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Rapid classification of proteins suspended in an evaporated sessile drop

Talanta 2025年 294卷 128224页

作者： Liu, Maoxi Jiao, Feng He, Yongqing School of Chemical Engineering Kunming University of Science and Technology Kunming650500 China Chongqing Key Laboratory of Micro-Nano System and Intelligent Transduction National Research Base of Intelligent Manufacturing Service Chongqing Technology and Business University Chongqing400067 China

Reliable and accessible technologies for biological sample analysis are crucial for rapid, accurate illness diagnosis in resource-limited settings. Conventional methods like mass spectrometry and enzyme-linked immunosorbent assay (ELISA) often face challenges of technological complexity and equipment immobility, leading to delayed diagnoses and elevated costs. This study introduces evaporative deposition patterns from sessile droplets as a simple, cost-effective approach for classifying proteins in protein-salt mixtures, leveraging quantitative texture analysis to achieve high diagnostic accuracy. Using mixtures of potassium chloride (KCl) or sodium chloride (NaCl) with Bovine Serum Albumin (BSA) or Ovalbumin (OVA) as model systems, we varied salt (0.25–2 wt%) and protein (0.5–1.5 wt%) concentrations, observing distinct deposition morphologies such as coffee rings, cruciform/dendritic crystals at high salt levels, and volcano-shaped /spoke-like patterns at low or high protein levels. A novel quantitative framework integrating radial density distributions, gray-level co-occurrence matrix (GLCM) texture features, and receiver operating characteristic (ROC) curves achieved a 96.74 % classification accuracy for NaCl-protein mixtures, surpassing traditional texture analysis in simplicity and efficacy. These findings demonstrate the potential of evaporative deposition analysis as a simple tool for distinguishing molecular mixtures, laying the groundwork for future diagnostic applications. Unlike prior qualitative studies, this work provides a robust, quantitative method for protein classification, advancing the understanding of protein-salt interactions. © 2025 Elsevier B.V.

关键词： Body fluids

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Cutting-edge RNA quantitative detection methods for rapid and on-site analysis

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TrAC - Trends in Analytical Chemistry 2025年 190卷

作者： Dong, Tao Yu, Chenghui Han, Feng Mao, Qi Jing, Weixuan Yang, Zhaochu Matos Pires, Nuno Miguel Correia, José Higino Lin, Qijing Hu, Fei Yao, Honghong Hu, Kui Xu, Tao Jiang, Zhuangde Chongqing Key Laboratory of Micro-Nano Transduction and Intelligent Systems Collaborative Innovation Center on Micro-Nano Transduction and Intelligent Eco-Internet of Things Chongqing Key Laboratory of Colleges and Universities on Micro-Nano Systems Technology and Smart Transducing National Research Base of Intelligent Manufacturing Service Chongqing Technology and Business University Nan'an District Chongqing400067 China X Multidisciplinary Research Institute School of Instrument Science and Technology Xi'an Jiaotong University Xi'an710049 China State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an710049 China Department of Industrial Electronics University of Minho Campus Azurem Guimaraes4800 Portugal Department of Pharmacology School of Medicine Southeast University Jiangsu Nanjing China Department of Cardiothoracic Surgery Chongqing Fifth People's Hospital China The Third People's Hospital of Nan ‘an District Chongqing China

RNA, a vital biomarker, is crucial for molecular diagnostics, encompassing pathogen detection, gene expression, tumor diagnosis, prognosis, and drug efficacy. Since the COVID-19 outbreak, its role in clinical settings has grown. This review examines established RNA detection methods like qPCR, sequencing, nanostring, and fluorescence in situ hybridization (FISH), highlighting recent progress and trends. It also focuses on new Point-of-Care Testing (POCT) methods developed over the last five years, categorizing them by the necessity for reverse transcription and nucleic acid amplification. The review emphasizes advances in multiplex detection tailored for POCT, aiming to update researchers and clinicians on the latest RNA detection technologies. Among various RNA detection methods, the amplification-free approach is preferable for POCT applications compared to those requiring reverse transcription and sequence-dependent amplification, as they simplify the detection process by reducing technical complexity while retaining high sensitivity. © 2025

