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Electrochemical Release of Immobilized IgG Protein

MRS Online Proceedings Library 2007年第1期1010卷 1-6页

作者： Tanveer Mahmud Wojtek Wlodarski Arnan Mitchell Sally Gras Adrian Trinchi Kourosh Kalantar-zadeh School of Electrical and Computer Engineering RMIT University Melbourne Australia Department of Chemical and Biomolecular Engineering and The Bio21 Molecular Science & Biotechnology The University of Melbourne Melbourne Australia Manufacturing and Materials Technology CSIRO Melbourne Australia

In this paper, we present the electrochemically programmed release of immobilized IgG protein molecules that have been attached to gold coated surfaces via a thiol-gold linkage. Fluorescence microscopy has been used to image the release of fluorescently tagged IgGs in phosphate buffered saline. In this technique, the reductive desorption of self-assembled monolayers is employed for the release of proteins, which are immobilized on the surface either by non-covalent or covalent interactions. The voltage applied for the release of proteins is in a range of -1.5V to -60V.

关键词： surface chemistry biological self-assembly

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Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis (vol 69, pg 298, 2007)

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chemical BIOLOGY & DRUG DESIGN 2007年第6期69卷 455-455页

作者： Chellappan, S. Center for Advanced Research in Biotechnology University of Maryland Biotechnology Institute 9600 Gudelsky Drive Rockville MD 20850 USA Chemical Biology Program Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School Worcester MA 01605 USA Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School Worcester MA 01605 USA Department of Chemistry Massachusetts Institute of Technology Cambridge MA 02139 USA Biological Engineering Division Department of Electrical Engineering & Computer Science Massachusetts Institute of Technology Cambridge MA 02139 USA *Correspondence: Michael K. Gilson *Correspondence: * Michael K. Gilson gilson@umbi.umd.edu http://gilsonlab.umbi.umd.edu[?][?]These authors contributed equally to this study.

There is a clinical need for HIV protease inhibitors that can evade resistance mutations. One possible approach to designing such inhibitors relies upon the crystallographic observation that the substrates of HIV protease occupy a rather constant region within the binding site. In particular, it has been hypothesized that inhibitors which lie within this region will tend to resist clinically relevant mutations. The present study offers the first prospective evaluation of this hypothesis, via computational design of inhibitors predicted to conform to the substrate envelope, followed by synthesis and evaluation against wild-type and mutant proteases, as well as structural studies of complexes of the designed inhibitors with HIV protease. The results support the utility of the substrate envelope hypothesis as a guide to the design of robust protease inhibitors.

关键词： AIDS crystal drug design inhibitor protease

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Contributors to the Lab on a Chip cell and tissue engineering in microsystems special issue

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Lab on a Chip 2007年第6期7卷 667-671页

作者： Bhatia, Sangeeta N. Chen, Christoper Bashir, Rashid Beebe, David J. Desai, Tejal Gottwald, Eric Khademhosseini, Ali Langer, Robert S. Piel, Matthieu Takayama, Shuichi Thorsen, Todd Tien, Joe Voldman, Joel Vunjak-Novakovic, Gordana Wu, Mingming Yu, Hanry Massachusetts Institute of Technology Harvard-MIT Division of Health Sciences and Technology Department of Electrical Engineering and Computer Science United States Laboratory for Multiscale Regenerative Technologies United States Department of Innovation University of Pennsylvania Department of Bioengineering United States Cell Biology and Physiology Program Cell Growth and Cancer Program Tissue Microfabrication Laboratory Department of Electrical and Computer Engineering and Biomedical Engineering Purdue University United States Department of Electronics University of Glasgow United Kingdom Department of Physiology and Bioengineering University of California San Francisco CA United States California Institute for Quantitative Biomedical Research UCSF/UC Berkeley Graduate Group in Bioengineering United States Laboratory of Therapeutic Micro and Nanotechnology Institute for Biological Interfaces Germany 3D-Cell Culture Techniques Group Institute for Biological Interfaces Germany Department of Medicine and Health Sciences and Technology Massachusetts Institute of Technology (MIT) United States Institut Curie UMR 144 IC/CNRS France Biomedical Engineering Department University of Michigan United States Department of Biomedical Engineering Macromolecular Science and Engineering Program United States Sibley School of Mechanical and Aerospace Engineering School of Chemical and Molecular Engineering Cornell University United States National University of Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR Singapore

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Real-space pseudopotential calculations of spin-dependent electron transport in magnetic molecular junctions

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Physical Review B 2007年第23期76卷 235422-235422页

作者： Lingzhu Kong James R. Chelikowsky J. B. Neaton Steven G. Louie Department of Chemical Engineering and Materials Science University of Minnesota Minneapolis Minnesota 55455 USA Center for Computational Material Institute for Computational Engineering and Sciences and Departments of Physics and Chemical Engineering University of Texas Austin Texas 78712 USA Molecular Foundry Lawrence Berkeley National Laboratory Berkeley California 94720 USA Department of Physics University of California Berkeley California 94720 USA

