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Compressive holographic sensing simplifies quantitative phase imaging

Light(Science & Applications) 2023年第6期12卷 946-948页

作者： Jiawei Sun Juergen W.Czarske Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenDresdenGermany Laboratory of Measurement and Sensor System Technique(MST) TU DresdenHelmholtzstrasse 1801069 DresdenGermany Cluster of Excellence Physics of Life TU DresdenDresdenGermany Institute of Applied Physics TU DresdenDresdenGermany

Quantitative phase imaging (QPI) has emerged as method for investigating biological specimen and technical objects. However, conventional methods often suffer from shortcomings in image quality, such as the twin image artifact. A novel computational framework for QPI is presented with high quality inline holographic imaging from a single intensity image. This paradigm shift is promising for advanced QPI of cells and tissues.

关键词： holographic phase shortcomings

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Single-shot 3D incoherent imaging with diffuser endoscopy

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Light(Advanced Manufacturing) 2024年第2期5卷 64-74页

作者： Julian Lich Tom Glosemeyer Jürgen Czarske Robert Kuschmierz Laboratory of Measurement and Sensor System Technique TU DresdenGermany Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenGermany Else Kroner Fresenius Center for Digital Health(EKFZ) TU DresdenGermany Cluster of Excellence Physics of Life TU DresdenGermany

Minimally invasive endoscopy offers a high potential for biomedical imaging ***,conventional fiberoptic endoscopes require lens systems which are not suitable for real-time 3D ***,a diffuser is utilized for passively encoding incoherent 3D objects into 2D speckle *** networks are employed for fast computational image reconstruction beyond the optical memory *** this paper,we demonstrate single-shot 3D incoherent fiber imaging with keyhole access at video *** the diffuser fiber endoscope for fluorescence imaging is promising for in vivo deep brain diagnostics with cellular resolution.

关键词： Endoscopy Diffuser Deep learning Coherent fiber bundle Multicore fiber Neural networks Fiber optics Speckle patterns Fluorescence imaging

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Multicore fiber with thermally expanded cores for increased collection efficiency in endoscopic imaging

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Light(Advanced Manufacturing) 2024年第4期5卷 102-109页

作者： Kinga Zolnacz Ronja Stephan Jakob Dremel Katharina Hausmann Matthias Lieβmann Michael Steinke Juergen Czarske Robert Kuschmierz Chair of Measurement and Sensor System Technique TU Dresden01069 DresdenGermany Department of Optics and Photonics Wroclaw University of Science and Technology50370 WroclawPoland Institute of Quantum Optics Leibniz University Hannover30167 HannoverGermany Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU Dresden01069 DresdenGermany Else Kroner Fresenius Center for Digital Health(EKFZ) TU Dresden01307 DresdenGermany Cluster of Excellence PhoenixD Leibniz University Hannover30167 HannoverGermany

Fiber-based endoscopes are promising for minimally invasive in vivo biomedical *** fibers offer high resolution ***,to avoid image deterioration induced by inter-core coupling,significant spacing between cores is required,which limits the active image guiding area of the ***,they suffer from low light collection efficiency and decreased signal-to-noise *** this paper,we present a method to increase the collection efficiency by thermally expanding the cores at the facet of a multicore *** expansion is based on the diffusion of doping material of the cores,thus the fiber’s original outer diameter is *** enlarging the core diameter by a factor of 2.8,we increase the intensity of the transmitted light by a factor of up to *** results in a signal-to-noise ratio increase by a factor of up to 4.6 and significant improvement in the image *** improvement increases with increasing working distance but is already prominent for as small working distance as 0.5 *** feasibility of the method is proved experimentally by lensless single-shot imaging of a test chart and incoherent light reflected from clusters of *** demonstrated approach is an important tool especially in imaging of biological specimens,for which phototoxicity must be avoided,and therefore,high collection efficiency is required.

关键词： Thermally expanded cores fiber Multicore fiber Lensless imaging

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Lensless fiber endomicroscopy in biomedicine

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PhotoniX 2024年第1期5卷 402-410页

作者： Jiawei Sun Robert Kuschmierz Ori Katz Nektarios Koukourakis Juergen W.Czarske Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenDresden 01069Germany Shanghai Artificial Intelligence Laboratory Longwen Road 129Xuhui DistrictShanghai 200232China Laboratory of Measurement and Sensor System Technique(MST) TU DresdenHelmholtzstrasse 18Dresden 01069Germany Else Kroner Fresenius Center for digital Heath TU DresdenDresden 01062Germany Institute of Applied Physics The Hebrew University of JerusalemJerusalemIsrael Cluster of Excellence Physics of Life TU DresdenDresden 01062Germany Institute of Applied Physics TU DresdenDresden 01062Germany

Lensless fiber endomicroscopy,an emergent paradigm shift for minimally-invasive microscopic optical imaging and targeted light delivery,holds transformative potential,especially in *** holographic detection and physical or computational wavefront correction,it enables three-dimensional imaging in an unprecedentedly small footprint,which is crucial for various applications such as brain *** perspective reviews the recent breakthroughs,highlighting potential emerging applications,and pinpointing gaps between innovation and real-world *** the research in this realm accelerates,the novel breakthroughs and existing frontiers highlighted in this perspective can be used as guidelines for researchers joining this exciting domain.

