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Nuclear Mechanics: Nuclear Mechanics within Intact Cells Is Regulated by Cytoskeletal Network and Internal Nanostructures (Small 18/2020)

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Small 2020年第18期16卷

作者： Jitao Zhang Farid Alisafaei Miloš Nikolić Xuefei A. Nou Hanyoup Kim Vivek B. Shenoy Giuliano Scarcelli Fischell Department of Bioengineering University of Maryland College Park MD 20742 USA Department of Materials Science and Engineering School of Engineering and Applied Science University of Pennsylvania Philadelphia PA 19104 USA Center for Engineering Mechanobiology University of Pennsylvania Philadelphia PA 19104 USA Maryland Biophysics Program University of Maryland College Park MD 20742 USA Canon U.S. Life Sciences Inc. 9800 Medical Center Drive Suite C-120 Rockville MD 20850 USA

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Surface tension assisted dynamic and uniform size generation of 3D spherical hydrogels (STA-DUH) 22

Surface tension assisted dynamic and uniform size generation...

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22nd International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2018

作者： Koduri, Manohar Prasad Garden, Tom Hunt, John A. Henstock, James Curran, Judith Tseng, Fan-Gang International Intercollegiate PhD Program NTHU Hsinchu Taiwan Department of Mechanical Materials and Aerospace School of Engineering University of Liverpool United Kingdom School of Science and Technology Nottingham Trent University NottinghamNG11 8NS United Kingdom Institute of Ageing and Chronic Disease William Henry Duncan Building University of Liverpool United Kingdom Engineering and System Science Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Taiwan

ISBN: (纸本)9781510897571

Technologies like additive manufacturing, microfluidics, and electrospray show a possibility of generating a variety of 3-Dimensional structures but seriously suffer in adapting and utilizing the wide variety of available biocompatible materials because of innate diverse physical and chemical properties of biomaterials. It is very important to have a technology which can be viable and dynamically adaptable for different types of materials in generating uniform structures. This work presents a novel cell-laden hydrogel generation using the surface tension phenomenon in controlling the size of the hydrogel. Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved.

关键词： Surface tension

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Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

Journal of Extracellular Biology

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Journal of Extracellular Biology 2022年第10期1卷 e63页

作者： Paolini, Lucia Monguió-Tortajada, Marta Costa, Marta Antenucci, Fabio Barilani, Mario Clos-Sansalvador, Marta Andrade, André Cronemberger Driedonks, Tom A. P. Giancaterino, Sara Kronstadt, Stephanie M. Mizenko, Rachel R. Nawaz, Muhammad Osteikoetxea, Xabier Pereira, Carla Shrivastava, Surya Boysen, Anders Toftegaard van de Wakker, Simonides Immanuel van Herwijnen, Martijn J. C. Wang, Xiaoqin Watson, Dionysios C. Gimona, Mario Kaparakis-Liaskos, Maria Konstantinov, Konstantin Lim, Sai Kiang Meisner-Kober, Nicole Stork, Michiel Nejsum, Peter Radeghieri, Annalisa Rohde, Eva Touzet, Nicolas Wauben, Marca H. M. Witwer, Kenneth W. Bongiovanni, Antonella Bergese, Paolo Department of Molecular and Translational Medicine University of Brescia Brescia Italy Center for Colloid and Surface Science (CSGI) Department of Chemistry University of Florence Sesto Fiorentino (FI) Italy Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia Italy CREC Research Program Health Science Research Institute Germans Trias i Pujol (IGTP) Badalona Spain Heart Institute (iCor) Cardiology Department Germans Trias i Pujol University Hospital Badalona Spain iBET Instituto de Biologia Experimental e Tecnológica Oeiras Portugal Instituto de Tecnologia Química e Biológica António Xavier Universidade Nova de Lisboa Oeiras Portugal Department of Veterinary and Animal Sciences University of Copenhagen Copenhagen Denmark Laboratory of Regenerative Medicine ‒ Cell Factory Department of Transfusion Medicine and Hematology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy REMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department University Hospital Germans Trias i Pujol (HUGTiP) Catalonia Badalona (Barcelona) Spain Department of Cell Biology Physiology and Immunology Universitat Autònoma de Barcelona (UAB) Bellaterra Spain Experimental and Clinical Cell Therapy Institute (ExCT) Spinal Cord Injury and Tissue Regeneration Center Paracelsus Medical University Salzburg Austria CDL Research University Medical Center Utrecht Utrecht University Utrecht Netherlands Department of Molecular and Comparative Pathology Johns Hopkins School of Medicine Baltimore MD United States Department of Civil Chemical Environmental and Materials Engineering Alma Mater Studiorum University of Bologna Bologna Italy Fischell Department of Bioengineering University of Maryland College Park MD United States Department of Biomedical Engineering University of California Davis CA United States Department of Rheumatology and Inflammation Research Institute of Medicine

Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, “The Extracellular Vesicle Foundry” (evFOUNDRY) and “Extracellular vesicles from a natural source for tailor-made nanomaterials” (VES4US), organized a workshop entitled “massivEVs” to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during “massivEVs”, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field. © 2022 The Authors. Journal of Extracellular Biology published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

关键词： EV-based products extracellular vesicles ISEV workshop large-scale production manufacturing processing regulatory issues

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Counterrotating magnetic order in the honeycomb layers of NaNi2BiO6−δ

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Physical Review B 2019年第21期100卷 214421-214421页

作者： A. Scheie K. Ross P. Peter Stavropoulos E. Seibel J. A. Rodriguez-Rivera J. A. Tang Yi Li Hae-Young Kee R. J. Cava C. Broholm Institute for Quantum Matter and Department of Physics and Astronomy Johns Hopkins University Baltimore Maryland 21218 USA Department of Physics Colorado State University Fort Collins Colorado 80523 USA Quantum Materials Program Canadian Institute for Advanced Research (CIFAR) Toronto Ontario Canada M5G 1Z8 Department of Physics University of Toronto Toronto Ontario Canada M5S 1A7 Department of Chemistry Princeton University Princeton New Jersey 08544 USA NIST Center for Neutron Research National Institute of Standards and Technology Gaithersburg Maryland 20899 USA Department of Materials Sciences University of Maryland College Park Maryland 20742 USA Department of Chemistry Johns Hopkins University Baltimore Maryland 21218 USA Department of Materials Science and Engineering Johns Hopkins University Baltimore Maryland 21218 USA

We report the magnetic structure and electronic properties of the honeycomb antiferromagnet NaNi2BiO5.66. We find magnetic order with moments along the c axis for temperatures below Tc1=6.3(1)K and then in the honeyco... 详细信息

关键词： Exchange interaction Magnetic interactions Magnetic order Magnetism Phase transitions Quantum spin liquid Specific heat Electron spin resonance Kitaev model Neutron scattering

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Anti-Inflammatory Glycosides from Gomphandra mollis Merr.: Structural Elucidation and Mechanistic Insights

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Phytochemistry 2025年

作者： Quoc-Dung Tran Huynh Thuy-Tien Thi Phan Man-Hsiu Chu Thanh-Vu Nguyen Truc-Ly Thi Duong Su-Jung Hsu Yun-Han Wang Ngoc-Thac Pham Bien-Thuy Nguyen Bui Dang-Khoa Nguyen Thanh-Hoa Vo Ta-Wei Liu Ching-Kuo Lee Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Institute of Pharmaceutical Education and Research Binh Duong University Thu Dau Mot 820000 Binh Duong Vietnam Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Biotechnology Center Of Ho Chi Minh City Ho Chi Minh 700000 Vietnam Faculty of Traditional medicine Can Tho University of Medicine and Pharmacy Can Tho 900000 Vietnam Faculty of Pharmacy Can Tho University of Medicine and Pharmacy Can Tho 900000 Vietnam Institute of Fisheries Science National Taiwan University Taipei 106 Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 11221 Taiwan University of Health Sciences Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam School of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Vietnam Center for Discovery and Development of Healthcare Product Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam Institute of Pharmaceutical Sciences Department of Pharmacognosy University of Graz Universitätsplatz 4 8010 Graz Austria Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Department of Chemistry Chung Yuan Christian University Zhongli District Taoyuan 32023 Taiwan

