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Zinc Oxide/Carbon Material-Embedded Supramolecular Drug Delivery System with Photoswitching Properties for Highly Selective and Effective Chemotherapy

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ACS applied Bio Materials 2024年第8期7卷 5506-5518页

作者： Ilhami, Fasih Bintang Munasir, None Gultom, Noto Susanto Cheng, Chih-Chia Department of Natural Science Faculty of Mathematics and Natural Science Universitas Negeri Surabaya Surabaya60231 Indonesia Department of Physics Faculty of Mathematics and Natural Science Universitas Negeri Surabaya Surabaya60231 Indonesia Department of Physics Universitas Padjadjaran Bandung45363 Indonesia Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Advanced Membrane Materials Research Center National Taiwan University of Science and Technology Taipei10607 Taiwan

Phototherapy has become a hopeful procedure for the treatment of cancer. Nevertheless, the straightforward creation of a theranostic system that can achieve both tumor localization and production of oxygen species is greatly desired yet remains a challenging endeavor. In this study, we synthesized spherical nanostructures by decorating zinc oxide (ZnO) with peanut shell-based carbon (PNS-C) in an aqueous solution. The PNS-C-decorated ZnO (ZnO/PNS-C)-embedded supramolecular system exhibited spontaneous self-assembly. The nanogels that are produced have several desirable characteristics, including exceptional resistance to degradation by light, highly stable nanostructures that form spontaneously in biological environments, outstanding ability to prevent the destruction of red blood cells, and a high level of sensitivity to changes in pH and light. Under light irradiation, the addition of ZnO/PNS-C-incorporated supramolecular provided high reactive oxygen species production. Moreover, in vitro cellular assays demonstrated ZnO/PNS-C-incorporated supramolecular exhibited highly selective and induced phototoxicity into cancer cells and no effect on the viability of normal cells both before and after irradiation. Overall, the ZnO/PNS-C-incorporated supramolecular system has the potential to stimulate advancements in phototherapy by utilizing highly tumor-selective therapeutic molecules. This can lead to a more effective targeted therapy for cancers. © 2024 American Chemical Society.

关键词： Diseases

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Phosphorous and selenium tuning Co-based non-precious catalysts for electrosynthesis of H_(2)O_(2)in acidic media

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Chinese Chemical Letters 2024年第1期35卷 475-481页

作者： Jingxin Xie Lijie Zhong Xin Yang Dequan He Kanglong Lin Xiaoxia Chen Huan Wang Shiyu Gan Li Niu Guangdong Engineering Technology Research Center for Photoelectric Sensing Materials&Devices Guangzhou Key Laboratory of Sensing Materials&DevicesCenter for Advanced Analytical ScienceSchool of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China Department of Chemistry and Environment Science Fujian Provincial Key Laboratory of Modern Analytical Science and Separation TechnologyMinnan Normal UniversityZhangzhou 363000China

Electrosynthesis of hydrogen peroxide(H2O2)is an on-site method that enables independent distribution applications in many fields due to its small-scale and sustainable *** crucial point remains developing highly active,selective and cost-effective *** electrosynthesis of H2O2 in acidic media is more practical owing to its stability and no need for further *** herein report a phosphorus and selenium tuning Co-based non-precious catalyst(CoPSe)toward two-electron oxygen reduction reaction(2e–ORR)to produce H2O2 in acidic *** starting point of using both P and Se is finding a balance between strong ORR activity of CoSe and weak activity of *** results demonstrated that the CoPSe catalyst exhibited the optimized 2e–ORR activity compared with CoP and *** disclosed an onset potential of 0.68 V and the H2O2 selectivity 76%-85%in a wide potential range(0–0.5 V).Notably,the CoPSe catalyst overcomes a significant challenge of a narrow-range selectivity for transitionmetal based 2e–ORR ***,combining with electro-Fenton reaction,an on-site system was constructed for efficient degradation of organic *** work provides a promising non-precious Co-based electrocatalyst for the electrosynthesis of H2O2 in acidic media.