关键词： Lensless endomicroscope Biomedical imaging Multimode fibers Multicore fibers Translation to real-world applications

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Image restoration via learning on a digital twin for multi-core fiber endoscopy

Image restoration via learning on a digital twin for multi-c...

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2024 Imaging systems and Applications, ISA 2024 - Part of Optica Imaging Congress

作者： Wang, Tijue Dremel, Jakob Richter, Sven Polanski, Witold Uckermann, Ortrud Eyüpoglu, Ilker Czarske, Jürgen W. Kuschmierz, Robert Laboratory of Measurement and Sensor System Technique TU Dresden Dresden01069 Germany Competence Center BIOLAS TU Dresden Dresden Germany Department of Neurosurgery University Hospital Carl Gustav Carus TU Dresden Dresden Germany Division of Medical Biology Department of Psychiatry Faculty of Medicine University Hospital Carl Gustav Carus TU Dresden Germany Else Kröner Fresenius Center for Digital Health TU Dresden Germany Excellence Cluster Physics of Life TU Dresden Dresden Germany Faculty of Physics School of Science TU Dresden Dresden Germany

Fiber endoscopy has great potential in all-optical biopsies but suffers fiber-specific distortions. We propose a method based on deep learning and digital twins for image reconstruction with a few training samples to ... 详细信息

关键词： Endoscopy

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Quantitative phase imaging through an ultra-thin lensless fiber endoscope

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Light(Science & Applications) 2022年第8期11卷 1843-1852页

作者： Jiawei Sun Jiachen Wu Song Wu Ruchi Goswami Salvatore Girardo Liangcai Cao Jochen Guck Nektarios Koukourakis Juergen W.Czarske Laboratory of Measurement and Sensor System Technique(MST) TU DresdenHelmholtzstrasse 1801069DresdenGermany Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenDresdenGermany State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentsTsinghua University100084BeijingChina Institute for Integrative Nanosciences IFW DresdenHelmholtzstraße 2001069DresdenGermany Max Planck Institute for the Science of Light&Max-Planck-Zentrum für Physik und Medizin 91058ErlangenGermany Cluster of Excellence Physics of Life TU DresdenDresdenGermany Institute of Applied Physics TU DresdenDresdenGermany

Quantitative phase imaging(QPI)is a label-free technique providing both morphology and quantitative biophysical information in ***,applying such a powerful technique to in vivo pathological diagnosis remains ***-core fiber bundles(MCFs)enable ultra-thin probes for in vivo imaging,but current MCF imaging techniques are limited to amplitude imaging *** demonstrate a computational lensless microendoscope that uses an ultra-thin bare MCF to perform quantitative phase imaging with microscale lateral resolution and nanoscale axial sensitivity of the optical path *** incident complex light field at the measurement side is precisely reconstructed from the far-field speckle pattern at the detection side,enabling digital refocusing in a multi-layer sample without any mechanical *** accuracy of the quantitative phase reconstruction is validated by imaging the phase target and hydrogel beads through the *** the proposed imaging modality,three-dimensional imaging of human cancer cells is achieved through the ultra-thin fiber endoscope,promising widespread clinical applications.

关键词： fiber phase thin

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Ultra-thin 3D lensless fiber endoscopy using diffractive optical elements and deep neural networks

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Light(Advanced Manufacturing) 2021年第4期2卷 57-66页

作者： Robert Kuschmierz Elias Scharf David F.Ortegón-González Tom Glosemeyer Jürgen W.Czarske Laboratory of Measurement and Sensor System Technique TU DresdenHelmholtzstrasse 1801069 DresdenGermany Competence center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenGermany Institute of Applied Physics School of SciencesTU DresdenGermany Excellence Cluster Physics of Life TU DresdenGermany

Minimally invasive endoscopes are indispensable in *** fiber bundles(CFBs)enable ultrathin lensless ***,the propagation of light through a CFB suffers from phase distortions and aberrations that can cause images to be *** correction of such aberrations has been demonstrated using various techniques for wavefront control,especially using spatial light modulators(SLMs).This study investigates a novel aberration correction without SLM for the creation of an efficient and compact *** memory effect of CFBs enables a paradigm shift in the use of static diffractive optical elements(DOEs)instead of dynamic modulation with *** introduce DOEs produced by 2-photon polymerization lithography for phase conjugation on a CFB for focusing,raster scanning,and ***,a DOE with random patterns is used to encode the three-dimensional(3D)object information in a 2D speckle pattern that propagates along the ultra-thin *** networks decode the speckles to retrieve the 3D object information using single-shot *** DOE methods have compact low-cost concepts in common,and both pave the way for minimally invasive 3D endomicroscopy with benefits for optical imaging in biomedicine.

