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A Rapid Manual Solid Phase Peptide Synthesis Method for High-Throughput Peptide Production

Journal of Biomedical materials Research - Part A 2025年第5期113卷 e37922页

作者： Overby, Clyde Abraham, Brittany Adjei-Sowah, Emmanuella March, Alyson Ling, Kevin Basu, Sayantani Benoit, Danielle S. W. Department of Biomedical Engineering University of Rochester RochesterNY United States Center for Musculoskeletal Research University of Rochester RochesterNY United States Department of Chemical Engineering University of Rochester RochesterNY United States Materials Science Program University of Rochester RochesterNY United States Department of Bioengineering Knight Campus for Accelerating Scientific Impact University of Oregon EugeneOR United States

Solid phase peptide synthesis (SPPS) techniques are critical for developing and using peptides in various biomedical applications. However, typical synthesis routes used in SPPS are either resource-intensive (e.g., with automated synthesis or commercial services) or time-consuming (e.g., with manual benchtop synthesis). Here, a rapid manual synthesis method was developed to produce up to 8 peptides with fast cycle times simultaneously. Peptides synthesized manually were of equivalent or superior quality to those produced by in-house microwave-assisted automated peptide synthesis, with higher average crude purity of 70% compared to 50%. The method significantly reduced synthesis time, enabling the parallel coupling of up to 8 amino acids simultaneously in 15–20 min, as opposed to traditional benchtop peptide synthesis, which requires 80–150 min per amino acid. This approach offers an intermediate throughput between milligram-scale libraries and gram-scale single peptide synthesis, enabling rapid iteration for novel peptide designs without the need for expensive automated systems. As a result, peptide modifications, including incorporation of unnatural amino acids, can be explored, accelerating the development of peptides for a wide range of applications. © 2025 The Author(s). Journal of Biomedical materials Research Part A published by Wiley Periodicals LLC.

关键词： Medical applications

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Enhanced Photocatalytic Reduction of Cr (Vi) Using Porous Hierarchical Bi2o3/Bi2s3 High-Low Heterojunctions: Novel Strategies And Charge Transfer Mechanisms

SSRN

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SSRN 2024年

作者： Sang, Yan Xue, Jingwei Hu, Junjie Zhang, Peng Zhao, Fugang He, Yanping College of Chemistry and Materials Science Center for Nano Science and Technology Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Normal University Wuhu241002 China Department of Environmental Science and Engineering University of Science and Technology of China Hefei230026 China School of Chemistry and Chemical Engineering Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province Zhejiang Sci-Tech University Zhejiang Hangzhou310018 China

High-low heterojunctions derived from metal-organic frameworks (MOFs) have promising applications in photocatalytic wastewater treatment because of their high photo-redox ability and boosted charge separation efficiency. Herein, Bi-MOF derived porous hierarchical Bi2O3/Bi2S3 nanoflower-like heterojunctions were prepared by the calcination-hydrothermal method. The optimized Bi2O3/Bi2S3-2 composite showed a higher degradation rate of Cr (VI) (99.79% in 30 min) than the pure substance. Moreover, comprehensive studies were conducted on the kinetics, stability and recycling of Bi2O3/Bi2S3, as well as optical characteristics. The active species trapping experiments confirmed that e- plays a dominant role in the elimination of Cr (VI). These findings provided novel strategies for construction of porous hierarchical heterojunctions with advanced visible-light-induced degradation performance. The enhanced photo-degradation efficiency of the optimal nanocomposite was assigned to the higher visible-light absorbance, separation of photogenerated carriers, reduced recombination of photo-induced carriers, and enhanced redox capability owing to the construction of porous hierarchical heterojunctions amongst the components. © 2024, The Authors. All rights reserved.