A real-space pseudopotential approach is developed to calculate the spin-dependent transport in nanoscale junctions. Our method is based on self-consistent solution of the Kohn-Sham equation of density functional theory with asymptotic boundary conditions. This method is applied to a simple magnetic molecule, the Sc dimer, bridging nonmagnetic, planar jellium electrodes for a series of molecule-lead spacing. We find that the spin-dependent conductance within this formalism is rather robust over a wide range of electronic coupling parameters. The minority channel of parallel-aligned Sc2 produces a fairly stable conductance of roughly half of a quantum unit (e2∕h). Other systems show sensitive dependence on the coupling strength. Atomic origins of the dependence are discussed.

关键词： electronic transport in nanoscale materials and structures spin polarized transport ballistic magnetoresistance methods of electronic structure calculations spin polarised transport DEPENDENCE Ballistic magnetoresistance

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Interfaces behaving wellAssociated Content

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Nature materials 2007年第8期6卷 551-552页

作者： Brian A. Korgel Brian A. Korgel is in the Department of Chemical Engineering Center for Nano- and Molecular Science and Technology Texas Materials Institute The University of Texas at Austin Austin Texas 78712 USA. korgel@mail.che.utexas.edu

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High sensitivity detection of biomolecules using surface molecular imprinting technology

High sensitivity detection of biomolecules using surface mol...

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7th World Congress: Enabling Technologies and New Markets, Nanocomposites 2007

作者： Wang, Yantian Zhang, Zhiquan Jain, Vijay Yi, Jinju Mueller, Steffen Sokolov, Jonathan Levon, Kalle Rigas, Basil Rafailovich, Miriam Department of Materials Science and Engineering Stony Brook University Stony Brook NY 11794 United States Department of Medicine Stony Brook University Stony Brook NY 11794 United States Herricks High School New Hyde Park NY 11040 United States Plainview Old-Bethpage John F. Kennedy High School Plainview NY 11803 United States Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794 United States Department of Chemical and Biological Science and Engineering Polytechnic University Brooklyn NY 11201 United States

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Hydrogen production by photoreactive nanoporous latex coatings of nongrowing Rhodopseudomonas palustris CGA009

Hydrogen production by photoreactive nanoporous latex coatin...

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作者： Gosse, Jimmy L. Engel, Brian J. Rey, Federico E. Harwood, Caroline S. Scriven, L.E. Flickinger, Michael C. BioTechnology Institute 140 Gortner Laboratory University of Minnesota St. Paul MN 55108 United States Department of Biochemistry Molecular Biology and Biophysics University of Minnesota 1479 Gortner Avenue St. Paul MN 55108 United States Department of Microbiology University of Washington Box 357242 Seattle WA 98195 United States Department of Chemical Engineering and Materials Science University of Minnesota 151 Amundson Hall 421 Washington Ave. SE Minneapolis MN 55455 United States

Nonuniform light distribution is a fundamental limitation to biological hydrogen production by phototrophic bacteria. Numerous light distribution designs and culture conditions have been developed to reduce self-shading and nonuniform reactivity within bioreactors. In this study, highly concentrated (2.0 × 108 CFU/μL formulation) nongrowing Rhodopseudomonas palustris CGA009 were immobilized in thin, nanoporous, latex coatings. The coatings were used to study hydrogen production in an argon atmosphere as a function of coating composition, thickness, and light intensity. These coatings can be generated aerobically or anaerobically and are more reactive than an equivalent number of suspended or settled cells. Rhodopseudomonas palustris latex coatings remained active after hydrated storage for greater than 3 months in the dark and over 1 year when stored at -80°C. The initial hydrogen production rate of the microphotobioreactors containing 6.25 cm2, 58.4 μm thick Rps. palustris latex coatings illuminated by 34.1 PAR μmol photons m-2 s-1 was 6.3 mmol H2 m-2 h-1 and had a final yield of 0.55 mol H2 m-2 in 120 h. A dispersible latex blend has been developed for direct comparison of the specific activity of settled, suspended, and immobilized Rps. palustris. © 2007 American chemical Society and American Institute of chemical Engineers.

关键词： Bacteria

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Ultrafast switching of Si inverse opal photonic band gap crystals

Ultrafast switching of Si inverse opal photonic band gap cry...

