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2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023

作者： Li, Wenjun Zhou, Yiqiang Tang, Xiwei Changsha University of Science and Technology Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Hunan Changsha China Hunan First Normal University School of Computer Science Hunan Changsha China

ISBN: (纸本)9798350337488

Bioinformatics is a rapidly growing field that involves the application of computational methods to analyze and interpret biological data. One important task in bioinformatics is predicting the drug-target affinity (DTA), which plays a significant role in drug discovery through virtual screening. Effectively predicting the association between drug molecules and target molecules can speed up the drug discovery process. The DTA can be quantitatively measured. This quantifiable affinity is more precise than a simple binary relationship. In this study, we propose a deep learning model for DTA prediction that utilizes the encoder module of the Transformer architecture. Our proposed model utilizes Convolutional Neural Networks (CNNs) and the encoder module of Transformer to characterize protein and drug sequences. The model outperforms some methods such as KronRLS, SimBoost and DeepDTA as evidenced by superior evaluation metrics such as Mean Squared Error (MSE), Concordance Index (CI), and Regression toward the Mean Index (rm2). These results demonstrate the effectiveness of the Transformer's encoder in extracting meaningful representations from sequences, thereby improving the accuracy of DTA prediction. Deep learning models for DTA prediction can accelerate drug discovery by identifying drug candidates with high binding affinity to specific targets. Compared to traditional methods, the use of machine learning technology enables more effective and efficient drug discovery. © 2023 IEEE.

关键词： deep learning drug-target affinity multi-head attention mechanism

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Hybrid Pruning Method Based on Convolutional Neural Network Sensitivity and Statistical Threshold 2

Hybrid Pruning Method Based on Convolutional Neural Network ...

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2nd International Conference on Computer, big data and Artificial Intelligence, ICCBDAI 2021

作者： Guo, Changyi Li, Ping School of Computer and Communication Engineering Changsha University of Science and Technology Hunan Changsha410114 China Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Hunan Changsha410114 China

The hybrid pruning algorithm can not only ensure the precision of the network, but also achieve a good balance between pruning ratio and computation. However, traditional pruning algorithms use coarse-grained or fine-grained pruning networks, which have the tradeoff problem between pruning rate and computation amount. To this end, this paper presents. A hybrid pruning method of sensitivity and statistical threshold. Firstly, coarse-grained pruning is carried out on the network, and a fast sensitivity test is conducted on the convolutional layer of the network to determine the channels that need pruning within the tolerance range of network precision decline. Then, fine-grained pruning is performed on the network. Count the weights of the pruned network, calculate the thresholds of the weights of each layer, and delete the weights less than the thresholds so as to further reduce the size of the network and the amount of calculation. Hybrid pruning performs very well in AlexNet and Resnet networks. In particular, the method proposed in this paper is used in CIFAR-10 dataset, and the compression of FLOPs is 60%, while the compression of parameter number is nearly 80%. Compared with single pruning method, Hybrid pruning is better. © 2022 Institute of Physics Publishing. All rights reserved.

关键词： Convolution

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Reversible Natural Language Watermarking Using Synonym Substitution and Arithmetic Coding

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Computers, Materials & Continua 2018年第6期55卷 541-559页

作者： Lingyun Xiang Yan Li Wei Hao Peng Yang Xiaobo Shen Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha University of Science and TechnologyChangsha 410114HunanChina School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha 410114HunanChina School of Traffic&Transportation Engineering Changsha University of Science&TechnologyChangsha 410114HunanChina Hunan Branch of CNCERT/CC Changsha 410004HunanChina School of Computer Science and Engineering Nanyang Technological University639798Singapore

For protecting the copyright of a text and recovering its original content harmlessly,this paper proposes a novel reversible natural language watermarking method that combines arithmetic coding and synonym substitution *** analyzing relative frequencies of synonymous words,synonyms employed for carrying payload are quantized into an unbalanced and redundant binary *** quantized binary sequence is compressed by adaptive binary arithmetic coding losslessly to provide a spare for accommodating additional ***,the compressed data appended with the watermark are embedded into the cover text via synonym substitutions in an invertible *** the receiver side,the watermark and compressed data can be extracted by decoding the values of synonyms in the watermarked text,as a result of which the original context can be perfectly recovered by decompressing the extracted compressed data and substituting the replaced synonyms with their original *** results demonstrate that the proposed method can extract the watermark successfully and achieve a lossless recovery of the original ***,it achieves a high embedding capacity.

关键词： Arithmetic coding synonym substitution lossless compression reversible watermarking.