关键词： Bismuth compounds

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An Aggregation-Induced Emission Optical Highlighter for the Studies of Endoplasmic Reticulum-Lipid Droplet Content Dynamics

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CCS Chemistry 2022年第2期4卷 515-525页

作者： Engui Zhao Chuen Kam Ming-Yu Wu Erjing Wang Jiawei Wang Ben Zhong Tang Sijie Chen School of Science School of Electronics and Information EngineeringHarbin Institute of TechnologyShenzhenHIT Campus of University TownShenzhen 518055 Ming Wai Lau Centre for Reparative Medicine Karolinska InstitutetHong Kong 999077 Overseas Expertise Introduction Center for Discipline Innovation(D18025) Collaborative Innovation Center for Advanced Organic Chemical Materials Co-Constructed by the Province and MinistrySchool of Material Science and EngineeringHubei UniversityWuhan 430062 Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionSCUT-HKUST Joint Research InstituteInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 Shenzhen Institute of Molecular Aggregate Science and Engineering School of Science and EngineeringGuangdong of Electronic and Information EngineeringThe Chinese University of Hong KongShenzhen2001 Longxiang BoulevardLonggang DistrictShenzhen CityGuangdong 518172

The lipid droplet(LD)is a dynamic organelle responsible for lipid storage and metabolism that plays important roles in maintaining lipid ***,limited strategies are available for tracking the LD content *** this contribution,we report a novel fluorescent probe,TPEAmAl,for real-time LD content dynamics ***-AmAl is LD-specific,but emits faintly due to its intramolecular *** photoactivation,it undergoes a photocyclodehydrogenation reaction and shows a large fluorescence ***,it can be used for highlighting selected LDs with high spatial *** measuring the fluorescence changes in the distal region,the lipid content exchange efficiency can be *** our experiment,LD content exchange rate differences between nascent and mature LDs as well as cells with normal and deficient LD budding machinery are *** probe expands the fluorescence-based toolbox for LD content dynamics studies.

关键词： aggregation-induced emission lipid droplet-ER content dynamics optical highlighter photoactivation

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Enhanced Photocatalytic Reduction of Cr (Vi) Using Porous Hierarchical Bi2o3/Bi2s3 High-Low Heterojunctions: Novel Strategies and Charge Transfer Mechanisms

SSRN

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SSRN 2024年

作者： Sang, Yan Xue, Jingwei Hu, Junjie Zhang, Peng Zhao, Fu-Gang He, Yanping College of Chemistry and Materials Science Center for Nano Science and Technology Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Normal University Wuhu241002 China Department of Environmental Science and Engineering University of Science and Technology of China Hefei230026 China School of Chemistry and Chemical Engineering Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province Zhejiang Sci-Tech University Zhejiang Hangzhou310018 China

关键词： Bismuth compounds

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High electron mobility fluorinated indacenodithiophene small molecule acceptors for organic solar cells

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Chinese chemical Letters 2021年第3期32卷 1257-1262页

作者： Fei Pan Xiaojun Li Song Bai Tianhao Liu Xian Wei Yingfen Li Shanshan Chen Changduk Yang Xiwen Chen Menglan Lv Yongfang Li School of Chemical Engineering Guizhou Institute of TechnologyGuiyang 550003China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems CQU-NUS Renewable Energy Materials&Devices Joint LaboratorySchool of Energy&Power EngineeringChongqing UniversityChongqing 400044China Department of Energy Engineering School of Energy and Chemical EngineeringLow Dimensional Carbon Materials CenterUlsan National Institute of Science and Technology(UNIST)Ulsan 689-798South Korea Guangzhou Polyforte Chemical Technology Co.Ltd. Guangzhou 510520China

Indacenodithiophene(IDT)derivatives are kinds of the most representative and widely used cores of small molecule acceptors(SMAs)in organic solar cells(OSCs).Here we systematically investigate the influence of end-group fluo rination density and position on the photovoltaic properties of the IDT-based SMAs IDIC-nF(n=0,2,4).The absorption edge of IDIC-nF red-shifts with theπ-πstacking and crystallinity improvement,and their electronic energy levels downshift with increasing *** to the advantages of J_(sc)and FF as well as acceptable V_(oc),the difluorinated IDIC-2 F acceptor based OSCs achieve the highest power conversion efficiency(PCE)of 13%,better than the OSC devices based on IDIC and IDIC-4 F as *** the photovoltaic performance of the PTQ10:IDIC-2 F OSCs is insensitive to the active layer thickness:PCE still keep high values of 12.00%and 11.46%for the devices with active layer thickness of 80 and 354 nm,*** work verifies that fine and delicate modulation of the SMAs molecular structure could optimize photovoltaic performance of the corresponding ***,the thickness-insensitivity property of the OSCs has potential for large-scale and printable fabrication technology.

