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Prioritizing Strategies for Building the Resilience of Public health systems to Disasters Across Multiple Communities and Countries

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International Journal of Disaster Risk science 2024年第1期15卷 1-17页

作者： Benjamin J.Ryan Mayumi Kako Shelby Garner Rok Fink Ismail Tayfur Jonathan Abrahams Sanjaya Bhatia Adriana Campelo Matthew Fendt Alicia Fontenot Nahuel Arenas Garcia Tim Hatch Ryoma Kayano LaShonda Malrey‑Horne Makiko MacDermot Md Moshiur Rahman Chaverle Noel Shuhei Nomura Jeremy P.Novak Maria Opazo Kendell Oliver Luciana Peters Sohel Rahman PerihanŞimşek Andrew Stricklin Raymond Swienton Bryan W.Brooks Frist College of Medicine Belmont UniversityNashvilleTN 37212USA Department of Environmental Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Health Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Faculty of Health Sciences University of Ljubljana1000 LjubljanaSlovenia Department of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Monash University Accident Research Center MelbourneVIC 3800Australia Global Education and Training Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for the Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering and Computer Science Baylor UniversityWacoTX 76798USA Department of Public Health Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA Alabama Department of Public Health MontgomeryAL 36092USA World Health Organization Centre for Health Development(WHO Kobe Centre) Kobe 651-0073Japan Waco-McLennan County Public Health District WacoTX 76707USA Department of Health Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tokyo Foundation for Policy Research Tokyo 106-6234Japan Global Development College BrisbaneQLD 4000Australia Municipality of Pudahuel 13124 PudahuelChile City Hall of Porto Alegre Porto Alegre 90010-170Brazil Ministry of Health and Family Welfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Department of Emergency Aid and Disaster Management Trabzon University61335 TrabzonTurkey Department of Emergency Medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pandemic highlighted the urgent need to strengthen public health *** response,the United Nations Disaster Risk Reduction(UNDRR) Public health system Resilience Scorecard(Scorecard) was applied in workshops across multiple *** aim of our research was to explore the workshop findings to develop priority strategies for strengthening public health system *** conducted a workshop from 14 to 16 March 2023,at the UNDRR Global Education and Training Institute in Incheon,Republic of Korea.A sequential modified Delphi method was utilized to develop a set of prioritized resilience *** were drawn from 70 strategies identified from 13 distinct workshops in eight *** two surveys,23 strategies were *** received ratings of "High" or Very High" from89% of *** related to the inclusion of public health risks in emergency plans,integrating multidisciplinary teams into public health,enabling local transport mechanisms,and improving the ability to manage an influx of *** Scorecard provides an adaptable framework to identify and prioritize strategies for strengthening public health system *** leveraging this methodology,our study demonstrated how resilience strategies could inform disaster risk reduction funding,policies,and actions.

关键词： health system resilience Public policy Resilience scorecard Workshops

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multi-kernel and multi-scale learning based deep ensemble model for predicting recurrence of non-small cell lung cancer

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PeerJ Computer science 2023年 9卷

作者： Kim, Gihyeon Park, Young Mi Yoon, Hyun Jung Choi, Jang-Hwan Department of Computational Medicine Graduate Program in System Health Science and Engineering Ewha Womans University Seoul Korea Republic of Department of Molecular Medicine College of Medicine Ewha Womans University Seoul Korea Republic of Department of Radiology Veterans Health Service Medical Center Seoul Korea Republic of Division of Mechanical and Biomedical Engineering Graduate Program in System Health Science and Engineering Ewha Womans University Seoul Korea Republic of Department of Artificial Intelligence Ewha Womans University Seoul Korea Republic of

