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Nature Reviews Bioengineering 2023年 680页

作者： W. Taylor Kimberly Annabel J. Sorby-Adams Andrew G. Webb Ed X. Wu Rachel Beekman Kevin N. Sheth Ritvij Bowry Steven J. Schiff Adam de Havenon Francis X. Shen Gordon Sze Pamela Schaefer Juan Eugenio Iglesias Matthew S. Rosen Department of Neurology and the Center for Genomic Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA Department of Radiology Leiden University Medical Center Leiden The Netherlands Laboratory of Biomedical Imaging and Signal Processing Department of Electrical and Electronic Engineering The University of Hong Kong Hong Kong SAR China Division of Neurocritical Care and Emergency Neurology Department of Neurology Yale New Haven Hospital and Yale School of Medicine Yale Center for Brain & Mind Health New Haven CT USA Departments of Neurosurgery and Neurology McGovern Medical School University of Texas Health Neurosciences Houston TX USA Department of Neurosurgery Yale School of Medicine New Haven CT USA Division of Vascular Neurology Department of Neurology Yale New Haven Hospital and Yale School of Medicine New Haven CT USA Harvard Medical School Center for Bioethics Harvard law School Boston MA USA Department of Psychiatry Massachusetts General Hospital Boston MA USA Department of Radiology Yale New Haven Hospital and Yale School of Medicine New Haven CT USA Division of Neuroradiology Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston MA USA Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston MA USA Centre for Medical Image Computing University College London London UK Computer Science and AI Laboratory Massachusetts Institute of Technology Boston MA USA

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Roadmap on quantum nanotechnologies

arXiv

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arXiv 2021年

作者： Laucht, Arne Hohls, Frank Ubbelohde, Niels Fernando Gonzalez-Zalba, M. Reilly, David J. Stobbe, Søren Schröder, Tim Scarlino, Pasquale Koski, Jonne V. Dzurak, Andrew Yang, Chih-Hwan Yoneda, Jun Kuemmeth, Ferdinand Bluhm, Hendrik Pla, Jarryd Hill, Charles Salfi, Joe Oiwa, Akira Muhonen, Juha T. Verhagen, Ewold LaHaye, M.D. Kim, Hyun Ho Tsen, Adam W. Culcer, Dimitrie Geresdi, Attila Mol, Jan A. Mohan, Varun Jain, Prashant K. Baugh, Jonathan Centre for Quantum Computation and Communication Technology School of Electrical Engineering and Telecommunications UNSW SydneyNSW2052 Australia Physikalisch-Technische Bundesanstalt Braunschweig38116 Germany Quantum Motion Technologies Nexus Discovery Way LeedsLS2 3AA United Kingdom School of Physics University of Sydney SydneyNSW2006 Australia Microsoft Corporation Station Q Sydney University of Sydney SydneyNSW2006 Australia Department of Photonics Engineering DTU Fotonik Technical University of Denmark Building 343 Kgs. LyngbyDK-2800 Denmark Department of Physics Humboldt-Universität zu Berlin Berlin12489 Germany Department of Physics ETH Zürich ZürichCH-8093 Switzerland Niels Bohr Institute University of Copenhagen Copenhagen2100 Denmark JARA-FIT Institute for Quantum Information RWTH Aachen University and Forschungszentrum Jülich Aachen52074 Germany School of Physics University of Melbourne Melbourne Australia Department of Electrical and Computer Engineering The University of British Columbia VancouverBCV6T 1Z4 Canada The Institute of Scientific and Industrial Research Osaka University Ibaraki Osaka567-0047 Japan Center for Quantum Information and Quantum Biology Institute for open and Transdisciplinary Research Initiative Osaka University Osaka560-8531 Japan Center for Nanophotonics AMOLF Amsterdam1098 XG Netherlands School of Physics The University of New South Wales Sydney2052 Australia Australian Research Council Centre of Excellence in Future Low-Energy Electronics Technologies UNSW Node The University of New South Wales Sydney2052 Australia QuTech and Kavli Institute of Nanoscience Delft University of Technology Delft2600 GA Netherlands School of Physics and Astronomy Queen Mary University of London E1 4NS United Kingdom Department of Materials Science and Engineering University of Illinois at Urbana-Champaign UrbanaIL61801 United States Department of Chemistry University of Illinois at Urbana-Champaign Urbana

