Background Genetic frontotemporal dementia (FTD) is highly heterogeneous, with carriers of mutations in the same gene manifesting different phenotypes. Using in vivo MR images from the Genetic FTD Initiative (GENFI), ...
Background Genetic frontotemporal dementia (FTD) is highly heterogeneous, with carriers of mutations in the same gene manifesting different phenotypes. Using in vivo MR images from the Genetic FTD Initiative (GENFI), we aimed to identify subgroups within the same genetic group whose brains were affected differently. Method Cortical and subcortical volumes of interest were generated using automated parcellation methods on volumetric 3T T1-weighted MRI scans for 479 carriers (198 GRN , 202 C9orf72 , and 79 MAPT mutation carriers). W-scores for 85 volumes of interest were computed from a linear regression model carried out on 298 non-carrier cognitively normal controls adjusting for the effect of age, sex, total intracranial volume and scanner type. cluster analyses with the Ward agglomerating method were performed on all w-scores while considering the three genetic groups independently. The identified clusters were then compared for age, estimated years from onset, global and sum of boxes scores of the CDR® plus NACC FTLD (at baseline and after one year), neurofilament light chain (NfL) levels in the plasma and w-scores in brain regions typically showing early atrophy (Kruskal-Wallis test). Result We identified three clusters among the GRN mutation carriers and four in the MAPT and C9orf72 groups, which were all significantly different for the variables reported in the Table (p-value<0.003). For all three genetic groups, one cluster was formed by patients with a clinical diagnosis of FTD, with more extensive atrophy and increased disease severity. For the remaining clusters, there seemed to be an association with disease severity for MAPT and GRN mutation carriers but not so for C9orf72 expansion carriers where clinical scores were not clearly associated with a specific cluster. Conclusion By only looking at regional brain volumes, we were able to detect different clusters within carriers of mutations in the same gene, with C9orf72 expansion carriers being the most he
Measurements of ZZ production in the ℓ+ℓ−ℓ′+ℓ′− channel in proton–proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 fb−1 of collisions collec...
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Measurements of ZZ production in the ℓ+ℓ−ℓ′+ℓ′− channel in proton–proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 fb−1 of collisions collected by the ATLAS experiment in 2015 and 2016. Here ℓ and ℓ′ stand for electrons or muons. Integrated and differential ZZ→ℓ+ℓ−ℓ′+ℓ′− cross sections with Z→ℓ+ℓ− candidate masses in the range of 66 GeV to 116 GeV are measured in a fiducial phase space corresponding to the detector acceptance and corrected for detector effects. The differential cross sections are presented in bins of twenty observables, including several that describe the jet activity. The integrated cross section is also extrapolated to a total phase space and to all standard model decays of Z bosons with mass between 66 GeV and 116 GeV, resulting in a value of 17.3±0.9[±0.6(stat)±0.5(syst)±0.6(lumi)] pb. The measurements are found to be in good agreement with the standard model. A search for neutral triple gauge couplings is performed using the transverse momentum distribution of the leading Z boson candidate. No evidence for such couplings is found and exclusion limits are set on their parameters.
This paper presents a study of and triboson production using events from proton-proton collisions at a centre-of-mass energy of recorded with the ATLAS detector at the LHC and corresponding to an integrated luminos...
This paper presents a study of and triboson production using events from proton-proton collisions at a centre-of-mass energy of recorded with the ATLAS detector at the LHC and corresponding to an integrated luminosity of 20.2 fb . The production cross-section is determined using a final state containing an electron, a muon, a photon, and neutrinos ( ). Upper limits on the production cross-section of the final state and the and final states containing an electron or a muon, two jets, a photon, and a neutrino ( or ) are also derived. The results are compared to the cross-sections predicted by the Standard Model at next-to-leading order in the strong-coupling constant. In addition, upper limits on the production cross-sections are derived in a fiducial region optimised for a search for new physics beyond the Standard Model. The results are interpreted in the context of anomalous quartic gauge couplings using an effective field theory. Confidence intervals at 95% confidence level are derived for the 14 coupling coefficients to which and production are sensitive.
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