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The applied principles of EEG analysis methods in neuroscience and clinical neurology

Military Medical research 2024年第6期11卷 907-941页

作者： Hao Zhang Qing-Qi Zhou He Chen Xiao-Qing Hu Wei-Guang Li Yang Bai Jun-Xia Han Yao Wang Zhen-Hu Liang Dan Chen Feng-Yu Cong Jia-Qing Yan Xiao-Li Li School of Systems Science Beijing Normal UniversityBeijing 100875China College of Electrical and Control Engineering North China University of TechnologyBeijing 100041China School of Automation Science and Engineering South China University of TechnologyGuangzhou 510641China Department of Psychology the State Key Laboratory of Brain and Cognitive Sciencesthe University of Hong KongHong Kong SAR 999077China HKU-Shenzhen Institute of Research and Innovation Shenzhen 518057GuangdongChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong SAR 999077China Department of Rehabilitation Medicine the First Afliated Hospital of Nanchang UniversityNanchang 330006China Rehabilitation Medicine Clinical Research Center of Jiangxi Province Nanchang 330006China Beijing Key Laboratory of Learning and Cognition School of PsychologyCapital Normal UniversityBeijing 100048China School of Communication Science Beijing Language and Culture UniversityBeijing 100083China Institute of Electrical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina School of Computer Science Wuhan UniversityWuhan 430072China School of Biomedical Engineering Faculty of Electronic Information and Electrical EngineeringDalian University of TechnologyDalian 116081LiaoningChina Guangdong Artifcial Intelligence and Digital Economy Laboratory(Guangzhou) Guangzhou 510335China.

Electroencephalography(EEG)is a non-invasive measurement method for brain *** to its safety,high resolution,and hypersensitivity to dynamic changes in brain neural signals,EEG has aroused much interest in scientific research and medical *** article reviews the types of EEG signals,multiple EEG signal analysis methods,and the application of relevant methods in the neuroscience feld and for diagnosing neurological ***,3 types of EEG signals,including time-invariant EEG,accurate event-related EEG,and random event-related EEG,are ***,5 main directions for the methods of EEG analysis,including power spectrum analysis,time-frequency analysis,connectivity analysis,source localization methods,and machine learning methods,are described in the main section,along with diferent sub-methods and effect evaluations for solving the same ***,the application scenarios of different EEG analysis methods are emphasized,and the advantages and disadvantages of similar methods are *** article is expected to assist researchers in selecting suitable EEG analysis methods based on their research objectives,provide references for subsequent research,and summarize current issues and prospects for the future.

关键词： Electroencephalogram analysis methods Applied principles Neuroscience Diagnosis Neurological diseases

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ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices

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Biological Psychiatry: cognitive Neuroscience and Neuroimaging 2025年第4期10卷 425-436页