关键词： Oxygen reduction reaction Electrochemical H2O2 production Electrocatalysis Non-precious electrocatalyst Acidic media

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Ground Deformation in Afar Detected by ALOS-2 ScanSAR InSAR Time Series Analysis 8

Ground Deformation in Afar Detected by ALOS-2 ScanSAR InSAR ...

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8th Asia-Pacific Conference on Synthetic Aperture Radar, APSAR 2023

作者： Sugimoto, Ryu Morishita, Yu Shimada, Masanobu Natsuaki, Ryo Nakamura, Ryosuke Tsutsumi, Chiaki Yamaguchi, Yoshio Sobue, Shinichi Digital Architecture Research Center National Institute of Advanced Industrial Science and Technology Tokyo Japan

ISBN: (纸本)9798350393590

The ground deformation associated with rifting and volcanic activities in Afar has been gradually revealed by geodetic measurements such as Global Navigation Satellite System (GNSS) and Interferometric Synthetic Aperture Radar (InSAR) time series analysis using Sentinel-1 data. However, decorrelation of the C-band InSAR data especially in vegetated areas is still a limiting factor to obtain the spatially complete deformation signals. Recently, all ScanSAR data from L-band advanced Land Observing Satellite-2 (ALOS-2) have been released by Japan Aerospace Exploration Agency as open and free datasets. While ALOS-2 ScanSAR InSAR may be able to detect ground deformation with high coverage, there are some challenges to overcome. For example, ALOS-2 data are strongly affected by ionospheric turbulence compared to Sentinel-1 data because of its longer wavelength. Also, ALOS-2 has a longer repeat cycle (i.e., less observation frequency) than Sentinel-1, which increases the uncertainty in velocity estimation. We carefully reduced such noise by applying methods proposed in the previous studies in ALOS-2 ScanSAR InSAR time series analysis. Consequently, both tectonic and volcanic ground deformations were successfully obtained with comparable accuracy to Sentinel-1. The derived deformation using ALOS-2 ScanSAR data has better coverage than that from Sentinel-1 data and it will enable a more detailed interpretation of the ground deformation. ©2023 IEEE.

关键词： Time series analysis

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Crystal and electronic structure of a quasi-two-dimensional semiconductor Mg_(3)Si_(2)Te_(6)

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Chinese Physics B 2023年第3期32卷 549-553页

作者：黄潮欣程本源张云蔚姜隆李历斯霍梦五刘晖黄星梁飞翔陈岚孙华蕾王猛 Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-Sen UniversityGuangzhou 510275China Shanghai Institute of Laser Plasma Shanghai 201800China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China Instrumentation Analysis and Research Center Sun Yat-Sen UniVersityGuangzhou 510275China

We report the synthesis and characterization of a Si-based ternary semiconductor Mg_(3)Si_(2)Te_(6),which exhibits a quasitwo-dimensional structure,where the trigonal Mg_(3)Si_(2)Te_(6)layers are separated by Mg ***-visible absorption spectroscopy and density functional theory calculations were performed to investigate the electronic *** experimentally determined direct band gap is 1.39 eV,consistent with the value of the density function theory *** results reveal that Mg_(3)Si_(2)Te_(6)is a direct gap semiconductor,which is a potential candidate for near-infrared optoelectronic devices.

关键词： semiconductors semiconductor compounds narrow-band systems methods of crystal growth

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Fermi Rubik's Cube in High-Pressure Induced Chlorine-Rich Compounds

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Chinese Physics Letters 2024年第10期41卷 78-83页

作者： Jun Kong Lei Su Haixu Cui Hairui Ding Jingyu Hou Chunxia Chi Shiyang Liu Xiang-Feng Zhou Hui-Tian Wang Xiao Dong Key Laboratory of Weak-Light Nonlinear Photonics and School of Physics Nankai UniversityTianjin 300071China Center for High Pressure Science and Technology Advanced Research Beijing 100093China Key Laboratory of Photochemistry Institute of ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190China College of Physics and Materials Science Tianjin Normal UniversityTianjin 300387China Center for High Pressure Science State Key Laboratory of Metastable Materials Science and TechnologySchool of ScienceYanshan UniversityQinhuangdao 066004China National Laboratory of Solid State Microstructures School of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

In the quasi-free electron model,the Fermi surface spreads into a sphere in the Brillouin zone,i.e.,the Fermi *** Fermi sphere exists widely in metal systems,no matter whether the crystal is in a body-center cubic,face-center cubic,or hexagonal close-packed ***,we report a class of compounds stabilized at high pressure with Rubik’s cubic Fermi surface.

