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arXiv 2020年

作者： Broughton, Michael Verdon, Guillaume McCourt, Trevor Martinez, Antonio J. Yoo, Jae Hyeon Isakov, Sergei V. Massey, Philip Halavati, Ramin Niu, Murphy Yuezhen Zlokapa, Alexander Peters, Evan Lockwood, Owen Skolik, Andrea Jerbi, Sofiene Dunjko, Vedran Leib, Martin Streif, Michael Von Dollen, David Chen, Hongxiang Cao, Shuxiang Wiersema, Roeland Huang, Hsin-Yuan McClean, Jarrod R. Babbush, Ryan Boixo, Sergio Bacon, Dave Ho, Alan K. Neven, Hartmut Mohseni, Masoud Google Quantum Ai Mountain ViewCA United States Sandbox Alphabet Mountain ViewCA United States Google Mountain ViewCA United States Institute for Quantum Computing University of Waterloo WaterlooONN2L 3G1 Canada School of Computer Science University of Waterloo WaterlooONN2L 3G1 Canada Department of Applied Mathematics University of Waterloo WaterlooONN2L 3G1 Canada Department of Mechanical and Mechatronics Engineering University of Waterloo WaterlooONN2L 3G1 Canada Department of Physics and Astronomy University of Waterloo WaterlooONN2L 3G1 Canada Division of Physics Mathematics and Astronomy Caltech PasadenaCA91125 United States Fermi National Accelerator Laboratory P.O. Box 500 BataviaIL605010 United States Department of Computer Science Rensselaer Polytechnic Institute TroyNY12180 United States Data:Lab Volkswagen Group Ungererstr. 69 München80805 Germany Leiden University Niels Bohrweg 1 Leiden2333 CA Netherlands Institute for Theoretical Physics University of Innsbruck Technikerstr. 21a InnsbruckA-6020 Austria Institute of Theoretical Physics Staudtstr. 7 Erlangen91058 Germany Volkswagen Group Advanced Technologies San FranciscoCA94108 United States Rahko Ltd. Finsbury Park LondonN4 3JP United Kingdom Department of Computer Science University College London WC1E 6BT United Kingdom Clarendon Laboratory Department of Physics University of Oxford OxfordOX1 3PU United Kingdom Vector Institute MaRS Centre TorontoONM5G 1M1 Canada Department of Physics and Astronomy University of Waterloo ONN2L 3G1 Canada Institute for Quantum Information and Matter Caltech PasadenaCA United States Department of Computing and Mathematical Sciences Caltech PasadenaCA United States

We introduce TensorFlow Quantum (TFQ), an open source library for the rapid prototyping of hybrid quantum-classical models for classical or quantum data. This framework offers high-level abstractions for the design and training of both discriminative and generative quantum models under TensorFlow and supports high-performance quantum circuit simulators. We provide an overview of the software architecture and building blocks through several examples and review the theory of hybrid quantum-classical neural networks. We illustrate TFQ functionalities via several basic applications including supervised learning for quantum classification, quantum control, simulating noisy quantum circuits, and quantum approximate optimization. Moreover, we demonstrate how one can apply TFQ to tackle advanced quantum learning tasks including meta-learning, layerwise learning, Hamiltonian learning, sampling thermal states, variational quantum eigensolvers, classification of quantum phase transitions, generative adversarial networks, and reinforcement learning. We hope this framework provides the necessary tools for the quantum computing and machine learning research communities to explore models of both natural and artificial quantum systems, and ultimately discover new quantum algorithms which could potentially yield a quantum advantage. Copyright © 2020, The Authors. All rights reserved.

关键词： Open source software

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Modified cuckoo search ased neural networks for forest types classification 2

Modified cuckoo search ased neural networks for forest types...

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2nd International Conference on Information Technology and Intelligent Transportation Systems, ITITS 2017

作者： Chatterjee, Sankhadeep Dey, Nilanjan Sen, Soumya Ashour, Amira S. Fong, Simon James Shi, Fuqian Department of Computer Science and Engineering University of Calcutta Kolkata India Department of Information Technology Techno India College of Technology Kolkata India A. K. Choudhury School of Information Technology University of Calcutta Kolkata West Bengal India Department of Electronics and Electrical Communications Engineering Faculty of Engineering Tanta University Egypt Department of Computer and Information Science Data Analytics and Collaborative Computing Laboratory University of Macau Taipa China College of Information and Engineering Wenzhou Medical University Wenzhou China