Predicting recurrence in patients with non-small cell lung cancer (NSCLC) before treatment is vital for guiding personalized medicine. Deep learning techniques have revolutionized the application of cancer informatics, including lung cancer timeto-event prediction. Most existing convolutional neural network (CNN) models are based on a single two-dimensional (2D) computational tomography (CT) image or three-dimensional (3D) CT volume. However, studies have shown that using multiscale input and fusing multiple networks provide promising performance. This study proposes a deep learning-based ensemble network for recurrence prediction using a dataset of 530 patients with NSCLC. This network assembles 2DCNNmodels of various input slices, scales, and convolutional kernels, using a deep learning-based feature fusion model as an ensemble strategy. The proposed framework is uniquely designed to benefit from (i) multiple 2D in-plane slices to provide more information than a single central slice, (ii) multi-scale networks and multi-kernel networks to capture the local and peritumoral features, (iii) ensemble design to integrate features from various inputs and model architectures for final prediction. The ensemble of five 2D-CNN models, three slices, and two multi-kernel networks, using 5×5 and 6×6 convolutional kernels, achieved the best performance with an accuracy of 69.62%, area under the curve (AUC) of 72.5%, F1 score of 70.12%, and recall of 70.81%. Furthermore, the proposed method achieved competitive results compared with the 2D and 3D-CNN models for cancer outcome prediction in the benchmark studies. Our model is also a potential adjuvant treatment tool for identifying NSCLC patients with a high risk of recurrence. © 2023 Kim et al.

关键词： Neural network models

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Frailty and Other Factors Associated With Early Outcomes in Middle-to Older Age Trauma Patients: A Prospective Cohort Study

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American Journal of Geriatric Psychiatry 2024年第2期32卷 244-255页

作者： Yeh, Tian-Shin Kang, Jiunn-Horng Littlejohns, Thomas J. Wu, Chia-Chieh Chen, Jin-Hua Piravej, Krisna Chiu, Wen-Ta Lam, Carlos Department of Physical Medicine and Rehabilitation School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Physical Medicine and Rehabilitation Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Epidemiology and Nutrition Harvard T. H. Chan School of Public Health Harvard University Boston MA United States Department of Physical Medicine and Rehabilitation National Taiwan University Hospital Taipei Taiwan Department of Physical Medicine and Rehabilitation College of Medicine National Taiwan University Taipei Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taipei Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan Nuffield Department of Population Health University of Oxford Oxford United Kingdom Emergency Department Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Emergency School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Data Science College of Management Taipei Medical University Taipei Taiwan Institutional Research Center Office of Data Science Taipei Medical University Taipei Taiwan Biostatistics Center Department of Medical Research Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Rehabilitation Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand Department of Chula Neuroscience Center King Chulalongkorn Memorial Hospital Bangkok Thailand Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei Taiwan AHMC Health System Alhambra CA United States

Objectives: To prospectively investigate associations of frailty and other predictor variables with functional recovery and health outcomes in middle-aged and older patients with trauma. Design: Single-center prospective cohort study. Setting: Emergency department of Wan Fang Hospital in Taiwan. Participants: Trauma patients aged 45 and older. Measurements: Frailty was assessed with the Clinical Frailty Scale (CFS). Injury mechanisms, pre-existing diseases, and fracture locations were recorded at baseline. The primary outcome was functional recovery assessed using the Barthel Index (BI). Secondary outcomes were new care needs, unscheduled return visits, and falls 3 months postinjury. Results: A total of 588 participants were included in the final analysis. For every one-point increase in the CFS, the multivariable-adjusted odds ratio (OR, 95% confidence interval [CI]) of failure to retain the preinjury BI was 1.34 (1.16–1.55);associations were consistent across levels of age and injury severities. Significant joint associations of frailty and age with poor functional recovery were observed. CFS was also associated with new care needs (OR for every one-point increase, 1.36, 95% CI, 1.17–1.58), unscheduled return visits (OR 1.26, 95% CI, 1.04–1.51), and falls (OR 1.23, 95% CI, 1.01–1.51). Other variables associated with failure to retain preinjury BI included road traffic accident and presence of hip fracture. Conclusion: Frailty was significantly associated with poor functional and health outcomes regardless of injury severity in middle-aged and older patients with trauma. Injury mechanisms and fracture locations were also significant predictors of functional recovery postinjury. © 2023 American Association for Geriatric Psychiatry

关键词： Clinical Frailty Scale Frailty functional recovery injury middle-to older age

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Association of postnatal exposure to mixture of bisphenol A, Di-n-butyl phthalate and Di-(2-ethylhexyl) phthalate with Children's IQ at 5 Years of age: Mothers and Children's environmental health (MOCEH) study

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Chemosphere 2024年 347卷 140626页

