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Design Management Review 2014年第3期25卷

作者： John Maeda Steven Heller Tim Hoover Has been a design partner at Kleiner Perkins Caufield & Byers since January 2014 helping entrepreneurs and portfolio companies to build design into their company cultures. He served as the president of Rhode Island School of Design for six years through 2013 and also served as an associate director of research at the MIT Media Lab. Maeda has been a practicing designer since 1990 and his work is in the permanent collections of the Museum of Modern Art San Francisco Museum of Modern Art and the Cartier Foundation. He serves on the boards of several corporations including Sonos and Wieden + Kennedy and is chair of eBay's Design Advisory Board. His four published books include The Laws of Simplicity and Redesigning Leadership. Maeda is the recipient of a variety of international awards for his creative work including induction into the Art Director's Club Hall of Fame. In 2001 he received the White House National Design Award in 2002 he received the Mainichi Design Prize in Japan and in 2005 he was awarded the Raymond Loewy Foundation Prize in Germany. Maeda earned a BS and an MS from MIT in computer science and electrical engineering. He received a PhD in design science from the University of Tsukuba Institute of Art and Design in Japan as well as an MBA from Arizona State University. Co‐chair and co‐founder of the MFA Designer as Author and Entrepreneur program at the School of Visual Arts in New York. He was the art director of The New York Times Book Review and now writes the VISUALS column for the NYTBR. He also writes “The Daily Heller” at *** a weekly online design column for Atlantic magazine. He is author co‐author and editor of more than 165 books on the history and practice of graphic design illustration and satiric art. His forthcoming books include 100 Classic Graphic Design Magazines (Laurence King Publishers) and Raw Data: The Process Behind Information Graphics (Thames + Hudson). Heller was the 2011 recipient of the Smithsonian National Design Award for Design Mind. He has also writ

John Maeda is a past president of Rhode Island School of Design and an internationally known designer. He's now involved in helping entrepreneurs build design into their company cultures. Writer and educator Steven Heller pairs up with Tim Hoover, head of product and design at Canary, to talk about designer CEOs, start‐ups, and cutting out the middleman.

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Structural insights into conformational stability of both wild-type and mutant Insulin Receptor Gene

Next Research

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Next Research 2024年第2期1卷

作者： Chisom Soremekun Daudi Jjingo David Kateete Oyekanmi Nash Harald Grallert Annette Peters Tinashe Chikowore Chiara Batini Opeyemi Soremekun Segun Fatumo The African Computational Genomics (TACG) Research Group MRC/UVRI and LSHTM Uganda Research Unit Entebbe Uganda Department of Immunology and Molecular Biology School of Biomedical Sciences Makerere University College of Health Sciences Kampala Uganda H3Africa Bioinformatics Network (H3ABioNet) Node Centre for Genomics Research and Innovation NABDA/FMST Abuja Nigeria Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Institute of Epidemiology Ingolstädter Landstr. 1 85764 Neuherberg Germany African Center of Excellence in Bioinformatics (ACE-B) Makerere University Kampala 10101 Uganda Department of Computer Science College of Computing and Information Sciences Makerere University P.O Box 7062 Kampala Uganda German Center for Diabetes Research (DZD) München-Neuherberg Ingolstädter Landstr. 1 85764 Neuherberg Germany Chair of Epidemiology Institute for Medical Information Processing Biometry and Epidemiology Medical Faculty Ludwig-Maximilians-Universität München Munich Germany MRC/Wits Developmental Pathways for Health Research Unit Department of Paediatrics Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA USA Division of Genetics Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA USA Genetic Epidemiology Group Department of Health Sciences University of Leicester Leicester UK Leicester National Institute for Health and Care Research Biomedical Research Centre Glenfield Hospital Leicester UK Institute of Translational Genomics Helmholtz Zentrum München – German Research Center for Environmental Health Neuherberg Germany Molecular Bio-computation and Drug Design Laboratory School of Health Sciences University of KwaZulu-Natal Westville Campus Durban 4001 South Africa MRC/UVRI and LSHTM Uganda Research Unit Entebbe Uganda De

Type 2 diabetes (T2D) poses a health challenge. It can lead to complications such as heart disease, hypertension, heart failure, and stroke. Factors like obesity and lack of activity can contribute to insulin resistance. The insulin receptor gene ( INSR ) is responsible for producing insulin receptors. When this gene malfunctions, it can contribute to the development of T2D. In this study, we investigated the stability of the structure of variants of INSR using an extended molecular dynamics simulation and the perturbation effect of compound CheBI_88339 on the protein structure. During the analysis, we observed that all three systems—the wild-type INSR , the R1191Q variant, and the R1191Q variant bound to compound CheBI_88339 (R1191Q-D) reached equilibrium in 30ns without any instability. Throughout the simulation process, it was generally observed that the wild-type INSR exhibited higher stability than the R1191Q variant and R1191Q-D. The root mean square deviation (RMSD) and root mean square fluctuation (RMSF) of INSR , R1191Q and the variant bound to compound CheBI_88339 (R1191Q-D) are 9.28Å, 10.35Å, 8.65Å, 2.59Å, 2.98Å, and 2.89Å respectively. These values indicate that the mutated INSR introduced levels of deviations and flexibility in the protein structure. However, considering the variant bound to compound CheBI_88339 suggests that this drug may contribute to stabilizing the dynamics of the mutant protein. Overall, our findings shed light on the effect of genetic variants and their impact on protein stability. This research provides further insight into the dynamics of INSR and the potential of CheBI_88339 in targeting INSR . However, this study is computational, and further experimental studies are required.

关键词： Insulin receptor Type-2 diabetes Molecular dynamic simulation

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Sensitivity estimates for diffuse, point-like and extended neutrino sources with KM3NeT/ARCA 37

Sensitivity estimates for diffuse, point-like and extended n...

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37th International Cosmic Ray Conference, ICRC 2021

