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9th International Conference on Computational Methods in systems Biology, CMSB'11

作者： Omony, Jimmy Mach-Aigner, Astrid R. De Graaff, Leo H. Van Straten, Gerrit Van Boxtel, Anton J. B. Systems and Control Group Laboratory of Systems and Synthetic Biology Wageningen University P.O. Box 17 6700 AA Wageningen Netherlands Gene Technology Department of Gene Technology and Applied Biochemistry Institute of Chemical Engineering A-1060 Wien Austria Laboratory of Systems and Synthetic Biology Wageningen University P.O. Box 10 6703 HB Wageningen Netherlands Systems and Control Group Wageningen University P.O. Box 17 6700 AA Wageningen Netherlands

ISBN: (纸本)9781450308175

One of the challenges in the reconstruction of genetic network is to find experimental designs that maximize the information content in the data. In this work the information value of time course experiments (TCEs) is used to rank experimental designs. The study concerns the dynamic response of genes in the XlnR regulon of Aspergillus niger, whereby it was the goal to find the best moment to administer an extra pulse of inducing D-xylose. Low and high trigger concentrations are considered. The models that govern the regulation of the target genes in this regulon are used for simulation. Parameter sensitivity analysis, Fisher Information Matrix (FIM) and the E-modified criterion are used for the design performance assessment. The results show that the best time to give a second pulse of a low concentration trigger of D-xylose is when the D-xylose concentration from the first pulse is not yet completed reduced. Secondly, pulses with high trigger concentrations were simulated, parameter sensitivities computed, and the experimental designs evaluated. Overall, after the first pulse of 1 mM D-xylose, using a second pulse of 5 (or 10) mM D-xylose yields the best experimental design - leading to improved parameter estimates. © 2011 ACM.

关键词： Design of experiments

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Output error method for identification of multiple-model process with transition

Output error method for identification of multiple-model pro...

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作者： Zhao, Yu Huang, Biao Su, Hongye Chu, Jian State Key Lab. of Industrial Control Technology Institute of Cyber Systems and Control Zhejiang University Hangzhou 310027 China University of Alberta Canada Department of Chemical and Materials Engineering University of Alberta Edmonton AB T6G 2G6 Canada

This paper is concerned with the identification of multiple model process with transition using the output error (OE) method. Local multiple linear models with output error model structure are identified at fixed operating points first and then a global nonlinear model is approximated by interpolating the multiple linear models with exponential weighting functions. With all the obtained initial values of the system's parameters, nonlinear optimization strategy is implemented to find the optimal values of the parameters for both the local multiple models and their corresponding weighting functions. Finally a more accurate global model can be obtained. The effectiveness of the proposed approach is demonstrated through simulation examples. © 2011 Zhejiang University.

关键词： Errors

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Automatic spike detection based on real-time multi-channel template

Automatic spike detection based on real-time multi-channel t...

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2011 4th International Conference on Biomedical engineering and Informatics(第四届生物医学工程与信息学国际会议 BMEI 2011)

作者： Zhanfeng Ji Xingyu Wang Satoru Goto Masatoshi Nakamura Takenao Sugi Key Laboratory of Advanced Control and Optimization for Chemical Processes Ministry of Education Sc Key Laboratory of Advanced Control and Optimization for Chemical Processes Ministry of Education Sc Department of Advanced Systems Control Engineering Saga University Saga Japan

Automatic EEG spike detection provide valuable information for diagnosis of epilepsy. In the past 30 years, a number of algorithms were proposed. However, the basic idea of most algorithms is to identify spike activities. We have developed an algorithm based on identify non-spike activities for off-line analysis. In this paper, we improved the algorithm for online application using real-time template. Template method is a typical spike detection method. It was not widely employed because of the difficulty of making template. Our results suggested that multichannel template is meaningful and effective for real-time detection. Spike activities can be detected with a delay of about 2 s. We also designed an simple user-friendly monitor interface for monitor and review spike events in real-time.

关键词： spike detection real-time multi-channel template

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Adaptive predictive control of a high purity distillation column using irregularly sampled multi-rate data

Adaptive predictive control of a high purity distillation co...

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International Symposium on Advanced control of Industrial Processes (ADCONIP)

作者： M. Muddu Sachin C. Patwardhan Visvesvaraya Technological University Belgaum Karnataka India Department of Systems and Control Engineering Indian Institute of Technology Bombay Mumbai India Faculty Department of Chemical Engineering Bapuji Institute of Engineering and Technology Davangere Karnataka India Faculty of Department of Chemical Engineering Indian Institute of Technology Bombay Mumbai India

This work aims at the development of multi-rate adaptive model predictive control (MR-AMPC) based on the fast rate model, which is identified from irregularly sampled multi-rate data. The model is assumed to have output error structure and is parameterized using generalized orthonormal basis filters. The identified model is used to generate inter-sample estimates of the irregularly sampled outputs and for performing future trajectory predictions in the proposed MRMPC formulation. The effectiveness of the proposed adaptive multi-rate control scheme is demonstrated by conducting simulation studies on a benchmark binary distillation column system. The results from the simulation reveals that the proposed adaptive multi-rate model predictive control successfully manages transition of the distillation column from moderate purity region to the high purity region where the system exhibits highly nonlinear dynamics.

关键词： Adaptation model Data models Mathematical model Predictive models Distillation equipment Feeds Trajectory

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Performance assessment of PID controller with time-variant disturbance dynamics

Performance assessment of PID controller with time-variant d...

