检索结果-内蒙古大学图书馆

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Nature Genetics 2025年 1-13页

作者： Strom, Nora I. Gerring, Zachary F. Galimberti, Marco Yu, Dongmei Halvorsen, Matthew W. Abdellaoui, Abdel Rodriguez-Fontenla, Cristina Sealock, Julia M. Bigdeli, Tim Coleman, Jonathan R. Mahjani, Behrang Thorp, Jackson G. Bey, Katharina Burton, Christie L. Luykx, Jurjen J. Zai, Gwyneth Alemany, Silvia Andre, Christine Askland, Kathleen D. Bäckman, Julia Banaj, Nerisa Barlassina, Cristina Nissen, Judith Becker Bienvenu, O. Joseph Black, Donald Bloch, Michael H. Børte, Sigrid Bosch, Rosa Breen, Michael Brennan, Brian P. Brentani, Helena Buxbaum, Joseph D. Bybjerg-Grauholm, Jonas Byrne, Enda M. Cabana-Dominguez, Judit Camarena, Beatriz Camarena, Adrian Cappi, Carolina Carracedo, Angel Casas, Miguel Cavallini, Maria Cristina Ciullo, Valentina Cook, Edwin H. Crosby, Jesse Cullen, Bernadette A. De Schipper, Elles J. Delorme, Richard Djurovic, Srdjan Elias, Jason A. Estivill, Xavier Falkenstein, Martha J. Fundin, Bengt T. Garner, Lauryn Gironda, Christina Goes, Fernando S. Grados, Marco A. Grove, Jakob Guo, Wei Haavik, Jan Hagen, Kristen Harrington, Kelly Havdahl, Alexandra Höffler, Kira D. Hounie, Ana G. Hucks, Donald Hultman, Christina Janecka, Magdalena Jenike, Eric Karlsson, Elinor K. Kelley, Kara Klawohn, Julia Krasnow, Janice E. Krebs, Kristi Lange, Christoph Lanzagorta, Nuria Levey, Daniel Lindblad-Toh, Kerstin Macciardi, Fabio Maher, Brion Mathes, Brittany McArthur, Evonne McGregor, Nathaniel McLaughlin, Nicole C. Meier, Sandra Miguel, Euripedes C. Mulhern, Maureen Nestadt, Paul S. Nurmi, Erika L. O’Connell, Kevin S. Osiecki, Lisa Ousdal, Olga Therese Palviainen, Teemu Pedersen, Nancy L. Piras, Federica Potluri, Sriramya Rabionet, Raquel Ramirez, Alfredo Rauch, Scott Reichenberg, Abraham Riddle, Mark A. Ripke, Stephan Rosário, Maria C. Sampaio, Aline S. Schiele, Miriam A. Skogholt, Anne Heidi Sloofman, Laura G. Smit, Jan Artigas, María Soler Thomas, Laurent F. Tifft, Eric Vallada, Homero van Kirk, Nathanial Veenstra-VanderWeele, Jeremy Vulink, Nienke N. Walker, Christopher P. Wang, Ying Wendland, Jens R. Winsvold Department of Psychology Humboldt-Universität zu Berlin Berlin Germany Department of Psychiatric Phenomics and Genomics (IPPG) Ludwig-Maximilians University Munich Munich Germany Centre for Psychiatry Research Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Services Region Stockholm Stockholm Sweden Department of Biomedicine Aarhus University Aarhus Denmark University Hospital of Psychiatry and Psychotherapy University of Bern Bern Switzerland Department of Mental Health and Neuroscience Translational Neurogenomics QIMR Berghofer Medical Research Institute Brisbane QLD Australia Department of Population Health and Immunity Healthy Development and Ageing Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia Department of Psychiatry Human Genetics Yale University New Haven CT United States VA Connecticut Healthcare System West Haven CT United States Department of Center for Genomic Medicine Psychiatric and Neurodevelopmental Genetics Unit Massachusetts General Hospital Boston MA United States Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA United States Department of Genetics University of North Carolina at Chapel Hill Chapel Hill NC United States Department of Psychiatry Amsterdam University Medical Centers University of Amsterdam Amsterdam Netherlands Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) Genomics and Bioinformatics University of Santiago de Compostela Santiago de Compostela Spain Grupo de Medicina Xenómica Genetics Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS) Santiago de Compostela Spain Vanderbilt Genetics Institute Vanderbilt University Nashville TN United States Department of Psychiatry and Behavioral Sciences SUNY Downstate Health Sciences University Brooklyn NY United States VA NY Harbor Healthcare System Brooklyn NY United States Social Genetic and Developmental Psychiatry Centre Insti