关键词： Organic solar cells Indacenodithiophene Electron mobility Fluorination π-πStacking Crystallinity

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Understanding Pressure Evolution During the Thermal Abuse of Li-Ion Batteries

SSRN

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SSRN 2024年

作者： Baakes, Florian Song, Roger Bernet, Thomas de León, Jorge Valenzuela García Jackson, George Adjiman, Claire S. Galindo, Amparo Krewer, Ulrike Institute for Applied Materials - Electrochemical Technologies Karlsruhe Institute of Technology Adenauerring 20b Karlsruhe76131 Germany Department of Chemical Engineering Sargent Centre for Process Systems Engineering Institute for Molecular Science and Engineering Imperial College South Kensington Campus LondonSW7 2AZ United Kingdom

Understanding and controlling the evolution of pressure during thermal events of Li-ion batteries is a key aspect when assessing the safety of Li-ion batteries. In this study we evaluate the impact of solvent composition, gas solubility, and conductive salts on the pressure built up during the exposure of the Li-ion battery to high temperatures. We employ a vapour-liquid equilibrium model based on the statistical associating fluid theory (SAFT)-γ Mie equation of state, extended to include an ion-pairing model to account for low degrees of salt dissociation in solvents with a low dielectric constant, such as linear carbonates. The effect of the degradation gases is accounted for by incorporating a CO2 evolving *** find that argon or nitrogen are good choices as inert gases during solvent storage and cell assembly, as they only gas out slightly during heating, i.e., they cause a negligible increase in pressure. Moreover, linear carbonates are found to be preferable over their cyclic counterparts regarding battery safety, as the higher solubility of degradation gases such as CO2 in the system will mitigate pressure evolution during a thermal event. The presence of the conductive salt is found not to substantially affect the pressure evolution. When considering open systems, however, the evaporation of low-boiling linear carbonates will lead to up to a 12% increase in salt dissociation. This should be taken into consideration when using open systems, such as online electrochemical mass spectrometry, to obtain reaction parameters. The insights into the sensitivities of the pressure evolution presented here will allow to precisely tailor the composition of an electrolyte mixture to mitigate safety-critical gas evolution during a thermal event in Li-ion batteries. © 2024, The Authors. All rights reserved.

关键词： Carbon dioxide

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Effect of Pt vacancies on magnetotransport of Weyl semimetal candidate GdPtSb epitaxial films

arXiv

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arXiv 2023年

作者： Du, Dongxue Thoutam, Laxman Raju Genser, Konrad T. Zhang, Chenyu Rabe, Karin M. Jalan, Bharat Voyles, Paul M. Kawasaki, Jason K. Materials Science and Engineering University of Wisconsin-Madison MadisonWI53706 United States Amrita School of Nanosciences and Molecular Medicine Amrita Vishwa Vidyapeetham Ponekkara Kochi682041 India Department of Chemical Engineering and Materials Science University of Minnesota Twin Cities United States Department of Physics and Astronomy Rutgers University United States

We examine the effects of Pt vacancies on the magnetotransport properties of Weyl semimetal candidate GdPtSb films, grown by molecular beam epitaxy on c-plane sapphire. Rutherford backscattering spectrometry (RBS) and x-ray diffraction measurements suggest that phase pure GdPtxSb films can accommodate up to 15% Pt vacancies (x = 0.85), which act as acceptors as measured by Hall effect. Two classes of electrical transport behavior are observed. Pt-deficient films display a metallic temperature dependent resistivity (dρ/dT>0). The longitudinal magnetoresistance (LMR, magnetic field B parallel to electric field E) is more negative than transverse magnetoresistance (TMR, B E), consistent with the expected chiral anomaly for a Weyl semimetal. The combination of Pt-vacancy disorder and doping away from the expected Weyl nodes;however, suggests conductivity fluctuations may explain the negative LMR rather than chiral anomaly. Samples closer to stoichiometry display the opposite behavior: semiconductor-like resistivity (dρ/dT © 2023, CC BY.