作者： Ganesan, Saampras Barrios, Fernando A. Batta, Ishaan Bauer, Clemens C.C. Braver, Todd S. Brewer, Judson A. Brown, Kirk Warren Cahn, Rael Cain, Joshua A. Calhoun, Vince D. Cao, Lei Chetelat, Gaël Ching, Christopher R.K. Creswell, J. David Dagnino, Paulina Clara Davanger, Svend Davidson, Richard J. Deco, Gustavo Dutcher, Janine M. Escrichs, Anira Eyler, Lisa T. Fani, Negar Farb, Norman A.S. Fialoke, Suruchi Fresco, David M. Garg, Rahul Garland, Eric L. Goldin, Philippe Hafeman, Danella M. Jahanshad, Neda Kang, Yoona Khalsa, Sahib S. Kirlic, Namik Lazar, Sara W. Lutz, Antoine McDermott, Timothy J. Pagnoni, Giuseppe Piguet, Camille Prakash, Ruchika S. Rahrig, Hadley Reggente, Nicco Saccaro, Luigi F. Sacchet, Matthew D. Siegle, Greg J. Tang, Yi-Yuan Thomopoulos, Sophia I. Thompson, Paul M. Torske, Alyssa Treves, Isaac N. Tripathi, Vaibhav Tsuchiyagaito, Aki Turner, Matthew D. Vago, David R. Valk, Sofie Zeidan, Fadel Zalesky, Andrew Turner, Jessica A. King, Anthony P. Department of Biomedical Engineering The University of Melbourne Carlton VIC Australia Contemplative Studies Centre Melbourne School of Psychological Sciences The University of Melbourne Melbourne VIC Australia Systems Lab of Neuroscience Neuropsychiatry and Neuroengineering The University of Melbourne Parkville VIC Australia Universidad Nacional Autónoma de México Instituto de Neurobiolgía México Querétaro Mexico Center for Translational Research in Neuroimaging and Data Science: Georgia State University Georgia Institute of Technology and Emory University Atlanta GA United States Department of Psychology Northeastern University Boston Massachusetts Brain and Cognitive Science McGovern Institute for Brain Research Massachusetts Institute of Technology Cambridge Massachusetts Department of Psychological and Brain Sciences Washington University St. Louis Missouri Department of Behavioral and Social Sciences Brown University School of Public Health Providence Rhode Island Department of Psychology Carnegie Mellon University Pittsburgh PA United States University of Southern California Department of Psychiatry & Behavioral Sciences Los Angeles California University of Southern California Center for Mindfulness Science Los Angeles California Institute for Advanced Consciousness Studies Santa Monica California Department of Psychiatry and Behavioral Health The Ohio State University College of Medicine Columbus OH United States Normandie University Université de Caen Normandie INSERM U1237 Neuropresage Team Cyceron Caen France Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine of the University of Southern California Los Angeles California Desert-Pacific Mental Illness Research Education and Clinical Center VA San Diego Healthcare System San Diego California Computational Neuroscience Group Center for Brain and Cognition Department of Information and Communication Technologies Universitat Pompeu Fa

Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past decade, neuroimaging has been used to examine the neuroscientific basis of meditation practices, effects, states, and outcomes for clinical and nonclinical populations. However, the generalizability and replicability of current neuroscientific models of meditation have not yet been established, because they are largely based on small datasets entrenched with heterogeneity along several domains of meditation (e.g., practice types, meditation experience, clinical disorder targeted), experimental design, and neuroimaging methods (e.g., preprocessing, analysis, task-based, resting-state, structural magnetic resonance imaging). These limitations have precluded a nuanced and rigorous neuroscientific phenotyping of meditation practices and their potential benefits. Here, we present ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)–Meditation, the first worldwide collaborative consortium for neuroscientific investigations of meditation practices. ENIGMA-Meditation will enable systematic meta- and mega-analyses of globally distributed neuroimaging datasets of meditation using shared, standardized neuroimaging methods and tools to improve statistical power and generalizability. Through this powerful collaborative framework, existing neuroscientific accounts of meditation practices can be extended to generate novel and rigorous neuroscientific insights that account for multidomain heterogeneity. ENIGMA-Meditation will inform neuroscientific mechanisms that underlie therapeutic action of meditation practices on psychological and cognitive attributes, thereby advancing the f

关键词： Consortium ENIGMA Magnetic resonance imaging (MRI) Meditation Mindfulness Neuroimaging

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The Localized Subtraction Approach For EEG and MEG Forward Modeling

arXiv

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arXiv 2023年

作者： Höltershinken, Malte B. Lange, Pia Erdbrügger, Tim Buschermöhle, Yvonne Wallois, Fabrice Buyx, Alena Pursiainen, Sampsa Vorwerk, Johannes Engwer, Christian Wolters, Carsten H. Institute for Biomagnetism and Biosignalanalysis University of Münster Münster Germany Institute of Medical Informatics University of Münster Münster Germany Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience University of Münster Münster Germany INSERM U1105 Research Group on Multimodal Analysis of Brain Function Jules Verne University of Picardie Amiens France Pediatric functional exploration of the nervous system department CHU Picardie Amiens France Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Computing Sciences Unit Faculty of Information Technology and Communication Sciences Tampere University Tampere Finland Institute of Electrical and Biomedical Engineering Private University for Health Sciences Medical Informatics and Technology Hall in Tyrol Austria Faculty of Mathematics and Computer Science University of Münster Münster Germany

