Cancer is one of the primary causes of death in the world and the prevalence in Indonesia reaches 1,4% per year. One method of the most developed cancer therapies right now is targeting drug delivery. Targeting drug d...
Cancer is one of the primary causes of death in the world and the prevalence in Indonesia reaches 1,4% per year. One method of the most developed cancer therapies right now is targeting drug delivery. Targeting drug delivery makes it possible for drugs to be delivered directly to the targeted cells and released once they reach the destination. The aim of this research is to develop a nanocarrier using folic acid-functionalized magnetic nanoparticles to improve the effectiveness of antitumor drugs for cancer therapy. The magnetic nanoparticles synthesis method used in this research is chemical synthesis. Chemical materials FeCl3 and FeCl2 are mixed with NH4OH until magnetic nanoparticles appear. The magnetic nanoparticles obtained are then coated using bovine serum albumin, loaded with the drug doxorubicin, and functionalized with folic acid. The characterization methods used are Brine Shrimp Lethal Test (BSLT), X-Ray Diffractometer (XRD), Particle Size Analyzer (PSA), and MTT Assay. The success of drug release test is performed using UV-Vis. The results of this research showed that the magnetic nanoparticles were non-toxic with no impurities, but had not passed the size requirement as a good nanocarrier. Drug release in acidic pH, which is 5.4, had the highest release rate, thus it would be suitable for cancer cells which have lower pH compared to normal cells. Cytotoxicity test using MTT Assay method with murine osteoblastic cell line MC3T3 cells showed quite high cell viability, so it will not affect normal tissues and cells. It can be concluded that folic acid-functionalized, doxorubicin-loaded magnetic nanoparticles have potential to be used as nanocarrier in drug delivery system.
The Bili-Bili Reservoir is located in the middle of the Jeneberang watershed in South Sulawesi Province, which was built for flood control, irrigation, raw water supply, and hydroelectric power plants. However, in the...
The Bili-Bili Reservoir is located in the middle of the Jeneberang watershed in South Sulawesi Province, which was built for flood control, irrigation, raw water supply, and hydroelectric power plants. However, in the latest development, there has been a decline in utilization of the reservoir service function due to changes in the catchment area condition because of sediment. Estimation of sediment concentration in the Bili-bili reservoir was analyzed using spectrometer data. Estimation of Total Suspended Sediment (TSS) using a spectrometer by reflectance testing of the ratio between bands with various regression equations. Algorithm estimation of TSS concentration based on spectrometer measurements provides a coefficient of determination (R2) of 0.800 and an RMS error of 0.088, with a 3rd order polynomial equation for the green/red bands ratio: y = 62.667x3 – 154.328x2 + 121.27x – 29.902.
Generation Z has a preference for individual learning using information and communication technology. Generation Z prefers digital audio-visual media to verbal media. The study aimed to develop a demonstration video i...
Generation Z has a preference for individual learning using information and communication technology. Generation Z prefers digital audio-visual media to verbal media. The study aimed to develop a demonstration video in the subject of make-up puff pastry for Pastry and Bakery course and assess the video feasibility. This study was a research & development (R & D) approach using 4D (define, design, develop, and disseminate) models. Problem, student, and curriculum analysis was performed in the define stage. Video scriptwriting and the production team selection were performed in the design stage. Develop stage consisted of video shooting, video editing, video revision, and assessment. The shooting was accomplished using Sony A6000 16-50 mm camera, Bestluck New Pro F600 lighting with ellipsoidal reflector, Libec 650EX tripod, and Zhiyun Crane V2 stabilizer. Voice was recorded using Boya Clip-on wireless microphone. The audio was edited using Adobe Audition 2017 and the video was compiled using Adobe Premiere pro CC 2017. In the disseminate stage, the video was uploaded to YouTube channel Boga UNY. Based on the feasibility assessment by 2 material experts, a media expert, and 31 potential users, the video was considered very feasible as learning media.
In general, noise is a problem and it can be found everywhere, including at the aero activity such as aircraft maintenance vicinity. The object of the noise case selected in this study is the Auxiliary Power Unit (APU...
In general, noise is a problem and it can be found everywhere, including at the aero activity such as aircraft maintenance vicinity. The object of the noise case selected in this study is the Auxiliary Power Unit (APU) which is the part of Airbus A330 aircraft with the APU type GTCP 331-350. The noise of APU while operate during maintenance can affect the occupational health and safety conditions of the worker. In this study, a micro-perforated panel (MPP) is used to absorb or reduce the sound intensity. MPP is made of a thin flat material where in this research using acrylic and placing small holes on its surface. Both experimental and numerical method are used in this research. The first step in performing the MPP design is numerically to obtain the geometry according to the absorption coefficient target at the specified noise frequency. For the experimental or testing phase of finished MPP design, a tool called an impedance tube is used. The test procedure refers to the ISO 10534-2 or ASTM E 1050-90 document. There are two types of impedance tube, first in diameter of 10 mm and the second one in 3 cm. The 10 mm impedance tube has the frequency range from low to medium frequency while the 3 mm for the high frequency testing. The absorption coefficient prediction value from numerically MPP design for the targeted frequency of 695 Hz gets 0.8819 versus the actual value after test in impedance tube is 0.8875. Furthermore, the highest absorption coefficient value for design or prediction and actual testing lies at the exact frequency of 750 Hz where for predictions has 0.95 and 1 for actual testing. Based on these results it can be concluded that MPP has the potency to reduce the APU noise. Henceforth it will be interesting to apply the MPP technology directly to the APU compartment on aircraft.