关键词： Platinum

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Introducing self-healing properties to polyethersulfone (PES) membrane via poly(vinyl alcohol)/ polyacrylic acid (PVA/PAA) surface coating

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Chemosphere 2024年 349卷 140772页

作者： Lim, Yi Heng Wong, Eng Cheong Chong, Woon Chan Mohammad, Abdul Wahab Koo, Chai Hoon Lau, Woei Jye Department of Chemical Engineering Lee Kong Chian Faculty of Engineering and Science Universiti Tunku Abdul Rahman Sungai Long Campus Jalan Sungai Long Cheras Selangor Kajang43000 Malaysia Centre for Advanced and Sustainable Materials Research Universiti Tunku Abdul Rahman Sungai Long Campus Jalan Sungai Long Cheras Selangor Kajang43000 Malaysia Chemical and Water Desalination Program College of Engineering University of Sharjah Sharjah27272 United Arab Emirates Chemical Engineering Programme Faculty of Engineering and Built Environment Universiti Kebangsaan Malaysia Selangor Bangi43600 Malaysia Faculty of Chemical and Energy Engineering Universiti Teknologi Malaysia Johor Johor Bahru81310 Malaysia

During membrane filtration, it is inevitable that a membrane will experience physical damage, leading to a loss of its integrity and a decrease in separation efficiency. Hence, the development of a water-responsive membrane capable of healing itself autonomously after physical damage is significantly important in the field of water filtration. Herein, a water-enabled self-healing composite polyethersulfone (PES) membrane was synthesized by coating the membrane surface using a mixed solution composed of poly (vinyl alcohol) and polyacrylic acid (PVA-PAA). The self-healing efficiency of the coated PES membrane was examined based on the changes in water flux at three stages which are pre-damaged, post-damaged, and post-healing. The self-healing process was initiated by the swelling of the water-responsive PVA and PAA, followed by the formation of reversible hydrogen bonds, completing the self-healing process. The coated PES membrane with three layers of PVA-PAA coatings (at 3:1 ratio) demonstrated high water flux and remarkable self-healing efficiency of up to 98.3%. The self-healing capability was evidenced by the morphology of the membrane observed via scanning electron microscope (SEM). The findings of this investigation present a novel architecture approach for fabricating self-healing membranes using PVA-PAA, in addition to other relevant parameters as reported. © 2023 Elsevier Ltd

关键词： Membranes

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Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy (Jun, 10.1038/s41566-024-01462-7, 2024)

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NATURE PHOTONICS 2024年第9期18卷 998-998页

作者： Shan, Xuchen Ding, Lei Wang, Dajing Wen, Shihui Shi, Jinlong Chen, Chaohao Wang, Yang Zhu, Hongyan Huang, Zhaocun Wang, Shen S. J. Zhong, Xiaolan Liu, Baolei Reece, Peter John Ren, Wei Hao, Weichang Lu, Xunyu Lu, Jie Su, Qian Peter Chang, Lingqian Sun, Lingdong Jin, Dayong Jiang, Lei Wang, Fan Beihang University School of Physics Beijing People’s Republic of China (GRID:grid.64939.31) (ISNI:0000 0000 9999 1211) University of Technology Sydney School of Biomedical Engineering Faculty of Engineering and Information Technology Sydney Australia (GRID:grid.117476.2) (ISNI:0000 0004 1936 7611) RMIT University Centre for Atomaterials and Nanomanufacturing School of Science Melbourne Australia (GRID:grid.1017.7) (ISNI:0000 0001 2163 3550) University of Technology Sydney Institute for Biomedical Materials and Devices (IBMD) School of Mathematical and Physical Sciences Faculty of Science Sydney Australia (GRID:grid.117476.2) (ISNI:0000 0004 1936 7611) The Australian National University Australian Research Council Centre of Excellence for Transformative Meta-Optical Systems Department of Electronic Materials Engineering Research School of Physics Canberra Australia (GRID:grid.1001.0) (ISNI:0000 0001 2180 7477) Beihang University Key Laboratory of Biomechanics and Mechanobiology (Ministry of Education) Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical Engineering Beijing People’s Republic of China (GRID:grid.64939.31) (ISNI:0000 0000 9999 1211) University of Melbourne Computing and Information Systems Department Melbourne School of Engineering Melbourne Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X) The University of New South Wales School of Physics Sydney Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432) Shaanxi Normal University School of Chemistry & Chemical Engineering Xi’an People’s Republic of China (GRID:grid.412498.2) (ISNI:0000 0004 1759 8395) The University of New South Wales Particles and Catalysis Research Laboratory School of Chemical Engineering Sydney Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432) University of Technology Sydney Australian Artificial Intelligence Institute Faculty of Engineering and IT Sydney Australia (GRID:grid.117476.2) (ISNI:0000 0004 1936 7611) University of