In FEM-based EEG and MEG source analysis, the subtraction approach has been proposed to simulate sensor measurements generated by neural activity. While this approach possesses a rigorous foundation and produces accurate results, its major downside is that it is computationally prohibitively expensive in practical applications. To overcome this, we developed a new approach, called the localized subtraction approach. This approach is designed to preserve the mathematical foundation of the subtraction approach, while also leading to sparse right-hand sides in the FEM formulation, making it efficiently computable. We achieve this by introducing a cut-off into the subtraction, restricting its influence to the immediate neighborhood of the source. In this work, this approach will be presented, analyzed, and compared to other state-of-the-art FEM right-hand side approaches. Furthermore, we discuss how to arrive at an efficient and stable implementation. We perform validation in multi-layer sphere models where analytical solutions exist. There, we demonstrate that the localized subtraction approach is vastly more efficient than the subtraction approach. Moreover, we find that for the EEG forward problem, the localized subtraction approach is less dependent on the global structure of the FEM mesh, while the subtraction approach is sensitive to the mesh structure even at a distance to the source. Additionally, we show the localized subtraction approach to rival, and in many cases even surpass, the other investigated approaches in terms of accuracy. Especially for the MEG forward problem, where Biot-Savart’s law is employed, we show the localized subtraction approach and the subtraction approach to produce highly accurate approximations of the volume currents close to the source. The localized subtraction approach thus reduces the computational cost of the subtraction approach to an extent that makes it usable in practical applications without sacrificing the rigorousness and

关键词： Mesh generation

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Roadmap on Neuromorphic Photonics

arXiv

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arXiv 2025年

作者： Brunner, Daniel Shastri, Bhavin J. Al-Qadasi, Mohammed A. Ballani, H. Barbay, Sylvain Biasi, Stefano Bienstman, Peter Bilodeau, Simon Bogaerts, Wim Böhm, Fabian Brennan, G. Buckley, Sonia Cai, Xinlun Strinati, Marcello Calvanese Canakci, B. Charbonnier, Benoit Chemnitz, Mario Chen, Yitong Cheung, Stanley Chiles, Jeff Choi, Suyeon Christodoulides, Demetrios N. Chrostowski, Lukas Chu, J. Clegg, J.H. Cletheroe, D. Conti, Claudio Dai, Qionghai Di Lauro, Luigi Diamantopoulos, Nikolaos-Panteleimon Dinc, Niyazi Ulas Ewaniuk, Jacob Fan, Shanhui Fang, Lu Franchi, Riccardo Freire, Pedro Gentilini, Silvia Gigan, Sylvain Giorgi, Gian Luca Gkantsidis, C. Gladrow, J. Goi, Elena Goldmann, M. Grabulosa, A. Gu, Min Guo, Xianxin Hejda, Matěj Horst, F. Hsieh, Jih-Liang Hu, Jianqi Hu, Juejun Huang, Chaoran Hurtado, Antonio Jaurigue, Lina Kalinin, K.P. Kamalian-Kopae, Morteza Kelly, D.J. Khajavikhan, Mercedeh Kremer, H. Laydevant, Jeremie Lederman, Joshua C. Lee, Jongheon Lenstra, Daan Li, Gordon H.Y. Li, Mo Li, Yuhang Lin, Xing Lin, Zhongjin Lis, Mieszko Lüdge, Kathy Lugnan, Alessio Lupo, Alessandro Lvovsky, A.I. Manuylovich, Egor Marandi, Alireza Marchesin, Federico Massar, Serge McCaughan, Adam N. McMahon, Peter L. Moralis-Pegios, Miltiadis Morandotti, Roberto Moser, Christophe Moss, David J. Mukherjee, Avilash Nikdast, Mahdi Offrein, B.J. Oguz, Ilker Oripov, Bakhrom O'Shea, G. Ozcan, Aydogan Parmigiani, F. Pasricha, Sudeep Pavanello, Fabio Pavesi, Lorenzo Peserico, Nicola Pickup, L. Pierangeli, Davide Pleros, Nikos Porte, Xavier Primavera, Bryce A. Prucnal, Paul Psaltis, Demetri Puts, Lukas Qiao, Fei Rahmani, B. Raineri, Fabrice Ríos Ocampo, Carlos A. Robertson, Joshua Romeira, Bruno Roques-Carmes, Charles Rotenberg, Nir Rowstron, A. Schoenhardt, Steffen Schwartz, Russell L.T. Shainline, Jeffrey M. Shekhar, Sudip Skalli, A. Sohoni, Mandar M. Sorger, Volker J. Soriano, Miguel C. Spall, James Stabile, Ripalta Stiller, Birgit Sunada, Satoshi Tefas, Anastasios Tossoun, Bassem Tsakyridis, Apostolos Turitsyn, Sergei K. Van der Sande, G Université Marie et Louis Pasteur CNRS UMR 6174 Institut FEMTO-ST Besançon25000 France Centre for Nanophotonics Department of Physics Engineering Physics & Astronomy Queen's University Canada Department of Electrical and Computer Engineering The University of British Columbia Vancouver Canada Microsoft Research Cambridge United Kingdom Université Paris-Saclay CNRS Centre de Nanosciences et de Nanotechnologies France Nanoscience Laboratory Department of Physics University of Trento Italy Photonics Research Group Department of Information Technology Ghent University imec Belgium Princeton University NJ United States Hewlett Packard Labs Hewlett Packard Enterprise Böblingen Germany National Institute of Standards and Technology BoulderCO United States State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information Technology Sun Yat-sen University China Enrico Fermi Research Center Rome Italy Université Grenoble-Alpes CEA Leti Grenoble France Leibniz-Institute of Photonic Technology Jena Germany Institute of Applied Optics and Biophysics Jena Germany Department of Automation Tsinghua University Beijing China Department of Electrical and Computer Engineering North Carolina State University NC United States Department of Electrical Engineering Stanford University CA United States University of Southern California Los AngelesCA United States Department of Physics Sapienza University Rome Italy Institute for Complex Systems National Research Council Rome Italy Varennes Canada NTT Device Technology Labs NTT Corporation Kanagawa Atsugi Japan Institute of Electrical and Microengineering School of Engineering École Polytechnique Fédérale de Lausanne Switzerland Edward L. Ginzton Laboratory Stanford University StanfordCA United States Department of Electronic Engineering Tsinghua University China Beijing National Research Center for Information Science and Technology Tsinghua University China Aston Univ

