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26th center for chemical process Safety International Conference 2011, CCPS - Topical Conference at the 2011 AIChE Spring Meeting and 7th Global Congress on process Safety

作者： Pariyani, Ankur Arbogast, Jeffrey Seider, Warren D. Oktem, Ulku Soroush, Masoud Cadet, Olivier Chemical and Biomolecular Engineering University of Pennsylvania Philadelphia PA United States Process Control and Logistics Air Liquide Newark DE United States Risk Management and Decision Center Wharton School University of Pennsylvania Philadelphia PA United States Department of Chemical and Biological Engineering Drexel University Philadelphia PA United States

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An optimal control problem in closed-loop neuroprostheses

An optimal control problem in closed-loop neuroprostheses

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IEEE Conference on Decision and control

作者： Gautam Kumar Vikram Aggarwal Nitish V. Thakor Marc H. Schieber Mayuresh V. Kothare Chemical Process Modeling and Control Center Department of Chemical Engineering Lehigh University Bethlehem PA USA Department of Biomedical Engineering Johns Hopkins University Baltimore MD USA Department of Neurobiology and Anatomy University of Rochester Medical Center Rochester NY USA

ISBN: (纸本)9781612848006;9781612848013

A control-theoretic study of complex systems such as closed-loop neural prostheses exhibits several challenges, from the design of an optimal feedback control problem to its solution. In this paper we study one such system, a closed-loop voluntary movement of a prosthetic finger using electrophysio-logical activities of a single cortical motor neuron. We develop an optimal feedback control problem in the nonlinear receding horizon based terminal set constraint framework. We analyze the feasibility and stability of the control problem. Further, we solve the control problem numerically by implementing a local optimum based nonconvex nonlinear programming algorithm. Finally, we study effects of visual and proprioceptive feedback pathways on the closed-loop system. Our results elucidate the importance of multiple feedback paths in designing a closed-loop neural prosthetic system.

关键词： Prosthetics Neurons Visualization Noise Optimization Torque Indexes

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A stochastic analysis of the inflammatory response

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Journal of Critical Care 2012年第3期27卷 e6-e7页

作者： Scheff, Jeremy D. Doyle, John Vodovotz, Yoram Androulakis, Ioannis P. Department of Biomedical Engineering Rutgers University Newark NJ Department of Control and Dynamical Systems California Institute of Technology Pasadena CA Department of Surgery University of Pittsburgh Pittsburgh PA Center for Inflammation and Regenerative Modeling McGowan Institute of Regenerative Medicine University of Pittsburgh Pittsburgh PA Department of Surgery UMDNJ-Robert Wood Johnson Medical School New Brunswick NJ Department of Chemical and Biochemical Engineering Rutgers University Newark NJ

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Optimal parameter estimation of the Izhikevich single neuron model using experimental Inter-Spike Interval (ISI) data

Optimal parameter estimation of the Izhikevich single neuron...

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作者： Kumar, Gautam Aggarwal, Vikram Thakor, Nitish V. Schieber, Marc H. Kothare, Mayuresh V. Department of Chemical Engineering Chemical Process Modeling and Control Center Lehigh University Bethlehem PA 18015 United States Department of Biomedical Engineering Johns Hopkins University Baltimore MD 21205 United States Department of Neurobiology and Anatomy University of Rochester Medical Center Rochester NY 14627 United States

ISBN: (纸本)9781424474264

We propose to use the Izhikevich single neuron model to represent a motor cortex neuron for studying a control-theoretic perspective of a neuroprosthetic system. The problem of estimating model parameters is addressed when the only available data from intracortical recordings of a neuron are the Inter-Spike Intervals (ISIs). Non-linear constrained and unconstrained optimization problems are formulated to estimate model parameters as well as synaptic inputs using ISIs data. The primal-dual interior-point method is implemented to solve the constrained optimization problem. Reasonable model parameters are estimated by solving these optimization problems which may serve as a template for studying and developing a model of ensemble cortical neurons for neuroprosthesis applications. © 2010 AACC.

关键词： Neurons

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Optimal parameter estimation of the Izhikevich single neuron model using experimental inter-spike interval (ISI) data

Optimal parameter estimation of the Izhikevich single neuron...