作者： Ham, Dajeong Ha, Mina Park, Hyesook Hong, Yun-Chul Kim, Yangho Ha, Eunhee Bae, Sanghyuk Department of Preventive Medicine College of Medicine The Catholic University of Korea Seoul Korea Republic of Department of Preventive Medicine College of Medicine Dankook University Cheonan Korea Republic of Department of Preventive Medicine College of Medicine Graduate Program in System Health Science and Engineering Ewha Womans University Seoul Korea Republic of Department of Preventive Medicine College of Medicine Seoul National University Seoul Korea Republic of Department of Occupational and Environmental Medicine University of Ulsan College of Medicine Ulsan Korea Republic of Department of Occupational and Environmental Medicine College of Medicine Ewha Womans University Seoul Korea Republic of Environmental Health Center College of Medicine The Catholic University of Korea Seoul Korea Republic of

Early childhood is important for neurodevelopment, and exposure to endocrine disruptors such as bisphenol A (BPA) and phthalates in this period may cause neurodevelopmental disorders and delays. The present study examined the association between exposure to mixtures of BPA and three metabolites of phthalates in early childhood and IQ at 5 years of age. The Mother and Children's Environmental health (MOCEH) study is a prospective birth cohort study conducted in Korea with 1751 pregnant women enrolled from 2006 to 2010. After excluding those without relevant data, 47 children were included in the final analysis. We measured children's urinary concentrations of metabolites of endocrine-disrupting chemicals (Bisphenol A, mono-(2-ethyl-5-oxohexyl) phthalate, mono-(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-butyl) phthalate) at ages of 24 and 36 months. We evaluated the children's IQ with the Korean Wechsler Intelligence Test at the age of 5 years. After adjusting for potential confounders, a multiple linear regression was conducted to examine the associations between individual endocrine-disrupting chemicals and the IQ of the children. Weighted Quantile Sum (WQS) regression and quantile-based g-computation were used to assess the association between IQ at age 5 and exposure to mixtures of BPA and phthalates. In the single-chemical analyses, mono-(2-ethyl-5-butyl) phthalate exposure at 36 months was adversely associated with children's IQ (β = −4.93, 95% confidence interval (CI): -9.22, −0.64). In the WQS regression and quantile-based g-computation analyses, exposure to the mixture of BPA and phthalates was associated with lower IQ [β = −9.13 (P-value = 0.05) and β = −9.18 (P-value = 0.05), respectively]. The largest contributor to the overall association was exposure to mono-(2-ethyl-5-butyl) phthalate at 36 months. In the present study, postnatal exposure to mixtures of BPA and three metabolites of phthalates was associated with decreased IQ of children at ag

关键词： Metabolites

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Fluctuating risk of acute kidney injury-related mortality for four weeks after exposure to air pollution: A multi-country time-series study in 6 countries

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Environment International 2024年 183卷 108367页

作者： Min, Jieun Kang, Duk-Hee Kang, Cinoo Bell, Michelle L. Kim, Ho Yang, Juyeon Gasparrini, Antonio Lavigne, Eric Hashizume, Masahiro Kim, Yoonhee Fook Sheng Ng, Chris Honda, Yasushi das Neves Pereira da Silva, Susana Madureira, Joana Leon Guo, Yue Pan, Shih-Chun Armstrong, Ben Sera, Francesco Masselot, Pierre Schwartz, Joel Maria Vicedo-Cabrera, Ana Pyo Lee, Jung Al-Aly, Ziyad Won Lee, Jung Kwag, Youngrin Ha, Eunhee Lee, Whanhee Department of Environmental Medicine College of Medicine Ewha Womans University Seoul Korea Republic of Graduate Program in System Health Science and Engineering College of Medicine Ewha Womans University Seoul Korea Republic of Division of Nephrology Department of Internal Medicine Ewha Womans University School of Medicine Ewha Medical Research Center Seoul Korea Republic of Department of Public Health Sciences Graduate School of Public Health Seoul National University Seoul Korea Republic of Yale School of the Environment Yale University New HavenCT United States Biostatistics Collaboration Unit Yonsei University College of Medicine Seoul Korea Republic of Lab Department of Public Health Environments and Society London School of Hygiene & Tropical Medicine London United Kingdom School of Epidemiology & Public Health Faculty of Medicine University of Ottawa Ottawa Canada Department of Global Health Policy Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Global Environmental Health Graduate School of Medicine University of Tokyo Tokyo Japan School of Tropical Medicine and Global Health Nagasaki University Nagasaki Japan Center for Climate Change Adaptation National Institute for Environmental Studies Tsukuba Japan Department of Epidemiology Instituto Nacional de Saúde Dr. Ricardo Jorge Lisbon Portugal EPIUnit-Institute of Public Health University of Porto Porto Portugal Porto Portugal College of Medicine and NTU Hospital Taipei Taiwan National Institute of Environmental Health Science National Health Research Institutes Zhunan Taiwan Department of Public Health Environments and Society London School of Hygiene & Tropical Medicine London United Kingdom Department of Statistics Computer Science and Applications "G. Parenti" University of Florence Florence Italy Department of Environmental Health Harvard T.H. Chan School of Public Health BostonMA United States Institute of Social and Preventive Medicine Universi