作者： Caiffi, B. Garcia Soto, A. Heijboer, A. Kulikovskiy, V. Muller, R.S. Sanguineti, M. Ageron, M. Aiello, S. Albert, A. Alshamsi, M. Alves Garre, S. Aly, Z. Ambrosone, A. Ameli, F. Andre, M. Androulakis, G. Anghinolfi, M. Anguita, M. Anton, G. Ardid, M. Ardid, S. Assal, W. Aublin, J. Bagatelas, C. Baret, B. Basegmez du Pree, S. Bendahman, M. Benfenati, F. Berbee, E. van den Berg, A.M. Bertin, V. Beurthey, S. van Beveren, V. Biagi, S. Billault, M. Bissinger, M. Boettcher, M. Bou Cabo, M. Boumaaza, J. Bouta, M. Boutonnet, C. Bouvet, G. Bouwhuis, M. Bozza, C. Brânzaş, H. Bruijn, R. Brunner, J. Bruno, R. Buis, E. Buompane, R. Busto, J. Caiffi, B. Caillat, L. Calvo, D. Campion, S. Capone, A. Carduner, H. Carretero, V. Castaldi, P. Celli, S. Cereseto, R. Chabab, M. Champion, C. Chau, N. Chen, A. Cherubini, S. Chiarella, V. Chiarusi, T. Circella, M. Cocimano, R. Coelho, J.A.B. Coleiro, A. Colomer Molla, M. Colonges, S. Coniglione, R. Cosquer, A. Coyle, P. Cresta, M. Creusot, A. Cruz, A. Cuttone, G. D’Amico, A. Dallier, R. De Martino, B. De Palma, M. Di Palma, I. Díaz, A.F. Diego-Tortosa, D. Distefano, C. Domi, A. Donzaud, C. Dornic, D. Dörr, M. Drouhin, D. Eberl, T. Eddyamoui, A. van Eeden, T. van Eijk, D. El Bojaddaini, I. Eljarrari, H. Elsaesser, D. Enzenhöfer, A. Espinosa, V. Fermani, P. Ferrara, G. Filipović, M.D. Filippini, F. Fransen, J. Fusco, L.A. Gajanana, D. Gal, T. García Méndez, J. Garcia Soto, A. Garçon, E. Garufi, F. Gatius, C. Geißelbrecht, N. Gialanella, L. Giorgio, E. Gozzini, S.R. Gracia, R. Graf, K. Grella, G. Guderian, D. Guidi, C. Guillon, B. Gutiérrez, M. Haefner, J. Hallmann, S. Hamdaoui, H. van Haren, H. Heijboer, A. Hekalo, A. Hennig, L. Henry, S. Hernández-Rey, J.J. Hofestädt, J. Huang, F. Idrissi Ibnsalih, W. Ilioni, A. Illuminati, G. James, C.W. Janezashvili, D. Jansweijer, P. de Jong, M. de Jong, P. Jung, B.J. Kadler, M. Kalaczyński, P. INFN - Sezione di Genova Via Dodecaneso 33 Genova16146 Italy Nikhef Science Park 105 Amsterdam1098 XG Netherlands University of Amsterdam Science Park 904 Amsterdam1098 XH Netherlands Dipartimento di Fisica dell’Università Via Dodecaneso 33 Genova16146 Italy Aix Marseille Univ CNRS IN2P3 CPPM Marseille France INFN Sezione di Catania Via Santa Sofia 64 Catania95123 Italy Université de Strasbourg CNRS IPHC UMR 7178 StrasbourgF-67000 France Université de Paris CNRS Astroparticule et Cosmologie ParisF-75013 France IFIC - Instituto de Física Corpuscular CSIC - Universitat de València c/Catedrático José Beltrán 2 Paterna Valencia46980 Spain INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo Via Cintia ed. G Napoli80126 Italy Università di Napoli "Federico II" Dip. Scienze Fisiche "E. Pancini" Complesso Universitario di Monte S. Angelo Via Cintia ed. G Napoli80126 Italy INFN Sezione di Roma Piazzale Aldo Moro 2 Roma00185 Italy Universitat Politècnica de Catalunya Laboratori d’Aplicacions Bioacústiques Centre Tecnològic de Vilanova i la Geltrú Avda. Rambla Exposició s/n Vilanova i la Geltrú08800 Spain NCSR Demokritos Institute of Nuclear and Particle Physics Ag. Paraskevi Attikis Athens15310 Greece INFN Sezione di Genova Via Dodecaneso 33 Genova16146 Italy University of Granada Dept. of Computer Architecture and Technology CITIC Granada18071 Spain Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Centre for Astroparticle Physics Erwin-Rommel-Straße 1 Erlangen91058 Germany Universitat Politècnica de València Instituto de Investigación para la Gestión Integrada de las Zonas Costeras C/Paranimf 1 Gandia46730 Spain Nikhef National Institute for Subatomic Physics PO Box 41882 Amsterdam1009 DB Netherlands University Mohammed V in Rabat Faculty of Sciences 4 av. Ibn Battouta B.P. 1014 RabatR.P. 10000 Morocco INFN Sezione di Bologna v.le C. Berti-Pichat 6/2 Bologna40127 Italy Dipartimento di Fisi

The identification of cosmic objects emitting high energy neutrinos could provide new insights about the Universe and its active sources. The existence of these cosmic neutrinos has been proven by the IceCube collaboration, but the big question of which sources these neutrinos originate from, remains unanswered. The KM3NeT detector for Astroparticle Research with Cosmics in the Abyss (ARCA), with a cubic kilometer instrumented volume, is currently being built in the Mediterranean Sea. It will excel at identifying cosmic neutrino sources due to its unprecedented angular resolution for muon neutrinos (◦ for E > 10 TeV neutrinos). KM3NeT has a view of the sky complementary to IceCube, and is sensitive to neutrinos across a wide range of energies. In order to identify the signature of cosmic neutrino sources in the background of atmospheric neutrinos and muons, statistical methods are being developed and tested with Monte-Carlo pseudo-experiments. This contribution presents the most recent sensitivity estimates for diffuse, point-like and extended neutrino sources with KM3NeT/ARCA. © Copyright owned by the author(s).

关键词： Cosmology

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Search for nuclearites with the KM3NeT detector 37

Search for nuclearites with the KM3NeT detector

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37th International Cosmic Ray Conference, ICRC 2021

