To understand the potential-dependent kinetics of reactions at solid-liquid interface,we derive a constant-charge reaction theory for understanding the coupled charge transfer during the chemical bond making/*** charg...
详细信息
To understand the potential-dependent kinetics of reactions at solid-liquid interface,we derive a constant-charge reaction theory for understanding the coupled charge transfer during the chemical bond making/*** charge transfer coefficient(CTC)for reactions is shown to be linearly proportional to the electrochemical potential change from the initial state to the transition state as well the interface differential capacitance at the constant-charge model,and can be further related to the net dipole change normal to the surface during the *** the constant-charge theory,the CTC can be explicitly calculated based on the first principles calculations without the need to assume the redox behavior of the elementary reactions and thus provide a unique possibility to evaluate and compare the magnitude of CTC for different reactions across different surfaces..The role of surface dipole,solvation and molecular adsorption strength on the CTC can now be clarified from first principles calculations.
Botulinum neurotoxin (BoNT) serotype A is the most lethal known toxin and has an occluded structure, which prevents direct inhibition of its active site before it enters the cytosol. Target‐guided synthesis by in sit...
详细信息
Botulinum neurotoxin (BoNT) serotype A is the most lethal known toxin and has an occluded structure, which prevents direct inhibition of its active site before it enters the cytosol. Target‐guided synthesis by in situ click chemistry is combined with synthetic epitope targeting to exploit the tertiary structure of the BoNT protein as a landscape for assembling a competitive inhibitor. A substrate‐mimicking peptide macrocycle is used as a direct inhibitor of BoNT. An epitope‐targeting in situ click screen is utilized to identify a second peptide macrocycle ligand that binds to an epitope that, in the folded BoNT structure, is active‐site‐adjacent. A second in situ click screen identifies a molecular bridge between the two macrocycles. The resulting divalent inhibitor exhibits an in vitro inhibition constant of 165 p M against the BoNT/A catalytic chain. The inhibitor is carried into cells by the intact holotoxin, and demonstrates protection and rescue of BoNT intoxication in a human neuron model.
Doxorubicin (DOX) is one of the most generally used chemotherapeutic drugs in antitumor ***,the severe side effect of DOX to normal tissues limits its dosage in treatment and reduces its curative effect in the ***,dev...
详细信息
Doxorubicin (DOX) is one of the most generally used chemotherapeutic drugs in antitumor ***,the severe side effect of DOX to normal tissues limits its dosage in treatment and reduces its curative effect in the ***,developing targeted carriers to deliver DOX specifically to cancer cells is a major task in rumor *** receptors (ASGPR) are considered as a promising target for liver cancer cells,since they are present on the surface of hepatocarcinoma cells with a high density and can facilitate efficient intracellular uptake of the galactose ligand-modified conjugates via receptor-mediated endocytosis [1].
Conjugation of synthetic polymers with protein/peptides is commonly employed to improve efficacy by increasing life time in vivo and decreasing *** maintain and even control the prote
Conjugation of synthetic polymers with protein/peptides is commonly employed to improve efficacy by increasing life time in vivo and decreasing *** maintain and even control the prote
Various functional groups have been suggested to play essential roles on biomineralization of calcium carbonate (CaCO3) in natural system. 2D and 3D models of regularly arranged functional groups have been established...
详细信息
Various functional groups have been suggested to play essential roles on biomineralization of calcium carbonate (CaCO3) in natural system. 2D and 3D models of regularly arranged functional groups have been established to investigate their effect on CaCO3 crystallization. This mini-review summarizes the recent progress and the future development is prospected.
暂无评论