Neuromorphic photonics are processors inspired by the human brain and enabled by light (photons) instead of traditional electronics. Neuromorphic photonics and its associated concepts are experiencing a significant resurgence, building on foundational research from the 1980s and 1990s. This renewed momentum is driven by breakthroughs in photonic integration, nonlinear optics, and advanced materials, alongside the growing necessity of neuro-inspired computing in numerous applications of economic and societal relevance. The increasing demand for energy-efficient artificial intelligence (AI) solutions underscores the need for innovation and a cohesive vision to address key challenges, including scalability, energy efficiency, precision, and standardized performance benchmarks. Together, these efforts present an opportunity to establish a unique photonic advantage with practical, real-world applications. This roadmap consolidates recent advances while exploring emerging applications, reflecting the remarkable diversity of hardware platforms, neuromorphic concepts, and implementation philosophies reported in the field. It emphasizes the critical role of cross-disciplinary collaboration in this rapidly evolving field. The roadmap introduces various approaches to embedding the high-complexity transformations central to neuromorphic computing, focusing on frequency, delay, and spectral embeddings. This is followed by a discussion of architectures of photonic neural networks (PNNs) and an in-depth analysis of methods for implementing these architectures in photonic hardware. Dedicated sections delve into integrated photonic hardware, the realization of photonic weights and memories, and the optimization of training processes for photonic neuromorphic architectures. The roadmap concludes by exploring numerous potential applications, highlighting the challenges and advances necessary to transition neuromorphic photonic computing from a primarily academic pursuit to a technolog

关键词： Philosophical aspects

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Head Motion Classification for Single-Accelerometer Virtual Reality Hardware

Head Motion Classification for Single-Accelerometer Virtual ...

