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The CRISPR/Cas9-mediated base editing design of HBV specific gRNA: A computational approach

AIP Conference Proceedings 2024年第1期3080卷

作者： Hartiyowidi Yuliawuri Jeanne Elvia Christian Edvan Arifsaputra Suherman Biology Study Program Faculty of Science and Engineering Calvin Institute of Technology Jl. Industri Blok B14 Kav. 1 Kemayoran Central Jakarta DKI Jakarta 10610 Indonesia

Therapy to cure a persistent infection of the Hepatitis B Virus (HBV) is needed to suppress viral replication. Current therapy with nucleoside analogues does not destroy HBV covalently closed circular DNA (cccDNA). A new strategy using Base Editing is required to tackle this viral latent infection. We designed guide RNAs (gRNAs) to target the pre-S and S genes of HBV for the development of antiviral, based on the dominant HBV genotype in Indonesia. The conserved regions of HBV, pre-S and S genes were used to determine a selected target of the Cas9-mediated base editing system. Base Editing (BE)-Designer web-based software to designed gRNA and SnapGene to visualized the expression vector. We identified 5 candidate sequences, including 3 sequences in the pre-S and 2 sequences in the S gene. These target sequences show no mismatches and GC contains between 45-60%. In addition, the gRNA sequences were checked in Nucleotide BLAST tools (NCBI) to prevent the off-target effect and ensure the differences with the human genome. This study provides the candidate target sequences to be developed in antiviral therapy. The utility and efficiency of the candidate sequences need to be evaluated in viral gene expression by in vitro HBV infection systems.

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Integration of Artificial Intelligence in Software Defined Networking Technology through Developing Machine Learning Algorithms

Integration of Artificial Intelligence in Software Defined N...

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Advance Computing and Innovative Technologies in engineering (ICACITE), International Conference on

作者： Lamhot Naibaho Pulkit Raj Saxena Kuldeep Sharma Badria Sulaiman Alfurhood L. Pallavi Bhasker Pant English Language Education Study Program Faculty of Letters and Languages Christian University of Indonesia College of Computing Science and Information Technology Teer Thanker Mahaveer University Moradabad Uttar Pradesh India Department of Computer Science and Engineering Lovely Professional University Phagwara Jalandhar Punjab India Department of Computer Sciences College of Computer Information Sciences Princess Nourah Bint Abdulrahman University Saudi Arabia CSE B V Raju Institute of Technology Narsapur Telangana India Computer Science & Engineering Graphic Era Deemed to be University Dehradun Uttarakhand India

A future networking design called "software-defined networking" combines network programmability with centralized administration (SDN). Network administration is currently handled by SDN, which, at the regulator, which acts as the cable network processor and divides the data plane into a control plane and a data aircraft. Recent breakthroughs in artificial intelligence (Al) have shown a stronger inclination for the science community to benefit from their ability to give learning capabilities and enhance Indicator. The author of this research provides a comprehensive analysis of initiatives underway to incorporate Al with SDN. The study concluded that the three primary Al thread where scientific research was centered were computer science, conceptual, and fuzzy reasoning systems. The authors of this paper explore the several fields in which these approaches may be used, their potential future applications, and the innovations made possible by the integration of AI-based methods into the SDN paradigm. By choosing the right SDN controller, any large organization may lower network complexity, implementation expenses, and maintenance costs. The focus of this article is software defined networking's benefits and downsides (SDN). Following is a basic explanation of artificial intelligence and a list of some of its most significant applications in SDN.

