Objects as Preprocessing Combined with Imitation Learning for Improved Generalization

Aligning Objects as Preprocessing Combined with Imitation Le...

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International Conference on Control and Robots (ICCR)

作者： Mücahid Barstuğan Shimpei Masuda Ryusuke Sagawa Fumio Kanehiro Department of Electrical and Electronics Engineering Konya Technical University Konya Türkiye CNRS-AIST JRL (Joint Robotics Laboratory) IRL National Institute of Advanced Industrial Science and Technology Tsukuba Japan Artificial Intelligence Research Center National Institute of Advanced Industrial Science and Technology Tsukuba Japan

ISBN: (数字)9798331518158

ISBN: (纸本)9798331518165

Imitation learning method transfers human behavior to the robots or machines. This method aims to allow robots or machines to learn by observing tasks performed by human operators and imitating these tasks, rather than direct programming. ACT as an imitation learning method shows the high capability for automating dexterous manipulation tasks. From the viewpoint of industrial application, pose of the target object will be varied. However, even if only for the initial object pose variation, imitation learning method like ACT usually needs a lot of demonstration data that covers pose variation to train the policy that can generalize for. Collecting large demonstration dataset takes many efforts. This study created an object pick-and-place controller to eliminate pose variation as a preprocess step with YOLOv8, which is a recent object detection technique. The preprocess step automatically moves the object to a specific position and eliminates the pose variation. We show that our system effectiveness on the randomly placed bag opening task that requires both generalization for object pose variation and dexterous bimanual manipulation. The bag opening task was conducted with ACT and preprocess applied ACT methods, and the results were evaluated to examine the effect of the preprocess method to generalization process.

关键词： Service robots Imitation learning Object detection Programming Behavioral sciences

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A Single-Layer Piezoelectric Composite Separator for Durable Operation of Li Metal Anode at High Rates

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Energy & Environmental Materials 2024年第1期7卷 265-274页

作者： Yuanpeng Ji Botao Yuan Jiawei Zhang Zhezhi Liu Shijie Zhong Jipeng Liu Yuanpeng Liu Mengqiu Yang Changguo Wang Chunhui Yang Jiecai Han Weidong He National Key Laboratory of Science and Technology on Advanced Composites in Special Environments and Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150080China School of Petroleum Engineering Chongqing University of Science and TechnologyChongqing 401331China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150080China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401151China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Piezoelectric ceramic and polymeric separators have been proposed to effectively regulate Li deposition and suppress dendrite growth,but such separators still fail to satisfactorily support durable operation of lithium metal batteries owing to the fragile ceramic layer or low-piezoelectricity polymer as ***,by combining PVDF-HFP and ferroelectric BaTiO_(3),we develop a homogeneous,single-layer composite separator with strong piezoelectric effects to inhibit dendrite growth while maintaining high mechanical *** squeezed by local protrusion,the polarized PVDF-HFP/BaTiO_(3)composite separator generates a local voltage to suppress the local-intensified electric field and further deconcentrate regional lithium-ion flux to retard lithium deposition on the protrusion,hence enabling a smoother and more compact lithium deposition morphology than the unpoled composite separator and the pure PVDF-HFP separator,especially at high ***,the homogeneous incorporation of BaTiO_(3)highly improves the piezoelectric performances of the separator with residual polarization of 0.086 pC cm^(-2)after polarization treatment,four times that of the pure PVDF-HFP separator,and simultaneously increases the transference number of lithium-ion from 0.45 to *** from the prominent piezoelectric mechanism,the polarized PVDF-HFP/BaTiO_(3)composite separator enables stable cyclic performances of Li||LiFePO_(4)cells for 400 cycles at 2 C(1 C=170 mA g^(-1))with a capacity retention above 99%,and for 600 cycles at 5 C with a capacity retention over 85%.

