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10th International Seminar on New Paradigm and Innovation of Natural Sciences and itsApplication, ISNPINSA 2020

作者： Gernowo, R. Subagio, A. Adi, K. Widodo, A.P. Widodo, C.E. Putranto, A.B. Department of Physics Faculty of Science and Mathematics Diponegoro University Indonesia Department of Informatics Faculty of Science and Mathematics Diponegoro University Indonesia Study Program of Automation Engineering Technology Vocational School Diponegoro University Jl. Prof. Soedarto SH. Tembalang Semarang50275 Indonesia

Natural disaster nowadays often occur in Indonesia due to climate change, especially those related to atmospheric dynamics anomalies. The statutory event of atmospheric turbulence statistically is quite significant in its improvement. This is an important issue to conduct research both in the analysis of atmospheric dynamics and early detection solutions for these events. The Windshear phenomenon is an atmospheric turbulence disaster that occurs below an altitude of 3000 feet, often known as low level windshear (LLWS), which is very dangerous for planes taking take-off or landing. Its effect on the aircraft will result in increased airflow on the wings, so this increased airflow will result in a sudden increase in aircraft speed. If the pilot is not aware of the indication of the windshear, he will instinctively throttle back to reduce/compensate for the aircraft's speed. However, once the plane passes through the wind shear zone, the wind suddenly turns into a downdraft. The design of windshear early detection devices have been developed to complement research on the dynamics of the atmosphere. The results obtained are anomalous changes in temperature and atmospheric pressure at this time, and the windshear sensor can detect it well. © Published under licence by IOP Publishing Ltd.

关键词： Aircraft

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Potassium oxide rich coconut husk ash for transesterification of Jatropha oil into biodiesel production

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AIP Conference Proceedings 2024年第1期3082卷

作者： Husni Husin Fahrizal Nasution Muhammad Zaki Ahmadi Ahmadi Pocut Nurul Alam Lia Mairiza Azhari Azhari Muhammad Lathiful Yazil Department of Chemical Engineering Faculty of Engineering Universitas Syiah Kuala Banda Aceh 23111 Indonesia Doctoral Program School of Engineering Universitas Syiah Kuala Banda Aceh 23111 Indonesia Department of Chemical Engineering Faculty of Engineering Universitas Malikussaleh Lhokseumawe Indonesia

The conversion of FFA from jatropha oil was synthesis using potassium oxide (K2O) as a catalyst. This study aims to obtain catalyst materials by simply burning coconut husk and investigate the use of the solid catalyst for the transesterification process of jatropha oil into biodiesel production. The ash catalysts were characterized by X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). From the XRD spectrum, it has been observed that the component of the catalyst is a crystalline nature of K2O as an active site. The catalysts derived from coconut husk ash grew into a hexagonal-shaped morphology, as depicted by SEM images. The effects of the methanol-to-oil ratio were studied to obtain maximum biodiesel production. The conversion of jatropha oil into biodiesel achieved 98.6% under the conditions: a reaction temperature of 65 oC, a methanol to jatropha oil molar ratio of 6:1, and a catalyst of 10 wt.%. Utilization of oil coconut husk ash as a solid catalyst for biodiesel production provides a environmentally friendly way of recycling this solid coconut husk waste, significantly reducing its environmental effects and making biodiesel competitive with petroleum diesel.

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A novel approach to CO2 utilization as a density agent in formulating palm shells and kernels separation fluid

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AIP Conference Proceedings 2024年第1期3082卷

作者： Muhammad Marwan Edi Munawar Muhammad Zaki Doctoral Program School of Engineering Post Graduate Program Universitas Syiah Kuala Banda Aceh 23111 Indonesia Department of Chemical Engineering Faculty of Engineering Universitas Serambi Mekkah Banda Aceh 23245 Indonesia Department of Chemical Engineering Faculty of Engineering Universitas Syiah Kuala Banda Aceh 23111 Indonesia

Reducing CO2 emissions from Palm Oil Mills (POMs) production activities contribute positively to global warming. This paper proposes a novel approach to CO2 utilization as a density agent in formulating palm shells and kernel separation fluid based on density difference. This work applied a chemical absorption method to ensure permanent CO2 absorption in the solution. Natrium hydroxide (NaOH) was selected as a chemical absorbent with a mass fraction varied from 2.5, 5, 7.5, 10, and 12.5% w/w. The formulated fluid was then tested for its performance in separating palm shells and kernels, represented by separation efficiency. It was conducted by g 15 % w/w of a mixture of palm shells and kernels into the formulated fluid. The results showed that the maximum separation efficiency ranged from 97.38 and 100%. It corresponds to optimum separation fluid densities ranging between 1.13 to 1.15 at NaOH 10 and 12.5% w/w, respectively. The finding of this experiment indicated that the CO2 utilization as a density agent was successfully performed in the separation fluid formulation. In conclusion, the formulated fluid was acceptable in separating palm shells and kernels and, simultaneously, became an alternative for reducing CO2 emissions in POMs.