Quantum phenomena are typically observable at length and time scales smaller than those of our everyday experience, often involving individual particles or excitations. The past few decades have seen a revolution in the ability to structure matter at the nanoscale, and experiments at the single particle level have become commonplace. This has opened wide new avenues for exploring and harnessing quantum mechanical effects in condensed matter. These quantum phenomena, in turn, have the potential to revolutionize the way we communicate, compute and probe the nanoscale world. Here, we review developments in key areas of quantum research in light of the nanotechnologies that enable them, with a view to what the future holds. Materials and devices with nanoscale features are used for quantum metrology and sensing, as building blocks for quantum computing, and as sources and detectors for quantum communication. They enable explorations of quantum behaviour and unconventional states in nano- and opto-mechanical systems, low-dimensional systems, molecular devices, nano-plasmonics, quantum electrodynamics, scanning tunnelling microscopy, and more. This rapidly expanding intersection of nanotechnology and quantum science/technology is mutually beneficial to both fields, laying claim to some of the most exciting scientific leaps of the last decade, with more on the horizon. © 2021, CC BY.

关键词： Quantum computers

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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IROS 2019 lifelong robotic vision challenge lifelong object recognition report

arXiv

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arXiv 2020年

作者： She, Qi Feng, Fan Liu, Qi Chan, Rosa H.M. Hao, Xinyue Lan, Chuanlin Yang, Qihan Lomonaco, Vincenzo Parisi, German I. Ma, Liang Wu, Jianwen Zhong, Qiaoyong Xie, Di Pu, Shiliang Graffieti, Gabriele Pellegrini, Lorenzo Lomonaco, Vincenzo Maltoni, Davide Wang, Zhengwei Brophy, Eoin Ward, Tomás E. Zhou, Liguang Yang, Lin Goel, Vidit Sheet, Debdoot Kumar, Somesh Song, Soonyong Bae, Heechul Han, Hyonyoung Son, Youngsung Piyasena, Duvindu Kanagarajah, Sathursan Lam, Siew-Kei Wu, Meiqing Department of Electrical Engineering City University of Hong Kong Hong Kong Department of Electronic Engineering Tsinghua University Beijing University of Posts and Telecommunications Beijing China School of Electronic Information Wuhan University Wuhan China ContinualAI Research University of Bologna Italy ContinualAI Research University of Hamburg Germany Intel Labs and ContinualAI Research Hikvision Research Institute Hangzhou China University of Bologna Bologna Italy V-SENSE School of Computer Science and Statistics Trinity College Dublin Dublin Ireland Inisht Centre for Data Analytics School of Computing Dublin City University Dublin Ireland Shenzhen China Shenzhen Institute of Artificial Intelligence and Robotics for Society China Peking University Beijing China Shandong University Qingdao China Beijing Film Academy Beijing China Indian Institute of Technology Kharagpur India Korea Republic of Nanyang Technological University Singapore Singapore

This report summarizes IROS 2019-Lifelong Robotic Vision Competition (Lifelong Object Recognition Challenge) with methods and results from the top 8 finalists (out of over 150 teams). The competition dataset (L)ifel(O)ng (R)obotic V(IS)ion (OpenLORIS) - Object Recognition (OpenLORIS-object) is designed for driving lifelong/continual learning research and application in robotic vision domain, with everyday objects in home, office, campus, and mall scenarios. The dataset explicitly quantifies the variants of illumination, object occlusion, object size, camera-object distance/angles, and clutter information. Rules are designed to quantify the learning capability of the robotic vision system when faced with the objects appearing in the dynamic environments in the contest. Individual reports, dataset information, rules, and released source code can be found at the project homepage. Copyright © 2020, The Authors. All rights reserved.