Precise force measurement is critical to probe biological events and physics processes, spanning from molecular motor’s motion to the Casimir effect, as well as the detection of gravitational waves. Yet, despite extensive technological developments, the three-dimensional nanoscale measurement of weak forces in aqueous solutions still faces major challenges. Techniques that rely on optically trapped nanoprobes are of significant potential but are beset with limitations, including probe heating induced by high trapping power, undetectable scattering signals and localization errors. Here we report the measurement of the long-distance interaction force in aqueous solutions with a minimum detected force value of 108.2 ± 510.0 attonewton. To achieve this, we develop a super-resolved photonic force microscope based on optically trapped lanthanide-doped nanoparticles coupled with nanoscale three-dimensional tracking-based force sensing. The tracking method leverages neural-network-empowered super-resolution localization, where the position of the force probe is extracted from the optical-astigmatism-modified point spread function. We achieve a force sensitivity down to 1.8 fN Hz–1/2, which approaches the nanoscale thermal limit. We experimentally measure electrophoresis forces acting on single nanoparticles as well as the surface-induced interaction force on a single nanoparticle. This work opens the avenue of nanoscale thermally limited force sensing and offers new opportunities for detecting sub-femtonewton forces over long distances and biomechanical forces at the single-molecule ***-resolved photonic force microscopy employs the fluorescence of lanthanide-doped nanoparticles as a force probe, enabling the measurement of sub-femtonewton forces with a sensitivity of 1.8 fN Hz–1/2, approaching the thermal limit.

关键词： Electrophoresis

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Sox2 induces glioblastoma cell sternness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications

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Signal Transduction and Targeted Therapy 2022年第3期7卷 790-801页

作者： Hernando Lopez-Bertoni Amanda Johnson Yuan Rui Bachchu Lai Sophie Sail Maureen Malloy Jonathan BCoulter Maria Lugo-Fagundo Sweta Shudir Harmon Khela Christopher Caputo Jordan J.Green John Laterra Hugo W.Moser Research Institute at Kennedy Krieger BaltimoreMDUSA Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Biomedical Engineering Institute for NanoBioTechnologyand the Translational Tissue Engineering CenterJohns Hopkins University School of MedicineBaltimoreMDUSA Bloomberg School of Public Health Department of Environmental Health and EngineeringThe Johns Hopkins University School of MedicineBaltimoreMDUSA The Department of Radiation Oncology and Molecular Radiation Sciences The Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Ophthalmology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Oncology Johns Hopkins University School of MedicineBaltimoreMDUSA Departments of Materials Science&Engineering and Chemical&Biomolecular Engineering Johns Hopkins UniversityBaltimoreMDUSA Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMDUSA

DNA methylation is a reversible process catalyzed by the ten-eleven translocation(TET)family of enzymes(TET1,TET2,TET3)that convert 5-methylcytosine(5mC)to 5-hydroxymethylcytosine(5hmC).Altered patterns of 5hmC and 5m... 详细信息

关键词： TET2 5hmC convert

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