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International Conference on Frontiers of Signal Processing (ICFSP)

作者： Tomasz Hachaj Marek R. Ogiela Institute of Computer Science Pedagogical University of Krakow Krakow Poland Cryptography and Cognitive Informatics Research Group AGH University of Science and Technology Krakow Poland

Head motions classification applied to virtual reality (VR) systems is still an open problem without a leading pattern recognition solution. In contrary to typical motion capture pattern recognition problem in this case we use only single inertial measurement unit (IMU) sensor. Head motions that we want to recognize in VR systems might be both natural head motions like nodding or shaking head (they might be used while interacting with VR avatars) and also elements of head-based navigation system or interface. The second type of actions is more challenging because it might contains actions that generate motion trajectories that do not appear in real-life, though they have to be possible to execute only by using a head. In this paper we propose a trajectory-based motion features description that is utilized by dynamic time warping (DTW) classificator. The training of the classificator requires using modified dynamic time warping barycenter averaging (DBA) heuristic algorithm which utilizes quaternions to represents rotations. The proposed pattern recognition system together with its evaluation on the set of head motions acquired by VR system is our original contribution. We have evaluated our method on dataset consisted of 8 types of motions performed by two persons (there are 160 motions samples). In leave-one-out evaluation we have obtained very good results: only 10% of one and 15% of another action has been incorrectly classified, while remaining 6 actions classes had been 100% correctly classified. Both dataset and implementation of proposed method can be downloaded, due to this our experiment can be reproduced.

关键词： Magnetic heads Trajectory Dynamics Quaternions Heuristic algorithms Pattern recognition Glass

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Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

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Nature genetics 2024年第5期56卷 1032-1033页

作者： Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain Department of Health Sciences University of Leicester Leicester UK. Population Health and Immunity Division The Walter and Eliza Hall Institute of Medical Research Parkville Victoria Australia. Department of Medical Biology University of Melbourne Parkville Victoria Australia. Channing Division of Network Medicine Brigham and Women's Hospital Boston MA USA. Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston MA USA. Target Sciences GlaxoSmithKline Collegeville PA USA. Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand. Division of Genetics Genomics and Precision Medicine Department of Medicine University of Arizona Tucson AZ USA. Nuffield Department of Population Health University of Oxford Oxford UK. Medical Research Council Population Health Research Unit University of Oxford Oxford UK. The University of British Columbia Centre for Heart Lung Innovation St Paul's Hospital Vancouver British Columbia Canada. Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Department of Epidemiology and Biostatistics MRC-PHE Centre for Environment & Health School of Public Health Imperial College London London UK. Interfaculty Institute for Genetics and Functional Genomics Department of Functional Genomics University Medicine Greifswald Greifswald Germany. Centre for Global Health Research Usher Institute for Population Health Sciences and Informatics University of Edinburgh Edinburgh UK. Centre for Cardiovascular Sciences Queen's Medical Research Institute University of Edinburgh Edinburgh UK. Department of Biostatistics University of Liverpool Liverpool UK. MRC/BHF Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Flatiron Institute Simons Foundation New York NY USA. Busselton Population Medical Research Institute Sir Charles Gairdner Hospital N

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An Early Stage researcher's Primer on Systems Medicine Terminology

Network and Systems Medicine

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Network and Systems Medicine 2021年第1期4卷 2-50页