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Tensile Properties of coconut Coir single fiber with alkali treatment and reinforcement effect on unsaturated polyester polymer

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Materials Today: Proceedings 2020年 22卷 300-305页

作者： Arya Widnyana I Gde Rian I Wayan Surata Tjokorda Gde Tirta Nindhia Under graduate student at Study Program ofMechanical Engineering Engineering Faculty Udayana University Jimbaran Bali 80361 Indonesia Study Program ofMechanical Engineering Engineering Faculty Udayana University Jimbaran Bali 80361 Indonesia

Many reports related with alkali treatment on coir of coconut are available but the data related with the stress-strain curve is not provided. In this research stress-strain curve of tensile test data of the coconut single fiber obtained from alkali treatment with 5% NaOH is provided. Seven repetitions was conducted. The results indicate that the fiber is linier elastic with no indication as ductile material. The average of tensile strength is 130.9 MPa, failure (maximum) strain is 22.4 % and modulus of elasticity is 681.4 MPa. Randomly addition of 3 cm length of coconut fiber with fraction 15% in to the unsaturated polyester give maximum reinforcement that reach tensile strength of the composite about 24.5 MPa

关键词： Coconut single fiber tensile strength reinforcement unsaturated polyester

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The Anticancer and Apoptotic Activity of the Endophytic Fungus Phomopsis Sp. Isolated from Soursop Leaves in Mcf-7 Breast Cancer Cells: In Vitro and Computational in Silico Studies

SSRN

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SSRN 2025年

作者： Dwicesaria, Maheswari Alfira Priosoeryanto, Bambang Pontjo Hasan, Akhmad Endang Zainal Irsal, Riyan Alifbi Putera Gholam, Gusnia Meilin Mahendra, Fachrur Rizal Suminto, Syaefudin Indonesia Department of Biochemistry Faculty of Mathematics and Natural Sciences IPB University Dramaga Campus Bogor16680 Indonesia School of Veterinary Medicine and Biomedicine IPB University Bogor16680 Indonesia Faculty of Engineering Kyushu University Nishi-ku Fukuoka819-0395 Japan Tropical Biopharmaca Research Center IPB University Bogor16128 Indonesia Bioinformatics Study Program Faculty of Mathematics and Natural Sciences IPB University Bogor16680 Indonesia

This study investigated the anticancer potential of the endophytic fungus Phomopsis sp., extracted from soursop leaves. The metabolite profile of Phomopsis sp. was analyzed and its anticancer and apoptotic activities were assessed in both human breast cancer cell (MCF-7) and normal Vero cell lines. Phomopsis sp. were cultivated in yeast malt broth, extracted with ethyl acetate, and separated using column chromatography. The brine shrimp lethality test gave ten fractions (F1–F10), with F1 demonstrating the highest cytotoxicity (LC50 = 2.33 µg/mL). The obtained fractions were evaluated for antiproliferative effects, revealing an IC50 of 5.65 µg/mL for MCF-7 cells and 5.21 µg/mL for Vero cells, indicating effective anti-proliferation through apoptosis, as confirmed by acridine orange-ethidium bromide staining. Liquid Chromatography-tandem Mass Spectrometry identified 38 active compounds in F1, including known anticancer agents such as cytosporone C, kynurenic acid, maraniol, (-)-caryophyllene oxide, and chalcone. Computational in silico analyses utilizing PASS online, molecular docking, ADMET/pharmacokinetic studies, density functional theory (DFT) analysis, and molecular dynamics (MD) simulations further validated chalcone as a promising anticancer candidate. Chalcone exhibited favorable ADMET/pharmacokinetic properties and achieved the highest docking score -8.392 kcal/mol among the compounds tested. MD simulations over 300 ns demonstrated that chalcone outperformed tamoxifen, with binding energy calculations revealing a value of -227.069 kJ/mol compared to -45.598 kJ/mol for tamoxifen. These findings highlight the therapeutic potential of Phomopsis sp. and its bioactive compounds, particularly chalcones, as candidates for effective anti-breast cancer therapies. © 2025, The Authors. All rights reserved.