The student of vocational high school nowadays are classified as generation Z. They are common to use information and communication technology. They prefer audio-visual learning media rather than podcast recording or ...
The student of vocational high school nowadays are classified as generation Z. They are common to use information and communication technology. They prefer audio-visual learning media rather than podcast recording or text media. This study aimed to develop a video on making dry banana for the Agriculture Product Processing course and assessing the video's feasibility. This study was a research & development (R&D) study using the 4D (define, design, develop, and disseminate) approach. Analysis of content, curriculum, and student needs was carried out in the define stage. The scriptwriting and production team selection was conducted in the design stage. Video recording, editing, and feasibility test from experts were performed in the development stage. The video was evaluated by two content experts and one media expert. In the disseminate stage, thirty students as prospective consumers evaluated the video feasibility. The data were analyzed descriptively. The video was in the mp4 format and had a duration of 13 minuter and 13 seconds. The video has been provided with high-definition images, captions, pictures, 2D animations, transitions, and effects. The experts and the students rated this video to be very feasible to be used as instructional media.
The research aims at developing a learning video to make shredded chicken and testing its feasibility. This video demonstrates the steps of product making. This research can be categorized as research and development ...
The research aims at developing a learning video to make shredded chicken and testing its feasibility. This video demonstrates the steps of product making. This research can be categorized as research and development (R&D) with a 4D model (Define, Design, Develop, and Disseminate). The video was taken with multiple camera angles and completed with text annotation, picture, animation, music, and voice lay-over. The were collected through interviews and questionnaires for feasibility testing. The data were analyzed using quantitative descriptive analysis. The stage of define was a needs analysis, while the design stage consisted of testing recipes, scriptwriting, selection of presenters, talents, dubber, and the video team and preparing tools and materials. The develop stage covered the process of shooting, recording, editing, and feasibility test by two material experts and a media expert. Meanwhile, the disseminate stage referred to the feasibility test among 30 students of State Vocational High School 1 Cangkringan, and the video dissemination was done through the YouTube channel. The feasibility test result based on the material experts was 90.96%, based on the media expert was 98.96%, and from the students was 85.35%, respectively. It means that this video is declared very suitable to be used as a learning medium.
Solenoids have been made with square and triangular cross-sections. Both kinds of solenoids are made with an iron core and without an iron core. The solenoids specification were 12 cm long and 3.5 cm wide with 220 win...
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Generation Z uses technology frequently and demands learning that is individualized, engaging, digital, and visually based. They prefer learning videos to learn about the product making process. The research objective...
Generation Z uses technology frequently and demands learning that is individualized, engaging, digital, and visually based. They prefer learning videos to learn about the product making process. The research objectives were to develop the video of making mango sorbet for the Agriculture Product Processing course and evaluate the feasibility of the video. This was a research & development (R&D) study using 4D models (Define, Design, Develop, and Disseminate). The video was captured using Sony NX100 camera and Kino Flo 6-bank lighting. The presenter and voice-over dubber's sound were recorded using Boya BY WM8 wireless microphone. The video was edited by Adobe Premiere Pro CC 2017. The video had a duration of 14 minutes 29 seconds with mp4 format. The video consisted of the opening section, the content section, and the closing section. The opening and closing section were delivered by the presenter. The content section was demonstrated by an actress and voice-over dubber. The video feasibility was evaluated by 2 material experts, a media expert, and 30 students of Vocational High School (VHS) 1 Cangkringan. The data were analysed descriptively. According to the feasibility evaluation, the making mango sorbet video was considered to be very feasible to be utilized as a learning media.
The use of groundwater is one of the alternatives used to increase productivity in rainfed rice fields. Various researches and technologies have been developed to suppress the negative effects of overuse of groundwate...
The use of groundwater is one of the alternatives used to increase productivity in rainfed rice fields. Various researches and technologies have been developed to suppress the negative effects of overuse of groundwater. One important parameter is the change in the water level around the well during the pumping process, which is observed through the observation well. For that, we need an instrument to measure changes in water level in real-time. This instrument was developed using the HDL 300 submersible liquid level sensor, which utilizes pressure changes from the water level. To connect the sensor with the Arduino Uno microcontroller module using the HW685 Module. The calibration results show that the linearity of the change in the sensor value to the change in the water level reaches 99% following the equation y = 86.297x + 73.522.
Whiteboard animation videos are engaging learning media for Generation Z. This study aimed to develop and assess the feasibility of a whiteboard animation video for vitamin in the Nutrition Science subject for class X...
Whiteboard animation videos are engaging learning media for Generation Z. This study aimed to develop and assess the feasibility of a whiteboard animation video for vitamin in the Nutrition Science subject for class X culinary vocational school. This study was research and development using a 4D approach (define, design, develop, disseminate). The define stage analyzed the curriculum, material, student character, learning media, and school facilities. The design stage included the writing and assessing the material, the writing and assessing of storyboards, and production team selection. The develop stage was making a video and assessing the feasibility. Animation images were created using Paint Tool Sai. Image conversion from JPEG to SVG was performed with Inkscape. The dubber's voice was recorded with Universal Audio using the Apollo Twin audio interface and Avantone CV12 microphone. The audio was edited in Pro Tools 2020.9. To produce a whiteboard animation video, animation images, captions, dubber's voice, and back sound were combined with VideoScribe. Videos used mpg format. In order to maintain video duration below 10 minutes, the video was divided into two parts. The assessment of video feasibility was carried out by one media expert and two content experts. The assessment of feasibility at the disseminate stage was carried out to 30 users. Based on the feasibility assessment, this video was very suitable to be applied as a learning medium.
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