关键词： composite separator Li metal anodes piezoelectric materials PVDF-HFP uniform Li deposition

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One‐dimensional nanomaterials for nerve tissue engineering to repair spinal cord injury

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BMEMat(BioMedical Engineering Materials) 2025年第1期3卷 1-40页

作者： Bingqi Shi Shan Lu Hongru Yang Shahid Mahmood Chunhui Sun Nik Ahmad Nizam Nik Malek Wan Hairul Anuar Kamaruddin Syafiqah Saidin Congcong Zhang Institute for Advanced Interdisciplinary Research Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongUniversity of JinanJinanChina Department of Materials Science and Engineering Johns Hopkins UniversityBaltimoreUSA Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJinanChina Centre for Sustainable Nanomaterials(CSNano) Ibnu Sina Institute for Scientific and Industrial Research(ISI‐ISIR)Universiti Teknologi Malaysia(UTM)Johor BahruMalaysia Pusat Pengurusan Makmal Universiti Johor BahruMalaysia IJN‐UTM Cardiovascular Engineering Centre Institute of Human Centered EngineeringUniversiti Teknologi MalaysiaJohor BahruMalaysia

In recent years,tissue engineering has emerged as a cutting‐edge approach for the treatment of spinal cord injury(SCI)owing to its remarkable *** can create living tissues with robust vitality,achieve maximal tissue repair with minimal cell usage,and facilitate seamless reconstruction with unmatched plasticity,all while addressing immune rejection *** these advancements,one‐dimensional(1D)materials have garnered significant *** morphology closely resembles the extracellular matrix environment,thereby fostering the elongation of dendrites and axons on neurons and greatly enhancing the prospects for SCI *** a keen focus on the latest advancements in the application of 1D nanomaterials in nerve tissue engineering for spinal nerve repair,this review delves into several key ***,it explores the“bottom‐up”approach to synthesizing 1D ***,it examines the mechanisms by which these nanomaterials influence neural tissue ***,it presents various cutting‐edge strategies aimed at optimizing the morphology and performance of 1D materials,thereby enhancing the efficiency of nerve tissue injury ***,it discusses the current challenges and future prospects facing this fascinating *** aspire that this comprehensive review will provide a profound understanding of the development of 1D materials in neural tissue engineering and inspire a wider audience with its potential.

关键词： 1D nanomaterials neural tissue engineering SCI repair tissue engineering

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Micromechanics of composites with interface effects

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Acta Mechanica Sinica 2022年第4期38卷 1-20,I0001页

作者： Huiling Duan Jianxiang Wang Zhuping Huang State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering Science.Beijing Innovation Center for Engineering Science and Advanced TechnologyCollege of EngineeringPeking University.Beijing 100871China Center for Applied Physics and Technology Key Laboratory of High Energy Density Physics Simulations and IFSA Collaborative Innovation Center of the Ministry'of EducationPeking UniversityBeijing 100871China

In terfaces that exist in composites greatly influence their mechanical and conductive *** are usually three interface models to characterize the elastic and conductive properties of the interface in *** elastic problems,they are the interface stress model(ISM),linear spring model(LSM),and interphase *** conductive problems,they are the high conducting(HC)interface model,low conducting(LC)interface model,and interphase *** elastic problems with the interface effects,they can be divided into two *** first kind of elastic problem concerns the solution of boundary value problems and aims to predict the effective properties of composites with interface *** second kind of elastic problem concerns the surface/interface stress effects on the elastic properties of nanostructured materials,which is usually characterized by the *** this paper,three aspects in the elastic problems with interface effects are first reviewed,i.e.,equivalent relations among the three interface models,Eshelby formalism,and micromechanical *** emphasis is placed on the ISM to show how classical models can be extended to the nano-scale by supplementing the interface elasticity to the basic equations of the classical elastic ***,the conductive problems of the composites with the interface effects are also reviewed,and the general frameworks for predicting the effective conductivity of the composites are ***,scaling laws depicting the size-dependent elastic and conductive properties of the composites are discussed.