关键词： Transcription

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Tuning 2D Black Phosphorus: Defect Tailoring and Surface Functionalization

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Chemistry of Materials 2019年第24期31卷 9917-9938页

作者： He, Guozhen Dong, Tao Yang, Zhaochu Ohlckers, Per Chongqing Key Laboratory of Micro-Nano Systems and Intelligent Sensing Chongqing Key Lab. of Colleges and Universities on Micro-Nano Syst. Technology and Smart Transducing Collaborative Innovation Center on Micro-Nano Transduction and Intelligent Eco-Internet of Things Chongqing Technology and Business University Nan'an District Chongqing400067 China Faculty of Technology Natural Sciences and Maritime Sciences University of South-Eastern Norway Postboks 235 Kongsberg3603 Norway

Within a decade, black phosphorus has become an important 2D material for sustainable energy areas and bioapplications due to its great electronic properties and biocompatibility. Pristine black phosphorus suffers from intrinsic shortages like rapid degradation and poor solubility, which require physical and chemical tuning methods. There also lacks an effective approach to synthesize single-crystal black phosphorus with large areas. This review article provides a forward-looking overview of significance, mechanism studies, status quo, and outlooks of defect-tailoring and surface functionalization in black phosphorus;the prior focuses on the lattice while the latter focuses on the surface. Particularly, both approaches can alter chemical and electronic properties such as air stability, solubility, carrier mobility, and band gap. Functionalization further enables the BP surface to immobilize various biomarkers and medical molecules, which largely boost its future applications in biosensors and theranotics. Finally, we discuss some unresolved issues and future applications, especially in tuning BP especially in BP synthesis, atomic modification methods, and bioapplications. Copyright © 2019 American Chemical Society.

关键词： Electronic properties

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Flexible and transparent triboelectric nanogenerator based on high performance well-ordered porous PDMS dielectric film

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nano Research 2016年第12期9卷 3714-3724页

作者： Xianming He Xiaojing Mu Quan Wen Zhiyu Wen Jun Yang Chenguo Hu Haofei Shi Department of Applied Physics Chongqing University Chongqing 400044 China Key Laboratory of Fundamental Science of Micro/Nano-Device and System Technology Chongqing University Chongqing 400044 China Microsystem Research Center Chongqing University Chongqing 400044 China Key Laboratory of Multi-Scale Manufacturing Technology Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China

A flexible and transparent triboelectric nanogenerator （FT-TENG） has great potential for application in self-powered biosensor systems, electronic skin and wearable electronic devices. However, improving the output performance with little damage to its optical properties is challenging. Herein, we have developed an FT-TENG that has a well-ordered nest-like porous polydimethylsiloxane （NP-PDMS） film and graphene transparent electrodes. The NP-PDMS film with ordered pores is fabricated by hydrochloric acid etching of 500 nm sized ZnO spheres made of aggregated nanoparticles, having a light transmittance of 81.8% and a water contact angle of 118.62°. The FT-TENG based on the NP-PDMS film with a porosity of 12%, gives a maximum output of 271 V and 7.8 μA, which are respectively, 3.7 and 2.1-fold of those of a TENG with a flat PDMS film. The peak output power reaches 0.39 mW with a load resistance of 9.01 MΩ. The dielectric constant and effective thickness of the NP-PDMS film and the capacitance and charge transfer of the FT-TENG are systematically investigated. This work provides a novel and effective method to enhance the performance of FT-TENGs with little damage to their optical properties.