Background: Recent studies have reported that air pollution is related to kidney diseases. However, the global evidence on the risk of death from acute kidney injury (AKI) owing to air pollution is limited. Therefore, we investigated the association between short-term exposure to air pollution—particulate matter ≤ 2.5 μm (PM2.5), ozone (O3), and nitrogen dioxide (NO2)—and AKI-related mortality using a multi-country dataset. Methods: This study included 41,379 AKI-related deaths in 136 locations in six countries during 1987–2018. A novel case time-series design was applied to each air pollutant during 0–28 lag days to estimate the association between air pollution and AKI-related deaths. Moreover, we calculated AKI deaths attributable to non-compliance with the World health Organization (WHO) air quality guidelines. Results: The relative risks (95% confidence interval) of AKI-related deaths are 1.052 (1.003, 1.103), 1.022 (0.994, 1.050), and 1.022 (0.982, 1.063) for 5, 10, and 10 µg/m3 increase in lag 0–28 days of PM2.5, warm-season O3, and NO2, respectively. The lag-distributed association showed that the risk appeared immediately on the day of exposure to air pollution, gradually decreased, and then increased again reaching the peak approximately 20 days after exposure to PM2.5 and O3. We also found that 1.9%, 6.3%, and 5.2% of AKI deaths were attributed to PM2.5, warm-season O3, and NO2 concentrations above the WHO guidelines. Conclusions: This study provides evidence that public health policies to reduce air pollution may alleviate the burden of death from AKI and suggests the need to investigate the several pathways between air pollution and AKI death. © 2023 The Author(s)

关键词： Air quality

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Technology Roadmap for Flexible Sensors

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ACS NANO 2023年第6期17卷 5211-5295页

