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AHR is a Zika virus host factor and a candidate target for antiviral therapy (vol 52, pg 941, 2020)

NATURE NEUROSCIENCE 2020年第10期23卷 1307-1307页

作者： Giovannoni, Federico Bosch, Irene Polonio, Carolina Manganeli Torti, Maria F. Wheeler, Michael A. Li, Zhaorong Romorini, Leonardo Rodriguez Varela, Maria S. Rothhammer, Veit Barroso, Andreia Tjon, Emily C. Sanmarco, Liliana M. Takenaka, Maisa C. Modaresi, Seyed Mohamad Sadegh Gutierrez-Vazquez, Cristina Zanluqui, Nagela Ghabdan dos Santos, Nilton Barreto Munhoz, Carolina Demarchi Wang, Zhongyan Damonte, Elsa B. Sherr, David Gehrke, Lee Peron, Jean Pierre Schatzmann Garcia, Cybele C. Quintana, Francisco J. Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital Harvard Medical School Boston MA USA Laboratorio de Estrategias Antivirales Departamento de Química Biológica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires. CONICET—Instituto de Química Biológica Buenos Aires Argentina Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA USA Department of Medicine Mount Sinai School of Medicine New York NY USA Neuroimmune Interactions Laboratory Immunology Department—ICB IV University of São Paulo São Paulo Brazil Scientific Platform Pasteur—USP University of São Paulo São Paulo Brazil Laboratorio de Investigación aplicada a Neurociencias Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia Buenos Aires Argentina Immunopathology and Allergy Post Graduate Program School of Medicine University of São Paulo São Paulo Brazil Department of Pharmacology Institute of Biomedical Science University of São Paulo São Paulo Brazil Dept. of Environmental Health Boston University School of Public Health Boston MA USA Program in Virology Division of Medical Sciences Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA

Zika virus (ZIKV) is a flavivirus linked to multiple birth defects including microcephaly, known as congenital ZIKV syndrome. The identification of host factors involved in ZIKV replication may guide efficacious therapeutic interventions. In genome-wide transcriptional studies, we found that ZIKV infection triggers aryl hydrocarbon receptor (AHR) activation. Specifically, ZIKV infection induces kynurenine (Kyn) production, which activates AHR, limiting the production of type I interferons (IFN-I) involved in antiviral immunity. Moreover, ZIKV-triggered AHR activation suppresses intrinsic immunity driven by the promyelocytic leukemia (PML) protein, which limits ZIKV replication. AHR inhibition suppressed the replication of multiple ZIKV strains in vitro and also suppressed replication of the related flavivirus dengue. Finally, AHR inhibition with a nanoparticle-delivered AHR antagonist or an inhibitor developed for human use limited ZIKV replication and ameliorated newborn microcephaly in a murine model. In summary, we identified AHR as a host factor for ZIKV replication and PML protein as a driver of anti-ZIKV intrinsic immunity.

关键词： Immunology Microbiology

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Visual assessment deterioration analysis of runways at Sultan Aji Muhammad Sulaiman Sepinggan Airport Balikpapan

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AIP Conference Proceedings 2019年第1期2114卷

作者： Yanti Sri Sunarjono Agus Riyanto Nurul Hidayati Alfia Magfirona 1Civil Engineering Post Graduate Program Universitas Muhammadiyah Surakarta Surakarta Central Java Indonesia

Sultan Aji Muhammad Sulaiman Sepinggan (SAMS) Airport has an important role as the gateway of economic activity in Balikpapan, East Kalimantan. Elements of the airport consist of runways, taxiway, apron and the terminal building of departure and arrival. The runway has an important role as a key element in airport infrastructure, this is related to aircraft and passenger safety in air traffic at SAMS Airport, which is currently one of the best airports in Indonesia that meets the International Standard qualification. The purpose of this study is to perform visual assessment of runway deterioration at SAMS Airport using PCI (Pavement Condition Index) method, to know the factors affecting runway deterioration and the effective distress treatment to overcome deterioration at a runway. The visual assessment data are collected from PT. Angkasa Pura I (Persero) Sepinggan, by measuring the types and area of deterioration occurring on the runway during 1-month period (in September 2018), then PCI is analyzed by using ASTM D 5340 – 98. The results show that the PCI value is 80.4 which means the rating is excellent. The most common typical distress occurred at Threshold Runway 25 section 1 with the type of distress is block cracking which mainly caused by asphalt concrete shrinkage and daily temperature condition resulting in stress or strain series, another type is depression initially caused by the settlement from the soil foundation or construction process. Since PCI shows excellent state, the distress repair treatment to be performed is surface repair or routine maintenance with partial mill and overlay method.

