Small‐angle neutron scattering, SANS, stands forth as one of the most important of the new tools for evaluating polymer chain conformation and morphology. This paper reviews the SANS literature through 1982, with a f...
Small‐angle neutron scattering, SANS, stands forth as one of the most important of the new tools for evaluating polymer chain conformation and morphology. This paper reviews the SANS literature through 1982, with a few early 1983 references added. The theory of SANS is outlined and compared to light scattering. SANS values of polymer molecular weights and radii of gyration obtained in the bulk state were found to be in agreement with values obtained from dilute solutions by light scattering. In each case, deuterated fractions of polymer were inserted into the hydrogeneous matrix, or vice versa, to provide contrast. Several new research areas are then discussed, including unidirectional stretching of elastomers, stress‐relaxation, polymer‐polymer miscibility, crystallization from the melt compared with crystallization from dilute solutions, nonclassical aggregation during bulk polymerization of thermoset systems, morphology of polymer blends, block copolymers and ionomers, the core‐shell structure of latexes and polymer blocks, and grafts as surfactants in emulsions and latexes. Much new and sometimes unexpected information is being provided by the SANS research now in progress.
作者：
KORWEK, ELEdward L. Korwek
Ph.D. J.D. is associated with the law offices of Keller and Heckman 1150 17th St. N.W. Washington D.C. 20036.REFERENCES Committee on Recombinant DNA "Potential Biohazards of Recombinant DNA Molecules" Nature250: 175 (1974) Proc. Nat. Acad. Sci.71: 2593 (1974)Science185: 303 (1974).|Article|Fed. Regist.48: 24556 (1983).Milewski
E. Editor's Note. Recombinant DNA Tech. Bull.4: i (1981).Inside EPA 4 1 (1983). EPA has already held a meeting and published a draft report on the subject of its regulation of this area under the TSCA. EPA "Administrator's Toxic Substances Advisory Committee Meeting"
Fed. Regist.48: 8342 (1983) Regulation of Genetically Engineered Substances Under TSCA
Chemical Control Division Office of Toxic Substances Office of Pesticides and Toxic Substances Environmental Protection Agency Washington D.C. (March 1982). Congress also recently held a hearing on the subject of existing federal authority over the release of R-DNA-containing organisms into environment. M. Sun Science221: 136 (1983).Sects. 2-30 15 U.S. Code sects. 2601-2629 (1976 and Supp. V 1981). Hereinafter all references in the text to TSCA refer to the section numbers as enacted and not to the corresponding U.S. Code sections.The Administrative Procedure Act specifically states that the reviewing court shall "hold unlawful and set aside agency action findings and conclusions found to be hellip in excess of statutory jurisdiction
authority or limitations or short of statutory right. hellip " 5 U.S. Code
sect. 706(2)(C) (1976).PHS Act 42 U.S. Code sects. 217a and 241 (1976) Charter
Recombinant DNA Advisory Committee Department of Health and Human Services (1982).Korwek E. Food Drug and Cosm. L. J.35: 633 (1980) p. 636.Although DHHS has some authority under Section 361 of the PHS Act to regulate R-DNA materials that cause human disease and are communicable most types of experimentation would not fall into this category. Because of this limitation the Sub committee of the Federal
Antibody-based therapeutics constitute a rapidly growing class of pharmaceutical compounds. However, monoclonal antibodies, which specifically engage only one target, often lack the mechanistic intricacy to treat comp...
Antibody-based therapeutics constitute a rapidly growing class of pharmaceutical compounds. However, monoclonal antibodies, which specifically engage only one target, often lack the mechanistic intricacy to treat complex diseases. To expand the utility of antibody therapies, significant efforts have been invested in designing multispecific antibodies, which engage multiple targets using a single molecule. These efforts have culminated in remarkable translational progress, including nine US Food and Drug Administration–approved multispecific antibodies, with countless others in various stages of preclinical or clinical development. In this review, we discuss several categories of multispecific antibodies that have achieved clinical approval or shown promise in earlier stages of development. We focus on the molecular mechanisms used by multispecific antibodies and how these mechanisms inform their customized design and formulation. In particular, we discuss multispecific antibodies that target multiple disease markers, multiparatopic antibodies, and immune-interfacing antibodies. Overall, these innovative multispecific antibody designs are fueling exciting advances across the immunotherapeutic landscape.