ISBN: (纸本)9781614997849

Pixel classification in land scape images is a challenging process especially in forest images due to the similar spectral features of pixels situated close to each other. Previously, meta-heuristic coupled artificial neural network (ANN) models have been used to classify the two-different species, namely Japanese Cedar, Japanese Cypress and one mixed forest class. Previous attempts have shown reasonable improvement in the classification process using genetic algorithm (GA) supported neural network over other traditional approaches. Consequently, in the current work, a modified Cuckoo Search (CS) supported Neural Network (NN-MCS) classifier is proposed. The lévy flight associated with cuckoo search has been modified using McCulloch's method of generating stable random numbers. The proposed approach is compared with GA-NN using single objective function and CS-NN (ANN trained with CS) classifiers in terms of confusion matrix based performance metrics. The results depicted the dominance of the suggested NN-MCS model compared to the CS-NN model to a greater extent. © 2017 The authors and IOS Press. All rights reserved.

关键词： Neural networks

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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Disease progression modeling and prediction through random effect Gaussian processes and time transformation

arXiv

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arXiv 2017年

作者： Lorenzi, Marco Filippone, Maurizio Alexander, Daniel C. Ourselin, Sebastien Asclepios Research Project Université Côte d'Azur Inria France Centre for Medical Image Computing University College London United Kingdom Department of Data Science EURECOM France

The development of statistical approaches for the joint modelling of the temporal changes of imaging, biochemical, and clinical biomarkers is of paramount importance for improving the understanding of neurodegenerative disorders, and for providing a reference for the prediction and quantification of the pathology in unseen individuals. Nonetheless, the use of disease progression models for probabilistic predictions still requires investigation, for example for accounting for missing observations in clinical data, and for accurate uncertainty quantification. We tackle this problem by proposing a novel Gaussian process-based method for the joint modeling of imaging and clinical biomarker progressions from time series of individual observations. The model is formulated to account for individual random effects and time reparameterization, allowing non-parametric estimates of the biomarker evolution, as well as high flexibility in specifying correlation structure, and time transformation models. Thanks to the Bayesian formulation, the model naturally accounts for missing data, and allows for uncertainty quantification in the estimate of evolutions, as well as for probabilistic prediction of disease staging in unseen patients. The experimental results show that the proposed model provides a biologically plausible description of the evolution of Alzheimer's pathology across the whole disease time-span as well as remarkable predictive performance when tested on a large clinical cohort with missing observations. Copyright © 2017, The Authors. All rights reserved.

关键词： Uncertainty analysis

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Keep Your Friends Close and Your Colleagues Nearby: The Hidden Ties That Improve STEM Education

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Change 2019年第1期51卷 42页

作者： Mestre, Jose P. Herman, Geoffrey L. Tomkin, Jonathan H. West, Matthew Jose P. Mestre (mestre@illinois.edu). A theoretical nuclear physicist by training Mestre’s research focuses on the learning of physics contributing in areas such as the acquisition and use of knowledge by experts and novices transfer of learning problem solving and instructional design. He has offered Congressional testimony on The Science of Learning has published numerous articles and books and is a Fellow of the American Physical Society.http://***/0000-0003-2110-1954 Geoffrey L. Herman (glherman@illinois.edu). Herman has a Ph.D. in Electrical and Computer Engineering and is a Teaching Assistant Professor in Computer Science and a Research Assistant Professor in the Department of Curriculum & Instruction at the University of Illinois. His research focuses on how students learn engineering and computing concepts and studying processes for creating systemic instructional change in college settings. Previously he was a postdoctoral researcher in Engineering Education at Purdue University.http://***/0000-0002-9501-2295 Jonathan H. Tomkin (tomkin@illinois.edu). Tomkin is a mathematically based geoscientist with two research focus areas: first he uses models and large data sets to determine how climates glaciers tectonics and landscapes interact. Second he explores how new technological and organizational approaches can improve STEM education. He produced the first geoscience MOOC is the editor of an open-source textbook and has published widely in both geoscience and STEM education. Matthew West (mwest@illinois.edu). Matthew West is an Associate Professor of Mechanical Science and Engineering at the University of Illinois with research interests in scientific computing that include time integration of deterministic and stochastic systems distributed computation and particle methods for simulation and estimation. In education he researches computer-based assessment and the development of innovative teaching cultures. Professor West is a University of Illinois Distinguished Teacher-Scholar and Colleg

A science department on the campus of the University of Illinois has received numerous national awards for excellence in undergraduate teaching. The secret to their success? For nearly two decades, they have collaboratively used evidence-based instructional practices (EBIP) in their introductory level courses. Despite these successes and efforts to spread their EBIP, no other departments followed this department's lead. Then, suddenly six years ago, many instructors from other departments began adopting EBIP in their classrooms. This article asks what was the catalyst for this change? Why had previous attempts at institutional change failed? The authors answer these questions by analyzing their efforts to transform the teaching practices in large-enrollment science and engineering introductory courses on their campus.