作者： Păun, Alice Păvălaș, Gabriela Popa, Vlad Ageron, M. Aiello, S. Albert, A. Alshamsi, M. Alves Garre, S. Aly, Z. Ambrosone, A. Ameli, F. Andre, M. Androulakis, G. Anghinolfi, M. Anguita, M. Anton, G. Ardid, M. Ardid, S. Assal, W. Aublin, J. Bagatelas, C. Baret, B. Basegmez du Pree, S. Bendahman, M. Benfenati, F. Berbee, E. van den Berg, A.M. Bertin, V. Beurthey, S. van Beveren, V. Biagi, S. Billault, M. Bissinger, M. Boettcher, M. Bou Cabo, M. Boumaaza, J. Bouta, M. Boutonnet, C. Bouvet, G. Bouwhuis, M. Bozza, C. Branza, H. Bruijn, R. Brunner, J. Bruno, R. Buis, E. Buompane, R. Busto, J. Caiffi, B. Caillat, L. Calvo, D. Campion, S. Capone, A. Carduner, H. Carretero, V. Castaldi, P. Celli, S. Cereseto, R. Chabab, M. Champion, C. Chau, N. Chen, A. Cherubini, S. Chiarella, V. Chiarusi, T. Circella, M. Cocimano, R. Coelho, J.A.B. Coleiro, A. Colomer Molla, M. Colonges, S. Coniglione, R. Cosquer, A. Coyle, P. Cresta, M. Creusot, A. Cruz, A. Cuttone, G. D’Amico, A. Dallier, R. De Martino, B. De Palma, M. Di Palma, I. Díaz, A.F. Diego-Tortosa, D. Distefano, C. Domi, A. Donzaud, C. Dornic, D. Dörr, M. Drouhin, D. Eberl, T. Eddyamoui, A. van Eeden, T. van Eijk, D. El Bojaddaini, I. Eljarrari, H. Elsaesser, D. Enzenhöfer, A. Espinosa, V. Fermani, P. Ferrara, G. Filipović, M.D. Filippini, F. Fransen, J. Fusco, L.A. Gajanana, D. Gal, T. García Méndez, J. Garcia Soto, A. Garçon, E. Garufi, F. Gatius, C. Geißelbrecht, N. Gialanella, L. Giorgio, E. Gozzini, S.R. Gracia, R. Graf, K. Grella, G. Guderian, D. Guidi, C. Guillon, B. Gutiérrez, M. Haefner, J. Hallmann, S. Hamdaoui, H. van Haren, H. Heijboer, A. Hekalo, A. Hennig, L. Henry, S. Hernández-Rey, J.J. Hofestädt, J. Huang, F. Idrissi Ibnsalih, W. Ilioni, A. Illuminati, G. James, C.W. Janezashvili, D. Jansweijer, P. de Jong, M. de Jong, P. Jung, B.J. Kadler, M. Kalaczynski, P. Kalekin, O. Katz, U.F. Kayzel, F. Keller, P. Khan Chowdhury, N.R. Institute of Space Science Atomistilor 409 Magurele Romania Faculty of Physics University of Bucharest Atomistilor 405 Magurele Romania Aix Marseille Univ CNRS IN2P3 CPPM Marseille France INFN Sezione di Catania Via Santa Sofia 64 Catania95123 Italy Université de Strasbourg CNRS IPHC UMR 7178 StrasbourgF-67000 France Université de Paris CNRS Astroparticule et Cosmologie ParisF-75013 France c/Catedrático José Beltrán 2 Paterna Valencia46980 Spain INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo Via Cintia ed. G Napoli80126 Italy Università di Napoli "Federico II" Dip. Scienze Fisiche "E. Pancini" Complesso Universitario di Monte S. Angelo Via Cintia ed. G Napoli80126 Italy INFN Sezione di Roma Piazzale Aldo Moro 2 Roma00185 Italy Universitat Politècnica de Catalunya Laboratori d’Aplicacions Bioacústiques Centre Tecnològic de Vi- lanova i la Geltrú Avda. Rambla Exposició s/n Vilanova i la Geltrú08800 Spain NCSR Demokritos Institute of Nuclear and Particle Physics Ag. Paraskevi Attikis Athens15310 Greece INFN Sezione di Genova Via Dodecaneso 33 Genova16146 Italy University of Granada Dept. of Computer Architecture and Technology/CITIC Granada18071 Spain Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Centre for Astroparticle Physics Erwin- Rommel-Straße 1 Erlangen91058 Germany Universitat Politècnica de València Instituto de Investigación para la Gestión Integrada de las Zonas Costeras C/ Paranimf 1 Gandia46730 Spain Nikhef National Institute for Subatomic Physics PO Box 41882 Amsterdam1009 DB Netherlands University Mohammed V in Rabat Faculty of Sciences 4 av. Ibn Battouta B.P. 1014 RabatR.P. 10000 Morocco INFN Sezione di Bologna v.le C. Berti-Pichat 6/2 Bologna40127 Italy Universitàdi Bologna Dipartimentodi Fisicae Astronomia v.le C. Berti-Pichat 6/2 Bologna40127 Italy KVI-CART University of Groningen Groningen Netherlands INFN Laboratori Nazionali del Sud Via S. Sofia 62 Catan

Strange quark matter (SQM) is a hypothetical type of matter composed of almost equal quantities of up, down and strange quarks. In [1], Edward Witten presented the SQM as a denser and more stable matter that could represent the ground state of Quantum Chromodynamics (QCD). Massive SQM particles are called nuclearites. These particles could have been produced in violent astrophysical processes, such as neutron star collisions and could be present in the cosmic radiation. Nuclearites with masses greater than 1013 GeV and velocities of about 250 km/s (typical galactic velocities) could reach the Earth and interact with atoms and molecules of sea water within the sensitive volume of the deep-sea neutrino telescopes. The SQM particles can be detected with the KM3NeT telescope (whose first lines are already installed and taking data in the Mediterranean Sea) through the visible blackbody radiation generated along their path inside or near the instrumented area. In this work the results of a study using Monte Carlo simulations of down-going nuclearites are discussed. © Copyright owned by the author(s).

关键词： Monte Carlo methods

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The control unit of the KM3NeT data acquisition system