关键词： Object recognition

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Author Correction: Greengenes2 unifies microbial data in a single reference tree

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Nature biotechnology 2024年第5期42卷 813页

作者： Daniel McDonald Yueyu Jiang Metin Balaban Kalen Cantrell Qiyun Zhu Antonio Gonzalez James T Morton Giorgia Nicolaou Donovan H Parks Søren M Karst Mads Albertsen Philip Hugenholtz Todd DeSantis Se Jin Song Andrew Bartko Aki S Havulinna Pekka Jousilahti Susan Cheng Michael Inouye Teemu Niiranen Mohit Jain Veikko Salomaa Leo Lahti Siavash Mirarab Rob Knight Department of Pediatrics University of California San Diego School of Medicine La Jolla CA USA. Department of Electrical and Computer Engineering University of California San Diego La Jolla CA USA. Bioinformatics and Systems Biology Program University of California San Diego La Jolla CA USA. Department of Computer Science and Engineering University of California San Diego La Jolla CA USA. School of Life Sciences Arizona State University Tempe AZ USA. Biodesign Center for Fundamental and Applied Microbiomics Arizona State University Tempe AZ USA. Biostatistics & Bioinformatics Branch Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA. Halicioglu Data Science Institute University of California San Diego La Jolla CA USA. Australian Centre for Ecogenomics School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Queensland Australia. Department of Obstetrics and Gynecology Columbia University New York NY USA. Department of Chemistry and Bioscience Aalborg University Aalborg Denmark. Department of Informatics Second Genome Brisbane CA USA. Center for Microbiome Innovation Jacobs School of Engineering University of California San Diego La Jolla CA USA. Finnish Institute for Health and Welfare Helsinki Finland. Institute for Molecular Medicine Finland FIMM-HiLIFE Helsinki Finland. Division of Cardiology Brigham and Women's Hospital Boston MA USA. Cedars-Sinai Medical Center Los Angeles CA USA. Cambridge Baker Systems Genomics Initiative Baker Heart and Diabetes Institute Melbourne Victoria Australia. Cambridge Baker Systems Genomics Initiative Department of Public Health and Primary Care University of Cambridge Cambridge UK. Division of Medicine Turku University Hospital and University of Turku Turku Finland. Sapient Bioanalytics LLC San Diego CA USA. Department of Computing University of Turku Turku Finland. Department of Pediatrics Uni

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Building a quantum engineering undergraduate program

arXiv

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arXiv 2021年

作者： Asfaw, Abraham Blais, Alexandre Brown, Kenneth R. Candelaria, Jonathan Cantwell, Christopher Carr, Lincoln D. Combes, Joshua Debroy, Dripto M. Donohue, John M. Economou, Sophia E. Edwards, Emily Fox, Michael F.J. Girvin, Steven M. Ho, Alan Hurst, Hilary M. Jacob, Zubin Johnson, Blake R. Johnston-Halperin, Ezekiel Joynt, Robert Kapit, Eliot Klein-Seetharaman, Judith Laforest, Martin Lewandowski, H.J. Lynn, Theresa W. McRae, Corey Rae H. Merzbacher, Celia Michalakis, Spyridon Narang, Prineha Oliver, William D. Palsberg, Jens Pappas, David P. Raymer, Michael G. Reilly, David J. Saffman, Mark Searles, Thomas A. Shapiro, Jeffrey H. Singh, Chandralekha IBM Quantum IBM T. J. Watson Research Center Yorktown HeightsNY United States Institut Quantique Département de Physique Université de Sherbrooke SherbrookeQCJ1K 2R1 Canada Canadian Institute for Advanced Research TorontoONM5G 1M1 Canada The Duke Quantum Center Department of Physics Department of Electrical and Computer Engineering Department of Chemistry Duke University DurhamNC27708 United States SystemX Program Department of Electrical Engineering Stanford University StanfordCA94305 United States Department of Physics and Astronomy University of Southern California Los AngelesCA90089 United States The Quantum Engineering Program Department of Physics Colorado School of Mines GoldenCO80401 United States The Department of Electrical Computer and Energy Engineering University of Colorado Boulder BoulderCO80309 United States The Institute for Quantum Computing University of Waterloo WaterlooONN2L 3G1 Canada The Department of Physics Virginia Tech BlacksburgVA24061 United States The IQUIST University of Illinois Urbana-Champaign UrbanaIL61801 United States JILA National Institute of Standards and Technology The University of Colorado BoulderCO80309 United States Department of Physics University of Colorado Boulder BoulderCO80309 United States The Department of Physics Imperial College London Prince Consort Road LondonSW7 2AZ United Kingdom The Yale Quantum Institute Department of Physics Yale University New HavenCT06520 United States Google Research VeniceCA90291 United States The Department of Physics & Astronomy San José State University San JoséCA95192 United States The School of Electrical and Computer Engineering Purdue University Indiana West Lafayatte47907 United States The Department of Physics The Ohio State University ColumbusOH43210 United States The Department of Physics University of Wisconsin-Madison 1150 University Avenue MadisonWI53706 United States The Quantitative Biosciences and Engineering

