The emergence of microneedle arrays(MNAs)as a novel,simple,and minimally invasive administration approach largely addresses the challenges of traditional drug *** particular,the dissolvable MNAs act as a promising,mul...
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The emergence of microneedle arrays(MNAs)as a novel,simple,and minimally invasive administration approach largely addresses the challenges of traditional drug *** particular,the dissolvable MNAs act as a promising,multifarious,and well-controlled platform for micro-nanotransport in medical research and cosmetic formulation *** effective delivery mostly depends on the behavior of the MNAs penetrated into the body,and accurate assessment is urgently *** imaging technologies offer high sensitivity and resolution visualization of cross-scale,multidimensional,and multiparameter information,which can be used as an important aid for the evaluation and development of new *** combination of MNA technology and imaging can generate considerable new knowledge in a cost-effective manner with regards to the pharmacokinetics and bioavailability of active substances for the treatment of various *** addition,noninvasive imaging techniques allow rapid,receptive assessment of transdermal penetration and drug deposition in various tissues,which could greatly facilitate the translation of experimental MNAs into clinical *** on the recent promising development of bioimaging,this review is aimed at summarizing the current status,challenges,and future perspective on in vivo assessment of MNA drug delivery by various imaging technologies.
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