Obsessive–compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along with D₁ and D₂ type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa and Tourette syndrome and was negatively associated with inflammatory bowel diseases, educational attainment and body mass index. © The Author(s) 2025.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018)

引用

NATURE GENETICS 2018年第12期50卷 1755-1755页

作者： Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Karaman, Ibrahim Fu Liang Ng Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Magi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stephanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Theriault, Sebastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renee Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Noordam, Raymond Pare, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Goncalo Amin, Najaf Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C. Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco, Fabiola M. Demirkale, Cumhur Yusuf Dorr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Franberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen Department of Epidemiology and Biostatistics Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK National Institute for Health Research Barts Cardiovascular Biomedical Research Center Queen Mary University of London London UK MRC-PHE Centre for Environment and Health Imperial College London London UK Department of Mathematics Imperial College London London UK Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Tennessee Valley Healthcare System (626)/Vanderbilt University Nashville TN USA Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Department of Obstetrics and Gynecology Vanderbilt University Medical Center Tennessee Valley Health Systems VA Nashville TN USA Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA Division of Aging Department of Medicine Brigham and Women’s Hospital Department of Medicine Harvard Medical School Boston MA USA Atlanta VAMC and Emory Clinical Cardiovascular Research Institute Atlanta GA USA VA Palo Alto Health Care System Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Nephrology Section Memphis VA Medical Center and University of Tennessee Health Science Center Memphis TN USA Estonian Genome Center University of Tartu Tartu Estonia Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Department Clinical Sciences Malmö Lund University Malmö Sweden MRC Human Genetics Un

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

关键词： Cardiovascular diseases Genome informatics Genome-wide association studies

来源：评论

学校读者我要写书评

暂无评论

Predicting breast tumor proliferation from whole-slide images: The TUPAC16 challenge

arXiv

引用

arXiv 2018年

作者： Veta, Mitko Heng, Yujing J. Stathonikos, Nikolas Bejnordi, Babak Ehteshami Beca, Francisco Wollmann, Thomas Rohr, Karl Shah, Manan A. Wang, Dayong Rousson, Mikael Hedlund, Martin Tellez, David Ciompi, Francesco Zerhouni, Erwan Lanyi, David Viana, Matheus Kovalev, Vassili Liauchuk, Vitali Phoulady, Hady Ahmady Qaiser, Talha Graham, Simon Rajpoot, Nasir Sjöblom, Erik Molin, Jesper Paeng, Kyunghyun Hwang, Sangheum Park, Sunggyun Jia, Zhipeng Chang, Eric I-Chao Xu, Yan Beck, Andrew H. Van Diest, Paul J. Pluim, Josien P.W. Medical Image Analysis Group Eindhoven University of Technology Eindhoven Netherlands Department of Pathology Beth Israel Deaconess Medical Center Harvard Medical School BostonMA United States Department of Pathology University Medical Center Utrecht Utrecht Netherlands Diagnostic Image Analysis Group Radboud University Medical Center Nijmegen Netherlands Department of Pathology Stanford University School of Medicine Biomedical Computer Vision Group University of Heidelberg BIOQUANT IPMB DKFZ Heidelberg Germany Harker School San Jose United States ContextVision AB Linköping Sweden Foundations of Cognitive Computing IBM Research Zürich Rüschlikon Switzerland Visual Analytics and Insights IBM Research Brazil Saõ Paulo Brazil Biomedical Image Analysis Department United Institute of Informatics Minsk Belarus Department of Computer Science and Engineering University of South Florida TampaFL United States Department of Computer Science University of Warwick Warwick United Kingdom Research Sectra Linköping Sweden Lunit Inc. Seoul Korea Republic of Institute for Interdisciplinary Information Sciences Tsinghua University Beijing China Microsoft Research Beijing China Biology and Medicine Engineering Beihang University Beijing China IBM Research Brazil

Tumor proliferation is an important biomarker indicative of the prognosis of breast cancer patients. Assessment of tumor proliferation in a clinical setting is a highly subjective and labor-intensive task. Previous efforts to automate tumor proliferation assessment by image analysis only focused on mitosis detection in predefined tumor regions. However, in a realworld scenario, automatic mitosis detection should be performed in whole-slide images (WSIs) and an automatic method should be able to produce a tumor proliferation score given a WSI as input. To address this, we organized the TUmor Proliferation Assessment Challenge 2016 (TUPAC16) on prediction of tumor proliferation scores from WSIs. The challenge dataset consisted of 500 training and 321 testing breast cancer histopathology WSIs. In order to ensure fair and independent evaluation, only the ground truth for the training dataset was provided to the challenge participants. The first task of the challenge was to predict mitotic scores, i.e., to reproduce the manual method of assessing tumor proliferation by a pathologist. The second task was to predict the gene expression based PAM50 proliferation scores from the WSI. The best performing automatic method for the first task achieved a quadratic-weighted Cohen's kappa score of κ = 0.567, 95% CI [0.464, 0.671] between the predicted scores and the ground truth. For the second task, the predictions of the top method had a Spearman's correlation coefficient of r = 0.617, 95% CI [0.581 0.651] with the ground truth. This was the first comparison study that investigated tumor proliferation assessment from WSIs. The achieved results are promising given the difficulty of the tasks and weakly-labeled nature of the ground truth. However, further research is needed to improve the practical utility of image analysis methods for this task. Copyright © 2018, The Authors. All rights reserved.