关键词： Column chromatography

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Recent advances in wearable electrochemical biosensors towards technological and material aspects

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Biosensors and Bioelectronics: X 2024年 19卷

作者： Hosseinzadeh Fakhr, Mahan Lopez Carrasco, Ivan Belyaev, Dmitry Kang, Jihun Shin, YeHyeon Yeo, Jong-Souk Koh, Won-Gun Ham, Jeongwoo Michaelis, Alexander Opitz, Joerg Beshchasna, Natalia Fraunhofer Institute for Ceramic Technologies and Systems IKTS Maria-Reiche-Straße 2 Dresden01109 Germany Faculty of Mechanical Science and Engineering Dresden University of Technology Dresden Germany School of Integrated Technology College of Computing Yonsei University Seoul Korea Republic of BK21 Graduate Program in Intelligent Semiconductor Technology Yonsei University Seoul Korea Republic of Department of Chemical and Biomolecular Engineering Yonsei University Seoul Korea Republic of

The next generation of wearable biosensors comes with the latest advancements in biosensor technology. Soft and stretchable electrode materials like hydrogels with the similar functionalities of human tissue including stretchability, self-healability, and responsiveness to different stimuli have emerged as the most versatile materials in wearable electronics. The incorporation of conductive nanofillers is found to enhance the sensitivity of the electrochemical biosensors significantly. Microfluidic technology has reduced the volume of samples and reagents required for the analysis, allowing continuous biomedical monitoring from a drop of biofluid. In this paper, the most advanced progress in electrochemical wearable platforms that can noninvasively and continuously monitor the biochemical markers in body fluids for the diagnosis and health management is reviewed. Innovation in microelectronics, modification, fabrication technologies, and detection methods are the main focus of the discussion. In particular, hydrogel-based sensors and microfluidic systems as the latest technology trends in wearable detection are discussed in detail. Integration of miniaturized electrochemical wearable biosensors with wireless technology as a great promise for real-time healthcare monitoring and point-of-care (POC) diagnostics is also summarized. Finally, we outline the most advanced wearable biosensors with optimized material and design as well as key challenges that need to be addressed to improve sensing performance (accuracy, sensitivity, selectivity, stability), portability (miniaturized size and light weight), and flexibility of the wearable biosensors. © 2024 The Authors

关键词： Body fluids

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Utilization plastic waste using pyrolysis fixed bed 1

Utilization plastic waste using pyrolysis fixed bed

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1st International Conference on Design, Energy, Materials and Manufacture, ICDEMM 2018

作者： Swamardika, I.B.A. Winaya, I.N.S. Hartati, R.S. Study Program of Electrical Engineering Faculty of Engineering University of Udayana Indonesia Study Program of Mechanical Engineering Faculty of Engineering University of Udayana Indonesia

This investigative research aims to convert urban non-organic waste fuels such as plastic waste into energy using fixed bed pyrolysis technology. Pyrolysis fixed bed (PFB) is one of the most efficient technologies for converting various types of undegradable solid waste into thermal energy and liquid fuels with high efficiency. The study was conducted on a lab-scale PFB reactor with dimensions of 15 cm and 55 cm in diameter and bed height respectively. The reactor is equipped with a cooling and decomposition system to accommodate liquid and gas products. Reactor temperature variations using an external heater were tested and quartz sands were selected as a bed material to improve the temperature function of the PFB reactor so as the maximum quality and quantity of liquid product were obtained. The fuel properties of the derived oil were tested including their physical properties, calorific value, elemental measurement (CHNOS) analysis. The results of the study showed that the increase in temperature resulted in an increased pyrolysis performance which was indicated by the increased volume and liquid caloric value. © Published under licence by IOP Publishing Ltd.