作者： Zanin, Massimiliano Aitya, Nadim A.A. Basilio, José Baumbach, Jan Benis, Arriel Behera, Chandan K. Bucholc, Magda Castiglione, Filippo Chouvarda, Ioanna Comte, Blandine Dao, Tien-Tuan Ding, Xuemei Pujos-Guillot, Estelle Filipovic, Nenad Finn, David P. Glass, David H. Harel, Nissim Iesmantas, Tomas Ivanoska, Ilinka Joshi, Alok Boudjeltia, Karim Zouaoui Kaoui, Badr Kaur, Daman Maguire, Liam P. McClean, Paula L. McCombe, Niamh De Miranda, João Luís Moisescu, Mihnea Alexandru Pappalardo, Francesco Polster, Annikka Prasad, Girijesh Rozman, Damjana Sacala, Ioan Sanchez-Bornot, Jose M. Schmid, Johannes A. Sharp, Trevor Solé-Casals, Jordi Spiwok, Vojtěch Spyrou, George M. Stalidzans, Egils Stres, Blaa Sustersic, Tijana Symeonidis, Ioannis Tieri, Paolo Todd, Stephen Van Steen, Kristel Veneva, Milena Wang, Da-Hui Wang, Haiying Wang, Hui Watterson, Steven Wong-Lin, Kongfatt Yang, Su Zou, Xin Schmidt, Harald H.H.W. Centro de Tecnología Biomédica Universidad Politécnica de Madrid Madrid Spain Intelligent Systems Research Centre School of Computing Engineering and Intelligent Systems Ulster University Ulster United Kingdom Center for Physiology and Pharmacology Institute of Vascular Biology and Thrombosis Research Medical University of Vienna Vienna Austria TUM School of Life Sciences Weihenstephan Technical University of Munich Freising Germany Holon Israel CNR National Research Council IAC Institute for Applied Computing Rome Italy Lab of Computing Medical Informatics and Biomedical Imaging Technologies School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece Université Clermont Auvergne INRAE UNH Plateforme d'Exploration du Métabolisme MetaboHUB Clermont Clermont-Ferrand France Université de Technologie de Compiègne Compiègne France Labex MS2T Control of Technological Systems-of-Systems CNRS and Université de Technologie de Compiègne Compiègne France Faculty of Engineering University of Kragujevac Kragujevac Serbia Kragujevac Serbia Steinbeis Advanced Risk Technologies Institute Doo Kragujevac Kragujevac Serbia Pharmacology and Therapeutics School of Medicine Galway Neuroscience Centre National University of Ireland Galway Ireland School of Computing Ulster University Ulster United Kingdom Holon Israel Department of Mathematics and Natural Sciences Kaunas University of Technology Kaunas Lithuania Faculty of Computer Science and Engineering Ss. Cyril and Methodius University Skopje Macedonia Medicine Faculty Université Libre de Bruxelles CHU de Charleroi Charleroi Belgium Northern Ireland Centre for Stratified Medicine Biomedical Sciences Research Institute Ulster University Ulster United Kingdom Escola Superior de Tecnologia e Gestão Instituto Politécnico de Portalegre Portalegre Portugal Instituto Superior Técnico Universidade de Lisboa Lisboa Portugal Faculty of Automatic Control and Computers University Politehnica of B

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. These include both modeling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. Results: This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for digging into the topic. © Massimiliano Zanin et al., 2021;Published by Mary Ann Liebert, Inc. 2021.

关键词： Semantics

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Nearest neighborhood-based deep clustering for source data-absent unsupervised domain adaptation

arXiv

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arXiv 2021年

作者： Tang, Song Yang, Yan Ma, Zhiyuan Hendrich, Norman Zeng, Fanyu Ge, Shuzhi Sam Zhang, Changshui Zhang, Jianwei The Institute of Machine Intelligence University of Shanghai for Science and Technology Shanghai China The State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Chengdu China Group Department of Informatics Universität Hamburg Hamburg Germany The Institute of Machine Intelligence University of Shanghai for Science and Technology Shanghai China The State Key Lab. for Novel Software Technology Nanjing University Nanjing China The Engineering Research Center of Wideband Wireless Communication Technology Ministry of Education Nanjing University of Posts and Telecommunications Nanjing China The Department of Electrical and Computer Engineering National University of Singapore Singapore Singapore The Department of Automation Tsinghua University Beijing China

In the classic setting of unsupervised domain adaptation (UDA), the labeled source data are available in the training phase. However, in many real-world scenarios, owing to some reasons such as privacy protection and information security, the source data is inaccessible, and only a model trained on the source domain is available. This paper proposes a novel deep clustering method for this challenging task. Aiming at the dynamical clustering at feature-level, we introduce extra constraints hidden in the geometric structure between data to assist the process. Concretely, we propose a geometry-based constraint, named semantic consistency on the nearest neighborhood (SCNNH), and use it to encourage robust clustering. To reach this goal, we construct the nearest neighborhood for every target data and take it as the fundamental clustering unit by building our objective on the geometry. Also, we develop a more SCNNH-compliant structure with an additional semantic credibility constraint, named semantic hyper-nearest neighborhood (SHNNH). After that, we extend our method to this new geometry. Extensive experiments on three challenging UDA datasets indicate that our method achieves state-of-the-art results. The proposed method has significant improvement on all datasets (as we adopt SHNNH, the average accuracy increases by over 3.0% on the large-scaled dataset). Code is available at https://***/tntek/N2DCX. Copyright © 2021, The Authors. All rights reserved.