关键词： Diseases

来源：评论

学校读者我要写书评

暂无评论

Bird's Eye View on Systems and Control - General View and Case Studies

引用

IFAC-PapersOnLine 2016年第6期49卷 274-279页

作者： Vámos, T. Bars, R. Sik, D. Institute of Computer Science and Control Hungarian Academy of Sciences MTA-SZTAKI Budapest Hungary Dept. of Automation and Applied Informatics Budapest University of Technology and Economics MTA-BME Control Engineering Research Group Budapest Hungary

Systems and control are all around us. System view, understanding systems and how they are controlled is important for everyone. The behavior of systems is determined by some fundamental principles which can be understood by everyone. The main principles governing systems and control are presented on different levels. The first level is dedicated for everyone. Comics-like interpretation is provided with explanations. The second level discusses the main topics dedicated for the interested students. Several case studies demonstrate how system view is considered in different areas of life. With this approach systems in different areas of life could be better understood contributing to better decisions influencing their performance. The third level provides deeper insight into some aspects of modern mathematical system theory, to geometric view of control systems. The material is available on a website on the internet. © 2016

关键词： Control theory Algorithms Case studies Control disciplines Control education Control structure Systems and control

来源：评论

学校读者我要写书评

暂无评论

Brain-computer interface with corrupted EEG data: A tensor completion approach

arXiv

引用

arXiv 2018年

作者： Solé-Casals, J. Caiafa, C.F. Zhao, Q. Cichocki, A. University of Vic Central University of Catalonia Data and Signal Processing Research Group Vic Catalonia Spain - CCT-La Plata CONICET CICPBA Villa Elisa Buenos Aires Argentina Department of Psychological and Brain Sciences Indiana University BloomingtonIN United States Tensor Learning Unit RIKEN Center for Advanced Intelligence Tokyo Japan School of Automation Guangdong University of Technology China Skolkovo Institute of Science and Technology Moscow Russia Department of Informatics Nicolaus Copernicus University Torun87-100 Poland College of Computer Science Hangzhou Dianzi University Hangzhou310018 China

Background / Introduction: One of the current issues in Brain-computer Interface (BCI) is how to deal with noisy Electroencephalography (EEG) measurements organized as multidimensional datasets (tensors). On the other hand, recently, significant advances have been made in multidimensional signal completion algorithms that exploit tensor decomposition models to capture the intricate relationship among entries in a multidimensional signal. We propose to use tensor completion applied to EEG data for improving the classification performance in a motor imagery BCI system with corrupted measurements. Noisy measurements (electrode misconnections, subject movements, etc.) are considered as unknowns (missing samples) that are inferred from a tensor decomposition model (tensor completion). Methods: We evaluate the performance of four recently proposed tensor completion algorithms, CP-WOPT (Acar et al, 2011), 3DPB-TC (Caiafa et al, 2013), BCPF (Zhao et al, 2015) and HaLRT (Liu et al. (2013), plus a simple interpolation strategy, first with random missing entries and then with missing samples constrained to have a specific structure (random missing channels), which is a more realistic assumption in BCI applications. Results: We measured the ability of these algorithms to reconstruct the tensor from observed data. Then, we tested the classification accuracy of imagined movement in a BCI experiment with missing samples. We show that for random missing entries, all tensor completion algorithms can recover missing samples increasing the classification performance compared to a simple interpolation approach. For the random missing channels case, we show that tensor completion algorithms help to reconstruct missing channels, significantly improving the accuracy in the classification of motor imagery (MI), however, not at the same level as clean data. Summarizing, compared to the interpolation case, all tensor completion algorithms succeed to increase the classification performance by