关键词： porouspolydimethylsiloxane(PDMS) surface charge density nanogenerator flexibility transparent electrode

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Small-size temperature/high-pressure integrated sensor via flip-chip method

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microsystems & nanoengineering 2024年第4期10卷 153-162页

作者： Mimi Huang Xiaoyu Wu Libo Zhao Xiangguang Han Yong Xia Yi Gao Zeyu Cui Cheng Zhang Xiaokai Yang Zhixia Qiao Zhikang Li Feng Han Ping Yang Zhuangde Jiang State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesXi’an Jiaotong UniversityXi’an 710049China Xi’an Jiaotong University(Yantai)Research Institute for Intelligent Sensing Technology and System Xi’an Jiaotong UniversityXi’an 710049China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 265503China School of Mechanical Engineering Xi’an Jiaotong University710049 Xi’anChina School of Instrument Science and Technology Xi’an Jiaotong University710049 Xi’anChina Chongqing Key Laboratory of Micro-Nano Systems and Intelligent Sensing Chongqing Academician WorkstationChongqing 2011 Collaborative Innovation Center of Micro/Nano Sensing and Intelligent Ecological Internet of ThingsChongqing Technology and Business UniversityNan’an DistrictChongqing 400067China Xi’an Aerospace Yuanzheng Fluid Control Co.Ltd. Xi’an 710049China

Hydraulic technology with smaller sizes and higher reliability trends,including fault prediction and intelligent control,requires high-performance temperature and pressure-integrated *** designs rely on planar wafer-or chip-level integration,which is limited by pressure range,chip size,and low *** propose a small-size temperature/high-pressure integrated sensor via the flip-chip *** pressure and temperature units are arranged vertically,and the sensing signals of the two units are integrated into one plane through silicon vias and gold–gold bonding,reducing the lateral size and improving the efficiency of signal *** flip-chip technique ensures a reliable electrical connection.A square diaphragm with rounded corners is designed and optimised with simulation to sense high pressure based on the piezoresistive *** temperature sensing unit with a thin-film platinum resistor measures temperature and provides back-end high-precision compensation,which will improve the precision of the pressure *** integrated chip is fabricated by MEMS technology and packaged to fabricate the extremely small integrated *** integrated sensor is characterised,and the pressure sensor exhibits a sensitivity and sensitivity drift of 7.97mV/MPa and−0.19%FS in the range of 0–20 MPa and−40 to 120℃.The linearity,hysteresis,repeatability,accuracy,basic error,and zero-time drift are 0.16%FS,0.04%FS,0.06%FS,0.18%FS,±0.23%FS and 0.04%FS,*** measurement error of the temperature sensor and temperature coefficient of resistance is less than±1°C and 3142.997 ppm/℃,*** integrated sensor has broad applicability in fault diagnosis and safety monitoring of high-end equipment such as automobile detection,industrial equipment,and oil drilling platforms.

关键词： size corners sizes

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A simple method for demodulation of long period fiber grating signals 7

A simple method for demodulation of long period fiber gratin...

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7th Global intelligent Industry Conference, GIIC 2024

作者： Ran, Qiuyue Tang, Yong Bai, Yunfeng Dang, Suihu Key Laboratory of Micro/Nano Optoelectronic Devices and Intelligent Sensing System College of Electronic Information and Engineering Yangtze Normal University Chongqing408100 China

ISBN: (纸本)9781510682986

In this paper, a comprehensive evaluation of a long period fiber grating sensor (LPFGs) based on the transmission intensity at a fixed wavelength is presented. Firstly, the application of spiral long-period fiber grating sensor (H-LPFGs) and tapered long-period fiber grating sensor (T-LPFGs) based on transmission intensity at fixed wavelength is studied, that is, the sensor of torsion, temperature, strain and liquid concentration. The transverse pressure and temperature are then evaluated using this method, and the optical signal is converted into an electrical signal using photoelectric conversion to prepare a complete LPFGs. The temperature sensor has a voltage-temperature sensitivity of -18.7mV / ℃ for a measuring range of 50-150℃ with an accuracy of 0.1℃, and the strain sensor has a voltage-strain sensitivity of 0.248 mV/μΕ for a measuring range of 0-1800μΕ with an accuracy of 1 μΕ. Compared with other long - period fiber grating sensors, the accuracy is improved and the measurement range is wider. The demodulation system of the LPFG sensor based on the transmission intensity ratio measurement method has the advantages of simple operation, wide application range, and low price, so it has a very good application prospect in the LPFG sensor. © 2024 SPIE.