arXiv

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arXiv 2019年

作者： Aiello, S. Ameli, F. Andre, M. Androulakis, G. Anghinolfi, M. Anton, G. Ardid, M. Aublin, J. Bagatelas, C. Barbarino, G. Baret, B. Basegmez Du Pree, S. Bendahman, M. Berbee, E. Van Den Berg, A.M. Bertin, V. Biagi, S. Biagioni, A. Bissinger, M. Boumaaza, J. Bourret, S. Bouta, M. Bouvet, G. Bouwhuis, M. Bozza, C. Brânzaş, H. Bruchner, M. Bruijn, R. Brunner, J. Buis, E. Buompane, R. Busto, J. Calvo, D. Capone, A. Celli, S. Chabab, M. Chau, N. Cherubini, S. Chiarella, V. Chiarusi, T. Circella, M. Cocimano, R. Coelho, J.A.B. Coleiro, A. Colomer Molla, M. Coniglione, R. Coyle, P. Creusot, A. Cuttone, G. D'Onofrio, A. Dallier, R. De Palma, M. Di Palma, I. Díaz, A.F. Diego-Tortosa, D. Distefano, C. Domi, A. Donà, R. Donzaud, C. Dornic, D. Dörr, M. Durocher, M. Eberl, T. El Bojaddaini, I. Eljarrari, H. Elsaesser, D. Enzenhöfer, A. Fermani, P. Ferrara, G. Filipović, M.D. Franco, A. Fusco, L.A. Gal, T. Garcia Soto, A. Garufi, F. Gialanella, L. Giorgio, E. Gozzini, S.R. Gracia, R. Graf, K. Grasso, D. Grégoire, T. Grella, G. Guderian, D. Guidi, C. Hallmann, S. Hamdaoui, H. Van Haren, H. Heijboer, A. Hekalo, A. Hernández-Rey, J.J. Hofestädt, J. Huang, F. Illuminati, G. James, C.W. De Jong, M. De Jong, P. Kadler, M. Kalaczyński, P. Kalekin, O. Katz, U.F. Khan Chowdhury, N.R. Van Der Knaap, F. Koffeman, E.N. Kooijman, P. Kouchner, A. Kulikovskiy, V. Lahmann, R. Larosa, G. Le Breton, R. Leone, F. Leonora, E. Levi, G. Lincetto, M. Lonardo, A. Longhitano, F. Lopez-Coto, D. Maggi, G. Mańczak, J. Mannheim, K. Margiotta, A. Marinelli, A. Markou, C. Martignac, G. Martin, L. Martínez-Mora, J.A. Martini, A. Marzaioli, F. Mazzou, S. Mele, R. Melis, K.W. Migliozzi, P. Migneco, E. Mijakowski, P. Miranda, L.S. Mollo, C.M. Morganti, M. Moser, M. Moussa, A. Muller, R. Musumeci, M. Nauta, L. Navas, S. Nicolau, C.A. Nielsen, C. Fearraigh, B.Ó. Organokov, M. Orlando, A. Panagopoulos, V. Papalashvili, G. Papaleo, R. Pastore, C. INFN Sezione di Catania Via Santa Sofia 64 Catania95123 Italy INFN Sezione di Roma Piazzale Aldo Moro 2 Roma00185 Italy Universitat Politècnica de Catalunya Laboratori d'Aplicacions Bioacústiques Centre Tecnològic de Vilanova i la Geltrú Avda. Rambla Exposició s/n Vilanova i la Geltrú08800 Spain NCSR Demokritos Institute of Nuclear and Particle Physics Ag. Paraskevi Attikis Athens15310 Greece INFN Sezione di Genova Via Dodecaneso 33 Genova16146 Italy Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Centre for Astroparticle Physics Erwin-Rommel-Straße 1 Erlangen91058 Germany Universitat Politècnica de València Instituto de Investigación para la Gestión Integrada de las Zonas Costeras C/ Paranimf 1 Gandia46730 Spain APC Université Paris Diderot CNRS/IN2P3 CEA/IRFU Observatoire de Paris Sorbonne Paris Cité Paris75205 France INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo Via Cintia ed. G Napoli80126 Italy Università di Napoli "Federico II" Dip. Scienze Fisiche "E. Pancini" Complesso Universitario di Monte S. Angelo Via Cintia ed. G Napoli80126 Italy Nikhef National Institute for Subatomic Physics PO Box 41882 Amsterdam1009 DB Netherlands University Mohammed V in Rabat Faculty of Sciences 4 av. Ibn Battouta B.P. 1014 R.P Rabat10000 Morocco KVI-CART University of Groningen Groningen Netherlands Aix Marseille Univ CNRS/IN2P3 CPPM Marseille France INFN Laboratori Nazionali del Sud Via S. Sofia 62 Catania95123 Italy University Mohammed I Faculty of Sciences BV Mohammed VI B.P. 717 R.P Oujda60000 Morocco Subatech IMT Atlantique IN2P3-CNRS Université de Nantes 4 rue Alfred Kastler - La Chantrerie Nantes BP20722 44307 France Università di Salerno e INFN Gruppo Collegato di Salerno Dipartimento di Fisica Via Giovanni Paolo II 132 Fisciano84084 Italy ISS Atomistilor 409 MagureleRO-077125 Romania University of Amsterdam Institute of Physics/IHEF PO Box 94216 Amsterdam1090 GE Netherlands TNO

The KM3NeT Collaboration runs a multi-site neutrino observatory in the Mediterranean Sea. Water Cherenkov particle detectors, deep in the sea and far off the coasts of France and Italy, are already taking data while incremental construction progresses. Data Acquisition Control software is operating off-shore detectors as well as testing and qualification stations for their components. The software, named Control Unit, is highly modular. It can undergo upgrades and reconfiguration with the acquisition running. Interplay with the central database of the Collaboration is obtained in a way that allows for data taking even if Internet links fail. In order to simplify the management of computing resources in the long term, and to cope with possible hardware failures of one or more computers, the KM3NeT Control Unit software features a custom dynamic resource provisioning and failover technology, which is especially important for ensuring continuity in case of rare transient events in multi-messenger astronomy. The software architecture relies on ubiquitous tools and broadly adopted technologies and has been successfully tested on several operating systems. Copyright © 2019, The Authors. All rights reserved.

关键词： Data acquisition

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ANTARES search for point-sources of neutrinos using astrophysical catalogs: A likelihood stacking analysis

arXiv

引用

arXiv 2020年

作者： Albert, A. André, M. Anghinolfi, M. Anton, G. Ardid, M. Aubert, J.-J. Aublin, Julien Baret, B. Basa, S. Belhorma, B. Bertin, V. Biagi, S. Bissinger, M. Boumaaza, J. Bouta, M. Bouwhuis, M.C. Brânzaş, H. Bruijn, R. Brunner, J. Busto, J. Capone, A. Caramete, L. Carr, J. Carretero, V. Celli, S. Chabab, M. Chau, T.N. El Moursli, R. Cherkaoui Chiarusi, T. Circella, M. Coleiro, A. Colomer-Molla, M. Coniglione, R. Coyle, P. Creusot, A. Díaz, A.F. de Wasseige, G. Deschamps, A. Distefano, C. Di Palma, I. Domi, A. Donzaud, C. Dornic, D. Drouhin, D. Eberl, T. El Khayati, N. Enzenhöfer, A. Fermani, P. Ferrara, G. Filippini, F. Fusco, L. Gatelet, Y. Gay, P. Glotin, H. Gozzini, R. Gracía, R. Graf, K. Guidi, C. Hallmann, S. van Haren, H. Heijboer, A.J. Hello, Y. Hernández-Rey, J.J. Hößl, J. Hofestädt, J. Huang, F. Illuminati, G. James, C.W. Jisse-Jung, B. de Jong, M. de Jong, P. Jongen, M. Kadler, M. Kalekin, O. Katz, U. Khan-Chowdhury, N.R. Kouchner, A. Kreykenbohm, I. Kulikovskiy, V. Lahmann, R. Le Breton, R. Lefèvre, D. Leonora, E. Levi, G. Lincetto, M. Lopez-Coto, D. Loucatos, S. Maderer, L. Manczak, J. Marcelin, M. Margiotta, A. Marinelli, A. Martínez-Mora, J.A. Mazzou, S. Melis, K. Migliozzi, P. Moser, M. Moussa, A. Muller, R. Nauta, L. Navas, S. Nezri, E. Nuñez-Castiñeyra, A. O’Fearraigh, B. Organokov, M. Păvălaş, G.E. Pellegrino, C. Perrin-Terrin, M. Piattelli, P. Pieterse, C. Poirè, C. Popa, V. Pradier, T. Randazzo, N. Reck, S. Riccobene, G. Greus, F. Salesa Samtleben, D.F.E. Sánchez-Losa, A. Sanguineti, M. Sapienza, P. Schnabel, J. Schüssler, F. Spurio, M. Stolarczyk, T. Taiuti, M. Tayalati, Y. Thakore, T. Tingay, S.J. Vallage, B. van Elewyck, V. Versari, F. Viola, S. Vivolo, D. Wilms, J. Zegarelli, A. Zornoza, J.D. Zúñiga, J. Buson, S. Université de Strasbourg CNRS IPHC UMR 7178 StrasbourgF-67000 France Université de Haute Alsace MulhouseF-68200 France Technical University of Catalonia Laboratory of Applied Bioacoustics Rambla Exposició Vilanova i la Geltrú Barcelona08800 Spain INFN - Sezione di Genova Via Dodecaneso 33 Genova16146 Italy Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Centre for Astroparticle Physics Erwin-Rommel-Str. 1 Erlangen91058 Germany Universitat Politècnica de València C/ Paranimf 1 Gandia46730 Spain Aix Marseille Univ CNRS/IN2P3 CPPM Marseille France Université de Paris CNRS Astroparticule et Cosmologie ParisF-75006 France Aix Marseille Univ CNRS CNES LAM Marseille France National Center for Energy Sciences and Nuclear Techniques B.P.1382 R. P. Rabat10001 Morocco Via S. Sofia 62 Catania95123 Italy University Mohammed V in Rabat Faculty of Sciences 4 av. Ibn Battouta B.P. 1014 RabatR.P. 10000 Morocco University Mohammed I Laboratory of Physics of Matter and Radiations B.P.717 Oujda6000 Morocco Nikhef Science Park Amsterdam Netherlands Institute of Space Science MăgureleRO-077125 Bucharest Romania Universiteit van Amsterdam Instituut voor Hoge-Energie Fysica Science Park 105 Amsterdam1098 XG Netherlands INFN - Sezione di Roma P.le Aldo Moro 2 Roma00185 Italy Dipartimento di Fisica dell’Università La Sapienza P.le Aldo Moro 2 Roma00185 Italy c/ Catedrático José Beltrán 2 PaternaValenciaE-46980 Spain LPHEA Faculty of Science - Semlali Cadi Ayyad University P.O.B. 2390 Marrakech Morocco INFN - Sezione di Bologna Viale Berti-Pichat 6/2 Bologna40127 Italy INFN - Sezione di Bari Via E. Orabona 4 Bari70126 Italy Department of Computer Architecture and Technology/CITIC University of Granada Granada18071 Spain Géoazur UCA CNRS IRD Observatoire de la Côte d’Azur Sophia Antipolis France Dipartimento di Fisica dell’Università Via Dodecaneso 33 Genova16146 Italy Université Paris-Sud Orsay Cedex91405 Franc