The rapidly growing quantum information science and engineering (QISE) industry will require both quantum-aware and quantum-proficient engineers at the bachelor's level. We provide a roadmap for building a quantum engineering education program to satisfy this need. For quantum-aware engineers, we describe how to design a first quantum engineering course accessible to all STEM students. For the education and training of quantum-proficient engineers, we detail both a quantum engineering minor accessible to all STEM majors, and a quantum track directly integrated into individual engineering majors. We propose that such programs typically require only three or four newly developed courses that complement existing engineering and science classes available on most larger campuses. We describe a conceptual quantum information science course for implementation at any post-secondary institution, including community colleges and military schools. QISE presents extraordinary opportunities to work towards rectifying issues of inclusivity and equity that continue to be pervasive within engineering. We present a plan to do so and describe how quantum engineering education presents an excellent set of education research opportunities. Finally, we outline a hands-on training plan on quantum hardware, a key component of any quantum engineering program, with a variety of technologies including optics, atoms and ions, cryogenic and solid-state technologies, nanofabrication, and control and readout electronics. Our recommendations provide a flexible framework that can be tailored for academic institutions ranging from teaching and undergraduate-focused two- and four-year colleges to research-intensive universities. © 2021, CC BY.

关键词： engineering education

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Learning from learning machines: A new generation of AI technology to meet the needs of science

arXiv

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arXiv 2021年

作者： Pion-Tonachini, Luca Bouchard, Kristofer Martin, Hector Garcia Peisert, Sean Holtz, W. Bradley Aswani, Anil Dwivedi, Dipankar Wainwright, Haruko Pilania, Ghanshyam Nachman, Benjamin Marrone, Babetta L. Falco, Nicola Prabhat Arnold, Daniel Wolf-Yadlin, Alejandro Powers, Sarah Climer, Sharlee Jackson, Quinn Carlson, Ty Sohn, Michael Zwart, Petrus Kumar, Neeraj Justice, Amy Tomlin, Claire Jacobson, Daniel Micklem, Gos Gkoutos, Georgios V. Bickel, Peter J. Cazier, Jean-Baptiste Müller, Juliane Webb-Robertson, Bobbie-Jo Stevens, Rick Anderson, Mark Kreutz-Delgado, Ken Mahoney, Michael W. Brown, James B. Pattern Computer Inc. Friday HarborWA98250 United States Biosciences Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Computational Research Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Helen Wils Neuroscience Institute Redwood Center for Theoretical Neuroscience Uc Berkeley BerkeleyCA94720 United States Doe Agile BioFoundry Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Joint BioEnergy Institute Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Bcam Basque Center for Applied Mathematics Bilbao48009 Spain Computer Science University of California Davis DavisCA95616 United States Cenic La MiradaCA90638 United States Health Informatics University of California Davis School of Medicine SacramentoCA95817 United States Berkeley Institute for Data Science University of California Berkeley BerkeleyCA94720 United States Industrial Engineering and Operations Research University of California Berkeley BerkeleyCA94720 United States Environmental & Earth Sciences Area Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Nuclear Engineering University of California Berkeley BerkeleyCA94720 United States Materials Science and Technology Division Los Alamos National Laboratory Los AlamosNM87545 United States Physics Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Bioscience Division Los Alamos National Laboratory Los AlamosNM87545 United States Earth and Environmental Sciences Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Energy Technologies Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Computing and Computational Sciences Oak Ridge National Laboratory Oak RidgeTN37831 United States Industrial & Systems Engineering The University of Tennessee KnoxvilleTN37996 United States Department of Computer Science University of Missouri-Saint Louis St. LouisMO63121 United