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Ergonomic and innovative design of the food packaging tool

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AIP Conference Proceedings 2024年第1期2920卷

作者： Ishlahuddin Abdullah Hartomo Soewardi Industrial Engineering Study Program Faculty of Industrial Technology Islamic University of Indonesia Yogyakarta Indonesia Kaliurang St No. Km. 14 5 Krawitan Umbulmartani Ngemplak Sleman Yogyakarta Indonesia

Tempe is a traditional food that is popular in Indonesia. Tempe consists of soaking, boiling, grinding, transferring, zymosis, packaging, and finally, the storage process. The packaging process is the process that causes the most musculoskeletal disorders. Complaints about the packaging process occur because of the wrong sitting position, repeated within 6-7 hours per day. Identification using Nordic Body Maps scored 71. This condition indicates a high level of risk for musculoskeletal disorders. The packaging process includes 88.89% complaints of pain in the buttocks, 77.78% in the hips, 66.78% in the waist, 55.56% on the back, and 44,44% on the right arm, 33.33% on the right wrist. This research develops a packaging process tool using the Kansei engineering method. The tool’s design is made according to the consumer’s wishes based on "Kansei words," and the manufacture of dimensions is based on anthropometry. Based on the validity test using a significance level of 5% obtained a marginal homogeneity value > 0.05 which indicates the design follows the wishes of consumers. Meanwhile, for the convenience attribute test using the Wilcoxon Signed Rank Test, the *** (2 tailed) value was obtained at 0.040<0.05, which indicates a significant difference between the packaging process before and after using the tool. The user satisfaction test using the User Experience Questionnaire (UEQ) shows an average value of > 0.8. A score of 0.8 on the UEQ indicates that the user is satisfied with the design.

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Facile Fabrication of Cobalt Doped Manganese Oxide with Hierarchical Porosity for Peroxymonosulfate Activation: Performance Investigation and Mechanistic Insight to Degrade Organic Pollutants in Water and Dft study

SSRN

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SSRN 2022年

作者： Afzal, Shahzad Mehmood, Andleeb Jin, Lingyue Pan, Ke Ahmad, Munir Duan, Dandan Wei, Yang Raza, Waseem Hao, Tianwei Sharif, Hafiz Muhammad Adeel Sohail, Muhammad Chen, Fengyuan Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced Study Shenzhen University Shenzhen518060 China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering Shenzhen University Shenzhen518060 China Department of Environmental Engineering China Jiliang University Zhejiang Hangzhou310018 China College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen518060 China College of Materials Science and Engineering Shenzhen University Shenzhen518060 China Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life Sciences Hainan Normal University Haikou571158 China Institute for Advanced Study Shenzhen University Shenzhen518060 China Department of Civil and Environmental Engineering Faculty of Science and Technology University of Macau China Research Center for Eco-Environmental Engineering Dongguan University of Technology Dongguan523808 China School of Electronic Science and Engineering State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of China Sichuan Chengdu610054 China

An economical and environment-friendly catalyst is needed for activating peroxymonosulfate (PMS) into reactive oxygen species (ROS). Cobalt-doped dumbbell-shaped MnO x was synthesized as a PMS-activator to abate organic pollutants in water. The microstructure contained nanoparticles that self-assembled into a maze-like dumbbell-shaped mesostructure. Phenol degradations after 9 min of Co18-MnO x /PMS, MnO x /PMS, Co 3 O 4 /PMS, PMS, and adsorption were 100%, 27%, 33%, 17%, and 5%, respectively. The Co18-MnO x morphology, microstructure, textural properties, and catalytic efficiency were well-retained after recycling. Compared to SO 4 •− and • OH, 1 O 2 and O 2 •− were the dominant ROS. The balance among redox couples (Co 2+ /Co 3+ , Mn 3+ /Mn 4+ , O 2− /O 2 ) and PMS decomposition enabled ROS production. The high catalytic efficiency was ascribed to the Mn/Co synergism, hierarchical microstructure, and ROS. Furthermore, the DFT study investigated the difference between the activation mechanism of PMS (adsorption and electron transfer) on MnOx and Co-MnOx surfaces. Our research devised a facile procedure to synthesize other transition metals doped MnO x for advanced oxidation processes and other applications. © 2022, The Authors. All rights reserved.

关键词： Manganese oxide

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3D model of Krakatau volcano subsurface structure based on gravity data 1

3D model of Krakatau volcano subsurface structure based on g...