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HSCS:a hybrid shared cache scheduling scheme for multiprogrammed workloads

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Frontiers of Computer Science 2018年第6期12卷 1090-1104页

作者： Jingyu ZHANG Chentao WU Dingyu YANG Yuanyi CHEN Xiaodong MENG Liting XU Minyi GUO Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation School of Computer and Communication EngineeringChangsha University of Science and TechnologyChangsha 410004China School of Electronics and Information Shanghai Dianji UniversityShanghai 200240China

The traditional dynamic random-access memory (DRAM) storage medium can be integrated on chips via modern emerging 3D-stacking technology to architect a DRAM shared cache in multicore systems. Compared with static random-access memory (SRAM), DRAM is larger but slower. In the existing research, a lot of work has been devoted to improving the workload performance using SRAM and stacked DRAM together in shared cache systems, ranging from SRAM structure improvement to optimizing cache tags and data access. However, little attention has been paid to designing a shared cache scheduling scheme for multiprogrammed workloads with different memory footprints in multicore systems. Motivated by this, we propose a hybrid shared cache scheduling scheme that allows a multicore system to utilize SRAM and 3D-stacked DRAM efficiently, thus achieving better workload performance. This scheduling scheme employs (1) a cache monitor, which is used to collect cache statistics; (2) a cache evaluator, which is used to evaluate the cache information during the process of programs being executed; and (3) a cache switcher, which is used to self-adaptively choose SRAM or DRAM shared cache modules. A cache data migration policy is naturally developed to guarantee that the scheduling scheme works correctly. Extensive experiments are conducted to evaluate the workload performance of our proposed scheme. The experimental results showed that our method can improve the multiprogrammed workload performance by up to 25% compared with state-of-the-art methods (including conventional and DRAM cache systems).

关键词： multicore system shared cache workload performance

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Image Inpainting Detection Based on High-Pass Filter Attention Network

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Computer Systems Science & Engineering 2022年第12期43卷 1145-1154页

作者： Can Xiao Feng Li Dengyong Zhang Pu Huang Xiangling Ding Victor S.Sheng Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha University of Science and TechnologyChangsha410114China School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan411004China Department of Computer Science Texas Tech UniversityLubbock79409USA

Image inpainting based on deep learning has been greatly *** original purpose of image inpainting was to repair some broken photos, suchas inpainting artifacts. However, it may also be used for malicious operations,such as destroying evidence. Therefore, detection and localization of imageinpainting operations are essential. Recent research shows that high-pass filteringfull convolutional network (HPFCN) is applied to image inpainting detection andachieves good results. However, those methods did not consider the spatial location and channel information of the feature map. To solve these shortcomings, weintroduce the squeezed excitation blocks (SE) and propose a high-pass filter attention full convolutional network (HPACN). In feature extraction, we apply concurrent spatial and channel attention (scSE) to enhance feature extraction and obtainmore information. Channel attention (cSE) is introduced in upsampling toenhance detection and localization. The experimental results show that the proposed method can achieve improvement on ImageNet.

关键词： Image inpainting detection spatial attention channel attention full convolutional network high-pass filter

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MultiAdapt: A Neural Network Adaptation for Pruning Filters Base on Multi-layers Group 2

MultiAdapt: A Neural Network Adaptation for Pruning Filters ...

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2021 2nd International Workshop on Electronic communication and Artificial Intelligence, IWECAI 2021

作者： Yang, Jie Xie, Zhihong Li, Ping School of Computer and Communication Engineering Changsha University of Science and Technology Changsha Changsha Hunan410114 China Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha University of Science and Technology Changsha Changsha Hunan410114 China

Deep convolutional neural networks have been widely used in various AI applications. The most advanced neural networks are becoming deeper and wider, which has caused some large convolutional neural networks to exceed the size limit of the server or application. The pruning algorithm provides a way to reduce the size of the neural network while keeping the accuracy as high as possible. The automatic progressive pruning algorithm is one of the widely used pruning algorithms. The progressive pruning algorithm prunes a certain layer of the network in each iteration to reduce the sparsity while preserving the accuracy as much as possible. In this article, we design a new automatic progressive pruning algorithm named MultiAdapt. MultiAdapt combines the combination method and the greedy algorithm. This multi-layers progressive pruning method greatly increases the search space of the greedy algorithm, making it possible to obtain a better pruning network. We use MultiAdapt to prune large neural networks VGG-16 and ResNet. The experimental results show that the MultiAdapt algorithm is better than other mainstream methods in the balance of neural network model size and accuracy. For image classification tasks on the ImageNet dataset, our method achieved 88.72% and 90.55% TOP-5 accuracy on the 50% sparsity VGG-16 and ResNet, while obtaining nearly 2 reduction in parameters and floating point numbers. The operation is reduced, and the reduction is higher than the recent popular method. © Published under licence by IOP Publishing Ltd.

关键词： Network layers

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A Polynomial-Time Algorithm for MCS Partial Search Order on Chordal Graphs 48

A Polynomial-Time Algorithm for MCS Partial Search Order on ...