Eight previously unreported glycosides, designated gomphandranosides I–VIII, along with nine known compounds, were isolated from the roots of Gomphandra mollis Merr. Their structures were elucidated through comprehensive spectroscopic analyses, including NMR, HR-ESI-MS, CD, DP4+ probability, and ECD calculations. The anti-inflammatory activities of the isolated compounds were assessed using nitric oxide inhibition assays in LPS-stimulated RAW264.7 macrophages. Compounds 5 , 10 , and 16 exhibited significant anti-inflammatory activity with IC 50 values of 7.56 ± 0.9, 15.0 ± 1.2, and 14.2 ± 0.9 μM, respectively. Network pharmacology, gene ontology, Kyoto Encyclopedia of Genes and Genomes analysis, and molecular docking studies identified IL-6, TNF-α, MMP9, PTGS2, and HIF1A as key targets, with potentially involved in the NF- κ B and IL-17 signaling pathways. These findings highlight G. mollis as a promising candidate for the treatment of inflammation-related diseases.

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ELIMÄKI Locus Is Required for Vertical Proprioceptive Response in Birch Trees

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Current Biology 2020年第4期30卷 589-599.e5页

作者： Alonso-Serra, Juan Shi, Xueping Peaucelle, Alexis Rastas, Pasi Bourdon, Matthieu Immanen, Juha Takahashi, Junko Koivula, Hanna Eswaran, Gugan Muranen, Sampo Help, Hanna Smolander, Olli-Pekka Su, Chang Safronov, Omid Gerber, Lorenz Salojärvi, Jarkko Hagqvist, Risto Mähönen, Ari Pekka Helariutta, Ykä Nieminen, Kaisa Organismal and Evolutionary Biology Research Program Faculty of Biological and Environmental Sciences Viikki Plant Science Centre University of Helsinki Helsinki 00014 Finland Institute of Biotechnology HiLIFE University of Helsinki Helsinki 00014 Finland Key Laboratory of Horticultural Plant Biology of Ministry of Education College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan 430070 China Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Institut Jean-Pierre Bourgin INRA AgroParisTech CNRS Université Paris-Saclay Versailles 78000 France Production Systems Natural Resources Institute Finland (Luke) Helsinki 00790 Finland Umeå Plant Science Center Department of Forest Genetics and Plant Physiology Swedish University of Agricultural Sciences Umeå 901 83 Sweden Department of Food and Nutrition Faculty of Agriculture and Forestry University of Helsinki Helsinki 00014 Finland Department of Physics Division of Materials Sciences X-ray Laboratory University of Helsinki Helsinki 00014 Finland Department of Chemistry and Biotechnology School of Science Tallinn University of Technology Tallinn Estonia Genome Institute of Singapore Singapore 138672 Singapore Singapore Centre for Environmental Life Sciences Engineering Nanyang Technological University Singapore 63755 Singapore

Tree architecture has evolved to support a top-heavy above-ground biomass, but this integral feature poses a weight-induced challenge to trunk stability. Maintaining an upright stem is expected to require vertical proprioception through feedback between sensing stem weight and responding with radial growth. Despite its apparent importance, the principle by which plant stems respond to vertical loading forces remains largely unknown. Here, by manipulating the stem weight of downy birch (Betula pubescens) trees, we show that cambial development is modulated systemically along the stem. We carried out a genetic study on the underlying regulation by combining an accelerated birch flowering program with a recessive mutation at the ELIMÄKI locus (EKI), which causes a mechanically defective response to weight stimulus resulting in stem collapse after just 3 months. We observed delayed wood morphogenesis in eki compared with WT, along with a more mechanically elastic cambial zone and radial compression of xylem cell size, indicating that rapid tissue differentiation is critical for cambial growth under mechanical stress. Furthermore, the touch-induced mechanosensory pathway was transcriptionally misregulated in eki, indicating that the ELIMÄKI locus is required to integrate the weight-growth feedback regulation. By studying this birch mutant, we were able to dissect vertical proprioception from the gravitropic response associated with reaction wood formation. Our study provides evidence for both local and systemic responses to mechanical stimuli during secondary plant development. Alonso-Serra et al. use birch trees to explore vertical proprioception, the growth response of stems to changes in aerial body weight. They identify a genetic locus, which is required for this developmental response, and study the consequences of cambial growth under mechanical stress. © 2019 Elsevier Ltd