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1st International Seminar on Science and Technology 2018, ISST 2018

作者： Oemaiya, D.V. Santoso, D. Geophysical Engineering Study Program Faculty of Mining and Petroleum Engineering Institute of Technology Bandung Indonesia Applied and Exploration Geophysics Research Group Faculty of Mining and Petroleum Engineering Institute Technology Bandung Indonesia

Krakatau is one of the volcano in Indonesia which has the destructive paroxysmal eruption. Eruption on 1883 was estimated had VEI of 6. The eruption was recorded as one among some most violent volcanic eruption event in the world. Gravity method is one of the geophysical methods that could delineate the subsurface structure base on density variation. Therefore, the objectives of this research are to reconstruct the 3D subsurface structure of the Krakatau volcano especially the approximate location and dimension of the magma chamber. The subsurface model of Krakatau was done by 3D modelling using residual anomaly map. In order to develop the status of magma chamber model, the available information on the geological map of Krakatau and surrounding area was used. Besides that, some information relative to the volcano such as the information derived from earthquake wave attenuation were utilized. The result of the study shows that position its volcano magma chamber is not directly vertical or oblique under the volcano crater and it has multiple chambers which trending northwest-southeast. © 2019 IOP Publishing Ltd. All rights reserved.

关键词： Volcanoes

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Effect of polyvinylidene fluoride concentration in PVDF-TiO₂-PVP composite membranes properties and its performance in bovine serum albumin rejection

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Case Studies in Chemical and Environmental engineering 2024年 9卷

作者： Gayatri, Rianyza Fizal, Ahmad Noor Syimir Yuliwati, Erna Zailani, Muhamad Zulhilmi Jaafar, Juhana Hossain, Md Sohrab Zulkifli, Muzafar Taweepreda, Wirach Ahmad Yahaya, Ahmad Naim Polymer Science Program Division of Physical Science Faculty of Science Prince of Songkla University Hat-Yai Songkhla 90110 Thailand Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology Alor Gajah Melaka 78000 Malaysia Centre for Sustainability of Ecosystem & Earth Resources (Pusat ALAM) Universiti Malaysia Pahang Lebuh Persiaran Tun Khalil Yaakob Pahang Gambang 26300 Malaysia Program Study of Chemical Engineering Faculty of Engineering Universitas Muhammadiyah Palembang Jalan A.Yani 13 Ulu Kota Palembang 30263 Indonesia Advanced Membrane Technology Research Centre (AMTEC) Faculty of Chemical and Energy Engineering Universiti Teknologi Malaysia Johor Skudai 81310 Malaysia HICoE-Centre for Biofuel and Biochemical Research Institute of Self-Sustainable Building Department of Fundamental and Applied Sciences Universiti Teknologi PETRONAS Perak Darul Ridzuan Seri Iskandar 32610 Malaysia Green Chemistry and Sustainability Cluster Universiti Kuala Lumpur Branch Campus Malaysian Institute of Chemical and BioEngineering Technology Alor Gajah Melaka 78000 Malaysia

In the present study, the polyvinylidene fluoride (PVDF) was incorporated with polyvinylpyrrolidone (PVP) and titanium dioxide (TiO2) nanoparticles to prepare PVDF-TiO2-PVP composite membrane for Bovine Serum Albumin ... 详细信息