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48th International Symposium on Mathematical Foundations of Computer Science, MFCS 2023

作者： Rong, Guozhen Yang, Yongjie Li, Wenjun Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha University of Science and Technology China Chair of Economic Theory Saarland University Saarbrücken Germany

ISBN: (纸本)9783959772921

We study the partial search order problem (PSOP) proposed recently by Scheffler [WG 2022]. Given a graph G together with a partial order on the set of vertices of G, this problem determines if there is an S-ordering that is consistent with the given partial order, where S is a graph search paradigm like BFS, DFS, etc. This problem naturally generalizes the end-vertex problem which has received much attention over the past few years. It also generalizes the so-called F-tree recognition problem which has just been studied in the literature recently. Our main contribution is a polynomial-time dynamic programming algorithm for the PSOP of the maximum cardinality search (MCS) restricted to chordal graphs. This resolves one of the most intriguing open questions left in the work of Scheffler [WG 2022]. To obtain our result, we propose the notion of layer structure and study numerous related structural properties which might be of independent interest. © Guozhen Rong, Yongjie Yang, and Wenjun Li

关键词： Dynamic programming

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MFCM-DTI model of multimodal feature fusion: Prediction of drug-target interaction

MFCM-DTI model of multimodal feature fusion: Prediction of d...

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2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024

作者： Li, Wenjun Ma, Wanjun Yang, Mengyun Tang, Xiwei Changsha University of Science and Technology Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha China Hunan First Normal University School of Computer Science Changsha China Hunan First Normal University School of Intelligent Manufacturing Changsha China

ISBN: (纸本)9798350386226

Drug repositioning is a vital area of biomedicine, where confirming interactions between drugs and specific targets is essential for establishing the efficacy of pharmaceutical agents. Traditional in vitro screening methods have limitations, prompting the use of computer simulations as an effective alternative for predicting drug-target interactions (DTI). This approach has gained significant attention in the scientific community. In this study, we introduce MFCM-DTI, a DTI prediction model that employs multimodal features to accurately capture the intricate interactions between drug molecular structures and key amino acids of target proteins. Our results demonstrate that MFCM-DTI outperforms existing models in prediction accuracy and robustness. Furthermore, MFCM-DTI has been successfully used to predict interactions between key SARS-CoV-2 proteins and existing drugs, providing a solid foundation for developing therapeutic agents against SARS-CoV-2 infection. This study underscores the broad applicability and strong predictive capabilities of MFCM-DTI in drug-protein interaction prediction, opening new avenues for research. The predicted drug targets and interaction data offer valuable insights for future experimental validation and clinical trials, potentially driving innovation in the biomedical field. © 2024 IEEE.

关键词： Prediction models

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Few-Shot Object Detection Based on the Transformer and High-Resolution Network

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Computers, Materials & Continua 2023年第2期74卷 3439-3454页

作者： Dengyong Zhang Huaijian Pu Feng Li Xiangling Ding Victor S.Sheng Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha University of Science and TechnologyChangsha410114China School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan411004China Department of Computer Science Texas Tech UniversityLubbock79409TXUSA

Now object detection based on deep learning tries different *** uses fewer data training networks to achieve the effect of large dataset ***,the existing methods usually do not achieve the balance between network parameters and training *** makes the information provided by a small amount of picture data insufficient to optimize model parameters,resulting in unsatisfactory detection *** improve the accuracy of few shot object detection,this paper proposes a network based on the transformer and high-resolution feature extraction(THR).High-resolution feature extractionmaintains the resolution representation of the *** and spatial attention are used to make the network focus on features that are more useful to the *** addition,the recently popular transformer is used to fuse the features of the existing *** compensates for the previous network failure by making full use of existing object *** on the Pascal VOC and MS-COCO datasets prove that the THR network has achieved better results than previous mainstream few shot object detection.

关键词： Object detection few shot object detection transformer high-resolution

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A survey of multi-object video tracking algorithms

A survey of multi-object video tracking algorithms

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International Conference on Applications and Techniques in Cyber Intelligence, ATCI 2018

作者： Zhou, Shuren Ke, Maolin Qiu, Jia Wang, Jin Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha University of Science and Technology Changsha410114 China School of Computer and Communication Engineering Changsha University of Science and Technology Changsha410114 China

ISBN: (纸本)9783319987750

Video multi-object tracking is one of the important research topics in the field of computer vision, which is widely used in military and civil areas. At present, the research of single object tracking algorithm is quite mature, however the research of multi-object tracking is still ongoing. This paper focuses on four important stages in the multi-object tracking process: feature extraction, detector, data association and the tracker. The feature extraction part introduces the current methods of feature extraction, as well as the merits and demerits of each method;In the stage of detection, the tracking effect of the object appearance model in specific applications is described, and then the paper analyze the multi-object tracking algorithm based on detection and tracking as well as the multi-object tracking algorithm based on deep learning;In the tracking stage, the establishment of object motion model and multi-object tracking with different tracker hybrid algorithm are introduced;During the stage of data association, the paper introduce the multi-object tracking based on energy minimization and commonly used data association algorithm, respectively. Then the current mainstream datasets and evaluation methods are introduced. Finally, the future development of the multi-object tracking is discussed and forecasted. © Springer Nature Switzerland AG 2019.

关键词： Feature extraction

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