作者： Luo, Yifei Abidian, Mohammad Reza Ahn, Jong-Hyun Akinwande, Deji Andrews, Anne M. Antonietti, Markus Bao, Zhenan Berggren, Magnus Berkey, Christopher A. Bettinger, Christopher John Chen, Jun Chen, Peng Cheng, Wenlong Cheng, Xu Choi, Seon-Jin Chortos, Alex Dagdeviren, Canan Dauskardt, Reinhold H. Di, Chong-an Dickey, Michael D. Duan, Xiangfeng Facchetti, Antonio Fan, Zhiyong Fang, Yin Feng, Jianyou Feng, Xue Gao, Huajian Gao, Wei Gong, Xiwen Guo, Chuan Fei Guo, Xiaojun Hartel, Martin C. He, Zihan Ho, John S. Hu, Youfan Huang, Qiyao Huang, Yu Huo, Fengwei Hussain, Muhammad M. Javey, Ali Jeong, Unyong Jiang, Chen Jiang, Xingyu Kang, Jiheong Karnaushenko, Daniil Khademhosseini, Ali Kim, Dae-Hyeong Kim, Il-Doo Kireev, Dmitry Kong, Lingxuan Lee, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Li, Fengyu Li, Jinxing Liang, Cuiyuan Lim, Chwee Teck Lin, Yuanjing Lipomi, Darren J. Liu, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Loh, Xian Jun Lu, Nanshu Lv, Zhisheng Magdassi, Shlomo Malliaras, George G. Matsuhisa, Naoji Nathan, Arokia Niu, Simiao Pan, Jieming Pang, Changhyun Pei, Qibing Peng, Huisheng Qi, Dianpeng Ren, Huaying Rogers, John A. Rowe, Aaron Schmidt, Oliver G. Sekitani, Tsuyoshi Seo, Dae-Gyo Shen, Guozhen Sheng, Xing Shi, Qiongfeng Someya, Takao Song, Yanlin Stavrinidou, Eleni Su, Meng Sun, Xuemei Takei, Kuniharu Tao, Xiao-Ming Tee, Benjamin C. K. Thean, Aaron Voon-Yew Trung, Tran Quang Wan, Changjin Wang, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Weiss, Paul S. Wen, Hanqi Xu, Sheng Xu, Tailin Yan, Hongping Yan, Xuzhou Yang, Hui Yang, Le Yang, Shuaijian Yin, Lan Yu, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Zamburg, Evgeny Zhang, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhao, Siyuan Zhao, Xuanhe Zheng, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zhou, Tao Zhu, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zou, Guijin Chen, Xiaodong 08-03 Innovis Singapore 138634 Republic of Singapore Innovative Centre for Flexible Devices (iFLEX) School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Biomedical Engineering University of Houston Houston Texas 77024 United States School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 United States Microelectronics Research Center The University of Texas at Austin Austin Texas 78758 United States Department of Chemistry and Biochemistry California NanoSystems Institute and Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior and Hatos Center for Neuropharmacology University of California Los Angeles Los Angeles California 90095 United States Colloid Chemistry Department Max Planck Institute of Colloids and Interfaces 14476 Potsdam Germany Department of Chemical Engineering Stanford University Stanford California 94305 United States Laboratory of Organic Electronics Department of Science and Technology Campus Norrköping Linköping University 83 Linköping Sweden Wallenberg Initiative Materials Science for Sustainability (WISE) and Wallenberg Wood Science Center (WWSC) SE-100 44 Stockholm Sweden Department of Materials Science and Engineering Stanford University Stanford California 94301 United States Department of Biomedical Engineering and Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh Pennsylvania 15213 United States Department of Bioengineering University of California Los Angeles Los Angeles California 90095 United States School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637457 Singapore Nanobionics Group Department of Chemical and Biological Engineering Monash University Clayton Australia 3800 Monash

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze continued...challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative

关键词： soft materials mechanics engineering flexible electronics conformable sensors bioelectronics human-machine interfaces body area sensor networks technology translation sustainable electronics

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Association of paternal cadmium and other heavy metal exposure to birth outcomes using propensity score matching.

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Chemosphere 2023年第Pt 1期311卷 136792页

作者： Lee, Yu Min Kim, Yangho Park, Hyesook Hong, Yun-Chul Ha, Mina Kim, Young Ju Ha, Eun Hee Department of Occupational and Environmental Medicine Severance Hospital Seoul Korea Republic of Department of Occupational and Environmental Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan Korea Republic of Department of Preventive Medicine College of Medicine Ewha Medical Research Center Ewha Womans University Seoul Korea Republic of Graduate Program in System Health Science and Engineering Ewha Womans University Korea Republic of Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea Republic of Department of Preventive Medicine College of Medicine Dankook University Cheonan Korea Republic of Department of Obstetrics and Gynecology College of Medicine Ewha Womans University Seoul Korea Republic of Department of Environmental Medicine College of Medicine Ewha Womans University Seoul Korea Republic of

Background: Human exposure to cadmium has various effects on health, especially on male reproductive organs. Although it is widely known that prenatal maternal cadmium exposure can affect birth outcomes, the effect of paternal exposure to cadmium remains unclear. Objectives: This study aimed to evaluate the effect of paternal cadmium exposure on fetal growth by considering maternal cadmium exposure and exposure to other heavy metals, namely mercury and lead. Methods: The Mothers and Children's Environmental health (MOCEH) study is a prospective birth cohort study in Korea. Overall, 1313 families (father-mother-child triple) without child abnormalities and who completed paternal whole blood cadmium assessments were included in this study. Families were divided into two subgroups based on the blood sampling periods, namely early and late pregnancy. Subjects were selected as follows: one family triple with a high level of paternal cadmium and two triples with low levels of paternal cadmium, using the method of propensity score matching. And linear regression analyses were performed. Results: The group with high paternal cadmium exposure (80% or more;1.93 μg/L) had lower birth weight infants compared to the group with low cadmium concentrations (β(se) = −0.21(0.10);p-value = 0.0283). After stratification by infant sex, prenatal paternal cadmium exposure significantly reduced the birth weight of females in subgroups of different sampling times, namely early pregnancy (β(se) = −0.52 (0.22);p-value = 0.0170) and late pregnancy (β(se) = −0.43 (0.18);p-value = 0.0160). Finally, after performing propensity score matching in the early pregnancy measurement group, it was found that the prenatal exposure of father to cadmium significantly reduced birth weight in females (β(se) = −0.72(0.25);p-value = 0.0047). Conclusion: This study assessed the effect of paternal cadmium exposure on birth outcomes in family units consisting of a father, mother, and child. Prenatal paternal cadmi