A search for astrophysical point-like neutrino sources using the data collected by the ANTARES detector between January 29, 2007 and December 31, 2017 is presented. A likelihood stacking method is used to assess the significance of an excess of muon neutrinos inducing track-like events in correlation with the location of a list of possible sources. Different sets of objects are tested in the analysis: a) a sub-sample of the Fermi 3LAC catalog of blazars, b) a jet-obscured AGN population, c) a sample of soft gamma-ray selected radio galaxies, d) a star-forming galaxy catalog, and e) a public sample of 56 very-high-energy track events from the IceCube experiment. None of the tested sources shows a significant association with the sample of neutrinos detected by ANTARES. The smallest p-value is obtained for the radio galaxies catalog with an equal weights hypothesis, with a pre-trial p-value equivalent to a 2.8 σ excess, equivalent to 1.6 σ post-trial. In addition, the results of a dedicated analysis for the blazar MG3 J225517+2409 are also reported: this source is found to be the most significant within the Fermi 3LAC sample, with 5 ANTARES events located at less than one degree from the source. This blazar showed evidence of flaring activity in Fermi data, in space-time coincidence with a high-energy track detected by IceCube. An a posteriori significance of 2.0 σ for the combination of ANTARES and IceCube data is reported. Copyright © 2020, The Authors. All rights reserved.

关键词： Galaxies

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Measurement of the atmospheric νe and νµ energy spectra with the ANTARES neutrino telescope

arXiv

引用

arXiv 2021年

作者： Albert, A. Alves, S. André, M. Anghinolfi, M. Anton, G. Ardid, M. Aubert, J.-J. Aublin, J. Baret, B. Basa, S. Belhorma, B. Bendahman, M. Bertin, V. Biagi, S. Bissinger, M. Boumaaza, J. Bouta, M. Bouwhuis, M.C. Brânzaş, H. Bruijn, R. Brunner, J. Busto, J. Capone, A. Caramete, L. Carr, J. Carretero, V. Celli, S. Chabab, M. Chau, T.N. El Moursli, R. Cherkaoui Chiarusi, T. Circella, M. Coleiro, A. Colomer-Molla, M. Coniglione, R. Coyle, P. Creusot, A. Díaz, A.F. de Wasseige, G. Deschamps, A. Distefano, C. Di Palma, I. Domi, A. Donzaud, C. Dornic, D. Drouhin, D. Eberl, T. El Khayati, N. Enzenhöfer, A. Fermani, P. Ferrara, G. Filippini, F. Fusco, L. García, R. Gatelet, Y. Gay, P. Glotin, H. Gozzini, R. Graf, K. Guidi, C. Hallmann, S. van Haren, H. Heijboer, A.J. Hello, Y. Hernández-Rey, J.J. Hößl, J. Hofestädt, J. Huang, F. Illuminati, G. James, C.W. Jisse-Jung, B. de Jong, M. de Jong, P. Jongen, M. Kadler, M. Kalekin, O. Katz, U. Khan-Chowdhury, N.R. Kouchner, A. Kreykenbohm, I. Kulikovskiy, V. Lahmann, R. Le Breton, R. Lefèvre, D. Leonora, E. Levi, G. Lincetto, M. Lopez-Coto, D. Loucatos, S. Maderer, L. Manczak, J. Marcelin, M. Margiotta, A. Marinelli, A. Martínez-Mora, J.A. Melis, K. Migliozzi, P. Moser, M. Moussa, A. Muller, R. Nauta, L. Navas, S. Nezri, E. Nuñez-Castiñeyra, A. O'Fearraigh, B. Organokov, M. Pavalaş, G.E. Pellegrino, C. Perrin-Terrin, M. Piattelli, P. Pieterse, C. Poirè, C. Popa, V. Pradier, T. Randazzo, N. Reck, S. Riccobene, G. Greus, F. Salesa Samtleben, D.F.E. Sánchez-Losa, A. Sanguineti, M. Sapienza, P. Schnabel, J. Schumann, J. Schüssler, F. Spurio, Maurizio Stolarczyk, Th. Taiuti, M. Tayalati, Y. Thakore, T. Tingay, S.J. Vallage, B. van Elewyck, V. Versari, F. Viola, S. Vivolo, D. Wilms, J. Zegarelli, A. Zornoza, J.D. Zúñiga, J. Université de Strasbourg CNRS IPHC UMR 7178 StrasbourgF-67000 France Université de Haute Alsace MulhouseF-68200 France Technical University of Catalonia Laboratory of Applied Bioacoustics Rambla Exposició Vilanova i la Geltrú Barcelona08800 Spain INFN - Sezione di Genova Via Dodecaneso 33 Genova16146 Italy Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Centre for Astroparticle Physics Erwin-Rommel-Str. 1 Erlangen91058 Germany Universitat Politècnica de València C/ Paranimf 1 Gandia46730 Spain Aix Marseille Univ CNRS IN2P3 CPPM Marseille France Université de Paris CNRS Astroparticule et Cosmologie ParisF-75006 France Aix Marseille Univ CNRS CNES LAM Marseille France National Center for Energy Sciences and Nuclear Techniques B.P.1382 R.P. Rabat10001 Morocco University Mohammed V in Rabat Faculty of Sciences 4 av. Ibn Battouta B.P. 1014 RabatR.P. 10000 Morocco Via S. Sofia 62 Catania95123 Italy University Mohammed I Laboratory of Physics of Matter and Radiations B.P.717 Oujda6000 Morocco Nikhef Science Park Amsterdam Netherlands Institute of Space Science Bucharest M agureleRO-077125 Romania Universiteit van Amsterdam Instituut voor Hoge-Energie Fysica Science Park 105 Amsterdam1098 XG Netherlands INFN - Sezione di Roma P.le Aldo Moro 2 Roma00185 Italy Dipartimento di Fisica dell'Università La Sapienza P.le Aldo Moro 2 Roma00185 Italy IFIC - Instituto de Física Corpuscular CSIC Universitat de València c/ Catedrático José Beltrán 2 Paterna ValenciaE-46980 Spain LPHEA Faculty of Science - Semlali Cadi Ayyad University P.O.B. 2390 Marrakech Morocco INFN - Sezione di Bologna Viale Berti-Pichat 6/2 Bologna40127 Italy INFN - Sezione di Bari Via E. Orabona 4 Bari70126 Italy Department of Computer Architecture and Technology CITIC University of Granada Granada18071 Spain Géoazur UCA CNRS IRD Observatoire de la Côte d'Azur Sophia Antipolis France Dipartimento di Fisica dell'Università Via Dodecan