In the present study, the polyvinylidene fluoride (PVDF) was incorporated with polyvinylpyrrolidone (PVP) and titanium dioxide (TiO₂) nanoparticles to prepare PVDF-TiO₂-PVP composite membrane for Bovine Serum Albumin (BSA) rejection from protein contaminated wastewater. The preparation of PVDF-TiO₂-PVP composite membrane was conducted by a non-solvent phase inversion (NIPS) process with varying PVDF weight percentages ranging from 16 to 19 wt%. The polymer concentration plays a critical role in the formation of composite membranes that is commonly overlooked. The primary goal of this study is to examine how the concentration of polymers affects the process of membrane creation, the ensuing structure, and the properties of these membranes. Presently, there is a restricted comprehension concerning the impact of PVDF polymer concentration in the fabrication of membranes using the NIPS approach, particularly for PVDF-TiO₂-PVP composite membranes. FE-SEM analysis revealed the lowest skin layer thickness and the number of macro-void formations in a PVDF composite membrane were at 16 wt% PVDF, compared to composite membranes over higher PVDF concentrations from 17 to 19 wt%. There were only slight variations in the percentages of individual elements across all PVDF-TiO₂-PVP membranes, yet the values were identical for C, O, F, and Ti. The viscosity was lowest at 16 wt percent PVDF (576.5 MPa s) and greatest at 19 wt percent PVDF (2054.3 MPa s). It showed that 19%wt PVDF viscosity increased fourfold higher than 16%wt. As the concentration of PVDF was increased, a related decrease in the surface porosity of the membrane was observed. The highest hydrophobicity with the contact angle of 79.62° of the composite membranes were detected at 19 wt% of PVDF loading. The maximum water flux (265.43 L/m²h) and BSA flux (250.31 L/m²h) were obtained at 19 wt% of PVDF loading. The lowest PVDF concentration of 16

关键词： Bovine serum albumin rejection Composite membrane Flat sheet Membrane separation Polymeric composite

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Achieving open defecation free in Surabaya city by 2019 2

Achieving open defecation free in Surabaya city by 2019

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2nd International Conference on Green civil and Environmental engineering, GCEE 2019

作者： Soedjono, E. Fitriani, N. Santoso, F.R.E. Destio, R. Fahmi, I. Gemardi, A. Ningsih, D.A. Environmental Engineering Department Institut Teknologi Sepuluh Nopember Surabaya Indonesia Study Program of Environmental Engineering Department of Biology Universitas Airlangga Indonesia Civil Engineering Narotama University Indonesia

Achieving open defecation free (ODF) in Indonesia by 2019 is closely monitored by the Government of Indonesia (GoI) as it is targeted in the RPJMN (national mid-year term). This achievement is also targeted at Surabaya City as the second largest city in Indonesia. There are still 15.527 houses in Surabaya which do not have proper sanitation system or still practicing open defecation. This study is aimed to assess how ODF would be achieved in Surabaya by 2019;including what type of toilets are to be used. A household survey was conducted to locate and assess the condition of those houses. Survey results show that 12.772 houses still practice defecation in the open area. These houses comprise of legal and illegal houses which are 5.586 and 7.186, respectively. Priority is given to legal houses as they are manageable to be given toilet under Surabaya's regulation procedure. Based on the available technologies to construct sanitation system then there will be 2.833 individual septic tank, 419 communal septic tanks, 15 communal toilet with bathing and washing (MCK), 12 communal wastewater treatment, and 1 centralized system in Keputih Sub-district of Surabaya to be constructed to set free these legal houses from open defecation practices. © Published under licence by IOP Publishing Ltd.

关键词： Houses

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Review of smart grids advancements of energy mix sources

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AIP Conference Proceedings 2023年第1期2746卷

作者： A. N. Woro W. M. W. Muda A. Z. Annuar B. Syaiful Electrical Engineering Study Program Faculty of Engineering Pamulang University Pamulang Tangerang Selatan Banten Indonesia Faculty of Ocean Engineering Technology and Informatics Universiti Malaysia Terengganu 2103 Kuala Nerus Terengganu Malaysia Electrical Engineering Department Faculty of Engineering Pamulang University Pamulang Tangerang Selatan Banten Indonesia. Centre for Nuclear Reactor Technology and Safety National Nuclear Energy Agency of Indonesia Tangerang Selatan Banten Indonesia

The successful implementation of smart grids depends on energy efficiency, mostly relying on the operation of electricity source infrastructure. The combination of energy sources undoubtedly provides complexity in real applications. Some of the challenges for a smart grids comes from the intermittent renewable energy characteristics such as bioenergy, geothermal, hydropower, solar, ocean power, and wind energy to the base load energy such as natural gas, coal, and nuclear. This paper aims to review the implementation of current advances of smart grids from combined energy mix sources. The review includes major components of smart grids, i.e. power plants, monitoring systems, substations, power transmission and distribution, controllers and smart meters. The review also investigates the state of the art contribution of power electronics, artificial intelligence and Internet of Things to more significant optimization, safety and efficiency in these areas. The results are expected to provide a further gap analysis of applicable technologies and best practices in mixed electricity generation sources. The final result will also consider its application in an archipelago country such as Indonesia.