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American control Conference

作者： Gautam Kumar Vikram Aggarwal Nitish V. Thakor Marc H. Schieber Mayuresh V. Kothare Chemical Process Modeling and Control Center Department of Chemical Engineering Lehigh University Bethlehem PA 18015 U.S.A. Department of Biomedical Engineering Johns Hopkins University Baltimore MD 21205 U.S.A. Department of Neurobiology and Anatomy University of Rochester Medical Center Rochester NY 14627 U.S.A.

ISBN: (纸本)9781424474264

关键词： Neurons model parameters optimal parameter UNCONSTRAINED OPTIMISATION Parameter estimation available data jigs(templates)

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Tension Soft Sensor of Continuous Annealing Lines Using Cascade Frequency Domain Observer with Combined PCA and Neural Networks Error Compensation

Tension Soft Sensor of Continuous Annealing Lines Using Casc...

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2010 49th IEEE Conference on Decision and control

作者： Qiang Liu Tianyou Chai Hong Wang S. Joe Qin Key Laboratory of Integrated Automation of Process Industry (Northeastern University) Ministry of Education and Research Center of Automation Northeastern University Shenyang China Control Systems Centre the University of Manchester Manchester M60 1QD the United Kingdom Mork Family Department of Chemical Engineering and Materials Science the Ming Hsieh Department of Electrical Engineering University of Southern California Los Angeles CA 90089-1211 USA

ISBN: (纸本)9781424477456

In continuous annealing processes, strip tension is an important factor which indicates whether the annealing line works steadily. The strip tension detection in the continuous annealing process, therefore, is essential for the reliable and stable operation of the units, and will help to improve the quality of strip products. However, in real annealing processes, only a limited number of strip tensions can be measured. Since installing tension sensors everywhere will be unrealistic and expensive, in this paper a cascade reduced-order observer method with principal component analysis (PCA) and neural networks (NN) compensation is proposed to estimate the unknown tensions between each two neighboring rolls so as to monitor the tension profile for the whole line. When the main observer model is established, the influences of strip inertia and roll eccentricity on tensions are taken into account for better estimation. Moreover, when the error compensation is designed, PCA scores are used as the inputs to the NN. The application results show the effectiveness of the proposed method, with the estimated tensions used for the analysis of the strip-breaks fault.

关键词： Error compensation Continuous annealing annealing tension strip tension stability operations Neural network cascades

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Corrigendum to "A new method for assessing domino effect in chemical process industry" [J. Hazard. Mater. 182 (2010) 416-426]

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Journal of hazardous materials 2010年第1-3期184卷 877页

作者： Bahman Abdolhamidzadeh Tasneem Abbasi D Rashtchian S A Abbasi Center for Process Design Safety and Loss Prevention Department of Chemical and Petroleum Engineering Sharif University of Technology Tehran Iran. Center for Pollution Control and Environmental Engineering Pondicherry University Kalapet Pondicherry 605 014 India. Center for Pollution Control and Environmental Engineering Pondicherry University Kalapet Pondicherry 605 014 India. Electronic address: prof.s.a.abbasi@***.

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Assessment of a Plantibody HB-01 Purification Strategy at Different Scales

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CHROMATOGRAPHIA 2009年第11-12期70卷 1673-1678页

作者： Padilla, Sigifredo Valdes, Rodolfo Gomez, Leonardo Geada, Deborah Ferro, Williams Mendoza, Otto Garcia, Cristina Mila, Lorely Pasin, Leonardo Issac, Yordan Gavilan, David Gonzalez, Tatiana Sosa, Raudel Leyva, Alberto Sanchez, Julio LaO, Mailin Calvo, Yodelis Sanchez, Rafael Fernandez, Eutimio Brito, Jose Monoclonal Antibody Department Center for Genetic Engineering and Biotechnology Ave 31 be/158 and 190 Havana 10600 Cuba Quality Assurance Direction Center for Genetic Engineering and Biotechnology Ave 31 be/158 and 190 Havana 10600 Cuba Process Control Department Center for Genetic Engineering and Biotechnology Ave 31 be/158 and 190 Havana 10600 Cuba Quality Control Direction Center for Genetic Engineering and Biotechnology Ave 31 be/158 and 190 Havana 10600 Cuba Regulatory Affair Direction Center for Genetic Engineering and Biotechnology Ave 31 be/158 and 190 Havana 10600 Cuba Production Direction Center for Genetic Engineering and Biotechnology Ave 31 be/158 and 190 Havana 10600 Cuba Tobacco Research Institute Tumbadero Road km 8&#189 . San Antonio de los Ba&#241 os Havana 3500 Cuba Center for Engineering and Chemical Researches F Street # 115 be/Ave 5th and Calzada Havana 10600 Cuba