关键词： Fiber Bragg gratings

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Facile assembly of flexible,stretchable and attachable symmetric microsupercapacitors with wide working voltage windows and favorable durability

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microsystems & nanoengineering 2024年第4期10卷 297-304页

作者： Xiangguang Han Xiaoyu Wu Libo Zhao Min Li Chen Jia Zhikang Li Jiaqi Xie Guoxi Luo Ping Yang Rabah Boukherroub Yurdanur Türker Mert UmutÖzkaynak Koray Bahadır Dönmez State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesXi’an Jiaotong University(Yantai)Research Institute for Intelligent Sensing Technology and SystemXi’an Jiaotong UniversityXi’an 710049China School of Instrument Science and Technology Xi’an Jiaotong UniversityXi’an 710049China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264000China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’anShaanxi 710049China Chongqing Key Laboratory of Micro-Nano Systems and Intelligent Sensing Chongqing Academician WorkstationChongqing 2011 Collaborative Innovation Center of Micro/Nano Sensing and Intelligent Ecological Internet of ThingsChongqing Technology and Business UniversityNan’an DistrictChongqing 400067China Univ.Lille CNRSUniv.Polytechnique Hauts-de-FranceUMR 8520-IEMNF-59000 LilleFrance Sabanci University Nanotechnology Research and Application Center(SUNUM) IstanbulTurkey Department of Materials Science and Engineering Istanbul Technical UniversityIstanbulTurkey

With the increasing development of intelligent robots and wearable electronics,the demand for high-performance flexible energy storage devices is drastically *** this study,flexible symmetric microsupercapacitors(MSCs)that could operate in a wide working voltage window were developed by combining laser-direct-writing graphene(LG)electrodes with a phosphoric acid-nonionic surfactant liquid crystal(PA-NI LC)gel *** increase the flexibility and enhance the conformal ability of the MSC devices to anisotropic surfaces,after the interdigitated LG formed on the polyimide(PI)film surface,the devices were further transferred onto a flexible,stretchable and transparent polydimethylsiloxane(PDMS)substrate;this substrate displayed favorable flexibility and mechanical characteristics in the bending ***,the electrochemical performances of the symmetric MSCs with various electrode widths(300,400,500 and 600μm)were *** findings revealed that symmetric MSC devices could operate in a large voltage range(0–1.5 V);additionally,the device with a 300μm electrode width(MSC-300)exhibited the largest areal capacitance of 2.3 mF cm^(−2)at 0.07 mA cm^(−2)and an areal(volumetric)energy density of 0.72μWh cm−2(0.36 mWh cm^(−3))at 55.07μWcm−2(27.54mWcm−3),along with favorable mechanical and cycling *** charging for~20 s,two MSC-300 devices connected in series could supply energy to a calculator to operate for~130 s,showing its practical application potential as an energy storage ***,the device displayed favorable reversibility,stability and *** 12 months of aging in air at room temperature,its electrochemical performance was not altered,and after charging-discharging measurements for 5000 cycles at 0.07 mA cm^(−2),~93.6%of the areal capacitance was still retained;these results demonstrated its practical long-term application potential as an energy storage device.

关键词： cycling durability electrode

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Investigation of the Synthesis and Thermal Insulation Properties of K 2 Ti 6 O 13 Whisker-Reinforced SiO 2 micro Powder Composite Coating Fabrics

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Energy 2025年

作者： Yi Man Chang Ge Yao Wang Yongqing He Wei Yang Yumin Qi Bohong Wang Petar Sabev Varbanov Jin Wang Nanjing Vocational University of Industry Technology Nanjing 210023 Jiangsu China School of Materials Science and Engineering Hebei University of Technology Tianjin 300401 China Hebei Key Laboratory of New Functional Materials School of Material Science and Engineering Hebei University of Technology Tianjin 300401 China School of Energy and Environmental Engineering Hebei University of Technology Tianjin 300401 China Chongqing Key Laboratory of Micro-Nano System and Intelligent Transduction National Research Base of Intelligent Manufacturing Service Chongqing Technology and Business University Chongqing 400067 China National & Local Joint Engineering Research Center of Harbor Oil & Gas Storage and Transportation Technology/Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control Zhejiang Ocean University No.1 Haida South Road 316022 Zhoushan China Széchenyi István University Egyetem tér 1 9026 Győr Hungary