关键词： Interface effect.Micromechanics Composites Effective properties Scaling law

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Non-coordinating charge transfer enables ultrafast desolvation of hydrated zinc ions in the outer Helmholtz layer for stable aqueous Zn metal batteries

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National science Review 2025年第4期 282-293页

作者： Xiuli Guo Qiaoling Peng Rui Yang Gengyou Cao Jianfeng Wen Kyungsoo Shin Ye Zheng Sarayut Tunmee Caineng Zou Yongping Zheng Xiaolong Zhou Yongbing Tang Advanced Energy Storage Technology Research Center Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences Nano Science and Technology Institute University of Science and Technology of China Shenzhen College of Advanced Technology University of Chinese Academy of Sciences Synchrotron Light Research Institute (Public Organization) Petro China Shenzhen New Eergy Research Institute Co. LTD.

The formation of a strong coordination structure,[Zn（H2O）6]2+often increases direct contact between the solvated H2O and Zn anodes in the inner Helmholtz layer,which exacerbates undesirable side reactions and dendrite growth,hindering the practical application of aqueous Zn metal ***,we show that the solvated H2O can be effectively minimized by an artificial solid electrolyte interphase（SEI） consisting of highly nitrogen-doped amorphous carbon（NC） and perfluorosulfonic acid polymer（Nafion）.Theoretical and experimental analyses reveal that NC raises the Fermi level of the composite SEI and activates the non-coordinating charge transfer from the SEI to [Zn（H2O）6]2+,which leads to ultrafast desolvation of hydrated Zn-ions in the outer Helmholtz layer;while the Nafion framework ensures selective transport channels for Zn ***,the derived NC-Nafion@Zn symmetric cell exhibits a long lifespan(3400 h,1 mA cm-2;2000 h,5 mA cm-2);moreover,the NC-Nafion@Zn//Mn4O3-carbon nano tubes full battery delivers ultralong cycling stability of 9300 cycles at 2 A g-1with a high retention of 91.3%.

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10-3:Distinguished Paper:Reducing Resolution Loss in Naked Eye 3D Display Using Dual Ferroelectric Liquid Crystal (FLC) Shutters for Time-multiplexed Light Field Display

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SID Symposium Digest of Technical Papers 2024年第1期55卷 96-99页

作者： Zhi-Bo SUN Zheng-Nan YUAN Yi-Peng HUO Shou-Cheng DONG Alex CHEUNG Valerii VASHCHENKO Olena VASHCHENKO Abhishek SRIVASTAVA Hoi-Sing KWOK State Key Laboratory of Advanced Displays and Optoelectronics Technologies and Center for Display research Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology Clear Water Bay Road Kowloon Hong Kong

Usually, the resolution loss is serious in light field display due to the spatial multiplexing of several neighboring pixels to display images from different directions. With the limitation in the resolution of the flat panel display, the light field 3D display shows insufficient display size, image depth, or resolution. This article utilized the FLC with a fast response at 2 kHz and the optimized charge compensation method to achieve a high refresh time multiplexing method, which can effectively increase the display resolution by up to 32 times and is very promising for light field 3D displays in the future.

关键词： Resolution loss Light field display Naked eye 3D display Ferroelectric liquid crystal Time multiplexing method

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Deep reinforcement learning for near-fieldwideband beamforming in STAR-RIS networks

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Frontiers of Information technology & Electronic Engineering 2024年第12期25卷 1651-1663页

作者： Ji WANG Jiayi SUN Wei FANG Zhao CHEN Yue LIU Yuanwei LIU Department of Electronics and Information Engineering College of Physical Science and TechnologyCentral China Normal UniversityWuhan 430079China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Faculty of Applied Sciences Macao Polytechnic UniversityMacao SARChina School of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK Department of Electrical and Electronic Engineering The University of Hong KongHong Kong 999077China

A simultaneously transmitting and reflecting reconfigurable intelligent surface(STAR-RIS)assisted multiuser near-field wideband communication system is investigated,in which a robust deep reinforcement learning(DRL)based algorithm is proposed to enhance the users’achievable rate by jointly optimizing the active beamforming at the base station(BS)and passive beamforming at the *** mitigate the beam split issue,the delay-phase hybrid precoding structure is introduced to facilitate wideband *** the coupled nature of the STARRIS phase-shift model,the passive beamforming design is formulated as a problem of hybrid continuous and discrete phase-shift control,and the proposed algorithm controls the high-dimensional continuous action through hybrid action ***,to address the issue of biased estimation encountered by existing DRL algorithms,a softmax operator is introduced into the algorithm to mitigate this *** results illustrate that the proposed algorithm outperforms existing algorithms and overcomes the issues of overestimation and underestimation.