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Investigation of the immersion resistance of the HRS-WC mixtures with applying static loading

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Journal of Physics: Conference Series 2021年第1期1858卷

作者： S Sunarjono N Hidayati A Magfirona AD Prakoso Civil Engineering Postgraduate Program Universitas Muhammadiyah Surakarta Indonesia Civil Engineering Study Program Universitas Muhammadiyah Surakarta Indonesia

The inclusion of rainwater often compounds the damage to the road before reaching the plan life through the surface and shoulders of roads. This can lead to the release of aggregates and exfoliation of asphalt on the surface layer. The study aims to determine the level of road durability against the Marshall, volumetric, and durability properties of the HRS-WC mixture. The study used various static loading 100 Kpa, 150 Kpa, and 200 Kpa with immersion. In the immersion method, there are two differences, namely, immersion with and immersion without loading. The test objects' loading using a simple and economical test tool utilizes the beams and iron cylinders obtained from the laboratory, testing using Marshall Test. The results of the analysis obtained the durability of unloading soaked value higher than the load. The analysis results showed that the durability of the mixture was soaked seven days with a load of 100 KPa was 77.40%, for 150 Kpa amounted to 52.02%, and for 200 KPa, which is 47.67%. Analysis results showed a 7-day immersion value with a cumulative load of 68.38%, while analysis results showed a seven day immersion value with periodic loading of 75.43%.

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Toward smart port: New national capital city of Indonesia

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AIP Conference Proceedings 2023年第1期2846卷

作者： Putra Apriyanto Habirun Okti Setyaningsih Cynthia Limas Ibnu Fauzi Okkie Putriani Civil Engineering Study Program Faculty of Engineering Universitas Atma Jaya Yogyakarta Jalan Babarsari No.44 Janti Caturtunggal Depok District Sleman Regency Special Region of Yogyakarta 55281 Indonesia National Research and Innovation Agency Jl. Graphic 02 Special Region of Yogyakarta 55281 Indonesia

The decision to relocate to the capital city of Indonesia needs to be supported by complete infrastructure, one of which is a technology-based smart port. Ports play an essential role in supporting the country’s economy. A port can be categorized as a smart port if it meets four main criteria: energy, operations, safety & security, and environment. This study will discuss the concept of smart port operation to realize the Master Plan of the New National Capital City of Indonesia (IKN) in terms of technology infrastructure, mobility, and smart city connectivity using the literature review method. The location of this research is in the Kaltim Kariangau Terminal (KKT), West Kalimantan Province. Most port activities in administration, loading, and unloading at the Kaltim Kariangau Terminal (KKT) still use conventional methods. There are three aspects of operations to fulfill smart port criteria: productivity, automation, and intelligent infrastructure. Productivity refers to the optimization level of activity on the port; RFID (Radio Frequency Identification) technology may increase the port’s productivity by decreasing the amount of time to identify every single container. AGV (Automated Guided Vehicle) with an automatic guiding device allow movement along a path that the system has determined to support the automation system. The application of automatic gates for checking goods in the entry gate supports the intelligence infrastructure to obtain data in real-time and quickly. The implementation of smart ports directly also supports the creation of IKN following the IKN Master Plan, which refers to Law No. 3 of 2022 concerning the State Capital covering aspects of Smart City implementation, Mobility and Connectivity, Technology, Information, Communication Infrastructure, and IKN Security Systems.

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