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Study of soil structure interaction on basement wall with variants in distance and depth of the basement on soil class SE

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Journal of Physics: Conference Series 2020年第5期1529卷

作者： Yetty Saragi Masyhur Irsyam Roesyanto Hendriyawan University of HKBP Nommensen Sutomo Street No.4A Medan 20234 Indonesia Post Graduate Program Civil Engineering Departement University of Sumatera Utara Medan North Sumatera 20155 Indonesia Institute of Technology Bandung Ganesha 10 Bandung West Java 40135 Indonesia Civil Engineering Departement University of Sumatera Utara Medan North Sumatera 20155 Indonesia

The function of the basement is to carry the weight of the upper structure into the soil and to resist lateral loads around the basement wall. One aspect of geotechnical engineering that often a problem in basement wall planning is the determination of lateral ground pressure in the basement wall due to earthquake which must be held by the basement wall. In this study, an analysis of the effects of local soil conditions due to dynamic loads is done through analysis of soil-structure interaction. The analysis is done by modeling the local soil with variations in basement depth and the adjacent basement distance to get the lateral pressure distribution due to dynamic load. The analyzed soil conditions are considered homogeneous at land sites SE (soft soil) with the dynamic load input from earthquake loads uses a 10% probability of exceedance in 50 years (500 years). The most influential parameter for soil displacement is the distance of the basement and then the depth of the basement. The most influential parameter on lateral forces is the depth of the basement followed by the distance of the basement.

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The Effect of Mangrove on Fish Catch Using Belat at Teluk Pemedas and Sanipah of Kutai Kartanegara Regency, East Kalimantan Province, Indonesia 2

The Effect of Mangrove on Fish Catch Using Belat at Teluk Pe...

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2nd International Conference on Energy, environmental and Information System, ICENIS 2017

作者： Sulaiman, Bustam Bambang, Azis Nur Purnaweni, Hartuti Lutfi, Mohammad Doctoral Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Faculty of Fishery and Ocean Diponegoro University Semarang50275 Indonesia Master Program of Environmental Science School of Post Graduate Studies Diponegoro University Semarang50275 Indonesia Faculty of Social Science and Political Science Diponegoro University Semarang50275 Indonesia Department of Oil and Gas Processing Engineering STT MIGAS Balikpapan76127 Indonesia Department of Petroleum Engineering STT MIGAS Balikpapan76127 Indonesia

The increasing population at Teluk Pemedas and Sanipah coastal areas of Kutai Kartanegara Regency, East Kalimantan Province, has led to coastal degradation. The problem was mainly caused by conversion of mangrove into aquaculture, agriculture, plantation industrial, and residential areas. This research was a study case, used descriptive analysis to describe the local fishermen activity using belat traditional device to catch fish. The results revealed that there were many fishermen still did not know the benefits of mangrove for economy growth, ecological, ecotourism etc. This condition affects to the decline of the mangrove function. Fisherman who used belat often move from one location to another location in order to find places that have many catches. The belat which are placed in good environment mangrove areas produces lots of catches that greatly benefit the fisherman, therefore mangrove ecosystem must be well preserved for the sustainability of fishermen's efforts to earn a living. © 2018 The Authors, published by EDP Sciences.

关键词： Fish

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Development of a smartphone-based app for determination of formaldehyde concentration indoors 15

Development of a smartphone-based app for determination of f...

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15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018

作者： Zhang, Siyang Shapiro, Nicholas Gehrke, Gretchen Castner, Jessica Liu, Zhenlei Guo, Beverly Zhang, Jianshun Haines, Sarah Kormos, David Frey, Paige Qin, Rongjun Dannemiller, Karen C. Department of Computer Science and Engineering Ohio State University United States Public Laboratory for Open Technology and Science Department of Mechanical and Aerospace Engineering Syracuse University Environmental Science Graduate Program Ohio State University United States Department of Civil Environmental and Geodetic Engineering College of Engineering Ohio State University United States Strand Associates Incorporated Department of Electrical and Computer Engineering Ohio State University United States Department of Environmental Health Sciences College of Public Health Ohio State University United States

ISBN: (纸本)9781713826514

Formaldehyde is a ubiquitous contaminant in the indoor environment that is both a carcinogen and irritant. The goal of this project is to develop a smartphone-based app for use by citizen scientists or researchers that can be paired with low-cost colorimetric badges for detection of indoor formaldehyde. We conducted both national and geographically-targeted surveys prior to app design. We have subsequently developed the app and conducted a beta test. Surveys of 147 individuals indicated broad public interest in formaldehyde testing using smartphone technology. Testing of the badges indicated consistent change in illumination with increasing formaldehyde exposure. Beta testing indicated users were able to navigate the existing app, and highlighted areas for improvement including incorporation of public surveys. Planned future analysis includes extensive calibration testing and a community-based field test. © 2018 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018. All rights reserved.