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Conference on Lasers and Electro-Optics Europe (CLEO EUROPE)

作者： Tijmen G. Euser Hong Wei Jeroen Kalkman Yunhoo Jun Albert Polman David J. Norris Willem L. Vos FOM-Institute of Atomic and Molecular Physics (AMOLF) Amsterdam Netherlands Department of Chemical Engineering & Materials Science University of Minnesota Minneapolis MN USA Complex Photonic Systems Group (COPS) MESA Research Institute University of Twente Enschede Netherlands

We present the first ultrafast optical switching of 3D photonic band gaps using Si inverse opals. Switching is achieved by homogeneously exciting free carriers by a two-photon process. We probe reflectivity over a broad frequency range, in particular the range where the photonic band gap is predicted. We observe a large frequency shift, and a fast decay time of 21 ps, which implies that switching could potentially be repeated at GHz rates, which is relevant to future switching and modulation applications. We also discuss the favorable prospects for ultrafast QED: switching spontaneous emission of light sources such as embedded quantum dots.

关键词： Photonic band gap Photonic crystals Reflectivity Frequency Light sources Physics materials science and technology Optical control Optical pumping Optical refraction

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Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically-targeted cancer therapy and diagnosis using magnetic resonance imaging

Novel multifunctional PHDCA/PEI nano-drug carriers for simul...

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2007 Pacific Rim Conference on Lasers and Electro-Optics (CLEO/PACIFIC RIM 2007), vol.2

作者： Sungbaek Seo Jaemoon Yang Woochan Hyung Eun-Jin Cho Yong Jin Song Ho-Geun Yoon Jin-Suck Suh Yong-Min Huh Seungjoo Haam Graduate Program for Nanomedical Science Yonsei University Seoul 120-749 South Korea Department of Chemical Engineering College of Engineering Yonsei University Seoul 120-749 South Korea Department of Radiology College of Medicine Yonsei University Seoul 120-752 South Korea Department of Physics College of Natural Science Ajou University Suwon 433-749 South Korea Department of Biochemistry and Molecular Biology Center for Chronic Metabolic Disease Research College of Medicine Yonsei University Seoul 120-752 South Korea

ISBN: (纸本)1424411742

Novel multifunctional magnetic polycation drug carriers (MPDCs) were synthesized to provide simultaneous magnetically targeted cancer therapy and diagnosis using magnetic resonance imaging (MRI). The MPDCs demonstrated ultra-sensitivity via MRI and sufficient magnetic mobility under an external magnetic field. Drug loading efficiency and release kinetics were also investigated to assess the therapeutic potential of the MPDCs.

关键词： In vivo imaging Magnetic fields Magnetic resonance imaging Microscopy Nanocrystals Nanoparticles

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Waters network's potential to transform environmental engineering education

Waters network's potential to transform environmental engine...

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114th Annual ASEE Conference and Exposition, 2007

作者： Eschenbach, Elizabeth Montgomery, Jami Johnson, James Brus, Chris Carlson, Patricia Giammar, Dan Grauer, Bette Hotaling, Liesl Oguntimein, Gbekeloluwa Safferman, Steven Wentling, Tim Humboldt State University United States Department of Environmental Resources Engineering Humboldt State University United States WATERS Network - CLEANER Project Office Network Howard University United States Department of Environmental Engineering College of Engineering Architecture and Computer Sciences Howard University United States American Academy of Environmental Engineers United States University of Iowa United States Program University of Iowa United States Rose-Hulman Institute of Technology United States Department of Rhetoric Rose-Hulman Institute of Technology United States National Research Council U. S. Air Force United States NASA's Classroom of the Future Wheeling WV United States Washington University United States Department of Energy Environmental and Chemical Engineering Washington University St. Louis United States Environmental Studies Program Center for Materials Innovation United States McPherson High School United States McPherson High School McPherson KS United States Stevens Institute of Technology United States Stevens Institute of Technology United States Morgan State University United States Michigan State University United States Biosystems and Agricultural Engineering Department Michigan State University United States University of Dayton United States Education Planning Committee National Center for Supercomputing Applications United States Department of Information Science Graduate School of Library and Information Science National Center for Supercomputing Applications University or Illinois United States Knowledge and Learning Systems Group NCSA United States

The WATERS Network (WATer and Environmental Research Systems Network) will be an integrated real-time distributed observing system which will enable academic and government scientists, engineers, educators, and practitioners to advance effective management of our nation's water resources by understanding human interactions with water and the natural and built environment. WATERS will provide easily accessible real time environmental data as well as analysis tools to engineers, scientists, educators, K- graduate students and policymakers so they can better understand how water quantity, quality and related components of the hydrologic cycle are impacted by natural and human influences. The WATERS strategic plan will be completed by July 2007 and requires constituent input. This paper describes the draft Conceptual Design and the Education Plan of WATERS Network. This paper will highlight the potential impact of WATERS on undergraduate and graduate environmental engineering education in order to elicit input from the environmental engineering education community on how WATERS Network could better meet the future needs of undergraduate and graduate students and educators. More information can be found at ***. © American Society for engineering Education, 2007.

关键词： Water resources

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