关键词： Betula forward genetics mechanosensing proprioception radial growth trees wood formation

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Search for the Magnetic Monopole at a Magnetoelectric Surface

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Physical Review X 2019年第1期9卷 011011-011011页

作者： Q. N. Meier M. Fechner T. Nozaki M. Sahashi Z. Salman T. Prokscha A. Suter P. Schoenherr M. Lilienblum P. Borisov I. E. Dzyaloshinskii M. Fiebig H. Luetkens N. A. Spaldin Department of Materials ETH Zurich CH-8093 Zürich Switzerland Max Planck Institute for the Structure and Dynamics of Matter 22761 Hamburg Germany Department of Electronic Engineering Tohoku University Sendai 980-8579 Japan ImPACT Program Japan Science and Technology Agency Tokyo 102-0076 Japan Laboratory for Muon Spin Spectroscopy Paul Scherrer Institute CH-5232 Villigen PSI Switzerland Department of Physics Loughborough University Loughborough LE11 3TU United Kingdom School of Physical Sciences University of California Irvine Irvine California 92697 USA

We show, by solving Maxwell’s equations, that an electric charge on the surface of a slab of a linear magnetoelectric material generates an image magnetic monopole below the surface provided that the magnetoelectric has a diagonal component in its magnetoelectric response. The image monopole, in turn, generates an ideal monopolar magnetic field outside of the slab. Using realistic values of the electric and magnetic field susceptibilities, we calculate the magnitude of the effect for the prototypical magnetoelectric material Cr2O3. We use low-energy muon spin rotation to measure the strength of the magnetic field generated by charged muons as a function of their distance from the surface of a Cr2O3 film and show that the results are consistent with the existence of the monopole. We discuss other possible routes to detecting the monopolar field, and show that, while the predicted monopolar field generated by Cr2O3 is above the detection limit for standard magnetic force microscopy, the detection of the field using this technique is prevented by surface charging effects.

关键词： Dielectric properties Magnetism

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Synthesis of Core@Shell Cu-Ni@Pt-Cu Nano-Octahedra and Their Improved MOR Activity

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Angewandte Chemie 2021年第14期133卷

作者： Can Li Xiaobo Chen Dr. Lihua Zhang Dr. Shaohui Yan Dr. Anju Sharma Dr. Bo Zhao Dr. Amar Kumbhar Prof. Dr. Guangwen Zhou Prof. Dr. Jiye Fang Department of Chemistry State University of New York at Binghamton Binghamton NY 13902 USA Materials Science and Engineering Program State University of New York at Binghamton Binghamton NY 13902 USA Center for Functional Nanomaterials Brookhaven National Laboratory Upton NY 11973 USA Present address: College of Environmental Science and Engineering Taiyuan University of Technology Taiyuan Shanxi Province China Analytical and Diagnostics Lab State University of New York at Binghamton Binghamton NY 13902 USA College of Arts & Sciences Microscopy Texas Tech University Lubbock TX 79409 USA Chapel Hill Analytical and Nanofabrication Laboratory University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Fabrication of 3 d metal-based core@shell nanocatalysts with engineered Pt-surfaces provides an effective approach for improving the catalytic performance. The challenges in such preparation include shape control of the 3 d metallic cores and thickness control of the Pt-based shells. Herein, we report a colloidal seed-mediated method to prepare octahedral CuNi@Pt-Cu core@shell nanocrystals using CuNi octahedral cores as the template. By precisely controlling the synthesis conditions including the deposition rate and diffusion rate of the shell-formation through tuning the capping ligand, reaction temperature, and heating rate, uniform Pt-based shells can be achieved with a thickness of <1 nm. The resultant carbon-supported CuNi@Pt-Cu core@shell nano-octahedra showed superior activity in electrochemical methanol oxidation reaction (MOR) compared with the commercial Pt/C catalysts and carbon-supported CuNi@Pt-Cu nano-polyhedron counterparts.