关键词： Formaldehyde

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Mechanisms of Geologically Stored CO2 for Energy Storage

SSRN

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SSRN 2019年

作者： Ogland-Hand, Jonathan D. Bielicki, Jeffrey M. Environmental Science Graduate Program Ohio State University 174 West 18th ColumbusOH43210 United States Department of Civil Environmental and Geodetic Engineering Ohio State University 2070 Neil Avenue ColumbusOH43210 United States John Glenn College of Public Affairs Ohio State University 1810 College Road ColumbusOH43210 United States

Carbon dioxide-Bulk Energy Storage (CO2-BES) is a bulk energy storage technology that uses carbon dioxide (CO2) in sedimentary basin geothermal resources to time-shift electricity production. Here, we investigated how the charging and discharging cycles affect the power storage capacity and power output capacity of a CO2-BES facility. We simulated the operation of CO2-BES with seven different operating cycles for fourteen years. Our results suggest that continuous charging and discharging cycles do not change the rate of heat depletion of the geothermal resource. But the power storage capacity and the power output capacity are affected because they rely on the magnitude of the overpressure. If, in a cycle, the duration of electricity dispatch is greater than the duration of electricity storage, overpressure may eventually deplete and a CO2-BES facility may cease to be operational. If idle periods where electricity is neither charged nor discharged are included in the cycle, there is a small increase in power output capacity and a small decrease in power storage capacity. In general, if electricity is dispatched and stored for equal amounts of time, the duration of dispatch/storage and of the idle period does not affect the power output capacity or the power storage capacity. As a result, as long as the cycles consist of equivalent charging and discharging durations throughout the lifetime of the facility, the length of those durations and frequency of idle periods could be based on financial incentives (e.g., diurnal variations in electricity prices), rather than process-level factors like the potential for heat or pressure depletion. © 2019, The Authors. All rights reserved.

关键词： Carbon dioxide

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Analytical model of retrofitted reinforced concrete beam column joints after experiencing severe damage from earthquake load simulation using SAP2000

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IOP Conference Series: Materials Science and engineering 2019年第1期508卷

作者： N Gosal I Imran M Riyansyah Post Graduate Program of Faculty of Civil Engineering Bandung Institute of Technology 40132 Bandung Indonesia Structural Engineering Department Faculty of Civil Engineering Bandung Institute of Technology 40132 Bandung Indonesia

An earthquake resistant structure should be able to perform as expected when it's struck by an earthquake such as it may experience slight damage and should be able to be repaired to its original state when struck by a design level earthquake. However, there are still debates whether reparation should also be viable when structures are experiencing severe damage. There are still a little to no studies about repairing severely damaged structures, therefore a study was made to see how severely damaged structures behaved after being repaired. Two beam column joints are used as specimens, which were severely damaged by an earthquake simulation before getting repaired. Both their initial and repaired condition are then modeled analytically using SAP2000. Their behaviors such as plastic hinges, joint's shear deformation, bond slip, and rebars' residual strain and stress due to previous loading are also implemented to the model. Although the lateral strength of the specimens are similar to their analytical model, the other behavior, especially their stiffness is not similar, therefore needing another parameter implemented in the model.

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Comparative study of asphalt concrete characteristic between ideal gradation and laboratory tested gradation with crumb rubber

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IOP Conference Series: Materials Science and engineering 2019年第1期650卷

作者： Asep Sundara Risna Rismiana Sari Tanya Audia Balqis Civil Engineering Department Politeknik Negeri Bandung Bandung Indonesia Post-Graduate Student of Infrastructure Engineering Study Program Applied Master Program Politeknik Negeri Bandung Bandung Indonesia

Modifying asphalt concrete with using Crumb Rubber (CR) can provide environmental benefits. The method used in this study is an experimental laboratory with Mashall machine. The tests used two types of gradation, namely the gradations of Ideal and Laboratory Test. CR used in a mixture with a dry process method to replacement 0%, 5%, 15% and 20% of the weight aggregate at fraction No. 30 (0.6 mm). The results showed that the Ideal gradation mixture has a better characteristic than the mixture of laboratory tested gradations. Ideal gradations can increased stability into 10% from Laboratory Test gradations for mixture without CR. Addition of CR contect in AC mixture did not significantly effect for the characteristics. To ensure the effect of CR in mixture, further test must be taken.