Semiconductor nanocrystals are promising materials for low-cost large-area electronic device fabrication. They can be synthesized with a wide variety of chemical compositions and size-tunable optical and electronic pr...
Semiconductor nanocrystals are promising materials for low-cost large-area electronic device fabrication. They can be synthesized with a wide variety of chemical compositions and size-tunable optical and electronic properties as well as dispersed in solvents for room-temperature deposition using various types of printing processes. This review addresses research progress in large-area electronic device applications using nanocrystal-based electrically active thin films, including thin-film transistors, light-emitting diodes, photovoltaics, and thermoelectrics.
作者：
AILOR, WILLIAM H.REINHART, FRED M.William H. Ailor has been a member of the Chemical Metallurgy Section of the Metallurgical Research Division
Reynolds Metals Company for nine years. He holds degrees in chemistry and chemical engineering from the University of Tampa Florida and North Carolina State. He is Task Force Chairman of an ASTM 20-Year Test Program for the atmospheric corrosion of metals secretary of ASTM Committee B-3 and is a member of the Electrochemical Society the National Association of Corrosion Engineers and the American Society of Naval Engineers. He formerly taught diesel engineering at North Carolina State. He is a Lieutenant Commander in the Naval Reserve. During World War II he served as engineering officer afloat and later as commanding officer of USS PC 616 and USS Belet (APD-109). Recalled to service in the Korean conflict he served 17 months as executive officer of the USS Robinson (DD 562). He is in the active reserve and formerly was commanding officer of Naval Reserve Surface Division 6–42 in Jacksonville Florida. Currently he is training officer of MSTS Co. 5-1 in Richmond Va. Fred M. Reinhart has been a Senior Project Scientist (Metallurgist) Materials Division
Civil Engineering Department U. S. Naval Civil Engineering Laboratory Port Hueneme California since September 1962. From 1937 to 1962 he was chemist metallurgist supervisory physical metallurgist and supervisory aeronautical materials research engineer Metallurgy Division National Bureau of Standards. Mr. Reinhart has written many papers that have been published in the technical literature and is the author of one technical publication ASTM STP290 “Twenty-Year Atmospheric Corrosion Investigation of Zinc-Coated and Uncoated Wire and Wire Products. He is a member of ASM and was Chairman of the Washington Chapter 1951-52 a member of ASTM with membership on Committees A-5
A-10 and B-3 and was Chairman of Subcommittee XV of A-5 from 1952 to 1962 a member of NACE and was Chairman of the Editorial Review Subcommittee of the Publications Committee f
This investigation provides the first reported viscosity measurements on cholesteryl myristate. Viscosities were measured as a function of both temperature and shear over temperatures corresponding to the isotropic li...
This investigation provides the first reported viscosity measurements on cholesteryl myristate. Viscosities were measured as a function of both temperature and shear over temperatures corresponding to the isotropic liquid, the cholesteric mesophase, and the smectic mesophase. The myristate ester was chosen for study because its multiple phase transitions have been previously shown to be reproducible. The phases also persist over relatively long temperature ranges. The viscosity measurements were made at lower shear rates than previously reported for esters of cholesterol by using a Weissenberg Rheogoniometer. These are the first cone-and-plate viscosity measurements reported for any esters of cholesterol. The shear rates in this cone-and-plate viscometer are homogeneous and variable. The results show large breaks in viscosity behavior at the independently-measured thermodynamic transitions between the crystal, smectic, cholesteric, and isotropic states. Viscosities for the isotropic state are Newtonian throughout. The viscosities for both the cholesteric and smectic mesophases are prominently non-Newtonian with a sharp transition between the two. This is the first time a change in rheology has been reported at a smectic-cholesteric transition. A prominent viscosity maximum is observed near the cholesteric-isotropic transition which depends on shear rate and perhaps on time of shearing.
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