关键词： Deep reinforcement learning Near-field beamforming Simultaneously transmitting and reflecting reconfigurable intelligent surface(STAR-RIS) Wideband beam split

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Tetrahedral versus octahedral interstitial sites for oxygen solutes in NbTiZr medium-entropy alloy

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Journal of Materials science & technology 2026年 241卷 229-237页

作者： Bozhao Zhang Yaqiong An Chang Liu Jun Ding Evan Ma Advanced Interdisciplinary Science Research (AiR) Center Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 China State Key Laboratory for Mechanical Behavior of Materials Center for Alloy Innovation and Design Xi’an Jiaotong University Xi’an 710049 China

Oxygen interstitial solutes have traditionally been thought to occupy only octahedral interstices in body-centered cubic (bcc) metals. However, the competition between tetrahedral and octahedral interstitial sites for oxygen solutes in multi-principal element alloys has become a topic of debate. The driving force and atomistic mechanism behind this observed preference switch remain unclear. In this study, we systematically investigate the competition between tetrahedral and octahedral sites for oxygen, nitrogen, and carbon solute atoms in bcc NbTiZr alloys using density functional theory calculations. At dilute concentrations, interstitial solutes exhibit a strong preference for octahedral sites, with 100 % of solutes initially placed in tetrahedral sites migrating to nearby octahedral sites after structural relaxation. Notably, a transition from octahedral site to tetrahedral site occupancy is observed under specific conditions, including lattice expansion, high interstitial solute concentrations, or significant spatial heterogeneity (reflecting locally aggregated oxygen interstitials), provided no phase transformation occurs. This transition is driven by a crossover in elastic strain energy between the two competing configurations of octahedral and tetrahedral interstices. Our findings provide mechanistic insights into the behavior of small interstitial solutes and their solid solution strengthening effects in bcc multi-principal element alloys, offering valuable guidance for alloy design.

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Temperature-induced structural and electronic phase transitions in λ-phase Ti3O5

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Physical Review Materials 2024年第3期8卷 035002-035002页

作者： K. Yoshimatsu H. Nakao H. Kumigashira Institute of Multidisciplinary Research for Advanced Materials Tohoku University Sendai Miyagi 980-8577 Japan Materials Research Center for Element Strategy (MCES) Tokyo Institute of Technology Yokohama 226-8503 Japan Institute of Materials Structure Science High Energy Accelerator Research Organization Oho Tsukuba 305-0801 Japan

We investigated changes in the structural and electronic properties of single-crystalline Ti3O5 films across temperature-induced phase transitions. Based on resistivity and synchrotron x-ray diffraction measurements, we determined the phase diagram of Ti3O5. The characteristic properties of Ti3O5 were classified into three temperature regions: the insulating λ phase at T ≤ 350 K, the conductive λ phase at 350 K ≤ T ≤ 460 K via the metal-insulator transition, and the metallic α phase at T ≥ 460 K. Detailed crystallographic analysis revealed that the monoclinic λ phase exhibited a second-order structural phase transition to the orthorhombic α phase, accompanied by a gradual deformation of the monoclinic angle. These results suggest that unusual temperature-induced changes in Ti3O5 originate from similar atomic conformations of the λ and α phases. Our findings provide guidelines for controlling multiple phase transitions in Ti3O5 polymorphs using external stimuli, which is crucial for optoelectronic and heat-storage applications of Ti3O5.

关键词： Electrical conductivity Phase transitions Functional materials Single crystal materials Thin films Epitaxy Film deposition X-ray diffraction

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