This letter presents a combined measurement of the energy spectra of atmospheric νe and νµ in the energy range between ∼100 GeV and ∼50 TeV with the ANTARES neutrino telescope. The analysis uses 3012 days of detector livetime in the period 2007-2017, and selects 1016 neutrinos interacting in (or close to) the instrumented volume of the detector, yielding shower-like events (mainly from νe + νe charged current plus all neutrino neutral current interactions) and starting track events (mainly from νµ+ν̅µ charged current interactions). The contamination by atmospheric muons in the final sample is suppressed at the level of a few per mill by different steps in the selection analysis, including a Boosted Decision Tree classifier. The distribution of reconstructed events is unfolded in terms of electron and muon neutrino fluxes. The derived energy spectra are compared with previous measurements that, above 100 GeV, are limited to experiments in polar ice and, for νµ, to Super-Kamiokande. © 2021, CC BY-NC-ND.

关键词： Tellurium compounds

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Observation of the cosmic ray shadow of the Sun with the ANTARES neutrino telescope

arXiv

引用

arXiv 2020年

作者： Albert, A. André, M. Anghinolfi, M. Anton, G. Ardid, M. Aubert, J.-J. Aublin, J. Baret, B. Basa, S. Belhorma, B. Bertin, V. Biagi, S. Bissinger, M. Boumaaza, J. Bouta, M. Bouwhuis, M.C. Brânzaş, H. Bruijn, R. Brunner, J. Busto, J. Capone, A. Caramete, L. Carr, J. Celli, S. Chabab, M. Chau, T.N. Cherkaoui El Moursli, R. Chiarusi, T. Circella, M. Coleiro, A. Colomer-Molla, M. Coniglione, R. Coyle, P. Creusot, A. Díaz, A.F. de Wasseige, G. Deschamps, A. Distefano, C. Di Palma, I. Domi, A. Donzaud, C. Dornic, D. Drouhin, D. Eberl, T. El Khayati, N. Enzenhöfer, A. Ettahiri, A. Fermani, P. Ferrara, G. Filippini, F. Fusco, L. Gay, P. Glotin, H. Gozzini, R. Graf, K. Guidi, C. Hallmann, S. van Haren, H. Heijboer, A.J. Hello, Y. Hernández-Rey, J.J. Hößl, J. Hofestädt, J. Huang, F. Illuminati, G. James, C.W. de Jong, M. de Jong, P. Jongen, M. Kadler, M. Kalekin, O. Katz, U. Khan-Chowdhury, N.R. Kouchner, A. Kreykenbohm, I. Kulikovskiy, V. Lahmann, R. Le Breton, R. Lefèvre, D. Leonora, E. Levi, G. Lincetto, M. Lopez-Coto, D. Loucatos, S. Maggi, G. Manczak, J. Marcelin, M. Margiotta, A. Marinelli, A. Martínez-Mora, J.A. Mele, R. Melis, K. Migliozzi, P. Moser, M. Moussa, A. Muller, R. Nauta, L. Navas, S. Nezri, E. Nielsen, C. Nuñez-Castiñeyra, A. O’Fearraigh, B. Organokov, M. Avalaş, G.E.P. Pellegrino, C. Perrin-Terrin, M. Piattelli, P. Poirè, C. Popa, V. Pradier, T. Randazzo, N. Reck, S. Riccobene, G. Romanov, A. Sánchez-Losa, A. Samtleben, D.F.E. Sanguineti, M. Sapienza, P. Schnabel, J. Schüssler, F. Spurio, M. Stolarczyk, Th. Strandberg, B. Taiuti, M. Tayalati, Y. Thakore, T. Tingay, S.J. Vallage, B. van Elewyck, V. Versari, F. Viola, S. Vivolo, D. Wilms, J. Zegarelli, A. Zornoza, J.D. Zúñiga, J. Université de Strasbourg CNRS IPHC UMR 7178 StrasbourgF-67000 France Université de Haute Alsace MulhouseF-68200 France Technical University of Catalonia Laboratory of Applied Bioacoustics Rambla Exposició Vilanova i la Geltrú Barcelona08800 Spain INFN - Sezione di Genova Via Dodecaneso 33 Genova16146 Italy Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Centre for Astroparticle Physics Erwin-Rommel-Str. 1 Erlangen91058 Germany Universitat Politècnica de València C/ Paranimf 1 Gandia46730 Spain Aix Marseille Univ CNRS/IN2P3 CPPM Marseille France Université de Paris CNRS Astroparticule et Cosmologie ParisF-75006 France Aix Marseille Univ CNRS CNES LAM Marseille France National Center for Energy Sciences and Nuclear Techniques B.P.1382 R. P. Rabat10001 Morocco Via S. Sofia 62 Catania95123 Italy University Mohammed V in Rabat Faculty of Sciences 4 av. Ibn Battouta B.P. 1014 RabatR.P. 10000 Morocco University Mohammed I Laboratory of Physics of Matter and Radiations B.P.717 Oujda6000 Morocco Nikhef Science Park Amsterdam Netherlands Institute of Space Science MagureleRO-077125 Bucharest Romania Universiteit van Amsterdam Instituut voor Hoge-Energie Fysica Science Park 105 Amsterdam1098 XG Netherlands INFN - Sezione di Roma P.le Aldo Moro 2 Roma00185 Italy Dipartimento di Fisica dell’Università La Sapienza P.le Aldo Moro 2 Roma00185 Italy LPHEA Faculty of Science - Semlali Cadi Ayyad University P.O.B. 2390 Marrakech Morocco INFN - Sezione di Bologna Viale Berti-Pichat 6/2 Bologna40127 Italy INFN - Sezione di Bari Via E. Orabona 4 Bari70126 Italy c/ Catedrático José Beltrán 2 PaternaValenciaE-46980 Spain Department of Computer Architecture and Technology/CITIC University of Granada Granada18071 Spain Géoazur UCA CNRS IRD Observatoire de la Côte d’Azur Sophia Antipolis France Dipartimento di Fisica dell’Università Via Dodecaneso 33 Genova16146 Italy Université Paris-Sud Orsay Cedex91405 Franc