Developing functional textiles with thermal insulation and hydrophobic properties is of significant interest. This study successfully synthesizes K 2 Ti 6 O 13 (potassium titanate, KTO) whiskers via the hydrothermal method and prepares KTO composite silica polyester fabric (KSP) through impregnation technology, exhibiting excellent thermal insulation and hydrophobic qualities. X-ray diffraction (XRD) analysis verifies the high purity and excellent crystallinity of KTO whiskers and SiO 2 micro-powder. Scanning electron microscopy (SEM) images reveal that the KTO whiskers retain their original morphology and exhibit uniform size distribution, with an average length of around 1 μm and an aspect ratio of 40. Transmission electron microscopy (TEM) images further validate the planar growth properties of the whiskers. Raman spectroscopy research elucidates the vibrational modes of various chemical bonds in the KTO whiskers. The ultraviolet-visible-near-infrared spectrophotometer test results demonstrate that the KSP fabric reflects 43.5% more light than standard polyester fabric and substantially lowers the temperature in the covered chamber under simulated sunlight exposure, achieving a maximum reduction of 7.4 °C. The KSP fabric has exceptional hydrophobic properties, completing a contact angle of 153.2° and maintaining reflectance stability, with a mere 5.92% reduction after 20 days of outside exposure. This work offers substantial reference value for the advancement of practical textiles.

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Heat transfer enhancement in a rectangular channel with pillars 4

Heat transfer enhancement in a rectangular channel with pill...

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4th International Conference on Mechanical, Electric and Industrial Engineering, MEIE 2021

作者： Jiao, Feng Li, Chengzhe Dai, Songjiang Hu, Meilin He, Yongqing School of Chemical Engineering Kunming University of Science and Technology Kunming650500 China Yunnan PetroChina Kunlun Gas Co. Ltd Kunming650500 China Chongqing Key Laboratory of Micro-Nano System and Intelligent Sensing Chongqing Technology and Business University Chongqing400067 China

This paper numerically studied the heat transfer performance of water flowing in a rectangular channel with pillar structures. We systematically investigated the influence of the pitch, inclination angle, shape, and pillar arrangement on the flow and heat transfer characteristics. The results show that adopting spacing with S/d=2 can improve heat transfer performance sufficiently for a low Reynolds number case. Meanwhile, the noticeable enhancement can also be observed by making the pillar inclination direction consistent with the flow direction or staggered rhombic-shaped. © Published under licence by IOP Publishing Ltd.

关键词： Reynolds number

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Broadband high-efficiency dielectric metalenses based on quasi-continuous nanostrips

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Opto-Electronic Advances 2024年第5期7卷 43-51页

作者： Xiaohu Zhang Qinmiao Chen Dongliang Tang Kaifeng Liu Haimo Zhang Lintong Shi Mengyao He Yongcai Guo Shumin Xiao Key Laboratory of optoelectronic Technology and Systems of the Education Ministry of China Chongqing UniversityChongqing 400044China Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education&Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and ElectronicsHunan UniversityChangsha 410082China

Benefiting from the abrupt phase changes within subwavelength thicknesses,metasurfaces have been widely applied for lightweight and compact optical *** broadband and high-efficiency characteristics are highly attractive for the practical implementation of ***,current metasurface devices mostly adopt discrete micro/nano structures,which rarely realize both merits *** this paper,dielectric metasurfaces composed of quasi-continuous nanostrips are proposed to overcome this *** quasi-continuous nanostrips metasurface,a normal focusing metalens and a superoscillatory lens overcoming the diffraction limit are designed and experimentally *** quasi-continuous metadevices can operate in a broadband wavelength ranging from 450 nm to 1000nm and keep a high power *** average efficiency of the fabricated metalens reaches 54.24%,showing a significant improvement compared to the previously reported metalenses with the same *** proposed methodology can be easily extended to design other metadevices with the advantages of broadband and high-efficiency in practical optical systems.

关键词： broadband high-efficiency metalens sub-diffraction quasi-continuous

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