关键词： core@shell CuNi@Pt-Cu MOR activity nanocatalysts nano-octahedra

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Author Correction: Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

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Nature communications 2024年第1期15卷 6413页

作者： Xiaobo Mao Hao Gu Donghoon Kim Yasuyoshi Kimura Ning Wang Enquan Xu Ramhari Kumbhar Xiaotian Ming Haibo Wang Chan Chen Shengnan Zhang Chunyu Jia Yuqing Liu Hetao Bian Senthilkumar S Karuppagounder Fatih Akkentli Qi Chen Longgang Jia Heehong Hwang Su Hyun Lee Xiyu Ke Michael Chang Amanda Li Jun Yang Cyrus Rastegar Manjari Sriparna Preston Ge Saurav Brahmachari Sangjune Kim Shu Zhang Yasushi Shimoda Martina Saar Haiqing Liu Sin Ho Kweon Mingyao Ying Creg J Workman Dario A A Vignali Ulrike C Muller Cong Liu Han Seok Ko Valina L Dawson Ted M Dawson Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. xmao4@jhmi.edu. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. xmao4@jhmi.edu. Adrienne Helis Malvin Medical Research Foundation New Orleans LA 70130-2685 USA. xmao4@jhmi.edu. Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology Nanjing Brain Hospital Nanjing Jiangsu 210029 PR China. Medical College Yangzhou University Yangzhou Jiangsu 225001 PR China. Department of Pharmacology College of Medicine Dong-A University 32 Daesin Gongwwon-ro Seo-gu Busan 49201 Republic of Korea. Adrienne Helis Malvin Medical Research Foundation New Orleans LA 70130-2685 USA. Department of Anesthesiology West China Hospital Sichuan University. The Research Units of West China (2018RU012)-Chinese Academy of Medical Sciences West China Hospital Sichuan University Chengdu Sichuan 610041 PR China. Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 26 Qiuyue Road Shanghai 201210 China. University of the Chinese Academy of Sciences 19 A Yuquan Road Shijingshan District Beijing 100049 China. Institute for NanoBioTechnology Johns Hopkins University Baltimore MD 21218 USA. Department of Materials Science and Engineering Whiting School of Engineering Johns Hopkins University Baltimore MD 21218 USA. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA. Picower Institute for Learning and Memory Cambridge MA 02139 USA. Harvard-MIT MD/PhD Program Harvard Medical School Boston MA 02115 USA. Department of Biological Science and Biotechnology Chungbuk Nati

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Unified theory of thermal quenching in inorganic phosphors

arXiv

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arXiv 2019年

作者： Amachraa, Mahdi Wang, Zhenbin Tang, Hanmei Hariyani, Shruti Chen, Chi Brgoch, Jakoah Ong, Shyue Ping Materials Science and Engineering Program University of California San Diego 9500 Gilman Dr Mail Code 0418 San diegoCA92093-0448 United States Department of NanoEngineering University of California San Diego 9500 Gilman Dr Mail Code 0448 San diegoCA92093-0448 United States Department of Chemistry University of Houston College of Natural Sciences and Mathematics Science & Research Building 1 3507 Cullen Blvd Room 214 HoustonTX77204-5008 United States

We unify two prevailing theories of thermal quenching (TQ) in rare-earth-activated inorganic phosphors – the cross-over and auto-ionization mechanisms – into a single predictive model. Crucially, we have developed computable descriptors for activator environment stability from ab initio molecular dynamics simulations to predict TQ under the cross-over mechanism, which can be augmented by a band gap calculation to account for auto-ionization. The resulting TQ model predicts the experimental TQ in 29 known phosphors to within ~ 10-11%. Finally, we have developed an efficient topological approach to rapidly screen vast chemical spaces for the discovery of novel, thermally robust phosphors. Copyright © 2019, The Authors. All rights reserved.

关键词： Light emission

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