关键词： Semantics

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Comparative cellular analysis of motor cortex in human, marmoset and mouse (vol 598, pg 111, 2021)

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NATURE 2022年第7904期604卷 E8-E8页

作者： Bakken, Trygve E. Jorstad, Nikolas L. Hu, Qiwen Lake, Blue B. Tian, Wei Kalmbach, Brian E. Crow, Megan Hodge, Rebecca D. Krienen, Fenna M. Sorensen, Staci A. Eggermont, Jeroen Yao, Zizhen Aevermann, Brian D. Aldridge, Andrew I. Bartlett, Anna Bertagnolli, Darren Casper, Tamara Castanon, Rosa G. Crichton, Kirsten Daigle, Tanya L. Dalley, Rachel Dee, Nick Dembrow, Nikolai Diep, Dinh Ding, Song-Lin Dong, Weixiu Fang, Rongxin Fischer, Stephan Goldman, Melissa Goldy, Jeff Graybuck, Lucas T. Herb, Brian R. Hou, Xiaomeng Kancherla, Jayaram Kroll, Matthew Lathia, Kanan van Lew, Baldur Li, Yang Eric Liu, Christine S. Liu, Hanqing Lucero, Jacinta D. Mahurkar, Anup McMillen, Delissa Miller, Jeremy A. Moussa, Marmar Nery, Joseph R. Nicovich, Philip R. Niu, Sheng-Yong Orvis, Joshua Osteen, Julia K. Owen, Scott Palmer, Carter R. Pham, Thanh Plongthongkum, Nongluk Poirion, Olivier Reed, Nora M. Rimorin, Christine Rivkin, Angeline Romanow, William J. Sedeno-Cortes, Adriana E. Siletti, Kimberly Somasundaram, Saroja Sulc, Josef Tieu, Michael Torkelson, Amy Tung, Herman Wang, Xinxin Xie, Fangming Yanny, Anna Marie Zhang, Renee Ament, Seth A. Behrens, M. Margarita Bravo, Hector Corrada Chun, Jerold Dobin, Alexander Gillis, Jesse Hertzano, Ronna Hof, Patrick R. Hollt, Thomas Horwitz, Gregory D. Keene, C. Dirk Kharchenko, Peter V. Ko, Andrew L. Lelieveldt, Boudewijn P. Luo, Chongyuan Mukamel, Eran A. Pinto-Duarte, Antonio Preiss, Sebastian Regev, Aviv Ren, Bing Scheuermann, Richard H. Smith, Kimberly Spain, William J. White, Owen R. Koch, Christof Hawrylycz, Michael Tasic, Bosiljka Macosko, Evan Z. McCarroll, Steven A. Ting, Jonathan T. Zeng, Hongkui Zhang, Kun Feng, Guoping Ecker, Joseph R. Linnarsson, Sten Lein, Ed S. Allen Institute for Brain Science Seattle WA USA Department of Physiology and Biophysics University of Washington Seattle WA USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Bioengineering University of California San Diego La Jolla CA USA The Salk Institute for Biological Studies La Jolla CA USA Epilepsy Center of Excellence Department of Veterans Affairs Medical Center Seattle WA USA Stanley Institute for Cognitive Genomics Cold Spring Harbor Laboratory Cold Spring Harbor NY USA Department of Genetics Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA LKEB Department of Radiology Leiden University Medical Center Leiden The Netherlands Pattern Recognition and Bioinformatics group Delft University of Technology Delft The Netherlands J. Craig Venter Institute La Jolla CA USA Department of Pathology University of California San Diego CA USA Division of Vaccine Discovery La Jolla Institute for Immunology La Jolla CA USA Genomic Analysis Laboratory The Salk Institute for Biological Studies La Jolla CA USA Computer Science and Engineering Program University of California San Diego La Jolla CA USA Howard Hughes Medical Institute The Salk Institute for Biological Studies La Jolla CA USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA Institute for Genomes Sciences University of Maryland School of Medicine Baltimore MD USA Center for Epigenomics Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA Ludwig Institute for Cancer Research La Jolla CA USA Department of Computer Science University of Maryland College Park College Park MD USA Sanford Burnham Prebys Medical Discovery Institute La Jolla CA USA Biomedical Sciences Program School of Medicine University of California San Diego La Jolla CA USA University of Connecticut Storrs CT USA Department

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Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker

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BIOLOGICAL PSYCHIATRY 2021年第8期90卷 529-539页