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International Symposium on Advanced control of Industrial Processes (ADCONIP)

作者： Mengfei Zhou Lei Xie Haitian Pan Shuqing Wang College of Chemical Engineering and Materials Science Zhejiang University of Technology Hangzhou China National Key Laboratory of Industrial Control Technology Institute of Cyber-Systems and Control University of Zhejiang Hangzhou China

A method is proposed for performance assessment of PID control loops subject to time-varying disturbance dynamics, which is often observed in industrial processes. The proposed method optimizes overall performance of the processes and presents a PID tradeoff curve which provides a useful lower bound on the achievable performance of the PID controller in terms of both the most significant disturbance rejection and the representative disturbance rejection. One can choose an optional benchmark to assess the PID control performance according to the tradeoff curve. The developed performance assessment technique is illustrated by simulation and industrial examples.

关键词： Benchmark testing Process control Transfer functions Materials Petroleum Furnaces Transient analysis

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A stochastic analysis of the inflammatory response

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Journal of Critical Care 2012年第3期27卷 e6-e7页

作者： Scheff, Jeremy D. Doyle, John Vodovotz, Yoram Androulakis, Ioannis P. Department of Biomedical Engineering Rutgers University Newark NJ Department of Control and Dynamical Systems California Institute of Technology Pasadena CA Department of Surgery University of Pittsburgh Pittsburgh PA Center for Inflammation and Regenerative Modeling McGowan Institute of Regenerative Medicine University of Pittsburgh Pittsburgh PA Department of Surgery UMDNJ-Robert Wood Johnson Medical School New Brunswick NJ Department of Chemical and Biochemical Engineering Rutgers University Newark NJ

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Output error method for identification of multiple-model process with transition

Output error method for identification of multiple-model pro...

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International Symposium on Advanced control of Industrial Processes (ADCONIP)

作者： Yu Zhao Biao Huang Hongye Su Jian Chu University of Alberta Canada State Key Laboratory of Industrial Control Technology Institute of Cyber Systems and Control University of Zhejiang Hangzhou China Department of Chemical and Materials Engineering University of Alberta Edmonton AB Canada

关键词： Interpolation Spline Optimization Data models Coolants Numerical models Zinc

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Modeling and control system design of an MCFC system

Modeling and control system design of an MCFC system

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International Symposium on Advanced control of Industrial Processes (ADCONIP)

作者： Huiyong K im June Ho Cho Kwang Soon Lee Simkyun Yook Wonhee Jung Department of Chemical and Biomolecular Engineering Sogang University Seoul Korea Plant Control Systems Development Team Doosan Heavy Industries and Construction Company Limited Algeria Doosan Heavy Industries and Construction Co. Ltd Plant Control Systems Development Team

A molten carbonate fuel cell (MCFC) system is modeled and a control strategy is proposed. A spatially distributed two-dimensional dynamic model of single cell direct internal reforming MCFC was developed as a numerical process by reducing the PDE model to a set of ODE's using the cubic spline collocation method and the finite difference method. Mean cell temperature, T s;m , maximum temperature difference over a cell, ΔT s;max , oxygen conversion, X O2 , and hydrogen mole fraction at the anode outlet, χ H2;o , were considered as controlled variables (CV's) under the assumption that their target values are determined by an optimizer in the upper level. Among the CV's, T s;m and ΔT s;max have much slower dynamics than the other two and keeping ΔT s;max below a certain safety limit is critical. Hence T s;m and ΔT s;max were designed to be separately controlled under model predictive controller (MPC). On the other hand, X O2 and χH 2;o have fast dynamics and were designed to be regulated by single loop PID controllers with feedforward compensation. The manipulated variables (MV's) for each CV group were determined through a system analysis using the singular value decomposition and relative gain array. The performance of the control scheme was evaluated against load (power demand) changes.

关键词： Anodes Mathematical model control systems Steady-state Cathodes Solids Equations

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Delta-operator-based adaptive MPC for an MCFC system

Delta-operator-based adaptive MPC for an MCFC system

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International Conference on control, Automation and systems ( ICCAS)

作者： June Ho Cho Huiyong Kim Kwang Soon Lee Simkyun Yook Wonhee Jung Department of Chemical and Biomolecular Engineering Sogang University Seoul South Korea Plant Control Systems Development Team Doosan Heavy Industries and Construction Company Limited South Korea

A delta-operator-based adaptive model predictive control (AMPC) technique has been proposed for stack temperature control of a molten carbonate fuel cell (MCFC) system. The MCFC system is unique in that the system should be kept as stable as possible to avoid potential electrode damage, which renders the identification experiment difficult; many stack variables should be monitored at a high frequency and constrained for safe and energy-efficient operation over a long period of time. To accommodate such characteristics, an MCFC simulator was developed and delta-operator-based adaptive MPC was devised and applied to the numerical MCFC system. The model for controller design was derived from the MCFC simulator. To cope with the model error from the true system, a small number of tunable parameters were introduced so that they can be adjusted on-line during the operation of the system. The performance of the proposed technique was investigated numerically.

关键词： Numerical models Adaptation models Load modeling Anodes Cathodes Temperature control

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On State-Constrained control of a CSTR *

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IFAC Proceedings Volumes 2011年第1期44卷 6079-6084页

作者： Florian Bayer Mathias Bürger Martin Guay Frank Allgöwer Institute for Systems Theory and Automatic Control University of Stuttgart Pfaffenwaldring 9 70550 Stuttgart Germany Department of Chemical Engineering Queen's University Kingston Ontario Canada K7L 3N6

Abstract In this note, we study the problem of multiple hard output constraints imposed on a continuous stirred tank reactor (CSTR) subject to external disturbances. Constraints on the concentration and on the temperature are considered. We show, analytically and with simulations, that there are critical combinations of constraints, where robust constraint satisfaction cannot be guaranteed. As a consequence violation of at least one constraint has to be allowed.

关键词： State-Constraints Process control Robust control

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