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INTRODUCTION

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Bulletin of the American Meteorological Society 2024年第8期105卷 S1-S11页

作者： Boyer, T. Blunden, J. Dunn, R.J.H. NOAA/NESDIS National Centers for Environmental Information Silver Spring Maryland NOAA/NESDIS National Centers for Environmental Information Asheville North Carolina Met Office Hadley Centre Exeter United Kingdom European Centre for Medium-Range Weather Forecasts Reading United Kingdom University of Maryland College Park Maryland Scripps Institution of Oceanography University of California San Diego La Jolla California NOAA/NWS National Centers for Environmental Prediction Climate Prediction Center College Park Maryland Brandenburg University of Technology (BTU) Cottbus-Senftenberg Germany Servicio Meteorológico Nacional Buenos Aires Argentina NOAA/OAR Physical Sciences Laboratory Boulder Colorado European Centre for Medium-Range Weather Forecasts Bonn Germany Center for Geophysical Research and School of Physics University of Costa Rica San José Costa Rica Department of Meteorology and National Centre for Earth Observation University of Reading Reading United Kingdom Centro Nacional de Monitoramento e Alertas de Desastres Naturais CEMADEN São Paulo Brazil Université Grenoble Alpes Institut des Géosciences de l’Environnement IRD CNRS Grenoble INP Grenoble France Hampton University Hampton Virginia Seychelles Meteorological Authority Mahe Seychelles Section for Glaciers Ice and Snow Norwegian Water Resources and Energy Directorate Oslo Norway National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Agriculture Osaka Metropolitan University Sakai Japan Science Faculty Universidad Nacional de Colombia Bogotá Colombia University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder Colorado Servicio Nacional de Meteorología e Hidrología del Perú Lima Perú Centro de Investigaciones sobre Desertificación – Spanish National Research Council (CSIC-UV-GVA) Valencia Spain Hydro-Climate Extremes Lab (H-CEL) Ghent University Ghent Belgium Department o

In 2023, La Niña conditions that generally prevailed in the eastern Pacific Ocean from mid-2020 into early 2023 gave way to a strong El Niño by October. Atmospheric concentrations of Earth’s major greenhouse gases—carbon dioxide, methane, and nitrous oxide—all increased to record-high levels. The annual global average carbon dioxide concentration in the atmosphere rose to 419.3±0.1 ppm, which is 50% greater than the pre-industrial level. The growth from 2022 to 2023 was 2.8 ppm, the fourth highest in the record since the 1960s. The combined short-term effects of El Niño and the long-term effects of increasing levels of heat-trapping gases in the atmosphere contributed to new records for many essential climate variables reported here. The annual global temperature across land and oceans was the highest in records dating as far back as 1850, with the last seven months (June–December) having each been record warm. Over land, the globally averaged temperature was also record high. Dozens of countries reported record or near-record warmth for the year, including China and continental Europe as a whole (warmest on record), India and Russia (second warmest), and Canada (third warmest). Intense and widespread heatwaves were reported around the world. In Vietnam, an all-time national maximum temperature record of 44.2°C was observed at Tuong Duong on 7 May, surpassing the previous record of 43.4°C at Huong Khe on 20 April 2019. In Brazil, the air temperature reached 44.8°C in Araçuaí in Minas Gerais on 20 November, potentially a new national record and 12.8°C above normal. The effect of rising temperatures was apparent in the cryosphere, where snow cover extent by June 2023 was the smallest in the 56-year record for North America and seventh smallest for the Northern Hemisphere overall. Heatwaves contributed to the greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Due to rapid volume loss beginning in 2021, St. A

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The Effect of EPS Addition to Soil Stabilized with Fly Ash as Lightweight Fill Materials for Embankment Construction

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Journal of Physics: Conference Series 2019年第1期1364卷

作者： Syahril Andri Krisnandi Somantri Aditia Febriansya Civil Engineering Department Politeknik Negeri Bandung Bandung Indonesia Civil Engineering Department Politeknik Negeri Bandun Bandung Indonesia Post-Graduate Student of Infrastructure Engineering Study Program Applied Master Program Politeknik Negeri Bandung Bandung Indonesia

Design and construction of road embankment presents several challenges, including the possibility of bearing capacity failure, large total settlement, differential settlement, and slope instability, which may result from the weight of the embankment construction itself, and/or weak foundation. A number of techniques have been developed and can be used to overcome these problems, one of them is by modifying the weight of the embankment itself with the use of lightweight materials, such as soil-EPS mixture. The use of soil-EPS mixture as lightweight material provides several advantages, among which can achieve the same volume or elevation requirement with a significantly lighter weight compared to ordinary materials, improving slope stability, embankment over high compressibility soil, and to reduce soil pressure to soil retaining structures, abutment or bridge pillar. Fly ash also added to act as binder to increase shear strength of mixture. The result of the compaction test shows that the addition of a small amount of EPS to the mixture can significantly reduce the maximum dry density of the mixture. Triaxial UU and UCS test results show a reduction in mixture strength as EPS contents increase, but due to the presence of fly ash increases the strength of mixture as the number of day increases, so that the use of lightweight materials has the potential to be one of soil improvement solutions.

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