作者： Qi, Shile Schumann, Gunter Bustillo, Juan Turner, Jessica A. Jiang, Rongtao Zhi, Dongmei Fu, Zening Mayer, Andrew R. Vergara, Victor M. Silva, Rogers F. Iraji, Armin Chen, Jiayu Damaraju, Eswar Ma, Xiaohong Yang, Xiao Stevens, Michael Mathalon, Daniel H. Ford, Judith M. Voyvodic, James Mueller, Bryon A. Belger, Aysenil Potkin, Steven G. Preda, Adrian Zhuo, Chuanjun Xu, Yong Chu, Congying Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Quinlan, Erin Burke Desrivieres, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Martinot, Jean-Luc Martinot, Marie-Laure Paillere Artiges, Eric Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomas Poustka, Luise Hohmann, Sarah Frohner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Calhoun, Vince D. Sui, Jing [a]Tri-institutional Center for Translational Research in Neuroimaging and Data Science Georgia State University Georgia Institute Technology and Emory University Atlanta Georgia [b]Department of Psychiatry University of New Mexico Albuquerque New Mexico [c]Department of Psychology Georgia State University Atlanta Georgia [d]Olin Neuropsychiatry Research Center Hartford Connecticut [e]Department of Psychiatry University of California San Francisco San Francisco California [f]Department of Radiology Duke University Durham North Carolina [g]Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill North Carolina [h]Department of Psychiatry University of Minnesota Minneapolis Minnesota [i]Department of Psychiatry University of California Irvine Irvine California [j]Departments of Psychiatry and Psychology University of Vermont Burlington Vermont [k]Centre for Population Neuroscience and Stratified Medicine Institute for Science and Technology of Brain-Inspired Intelligence Fudan University Shanghai China [l]University of Chinese Academy of Sciences Beijing China [dd]Department of Computer Science and Engineering Nanjing University of Aeronautics and Astronautics Nanjing China [m]Brainnetome Center and National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing China [ee]State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China [n]Psychiatric Laboratory and Mental Health Center the State Key Laboratory of Biotherapy West China Hospital of Sichuan University Chengdu China [o]Department of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory Nankai University Affiliated Anding Hospital Tianjin China [p]Department of Humanities and Social Science Shanxi Medical University Taiyuan China [q]Department of Psychiatry and Psychotherapy Charité – Universitätsmedizin Berlin Campus Charité Mitte corporate member of Freie Universität Berlin Humboldt-Univers

BACKGROUND: Dysfunctional reward processing is implicated in multiple mental disorders. Novelty seeking (NS) assesses preference for seeking novel experiences, which is linked to sensitivity to reward environmental cues. METHODS: A subset of 14-year-old adolescents (IMAGEN) with the top 20% ranked high-NS scores was used to identify high-NS-associated multimodal components by supervised fusion. These features were then used to longitudinally predict five different risk scales for the same and unseen subjects (an independent dataset of subjects at 19 years of age that was not used in predictive modeling training at 14 years of age) (within IMAGEN, n z 1100) and even for the corresponding symptom scores of five types of patient cohorts (non-IMAGEN), including drinking (n = 313), smoking (n = 104), attention-deficit/hyperactivity disorder (n = 320), major depressive disorder (n = 81), and schizophrenia (n = 147), as well as to classify different patient groups with diagnostic labels. RESULTS: Multimodal biomarkers, including the prefrontal cortex, striatum, amygdala, and hippocampus, associated with high NS in 14-year-old adolescents were identified. The prediction models built on these features are able to longitudinally predict five different risk scales, including alcohol drinking, smoking, hyperactivity, depression, and psychosis for the same and unseen 19-year-old adolescents and even predict the corresponding symptom scores of five types of patient cohorts. Furthermore, the identified reward-related multimodal features can classify among attention-deficit/hyperactivity disorder, major depressive disorder, and schizophrenia with an accuracy of 87.2%. CONCLUSIONS: Adolescents with higher NS scores can be used to reveal brain alterations in the reward-related system, implicating potential higher risk for subsequent development of multiple disorders. The identified high-NS- associated multimodal reward-related signatures may serve as a transdiagnostic neuroimaging bi

关键词： ADHD Attention-deficit/hyperactivity disorder Major depressive disorders MDD Novelty seeking Reward processing Schizophrenia Substance use

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