关键词： STEM Education Evidence Based Practice Teaching Methods Undergraduate Study college Faculty Educational Change Communities of Practice Mentors School CultureIllinois

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A question answering approach to emotion cause extraction

arXiv

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arXiv 2017年

作者： Gui, Lin Hu, Jiannan He, Yulan Xu, Ruifeng Lu, Qin Du, Jiachen Shenzhen Graduate School Harbin Institute of Technology College of Mathematics and Computer Science Fuzhou University School of Engineering and Applied Science Aston University Guangdong Provincial Engineering Technology Research Center for Data Science Department of Computing Hong Kong Polytechnic University

Emotion cause extraction aims to identify the reasons behind a certain emotion expressed in text. It is a much more difficult task compared to emotion classification. Inspired by recent advances in using deep memory networks for question answering (QA), we propose a new approach which considers emotion cause identification as a reading comprehension task in QA. Inspired by convolutional neural networks, we propose a new mechanism to store relevant context in different memory slots to model context information. Our proposed approach can extract both word level sequence features and lexical features. Performance evaluation shows that our method achieves the state-of-the-art performance on a recently released emotion cause dataset, outperforming a number of competitive baselines by at least 3.01% in F-measure. Copyright © 2017, The Authors. All rights reserved.

关键词： Extraction

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Capability of local operations and classical communication to distinguish bipartite unitary operations

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Physical Review A 2017年第5期96卷 052327-052327页

作者： Lvzhou Li Shenggen Zheng Haozhen Situ Daowen Qiu Institute of Computer Science Theory School of Data and Computer Science Sun Yat-Sen University Guangzhou 510006 China The Key Laboratory of Machine Intelligence and Advanced Computing (Sun Yat-Sen University) Ministry of Education Guangzhou 510006 China College of Mathematics and Informatics South China Agricultural University Guangzhou 510642 China

The problem studied in this paper is, if the number of queries to unitary operations is fixed, say k, then when do local operations and classical communication (LOCC) suffice for optimally distinguishing bipartite unitary operations? We consider the above problem for two-qubit unitary operations in the case of k=1, showing that for two two-qubit entangling unitary operations without local parties, LOCC achieves the same distinguishability as the global operations. Specifically, we obtain the following: (i) if such two unitary operations are perfectly distinguishable by global operations, then they are perfectly distinguishable by LOCC also, and (ii) if they are not perfectly distinguishable by global operations, then LOCC can achieve the same optimal discrimination probability as the global operations.

关键词： Quantum gates Resource theories

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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Analysis of the BraTS 2023 Intracranial Meningioma Segmentation Challenge