关键词： Pyrolysis

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An analysis of the damage level and reconstruction priority of elementary school buildings in the Central Lombok District

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AIP Conference Proceedings 2023年第1期2706卷

作者： Hariyadi Saifullah Akmaluddin Department of Civil Engineering Faculty of Engineering University of Mataram 83115 Indonesia Master Student of Civil Engineering Study Program Faculty of Engineering University of Mataram 83115 Indonesia

In Central Lombok District, the allocation of funds for the rehabilitation of elementary schools is very small compared to the number of schools that need reconstruction. The percentage of classroom rehabilitation work based on the target schools only reached 9.96%. Consequently, it needs to study to analyze the damage level of buildings and find out the most influenced criteria in formulating decisions for selecting school priorities that must be rehabilitated. Due to controlled aspects and standards are quite a lot and more sophisticated, accordingly the Analytical Hierarchy Process (AHP) method is the proper method for solving these complex problems. The sample in this study was 13 of the 25 schools that received special funds in 2018. The application of the AHP method was preceded by a survey involving experts who were competent in their fields. The results showed that the number of schools with moderate damage was six and severely damaged as many as seven schools. At the same time, based on the order of priority, building repairs are determined by the most influential criteria, namely the level of damage and primary education data.

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Scaling Ipsc Production in Different 3d Platforms in Suspension Culture for Their Use in Allogeneic Regenerative Therapies

SSRN

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SSRN 2024年

作者： Freire-Flores, Danton Kawles, Nyna Caviedes, Pablo Andrews, Barbara A. Asenjo, Juan A. Centre for Biotechnology and Bioengineering Faculty of Physical and Mathematical Sciences Universidad de Chile Beaucheff 851 Santiago8370448 Chile Department of Chemical Engineering Biotechnology and Materials Universidad de Chile Beaucheff 851 Santiago8370448 Chile Program of Molecular and Clinical Pharmacology ICBM Faculty of Medicine University of Chile Independencia 1027 Santiago8379482 Chile

Human induced pluripotent stem cells (iPSCs) exhibit significant potential for advancing regenerative medical treatments due to their pluripotency and proliferation capacity. However, the large-scale production required for allogeneic therapies necessitates efficient and scalable culture systems. Conventional 2D culture techniques are inadequate for this, driving interest for innovative bioreactor-based expansion techniques such as microcarrier-based or suspension aggregate cultures. In this study, we compare iPSC expansion and quality in microcarrier and aggregate cultures in spinner flasks, aiming to ascertain which 3D growth configuration yields superior cell mass while maintaining cellular product quality. We demonstrated comparable expansion of iPSCs on Cytodex 1 and Cultisphere G microcarriers, as well as in aggregates by day 6 in culture, achieving a final cell density of 2.6*10^6 cells/ml and 5.67*10^6 cells/ml on microcarriers respectively, and 9.76*10^6 cells/ml in aggregates, yielding 4- and 9-fold expansion on microcarriers and 15-fold in aggregates. The efficiency in the recovery of iPSCs in single-cell form was over 91.5% for all cultures. iPSCs cultured on microcarriers and as aggregates exhibit OCT3/4, SSEA4, TRA-1-60, and SOX2 pluripotency marker expression, as well as retention of differentiation potential into three germinal layers. This work supports the utilization of microcarriers and aggregates as an efficient 3D expansion platform for suspension cultures of iPSCs, in the quest to further scale production in larger stirred-tank bioreactor systems. © 2024, The Authors. All rights reserved.

关键词： Tanks (containers)

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Characteristics of microwave-assisted pyrolysis of palm kernel shell

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AIP Conference Proceedings 2023年第1期2837卷

作者： Novi Caroko Harwin Saptoadi Tri Agung Rohmat Mechanical Engineering Study Program Engineering Faculty Universitas Muhammadiyah Yogyakarta Jalan Brawijaya Tamantirta Bantul Yogyakarta 55163 Indonesia Mechanical Engineering Study Program Engineering Faculty Universitas Gadjah Mada Jalan Grafika No. 2 Yogyakarta 55281 Indonesia

The research aims to investigate the kinetic characteristic of microwave-assisted pyrolysis of palm kernel shells using microwave output power (800, 600, 450, and 300 watts). The research consists of three steps; thermogravimetry analysis, microwave-assisted pyrolysis, and kinetic study analysis. This research showed that increased output power affected the decreasing activated energy, increased heating rate, and accelerated pyrolysis. The findings showed that microwave output power significantly affected kinetic characteristics and the production yield of microwave-assisted pyrolysis. Microwave-assisted pyrolysis ran optimally at 800, 600, and 450 watts but had not yet entirely run at 300 watts. The shells produced high solid products because they had a high lignin content (38.76 wt.%). The shell had a volatile matter content of 67.84 wt. %. Analysis using GC-MS showed that the liquid product contains an aromatic compound which was acetic acid and phenol.

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