关键词： correction speckle elements

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Analysis of human iPSC-derived neuronal networks (hiPSCNN) using holographic single cell and full field optogenetic stimulation

Analysis of human iPSC-derived neuronal networks (hiPSCNN) u...

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Optics and the Brain, BRAIN 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021

作者： Schmieder, Felix Habibey, Rouhollah Busskamp, Volker Büttner, Lars Czarske, Jürgen W. Laboratory of Measurement and Sensor System Technique TU Dresden Helmholtzstraße 18 Dresden01062 Germany Universitäts-Augenklinik Bonn University of Bonn Ernst-Abbe-Straße 2 Bonn53127 Germany Competence Center BIOLAS and Excellence Cluster PoL TU Dresden Germany

HiPSCNN Functional connectivity was investigated using optogenetics. Time-distance-correlations can be obtained using holographic single-neuron stimulation and provide deeper insights into of structure-function relati... 详细信息

ISBN: (纸本)9781557528209

关键词： Holography

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Tracking of Magnetic Micromotors in Confined Channels Through Scattering Tissue 15

Tracking of Magnetic Micromotors in Confined Channels Throug...

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15th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2021

作者： Aziz, Azaam Karnaushenko, Dmitriy Koukourakis, Nektarios Czarske, Jurgen W. Schmidt, Oliver G. Medina-Sanchez, Mariana Institute For Integrative Nanosciences Leibniz Institute For Solid State And Materials Research Dresden01069 Germany Measurement And Sensor System Technique And Competence Center Biolas Tu Dresden School of Engineering Dresden01069 Germany School of Science Cluster of Excellence Physics of Life Tu Dresden Germany Faculty of Physics Dresden TU Germany Professorship of Material Systems For Nanoelectronics Chemnitz University of Technology Chemnitz09111 Germany

ISBN: (纸本)9781665458566

The field of small-scale microdevices is growing rapidly towards the development of tethered/untethered microsensors and therapeutic agents that can move through narrow vascular networks in living organisms to diagnose and treat for example vascular diseases. However, imaging and localization of such microdevices are challenging under scattering tissue due to the lack of high spatial and temporal resolution that compromises the penetration depth and therefore the application scenario. Here, we report the tracking of magnetically-driven rolling micromotors (20 μm in diameter) through scattering tissue (1.2 mm thickness) using reflective infrared (IR) imaging. This technique provides high spatiotemporal resolution for the tracking of micro-agents in a narrow vascular network. As a potential application, we suggest the use of such micro-agents as micro-viscosimeters, in which by analyzing their dynamics, one can extract some basic information on the surrounding fluid properties which might be related to certain health status. © 2021 IEEE.

关键词： Micromotors

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End-to-end brain cancer diagnosis using high-resolution fiber endoscopy with a learning-based digital twin 23

End-to-end brain cancer diagnosis using high-resolution fibe...

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Advanced Biomedical and Clinical Diagnostic and Surgical Guidance systems XXIII 2025

作者： Wang, Tijue Dremel, Jakob Richter, Sven Polanski, Witold Uckermann, Ortrud Eyüpoglu, Ilker Kuschmierz, Robert Czarske, Jürgen W. Laboratory of Measurement and Sensor System Technique TU Dresden Dresden01069 Germany Competence Center BIOLAS TU Dresden Dresden Germany Department of Neurosurgery University Hospital Carl Gustav Carus TU Dresden Dresden Germany Division of Medical Biology Department of Psychiatry Faculty of Medicine University Hospital Carl Gustav Carus TU Dresden Germany Else Kröner Fresenius Center for Digital Health TU Dresden Germany Excellence Cluster Physics of Life TU Dresden Dresden Germany Faculty of Physics School of Science TU Dresden Dresden Germany

ISBN: (纸本)9781510683600

Rapid diagnosis is crucial to cancer treatment. Multi-core fibers (MCF) are slim and enable access to deep tissue for all-optical biopsies in real-time. Deep neural network (DNN)-based image reconstruction can depixelate structural artifacts and enhance spatial resolution beyond physical limitations. However, limited available tissue samples for training and simulator performance for MCF imaging make DNN-assisted fiber endoscopy for in vivo brain cancer diagnosis still challenging. Here we propose using a digital twin to solve these difficulties. A dataset is simulated for pre-training a MCF reconstruction network. Then transfer learning is applied to the network on a few ten experimental image pairs of glioblastoma samples. The results show, even when transfer learning on only 10 experimental image pairs, the mean structural similarity value of the test set can be increased from 0.547 to 0.932. The reconstructed images can achieve a comparable resolution with widefield microscopes when increasing the data size to 50, which are hundreds of times less than the training from scratch. The digital twin provides an efficient and highly feasible approach towards minimally invasive all-optical biopsies in neurosurgeries. © 2025 SPIE.

关键词： Photointerpretation

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