关键词： Electroencephalography

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

引用

Nature communications 2021年第1期12卷 7260页

作者： Merel C Postema Daan van Rooij Evdokia Anagnostou Celso Arango Guillaume Auzias Marlene Behrmann Geraldo Busatto Filho Sara Calderoni Rosa Calvo Eileen Daly Christine Deruelle Adriana Di Martino Ilan Dinstein Fabio Luis S Duran Sarah Durston Christine Ecker Stefan Ehrlich Damien Fair Jennifer Fedor Xin Feng Jackie Fitzgerald Dorothea L Floris Christine M Freitag Louise Gallagher David C Glahn Ilaria Gori Shlomi Haar Liesbeth Hoekstra Neda Jahanshad Maria Jalbrzikowski Joost Janssen Joseph A King Xiang Zhen Kong Luisa Lazaro Jason P Lerch Beatriz Luna Mauricio M Martinho Jane McGrath Sarah E Medland Filippo Muratori Clodagh M Murphy Declan G M Murphy Kirsten O'Hearn Bob Oranje Mara Parellada Olga Puig Alessandra Retico Pedro Rosa Katya Rubia Devon Shook Margot J Taylor Michela Tosetti Gregory L Wallace Fengfeng Zhou Paul M Thompson Simon E Fisher Jan K Buitelaar Clyde Francks Department of Language & Genetics Max Planck Institute for Psycholinguistics Nijmegen The Netherlands. Department of Cognitive Neuroscience Donders Institute for Brain Cognition and Behaviour Donders Centre for Cognitive Neuroimaging Radboud University Medical Centre Nijmegen The Netherlands. Bloorview Research Institute Holland Bloorview Kids Rehabilitation Hospital and Department of Pediatrics University of Toronto Toronto ON USA. Child and Adolescent Psychiatry Department Gregorio Marañón General University Hospital School of Medicine Universidad Complutense IiSGM CIBERSAM Madrid Spain. Institut de Neurosciences de la Timone UMR 7289 Aix Marseille Université CNRS Marseille France. Department of Psychology Carnegie Mellon University Pittsburgh PA USA. Laboratory of Psychiatric Neuroimaging (LIM-21) Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo SP Brazil. IRCCS Stella Maris Foundation viale del Tirreno 331 56128 Pisa Italy. Department of Clinical and Experimental Medicine University of Pisa Pisa Italy. Department of Child and Adolescent Psychiatry and Psychology Hospital Clinic Psychiatry Unit Department of Medicine 2017SGR881 University of Barcelona IDIBAPS CIBERSAM Barcelona Spain. Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology & Neuroscience King's College London London UK. Institute for Pediatric Neuroscience NYU Child Study Center New York NY USA. Department of Psychology Ben-Gurion University of the Negev Beer Sheva Israel. Brain Center Rudolf Magnus Department of Psychiatry University Medical Center Utrecht Utrecht The Netherlands. Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy University Hospital Goethe University Frankfurt am Main Frankfurt Germany. Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University o

来源：评论

学校读者我要写书评

暂无评论

Using system entity structures to model the elements of a scenario in a research flight simulator

Using system entity structures to model the elements of a sc...

引用

AIAA Modeling and Simulation Technologies Conference, 2017

作者： Durak, Umut Pruter, Insa Gerlach, Torsten Jafer, Shafagh Pawletta, Thorsten Hartmann, Sven Institute of Flight Systems Lilienthalplatz 7 Braunschweig38108 Germany Department of Electrical Computer Software and Systems Engineering Embry-Riddle Aeronautical University - Daytona Beach Campus Lehman 343 600 S Clyde Morris Blvd Daytona BeachFL32114-3900 United States Computational Engineering & Automation Research Group University of Wismar PF 1210 WismarD-23952 Germany Department of Informatics Clausthal University of Technnology Julius-Albert-Strasse 4 Clausthal-Zellerfeld38678 Germany

ISBN: (数字)9781624104510

ISBN: (纸本)9781624104510

While any simulation study starts with a scenario, scenario development is usually conducted in an unstructured and ad hoc manner. In order to streamline scenario development, a formal approach is envisioned in the research flight simulator facility of German Aerospace Center (DLR), namely Air Vehicle Simulator (AVES). System Entity Structure (SES) which is a high level ontology that was introduced to specify a set of system structures and parameter settings is proposed as the foundations. The paper outlines a model-based methodology for scenario development. SES is exploited for metamodeling in order to capture all possible elements of a scenario that can be simulated in AVES. Then a scenario modeling methodology is built upon this metamodel. © 2017, American institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.