The ANTARES detector is an undersea neutrino telescope in the Mediterranean Sea. The search for point-like neutrino sources is one of the main goals of the ANTARES telescope, requiring a reliable method to evaluate the detector angular resolution and pointing accuracy. This work describes the study of the Sun "shadow" effect with the ANTARES detector. The shadow is the deficit in the atmospheric muon flux in the direction of the Sun caused by the absorption of the primary cosmic rays. This analysis is based on the data collected between 2008 and 2017 by the ANTARES telescope. The observed statistical significance of the Sun shadow detection is 3.9σ, with an estimated angular resolution of 0.45◦±0.12◦ for downward-going muons. The pointing accuracy is found to be consistent with the expectations and no evidence of systematic pointing shifts is observed. Copyright © 2020, The Authors. All rights reserved.

关键词： Cosmic rays

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Limits on the nuclearite flux using the ANTARES neutrino telescope

arXiv

引用

arXiv 2022年

作者： Albert, A. Alves, S. André, M. Ardid, M. Ardid, S. Aubert, J.-J. Aublin, J. Baret, B. Basa, S. Belhorma, B. Bendahman, M. Benfenati, F. Bertin, V. Biagi, S. Bissinger, M. Boumaaza, J. Bouta, M. Bouwhuis, M.C. Brânzaş, H. Bruijn, R. Brunner, J. Busto, J. Caiffi, B. Calvo, D. Capone, A. Caramete, L. Carr, J. Carretero, V. Celli, S. Chabab, M. Chau, T.N. El Moursli, R. Cherkaoui Chiarusi, T. Circella, M. Coelho, J.A.B. Coleiro, A. Coniglione, R. Coyle, P. Creusot, A. Díaz, A.F. de Wasseige, G. De Martino, B. Distefano, C. Di Palma, I. Domi, A. Donzaud, C. Dornic, D. Drouhin, D. Eberl, T. van Eeden, T. van Eijk, D. El Khayati, N. Enzenhöfer, A. Fermani, P. Ferrara, G. Filippini, F. Fusco, L. García, J. Gay, P. Glotin, H. Gozzini, R. Ruiz, R. Gracia Graf, K. Guidi, C. Hallmann, S. van Haren, H. Heijboer, A.J. Hello, Y. Hernández-Rey, J.J. Hößl, J. Hofestädt, J. Huang, F. Illuminati, G. James, C.W. Jisse-Jung, B. de Jong, M. de Jong, P. Kadler, M. Kalekin, O. Katz, U. Kouchner, A. Kreykenbohm, I. Kulikovskiy, V. Lahmann, R. Lamoureux, M. Le Breton, R. Lefèvre, D. Leonora, E. Levi, G. Le Stum, S. Lopez-Coto, D. Loucatos, S. Maderer, L. Manczak, J. Marcelin, M. Margiotta, A. Marinelli, A. Martínez-Mora, J.A. Melis, K. Migliozzi, P. Moussa, A. Muller, R. Nauta, L. Navas, S. Nezri, E. Fearraigh, B.Ó. Păun, A. Păvălaş, G.E. Pellegrino, C. Perrin-Terrin, M. Pestel, V. Piattelli, P. Pieterse, C. Poirè, C. Popa, V. Pradier, T. Randazzo, N. Real, D. Reck, S. Riccobene, G. Romanov, A. Sánchez-Losa, A. Greus, F. Salesa Samtleben, D.F.E. Sanguineti, M. Sapienza, P. Schnabel, J. Schumann, J. Schüssler, F. Seneca, J. Spurio, M. Stolarczyk, Th Taiuti, M. Tayalati, Y. Tingay, S.J. Vallage, B. Van Elewyck, V. Versari, F. Viola, S. Vivolo, D. Wilms, J. Zavatarelli, S. Zegarelli, A. Zornoza, J.D. Zúñiga, J. Université de Strasbourg CNRS IPHC UMR 7178 StrasbourgF-67000 France Université de Haute Alsace MulhouseF-68100 France c/ Catedrático José Beltrán Paterna Valencia2 E-46980 Spain Technical University of Catalonia Laboratory of Applied Bioacoustics Rambla Exposició Vilanova i la Geltrú Barcelona08800 Spain Universitat Politècnica de València C/ Paranimf 1 Gandia46730 Spain Aix Marseille Univ CNRS IN2P3 CPPM Marseille France Université de Paris CNRS Astroparticule et Cosmologie ParisF-75013 France Aix Marseille Univ CNRS CNES LAM Marseille France National Center for Energy Sciences and Nuclear Techniques B.P.1382 R. P.10001 Rabat Morocco Mohammed V University in Rabat Faculty of Sciences 4 av. Ibn Battouta B.P. 1014 RabatR.P. 10000 Morocco Institute of Applied Physics Mohammed VI Polytechnic University Lot 660 Hay Moulay Rachid Ben Guerir43150 Morocco INFN - Sezione di Bologna Viale Berti-Pichat 6/2 Bologna40127 Italy Dipartimento di Fisica e Astronomia dell’Università Viale Berti Pichat 6/2 Bologna40127 Italy Via S. Sofia 62 Catania95123 Italy Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Centre for Astroparticle Physics Erwin-Rommel-Str. 1 Erlangen91058 Germany University Mohammed I Laboratory of Physics of Matter and Radiations B.P.717 Oujda6000 Morocco Nikhef Science Park Amsterdam Netherlands Institute of Space Science Bucharest MăgureleRO-077125 Romania Universiteit van Amsterdam Instituut voor Hoge-Energie Fysica Science Park 105 Amsterdam1098 XG Netherlands INFN - Sezione di Genova Via Dodecaneso 33 Genova16146 Italy INFN - Sezione di Roma P.le Aldo Moro 2 Roma00185 Italy Dipartimento di Fisica dell’Università La Sapienza P.le Aldo Moro 2 Roma00185 Italy LPHEA Faculty of Science - Semlali Cadi Ayyad University MarrakechP.O.B. 2390 Morocco INFN - Sezione di Bari Via E. Orabona 4 Bari70126 Italy Department of Computer Architecture and Technology CITIC University of Granada Granada1

In this work, a search for nuclearites of strange quark matter by using nine years of ANTARES data taken in the period 2009-2017 is presented. The passage through matter of these particles is simulated taking into account a detailed description of the detector response to nuclearites and of the data acquisition conditions. A downgoing flux of cosmic nuclearites with Galactic velocities (β = 10−3) was considered for this study. The mass threshold for detecting these particles at the detector level is 4 × 1013 GeV/c2. Upper limits on the nuclearite flux for masses up to 1017 GeV/c2 at the level of ∼ 5 × 10−17 cm−2 s−1 sr−1 are obtained. These are the first upper limits on nuclearites established with a neutrino telescope and the most stringent ever set for Galactic velocities. © 2022, CC BY.