We outline emerging opportunities and challenges to enhance the utility of AI for scientific discovery. The distinct goals of AI for industry versus the goals of AI for science create tension between identifying patterns in data versus discovering patterns in the world from data. If we address the fundamental challenges associated with "bridging the gap" between domain-driven scientific models and data-driven AI learning machines, then we expect that these AI models can transform hypothesis generation, scientific discovery, and the scientific process itself. © 2021, CC BY.

关键词： Learning systems

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Music, computing, and Health: A Roadmap for the Current and Future Roles of Music Technology for Health Care and Well-Being

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Music and science 2021年 4卷

作者： Agres, Kat R. Schaefer, Rebecca S. Volk, Anja van Hooren, Susan Holzapfel, Andre Dalla Bella, Simone Müller, Meinard de Witte, Martina Herremans, Dorien Ramirez Melendez, Rafael Neerincx, Mark Ruiz, Sebastian Meredith, David Dimitriadis, Theo Magee, Wendy L. Yong Siew Toh Conservatory of Music National University of Singapore Singapore Social and Cognitive Computing Department Institute of High Performance Computing A*STAR Singapore Institute for Psychology Health Medical Neuropsychology Unit Leiden University Leiden Netherlands Leiden Institute for Brain and Cognition Leiden University Leiden Netherlands Academy of Creative and Performing Arts Leiden University Leiden Netherlands Department of Information and Computing Sciences Utrecht University Utrecht Netherlands Faculty of Health care Department of Arts Therapies Zuyd University of Applied Sciences Heerlen Netherlands KenVaK Research Centre for the Arts Therapies and Psychomotricity Heerlen Netherlands Faculty of Psychology Open University of The Netherlands Heerlen Netherlands Division of Media Technology and Interaction Design KTH Royal Institute of Technology Stockholm Sweden International Laboratory for Brain Music and Sound Research (BRAMS) Outremont QC Canada Department of Psychology University of Montreal Montreal QC Canada Centre for Research on Brain Language and Music (CRBLM) Montreal QC Canada University of Economics and Human Sciences in Warsaw Warsaw Poland International Audio Laboratories Erlangen Friedrich-Alexander Universität Erlangen-Nürnberg Erlangen Germany HAN University of Applied Sciences Department of Arts Therapies and Psychological Studies Nijmegen Netherlands University of Amsterdam Research Institute of Child Development and Education Amsterdam Netherlands Treatment Centre for People with Mild Intellectual Disabilities and Psychiatric and Behavioral Disorders Gennep Netherlands Information Systems Technology and Design Singapore University of Technology and Design Singapore Music and Machine Learning Lab Music Technology Group Universitat Pompeu Fabra Barcelona Spain Faculty of EEMCS Interactive Intelligence Group Delft University of Technology Delft Netherlands Centre for Digital Music School of Electronic Engineerin