关键词： surface. Fermi cubic

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Cell-Level Trajectory Prediction Using Time-embedded Encoder-Decoder Network 1

Cell-Level Trajectory Prediction Using Time-embedded Encoder...

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1st ACM SIGSPATIAL International Workshop on the Human Mobility Prediction Challenge, HuMob 2023

作者： Kim, Taehoon Kim, Kyoung-Sook Matono, Akiyoshi National Institute of Advanced Industrial Science and Technology Artificial Intelligence Research Center Tokyo Japan

ISBN: (纸本)9798400703560

Predicting human mobility is essential in various domains and applications (e.g., urban planning) and is one of the fundamental research topics in GIS. In recent years, there has been a lot of research on mobility (and trajectory) prediction using deep learning models. However, how to utilize irregular temporal information (i.e., the sampling time of coordinates is not regular) has not been studied enough. This paper describes the framework used in the Human Mobility Prediction Challenge (HuMob Challenge) 2023, which received the top-10 performance. Our framework consists of preprocessing cell-level trajectory data, then trains sequence encoder-decoder model using the processed spatio-temporal data, and predicts cell-level trajectories using the trained model. We also propose a model that can learn and infer even if there is a time gap by using embedded vectors that divide the time and day information. Finally, we conducted extensive experiments using 100K individual trajectory data of 90 days in an urban scale domain provided by HuMob Challenge 2023, and excellent results have been achieved. © 2023 ACM.

关键词： Trajectories

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Recent advances in breathable electronics

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Nano research 2023年第3期16卷 4130-4142页

作者： Zhuocheng Yan Jian Xiong Bin Wang Min Gao Guangqiang Yin Tao Hu Taisong Pan Xinzhong Wang Yuan Lin Department of Electronic Communication and Technology Shenzhen Institute of Information TechnologyShenzhen 518172China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054China School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu 610054China Engineering Cooperation on Applied Medicine Research Center University of Electronic Science and Technology of ChinaChengdu 610054China

The successful implementation of bioelectronic devices attached to living organism hinges on a number of material and device characteristics,including not only electrical and mechanical performances to gather physiological signals from living organism thus enabling status monitoring,but also permeability or breathability for gas/nutrient exchange between living organisms and surroundings to ensure minimum perturbation of the intrinsic biological ***,most bioelectronic devices built on planar polymeric substrates,such as polydimethylsiloxane(PDMS),polyurethane(PU),and polyimide(PI),lack efficient gas permeability,which may hinder the emission of volatile compounds from the surface of living organism,affecting the natural metabolism and reducing the comfort of ***,achieving permeability or breathability in bioelectronic devices is a significant ***,the devices made of gas-permeable materials with porous structures,that combine electronic components with daily garments,such as fibric and textile,offer exciting opportunities for breathable *** this review,several types of gas-permeable materials with their synthesis and processing routes are ***,two methods for measuring water vapor transmission rate of materials are discussed in ***,recent progress in the use of gaspermeable materials for the applications of plant-and skin-attached electronics is summarized systematically.