Transgenic plant investigations focus on fine-regulation of the recombinant protein expression and purification strategies. In this article, preliminary experiments were done at analytical-scale to decide the best plantibody HB-01 purification strategy. Once it was assumed, the purification efficiency was assessed at different scales (10-600 kg of biomass). The plantibody purity measured by SDS-PAGE and LC-GF was over 90%, yielding 9.9 +/- A 6.2-18.6 +/- A 0.9 mg plantibody kg(-1) of biomass and 39.9 +/- A 7.9-48.7 +/- A 2.1% of recovery. Significant differences were not observed among these parameters at these scales. Plant DNA contents were < 3.3 ng mg(-1) of plantibody, which is considered very low for the plantibody HB-01 application in the hepatitis B vaccine production.

关键词： Expanded bed adsorption chromatography Plantibody purification Transgenic plant

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Formation and stability study of Nano-emulsions: BTX- separation

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Open chemical engineering Journal 2009年 3卷 33-40页

作者： Barad, Jaydeep M. Chakraborty, Mousumi Bart, Hans-Jörg Department of Chemical Engineering S. V. National Institute of Technology Surat-395 007 Gujarat India Department of Mechanical and Process Engineering TU Kaiserslautern Germany Center of Mathematical and Computational Modeling TU Kaiserslautern 67663 Kaiserslautern Germany

The selective separation of aromatics (benzene, toluene and p-xylene, BTX) from aliphatic (n-heptane) is investigated using simple permeation and facilitated transport emulsion liquid membrane mechanism. The separation performances, represented by the permeation rate and separation factor, are analyzed systematically by varying the operating parameters. One of the major obstacles to the application of emulsion liquid membranes to industrial separations is the stability of emulsion globules. In the present study, stability of emulsion liquid membrane is studied by varying different parameters e.g. surfactant and feed phase concentration, stirrer speed for emulsification. Dispersion destabilisation of emulsion is detected by Turbiscan. Effects of interfacial tension on internal droplets size and size distribution are also systematically investigated. Stable emulsions under optimal conditions are used for the separation of aromatics (BTX) from aliphatic (n-heptane) in a synthetic feed mixture. © Barad et al.;Licensee Bentham Open.

关键词： Stability

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Performance assessment of run-to-run control in semiconductor manufacturing based on IMC framework

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International Journal of Production Research 2009年第15期47卷 4173-4199页

作者： Chen, Liang Ma, Mingda Jang, Shi-Shang Wang, David Shan-Hill Wang, Shuqing State Key Laboratory of Industrial Control Technology Institute of Advanced Process Control Hangzhou China Center for Control and Guidance Technology Harbin Institute of Technology Harbin China Department of Chemical Engineering National Tsing-Hua University Hsin-Chu Taiwan

The objective of this paper is to propose a universal methodology for performance assessment of run-to-run control in semiconductor manufacturing. The slope of the linear semiconductor process model is assumed to be known or subjected to mild plant/model mismatch. Based on an internal model control framework, analytical expressions of minimum variance performance (MVP) and best achievable performance (BAP) for a series of run-to-run control schemes are derived. In the methodology, closed-loop identification is utilised as the first step to estimate the noise dynamics via routine operating data, and numerical optimisation is employed as a second step to calculate the best achievable performance bounds of the run-to-run control loops. The validity of the methodology is justified by examples of performance assessment for EWMA control, double EWMA control and RLS-LT control, even under circumstances where the processes encounter model mismatch, metrology delay and more sophisticated noises. Several essential characteristics of run-to-run control are discovered by performance assessment, and valuable advice is offered to process engineers for improving the run-to-run control performance. Furthermore, a useful application example for online performance monitoring and optimal tuning of run-to-run controller demonstrates the advantage of the methodology.

关键词： Optimization

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