arXiv

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arXiv 2024年

作者： LaBella, Dominic Baid, Ujjwal Khanna, Omaditya McBurney-Lin, Shan McLean, Ryan Nedelec, Pierre Rashid, Arif Tahon, Nourel Hoda Altes, Talissa Bhalerao, Radhika Dhemesh, Yaseen Godfrey, Devon Hilal, Fathi Floyd, Scott Janas, Anastasia Kazerooni, Anahita Fathi Kirkpatrick, John Kent, Collin Kofler, Florian Leu, Kevin Maleki, Nazanin Menze, Bjoern Pajot, Maxence Reitman, Zachary J. Rudie, Jeffrey D. Saluja, Rachit Velichko, Yury Wang, Chunhao Warman, Pranav Adewole, Maruf Albrecht, Jake Anazodo, Udunna Anwar, Syed Muhammad Bergquist, Timothy Chen, Sully Francis Chung, Verena Conte, Gian-Marco Dako, Farouk Eddy, James Ezhov, Ivan Khalili, Nastaran Iglesias, Juan Eugenio Jiang, Zhifan Johanson, Elaine Van Leemput, Koen Li, Hongwei Bran Linguraru, Marius George Liu, Xinyang Mahtabfar, Aria Meier, Zeke Moawad, Ahmed W. Mongan, John Piraud, Marie Shinohara, Russell Takeshi Wiggins, Walter F. Abayazeed, Aly H. Akinola, Rachel Jakab, András Bilello, Michel de Verdier, Maria Correia Crivellaro, Priscila Davatzikos, Christos Farahani, Keyvan Freymann, John Hess, Christopher Huang, Raymond Lohmann, Philipp Moassefi, Mana Pease, Matthew W. Vollmuth, Phillipp Sollmann, Nico Diffley, David Nandolia, Khanak K. Warren, Daniel I. Hussain, Ali Fehringer, Pascal Bronstein, Yulia Deptula, Lisa Stein, Evan G. Taherzadeh, Mahsa de Oliveira, Eduardo Portela Haughey, Aoife Kontzialis, Marinos Saba, Luca Turner, Benjamin Brüßeler, Melanie M.T. Ansari, Shehbaz Gkampenis, Athanasios Weiss, David Maximilian Mansour, Aya Shawali, Islam H. Yordanov, Nikolay Stein, Joel M. Hourani, Roula Moshebah, Mohammed Yahya Abouelatta, Ahmed Magdy Rizvi, Tanvir Willms, Klara Martin, Dann C. Okar, Abdullah D'Anna, Gennaro Taha, Ahmed Sharifi, Yasaman Faghani, Shahriar Kite, Dominic Pinho, Marco Haider, Muhammad Ammar Aristizabal, Alejandro Karargyris, Alexandros Kassem, Hasan Pati, Sarthak Sheller, Micah Alonso-Basanta, Michelle Villanueva-Meyer, Javier Rauschecker, Andreas M. Nada, Ayman Aboian, Mariam Flanders, Adam E. Wiestler, Benedikt Bakas, Spyridon Ca Duke University Medical Center Department of Radiation Oncology DurhamNC United States Division of Computational Pathology Department of Pathology Laboratory Medicine Indiana University School of Medicine IndianapolisIN United States Center for Federated Learning in Medicine Indiana University IndianapolisIN United States Department of Neurosurgery Thomas Jefferson University PhiladelphiaPA United States University of California San FranciscoCA United States Yale University New HavenCT United States Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States University of Missouri ColumbiaMO United States Department of Biostatistics and Health Data Science Indiana University School of Medicine IndianapolisIN United States Children's Hospital of Philadelphia University of Pennsylvania PhiladelphiaPA United States University of Pennsylvania PhiladelphiaPA United States Helmholtz AI Helmholtz Munich Germany Department of Informatics Technical University Munich Germany TranslaTUM - Central Institute for Translational Cancer Research Technical University of Munich Germany Department of Diagnostic and Interventional Neuroradiology School of Medicine Klinikum rechts der Isar Technical University of Munich Germany San FranciscoCA United States Biomedical Image Analysis and Machine Learning Department of Quantitative Biomedicine University of Zurich Switzerland Department of Neuroradiology Technical University of Munich Munich Germany University of San Diego CA United States Cornell University IthacaNY United States Department of Radiology Northwestern University EvanstonIL United States Duke University Medical Center School of Medicine DurhamNC United States Lab Crestview Radiology Lagos Nigeria Sage Bionetworks United States McGill University MontrealQC Canada Children's National Hospital WashingtonDC United States George Washington University WashingtonDC United State

We describe the design and results from the BraTS 2023 Intracranial Meningioma Segmentation Challenge. The BraTS Meningioma Challenge differed from prior BraTS Glioma challenges in that it focused on meningiomas, which are typically benign extra-axial tumors with diverse radiologic and anatomical presentation and a propensity for multiplicity. Nine participating teams each developed deep-learning automated segmentation models using image data from the largest multi-institutional systematically expert annotated multilabel multi-sequence meningioma MRI dataset to date, which included 1000 training set cases, 141 validation set cases, and 283 hidden test set cases. Each case included T2, T2/FLAIR, T1, and T1Gd brain MRI sequences with associated tumor compartment labels delineating enhancing tumor, non-enhancing tumor, and surrounding non-enhancing T2/FLAIR hyperintensity. Participant automated segmentation models were evaluated and ranked based on a scoring system evaluating lesion-wise metrics including dice similarity coefficient (DSC) and 95% Hausdorff Distance. The top ranked team had a lesion-wise median dice similarity coefficient (DSC) of 0.976, 0.976, and 0.964 for enhancing tumor, tumor core, and whole tumor, respectively and a corresponding average DSC of 0.899, 0.904, and 0.871, respectively. These results serve as state-of-the-art benchmarks for future pre-operative meningioma automated segmentation algorithms. Additionally, we found that 1286 of 1424 cases (90.3%) had at least 1 compartment voxel abutting the edge of the skull-stripped image edge, which requires further investigation into optimal pre-processing face anonymization steps. © 2024, CC BY.

关键词： Tumors

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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