关键词： Flight simulators

来源：评论

学校读者我要写书评

暂无评论

Towards computational fluorescence microscopy: Machine learning-based integrated prediction of morphological and molecular tumor profiles

arXiv

引用

arXiv 2018年

作者： Binder, Alexander Bockmayr, Michael Hägele, Miriam Wienert, Stephan Heim, Daniel Hellweg, Katharina Stenzinger, Albrecht Parlow, Laura Budczies, Jan Goeppert, Benjamin Treue, Denise Kotani, Manato Ishii, Masaru Dietel, Manfred Hocke, Andreas Denkert, Carsten Müller, Klaus-Robert Klauschen, Frederick Machine-Learning Group Department of Software Engineering and Theoretical Computer Science Technical University of Berlin Marchstr. 23 Berlin10587 Germany Systems Pathology Lab Institute of Pathology Charité University Hospital Charitéplatz 1 Berlin10117 Germany Department of Internal Medicine Infectious Diseases and Pulmology Charitéplatz 1 Berlin10117 Germany Institute of Pathology University of Heidelberg Im Neuenheimer Feld 224 Heidelberg Germany Laboratory of Cellular Dynamics Immunology Frontier Research Center Osaka University 2-2 Yamada-oka Suita Osaka565-0871 Japan ISTD Pillar Singapore University of Technology and Design 8 Somapah Road Singapore487372 Singapore Charité Berlin Charitéplatz 1 Berlin10117 Germany Department of Brain and Cognitive Engineering Korea University 145 Anam-ro Seongbukgu Seoul136-713 Korea Republic of Max-Planck-Institute for Informatics Saarbrücken Germany Department of Pediatric Hematology and Oncology University Medical Center Hamburg-Eppendorf Hamburg Germany

Recent advances in cancer research largely rely on new developments in microscopic or molecular profiling techniques offering high level of detail with respect to either spatial or molecular features, but usually not both. Here, we present a novel machine learning-based computational approach that allows for the identification of morphological tissue features and the prediction of molecular properties from breast cancer imaging data. This integration of microanatomic information of tumors with complex molecular profiling data, including protein or gene expression, copy number variation, gene methylation and somatic mutations, provides a novel means to computationally score molecular markers with respect to their relevance to cancer and their spatial associations within the tumor microenvironment. Copyright © 2018, The Authors. All rights reserved.

关键词： Fluorescence microscopy

来源：评论

学校读者我要写书评

暂无评论

Clusters of Trends Detection in Microblogging: Simple Natural Language Processing vs Hashtags – Which is More Informative?

Clusters of Trends Detection in Microblogging: Simple Natura...

引用

International Conference on Complex, Intelligent and Software Intensive Systems, CISIS

作者： Tomasz Hachaj Marek R. Ogiela Pedagogical University of Krakow Institute of Computer Science Krakow Poland AGH University of Science and Technology Cryptography and Cognitive Informatics Research Group Krakow Poland

ISBN: (纸本)9781509009886

In this paper we introduce the initial proposition and evaluation of the method that enables detection of clusters of trends among microblogging posts gathered from a given social graph. By the cluster of trends we mean the trending words that are popular among same group of people and which describes their common interests. The information about shared interests of group of people in the social network is very important for business. Knowing it we can for example perform directed advertising campaign aimed at single community of people. We validate our approach on large datasets that contains 22 030 252 tweets posted by 20 130 followers of the world-known actress. We found that clusters of trends detection in microblogging with simple natural language processing (namely lemmatization) did not give any valuable information for business. For the other side hashtags frequency filtering and probability conditional probabilities graph clustering resulted in valuable informative about structure of interest in social network.

关键词： Twitter Tagging Market research Natural language processing Filtration

来源：评论

学校读者我要写书评

暂无评论

Rule-Based Action Recognition: Performance Comparison between Lua and GDL Script Language

Rule-Based Action Recognition: Performance Comparison betwee...

引用

International Conference on Innovative Mobile and Internet Services in Ubiquitous Computing (IMIS)

ISBN: (纸本)9781509009855

The main novelty of this paper is presenting the implementation of GDL classifier in pure Lua language. We also present the evaluation of this implementation for motion capture data classification in real-time and compare the execution time with GDL 1.1 implementation. The experiments showed that Lua implementation performance of GDL in most cases is several times slower than managed C# GDL script 1.1. That is due the fact the Lua is a general purpose language while GDL script is optimized only to cooperate with GDL classifier, however GDL Lua implementation presented and evaluated in this paper proved to be fast enough to be useful both in scientific and in commercial applications. The performance time in productions scenarios (classification on relatively "big", 40 kB rules definitions) can be done with frequency approximately 100 executions per seconds which should be enough for up-to-date motion capture solutions. The new GDL Lua Implementation seems to be a good successor of GDLs 1.1.

关键词： Real-time systems Standards Engines C# languages Time-frequency analysis Syntactics Arrays

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：