With the increasing take-up of PAT1 by the pharma- and bio-industries there is a critical need for robust spectral calibrations for processes which are subject to the variations in physical properties such as sample c...
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ISBN:
(纸本)9783902661616
With the increasing take-up of PAT1 by the pharma- and bio-industries there is a critical need for robust spectral calibrations for processes which are subject to the variations in physical properties such as sample compactness, surface topology, etc. The variation in the optical path-length materializing from the physical differences between samples may result in multiplicative light scattering influencing spectra in a nonlinear manner leading to the poor calibration performance. A new approach "Optical Path Length Estimation and Correction" overcomes the limitations of existing light scattering correction methods. Copyright 2007 IFAC.
With the increasing take-up of PAT 1 by the pharma- and bio- industries there is a critical need for robust spectral calibrations for processes which are subject to the variations in physical properties such as sample...
详细信息
With the increasing take-up of PAT 1 by the pharma- and bio- industries there is a critical need for robust spectral calibrations for processes which are subject to the variations in physical properties such as sample compactness, surface topology, etc. The variation in the optical path-length materializing from the physical differences between samples may result in multiplicative light scattering influencing spectra in a nonlinear manner leading to the poor calibration performance. A new approach “Optical Path Length Estimation and Correction” overcomes the limitations of existing light scattering correction methods.
Fault detection and diagnosis are important technologies for the safe and efficient operation of a chemical plant. This paper describes a sensor fault identification approach using variable reconstruction for dynamic ...
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The importance of the FDA PAT guidelines in pharmaceutical process design space can be influenced by the introduction of robust process malfunction and senor fault detection and diagnosis tools. The paper compares a m...
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The importance of the FDA PAT guidelines in pharmaceutical process design space can be influenced by the introduction of robust process malfunction and senor fault detection and diagnosis tools. The paper compares a m...
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The importance of the FDA PAT guidelines in pharmaceutical process design space can be influenced by the introduction of robust process malfunction and senor fault detection and diagnosis tools. The paper compares a multi-scale multi-block modelling approach with conventional multiway PCA approaches for batch process monitoring. A benchmark penicillin fermentation simulation is used to evaluate the two methodologies. Contributions plots with confidence bounds enhance the fault diagnosis potential of the approaches studied. The methodology is in the process of being evaluated in fermentation and batch cooling crystallisation.
Fault detection and diagnosis are important technologies for the safe and efficient operation of a chemical plant. This paper describes a sensor fault identification approach using variable reconstruction for dynamic ...
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Fault detection and diagnosis are important technologies for the safe and efficient operation of a chemical plant. This paper describes a sensor fault identification approach using variable reconstruction for dynamic systems. The proposed methodology extends sensor fault reconstruction for Canonical Variate Analysis based process performance monitoring which admits process dynamic behaviour in a natural way, and evaluates its capabilities compared to a dynamic PCA approach using a mathematical benchmark problem and a simulation of a closed loop controlled CSTR previously used for studying both simple and complex faults.
The objectives of dynamic data rectification are wide-ranging and include the estimation of the process states, process signal de-noising, and outlier detection and removal. One approach reported in the literature for...
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Fault detection and diagnosis are important for the safe and efficient operation of a chemical plant. This paper proposes a weighted combined contribution plot. Fault identification using either Q or T2 contribution p...
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A nonlinear multiscale multivariate statistical processcontrol method is proposed to address fault detection and diagnosis issues at different scales in nonlinear processes. A kernel principal component analysis (KPC...
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Fault detection and diagnosis are important for the safe and efficient operation of a chemical plant. This paper proposes a weighted combined contribution plot. Fault identification using either Q or T 2 contribution ...
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Fault detection and diagnosis are important for the safe and efficient operation of a chemical plant. This paper proposes a weighted combined contribution plot. Fault identification using either Q or T 2 contribution plot have shown to be incapable of identifying faults for correlated sensors systems. This paper proposes a combined index of Q and T 2 . The new index was able to uniquely identify the fault in the case of correlated sensors. The proposed approach is applied to a simulated CSTR process to show its performance.
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