The fields of music, health, and technology have seen significant interactions in recent years in developing music technology for health care and well-being. In an effort to strengthen the collaboration between the involved disciplines, the workshop “Music, computing, and Health” was held to discuss best practices and state-of-the-art at the intersection of these areas with researchers from music psychology and neuroscience, music therapy, music information retrieval, music technology, medical technology (medtech), and robotics. Following the discussions at the workshop, this article provides an overview of the different methods of the involved disciplines and their potential contributions to developing music technology for health and well-being. Furthermore, the article summarizes the state of the art in music technology that can be applied in various health scenarios and provides a perspective on challenges and opportunities for developing music technology that (1) supports person-centered care and evidence-based treatments, and (2) contributes to developing standardized, large-scale research on music-based interventions in an interdisciplinary manner. The article provides a resource for those seeking to engage in interdisciplinary research using music-based computational methods to develop technology for health care, and aims to inspire future research directions by evaluating the state of the art with respect to the challenges facing each field. © The Author(s) 2021.

关键词： health care interdisciplinarity MedTech music information retrieval (MIR) music neuroscience Music psychology music technology music therapy well-being

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Author Correction: Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data

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Nature communications 2021年第1期12卷 3169页

作者： Arman Eshaghi Alexandra L Young Peter A Wijeratne Ferran Prados Douglas L Arnold Sridar Narayanan Charles R G Guttmann Frederik Barkhof Daniel C Alexander Alan J Thompson Declan Chard Olga Ciccarelli Queen Square Multiple Sclerosis Centre Department of Neuroinflammation UCL Queen Square Institute of Neurology Faculty of Brain Sciences University College London London UK. a.eshaghi@ucl.ac.uk. Centre for Medical Image Computing (CMIC) Department of Computer Science Faculty of Engineering Sciences University College London London UK. a.eshaghi@ucl.ac.uk. Centre for Medical Image Computing (CMIC) Department of Computer Science Faculty of Engineering Sciences University College London London UK. Department of Neuroimaging Institute of Psychiatry Psychology and Neuroscience King's College London London UK. Queen Square Multiple Sclerosis Centre Department of Neuroinflammation UCL Queen Square Institute of Neurology Faculty of Brain Sciences University College London London UK. e-Health Centre Universitat Oberta de Catalunya Barcelona Spain. McConnell Brain Imaging Centre Montreal Neurological Institute McGill University Montreal QC Canada. Center for Neurological Imaging Brigham and Women's Hospital Harvard Medical School Boston MA USA. VU University Medical Centre Amsterdam The Netherlands. Department of Brain Repair and Rehabilitation UCL Queen Square Institute of Neurology Faculty of Brain Sciences University College London London UK. National Institute for Health Research University College London Hospitals Biomedical Research Centre London UK.

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Federated Learning Enables Big Data for Rare Cancer Boundary Detection