关键词： breathability gas permeability porous sponge foam nano materials plant electronics wearable electronics

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LncRNA01730 Affects Wnt/β-Catenin Signaling and Facilitates the Stage-Dependent Progression of Colorectal Cancer

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Cell and Tissue Biology 2025年第3期19卷 214-223页

作者： Lori, Abbas Heydari Askari, Nahid Pourghadamyari, Hossein Department of Biotechnology Institute of Sciences and High Technology and Environmental Sciences Graduate University of Advanced Technology Kerman 000 Iran Applied Cellular and Molecular Research Center Kerman University of Medical Sciences Kerman 000 Iran

Objective: Despite advancements in diagnosing and treating colorectal cancer (CRC), long-term survival rates remain low. Long non-coding RNA (lncRNA) plays a role in CRC development, but its specific function is unclear. This study focused on lncRNA01730 and its connection to the MYC and Wnt/β-catenin pathways in CRC. Material and methods: Using the clusterProfiler package in R, we conducted a detailed GO and pathway enrichment analysis to map the genetic landscape. Results and Discussion: We confirmed the expression levels of lncRNA01730, MYC, and related targets in 32 CRC specimens and their adjacent normal tissues, as well as in cell lines, through qRT-PCR. To assess the correlation between tumor stage and clinical features, we performed a comprehensive analysis using patient data collected from medical records. Our findings revealed that lncRNA01730 levels were significantly elevated in CRC tissues, particularly in advanced stages, compared to normal tissues (p < 0.01). We utilized bioinformatics and experimental analysis to investigate the overexpression of lncRNA01730 and its correlation with tumor characteristics, such as histologic grade. Additionally, we examined its impact on the overexpression of the MYC and Wnt pathways, focusing on the AXIN2 and CTNNB genes. High lncRNA01730 expression was associated with more aggressive tumor characteristics and reduced overall survival. Conclusions: Our results indicate that lncRNA01730 could be a new biomarker for predicting CRC prognosis, offering insights into the molecular mechanisms of CRC progression and potential therapeutic targets. This study highlights the importance of lncRNA01730 in CRC and suggests it could be a valuable tool for improving patient outcomes. © Pleiades Publishing, Ltd. 2025.

关键词： biomarkers colorectal cancer gene expression regulation long non-coding RNA MYC

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End-To-End Training Of Object Segmentation Task And Video Question-Answering Task 17

End-To-End Training Of Object Segmentation Task And Video Qu...

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17th International Conference on Ubiquitous Information Management and Communication, IMCOM 2023

作者： Nakada, Hidemoto Asoh, Hideki National Institute of Advanced Industrial Science and Technology Artificial Intelligence Research Center Tukuba Japan

ISBN: (纸本)9781665453486

For complicated Visual Question Answering(VQA) tasks that incorporates multiple objects, to train the VQA model using segmented objects data as inputs is proved to be effective for various downstream tasks. In this work, we tried to train the VQA task model and object segmentation model in end-to-end fashion instead of training independently. We employed CLEVRER as a target VQA task. We first trained MONet(Multiple Object Network), an object segmentation network, with the dataset, and trained Aloe, a VQA model, using the output of the trained MONet. Finally we connect MONet and Aloe to fine-tune them in end-to-end setting and confirmed that the performance of VOA task has been greatly improved. © 2023 IEEE.

关键词： Computer vision

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Kinetic control of high pressure phase transitions in anatase TiO2

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Physical Review B 2025年第10期111卷 104108-104108页

作者： XiaoHui Chen Yi Zhang Lei Liu Shijia Ye Shourui Li Qiumin Jing Junjie Gao Jun Li Qiang Wu Hao Wang Chuanlong Lin Center for High Pressure Science and Technology Advanced Research Beijing 100094 China

Understanding the interplay between the thermodynamics and kinetics of phase transition under high pressure is a current challenge in material and physical sciences. Here, we present the structural response of anatase TiO2 up to 20 GPa and over compression rates ranging from 0.03 to 3.61 GPa/s, using a piezo-driven dynamic diamond anvil cell coupled with time-resolved Raman spectroscopy. It is found that the phase evolution of anatase TiO2 follows the expected thermodynamics path (i.e., anatase→α−PbO2→baddeleyite) regardless of the applied compression rate, however, the formation conditions of high pressure phases are kinetically controlled. Both phase boundaries increase approximately linearly with the logarithm of compression rate, that seems to resolve apparent contradictions between previous high pressure results. We ascribe these to the sluggish transition kinetics of a typical reconstructive transition mechanism, and highlight that the compression rate behaves as the third dimension within a high pressure phase diagram.

关键词： Titanium dioxide

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