关键词： Telescopes

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Constraining the contribution of Gamma-Ray Bursts to the high-energy diffuse neutrino flux with 10 years of ANTARES data

arXiv

引用

arXiv 2020年

作者： Albert, A. André, M. Anghinolfi, M. Anton, G. Ardid, M. Aubert, J.-J. Aublin, J. Baret, B. Basa, S. Belhorma, B. Bertin, V. Biagi, S. Bissinger, M. Boumaaza, J. Bouta, M. Bouwhuis, M.C. Brânzaş, H. Bruijn, R. Brunner, J. Busto, J. Capone, A. Caramete, L. Carr, J. Celli, S. Chabab, M. Chau, T.N. Cherkaoui El Moursli, R. Chiarusi, T. Circella, M. Coleiro, A. Colomer-Molla, M. Coniglione, R. Coyle, P. Creusot, A. Díaz, A.F. de Wasseige, G. Deschamps, A. Distefano, C. Di Palma, I. Domi, A. Donzaud, C. Dornic, D. Drouhin, D. Eberl, T. El Khayati, N. Enzenhöfer, A. Ettahiri, A. Fermani, P. Ferrara, G. Filippini, F. Fusco, L. Gay, P. Glotin, H. Gozzini, R. Graf, K. Guidi, C. Hallmann, S. van Haren, H. Heijboer, A.J. Hello, Y. Hernández-Rey, J.J. Hößl, J. Hofestädt, J. Huang, F. Illuminati, G. James, C.W. de Jong, M. de Jong, P. Jongen, M. Kadler, M. Kalekin, O. Katz, U. Khan-Chowdhury, N.R. Kouchner, A. Kreykenbohm, I. Kulikovskiy, V. Lahmann, R. Le Breton, R. Lefèvre, D. Leonora, E. Levi, G. Lincetto, M. Lopez-Coto, D. Loucatos, S. Maggi, G. Manczak, J. Marcelin, M. Margiotta, A. Marinelli, A. Martínez-Mora, J.A. Mazzou, S. Melis, K. Migliozzi, P. Moser, M. Moussa, A. Muller, R. Nauta, L. Navas, S. Nezri, E. Nuñez-Castiñeyra, A. O’Fearraigh, B. Organokov, M. Păvălaş, G.E. Pellegrino, C. Perrin-Terrin, M. Piattelli, P. Poirè, C. Popa, V. Pradier, T. Randazzo, N. Reck, S. Riccobene, G. Sánchez-Losa, A. Samtleben, D.F.E. Sanguineti, M. Sapienza, P. Schnabel, J. Schüssler, F. Spurio, M. Stolarczyk, Th. Strandberg, B. Taiuti, M. Tayalati, Y. Thakore, T. Tingay, S.J. Vallage, B. van Elewyck, V. Versari, F. Viola, S. Vivolo, D. Wilms, J. Zegarelli, Angela Zornoza, J.D. Zúñiga, J. Université de Strasbourg CNRS IPHC UMR 7178 StrasbourgF-67000 France Université de Haute Alsace MulhouseF-68200 France Technical University of Catalonia Laboratory of Applied Bioacoustics Rambla Exposició Vilanova i la Geltrú Barcelona08800 Spain INFN - Sezione di Genova Via Dodecaneso 33 Genova16146 Italy Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Centre for Astroparticle Physics Erwin-Rommel-Str. 1 Eabrlangen91058 Germany Universitat Politècnica de València C/ Paranimf 1 Gandia46730 Spain Aix Marseille Univ CNRS/IN2P3 CPPM Marseille France Université de Paris CNRS Astroparticule et Cosmologie ParisF-75006 France Aix Marseille Univ CNRS CNES LAM Marseille France National Center for Energy Sciences and Nuclear Techniques B.P.1382 R. P.10001 Rabat Morocco Via S. Sofia 62 Catania95123 Italy University Mohammed V in Rabat Faculty of Sciences 4 av. Ibn Battouta B.P. 1014 R.P. 10000 Rabat Morocco University Mohammed I Laboratory of Physics of Matter and Radiations B.P.717 Oujda6000 Morocco Nikhef Science Park Amsterdam Netherlands Institute of Space Science MăgureleRO-077125 Bucharest Romania Universiteit van Amsterdam Instituut voor Hoge-Energie Fysica Science Park 105 Amsterdam1098 XG Netherlands INFN - Sezione di Roma P.le Aldo Moro 2 Roma00185 Italy Dipartimento di Fisica dell’Università La Sapienza P.le Aldo Moro 2 Roma00185 Italy LPHEA Faculty of Science - Semlali Cadi Ayyad University P.O.B. 2390 Marrakech Morocco INFN - Sezione di Bologna Viale Berti-Pichat 6/2 Bologna40127 Italy INFN - Sezione di Bari Via E. Orabona 4 Bari70126 Italy c/ Catedrático José Beltrán 2 PaternaValenciaE-46980 Spain Department of Computer Architecture and Technology/CITIC University of Granada Granada18071 Spain Géoazur UCA CNRS IRD Observatoire de la Côte d’Azur Sophia Antipolis France Dipartimento di Fisica dell’Università Via Dodecaneso 33 Genova16146 Italy Université Paris-Sud Orsay Cedex91405 Fra

Addressing the origin of the astrophysical neutrino flux observed by IceCube is of paramount importance. Gamma-Ray Bursts (GRBs) are among the few astrophysical sources capable of achieving the required energy to contribute to such neutrino flux through pγ interactions. In this work, ANTARES data have been used to search for upgoing muon neutrinos in spatial and temporal coincidence with 784 GRBs from 2007 to 2017. The expected neutrino fluxes have been calculated for each GRB, in the framework of the internal shock model. The impact in the neutrino flux calculation of the lack of knowledge on the majority of source redshifts and on other intrinsic parameters of the emission mechanism (e.g. minimum variability timescale, bulk Lorentz factor of the source ejecta) has been quantified. The minimum variability timescale is found to be the parameter which mostly affects the GRB-neutrino flux uncertainty. For the selected sources, ANTARES data have been analysed, maximising the discovery probability of the stacking sample through an extended maximum-likelihood strategy. Since no neutrino event passed the quality cuts set by the optimisation procedure, 90 % confidence level upper limits (with their uncertainty) on the total expected diffuse neutrino flux have been derived, according to the model. The GRB contribution to the observed diffuse astrophysical neutrino flux around 100 TeV is constrained to be less than 10 %. Copyright © 2020, The Authors. All rights reserved.

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