arXiv

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arXiv 2022年

作者： Pati, Sarthak Baid, Ujjwal Edwards, Brandon Sheller, Micah Wang, Shih-Han Reina, G. Anthony Foley, Patrick Gruzdev, Alexey Karkada, Deepthi Davatzikos, Christos Sako, Chiharu Ghodasara, Satyam Bilello, Michel Mohan, Suyash Vollmuth, Philipp Brugnara, Gianluca Preetha, Chandrakanth J. Sahm, Felix Maier-Hein, Klaus Zenk, Maximilian Bendszus, Martin Wick, Wolfgang Calabrese, Evan Rudie, Jeffrey Villanueva-Meyer, Javier Cha, Soonmee Ingalhalikar, Madhura Jadhav, Manali Pandey, Umang Saini, Jitender Garrett, John Larson, Matthew Jeraj, Robert Currie, Stuart Frood, Russell Fatania, Kavi Huang, Raymond Y. Chang, Ken Balana, Carmen Capellades, Jaume Puig, Josep Trenkler, Johannes Pichler, Josef Necker, Georg Haunschmidt, Andreas Meckel, Stephan Shukla, Gaurav Liem, Spencer Alexander, Gregory S. Lombardo, Joseph Palmer, Joshua D. Flanders, Adam E. Dicker, Adam P. Sair, Haris I. Jones, Craig K. Venkataraman, Archana Jiang, Meirui So, Tiffany Y. Chen, Cheng Heng, Pheng Ann Dou, Qi Kozubek, Michal Lux, Filip Michálek, Jan Matula, Petr Keřkovský, Miloš Kopřivová, Tereza Dostál, Marek Vybíhal, Václav Vogelbaum, Michael A. Mitchell, J. Ross Farinhas, Joaquim Maldjian, Joseph A. Yogananda, Chandan Ganesh Bangalore Pinho, Marco C. Reddy, Divya Holcomb, James Wagner, Benjamin C. Ellingson, Benjamin M. Cloughesy, Timothy F. Raymond, Catalina Oughourlian, Talia Hagiwara, Akifumi Wang, Chencai To, Minh-Son Bhardwaj, Sargam Chong, Chee Agzarian, Marc Falcão, Alexandre Xavier Martins, Samuel B. Teixeira, Bernardo C.A. Sprenger, Flávia Menotti, David Lucio, Diego R. LaMontagne, Pamela Marcus, Daniel Wiestler, Benedikt Kofler, Florian Ezhov, Ivan Metz, Marie Jain, Rajan Lee, Matthew Lui, Yvonne W. McKinley, Richard Slotboom, Johannes Radojewski, Piotr Meier, Raphael Wiest, Roland Derrick, Murcia Fu, Eric Haas, Rourke Thompson, John Ormond, David Ryan Badve, Chaitra Sloan, Andrew E. Vadmal, Vachan Waite, Kristin Colen, Rivka R. Pei, Linmin Ak, Murat Srinivasan, Ashok Bapuraj, J. Rajiv Rao, Arvind Wang, Nicholas Yoshiaki, Ota Moritani, Tos University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Pathology Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Informatics Technical University of Munich Bavaria Munich Germany Intel Corporation Santa ClaraCA United States Department of Quantitative Biomedicine University of Zurich Zurich Switzerland Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany Heidelberg Germany Department of Neuropathology Heidelberg University Hospital Heidelberg Germany Division of Medical Image Computing German Cancer Research Center Heidelberg Germany Neurology Clinic Heidelberg University Hospital Heidelberg Germany Department of Radiology & Biomedical Imaging University of California San Francisco San FranciscoCA United States Symbiosis Center for Medical Image Analysis Symbiosis International University Maharashtra Pune India Department of Neuroimaging and Interventional Radiology National Institute of Mental Health and Neurosciences Karnataka Bangalore India Department of Radiology School of Medicine and Public Health University of Wisconsin MadisonWI United States Department of Medical Physics School of Medicine and Public Health University of Wisconsin MadisonWI United States Department of Neuroradiology Clinical Neuroscience Center University Hospital Zurich University of Zurich Zurich Switzerland Leeds Teaching Hospitals Trust Department of Radiology Leeds United Kingdom Department of Radiology Brigham and Women's Hospital Harvard Medical School BostonMA United States Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital CharlestownMA United States Catalan Institute of Oncology Badalona Spain Consorci MAR Parc de Salut de Barcelona Catalonia Spain Josep Trueta University Hospital Girona Spain

Although machine learning (ML) has shown promise in numerous domains, there are concerns about generalizability to out-of-sample data. This is currently addressed by centrally sharing ample, and importantly diverse, data from multiple sites. However, such centralization is challenging to scale (or even not feasible) due to various limitations. Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here we present findings from the largest FL study to-date, involving data from 71 healthcare institutions across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, utilizing the largest dataset of such patients ever used in the literature (25,256 MRI scans from 6,314 patients). We demonstrate a 33% improvement over a publicly trained model to delineate the surgically targetable tumor, and 23% improvement over the tumor's entire extent. We anticipate our study to: 1) enable more studies in healthcare informed by large and diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further quantitative analyses for glioblastoma via performance optimization of our consensus model for eventual public release, and 3) demonstrate the effectiveness of FL at such scale and task complexity as a paradigm shift for multi-site collaborations, alleviating the need for data sharing. © 2022, CC BY.

关键词： Tumors

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