关键词： Cadmium

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In vitro biocompatibility of polycaprolactone/hydroxyapatite nanocomposite membranes modified by oleic acid for bone regeneration

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Colloids and Surfaces A: Physicochemical and engineering Aspects 2024年 688卷

作者： Lin, Ruei-Hong Hung, Huey-Shan Tang, Cheng-Ming Tsou, Hsi-Kai Chen, Po-Hsiang Yueh, Chun-Yu Wang, Hui-Min David Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung40293 Taiwan Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung40227 Taiwan Translational Medicine Research China Medical University Hospital Taichung404327 Taiwan Graduate Institute of Biomedical Science China Medical University Taichung404333 Taiwan Institute of Oral Sciences Chung Shan Medical University Taichung40201 Taiwan Department of Dentistry Chung Shan Medical University Hospital Taichung40201 Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung40293 Taiwan Department of Rehabilitation Jen-Teh Junior College of Medicine Nursing and Management Miaoli County35664 Taiwan College of Health National Taichung University of Science and Technology Taichung403027 Taiwan School of Medicine China Medical University Taichung404333 Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung80708 Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung40227 Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung40402 Taiwan

The bone defect is common in the orthopedic clinic, possibly due to trauma, tumor, or congenital diseases. Also, some patients with alveolar bone defects in the dental clinic result from the different proliferation speeds between soft and hard tissue. Biomaterials made of polymers and bioceramics have been developed to deal with these problems but mixing them directly can result in a low-mechanical strength complex. To solve this, we used oleic acid (C18) as a surfactant to improve the dispersity of hydroxyapatite (HA) in the polycaprolactone (PCL) matrix, and then immerse the material in a simulated biomineralization process. The results showed that the low crystallinity PCL formed an evenly distributed mineralized layer that had phosphate ions signal and a hydroxyapatite peak. The biocompatibility of the material was assessed using MC3T3 cells, and found that the PCL-HA membrane and PCL-C18-HA membranes had significant cell filopodia and lamellipodia. Additionally, the polycaprolactone/oleic acid/hydroxyapatite (PCL-C18-HA) membrane had the highest cell viability among all groups. The addition of C18 also decreased the platelets activation degree but had a significant difference in the reactive oxygen species (ROS) amount compared to the control, which requires further investigation. Overall, this study successfully fabricated a safe and promising polycaprolactone/hydroxyapatite/oleic acid nanocomposite membrane as a potential solution for bone biomaterials. © 2024 Elsevier B.V.

关键词： Hydroxyapatite

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Impact of particulate matter 2.5 on placental ultrastructure including mitochondrial damage through oxidative stress

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Reproductive toxicology (Elmsford, N.Y.) 2025年 136卷 108973页

作者： Gain Lee Jung Mi Han Young-Ah You Yoon-Young Go Sunwha Park Young Min Hur Soo Min Kim Ki-Hwan Han Young Ju Kim Graduate Program in System Health Science and Engineering Ewha Womans University. Nano Imaging Laboratory in the Ewha Medical Research Institute Ewha Womans University. Department of Obstetrics and Gynecology and Ewha Medical Institute College of Medicine Ewha Womans University. Department of Anatomy College of Medicine Ewha Womans University. Graduate Program in System Health Science and Engineering Ewha Womans University Department of Obstetrics and Gynecology and Ewha Medical Institute College of Medicine Ewha Womans University. Electronic address: kkyj@ewha.ac.kr.

INTRODUCTION:Particulate matter 2.5 (PM) refers to fine particles with a diameter of less than 2.5μm, associated with adverse pregnancy outcomes. The study aims to determine whether elevated prenatal PM levels were associated with alterations in the ultrastructure of the placenta and mitochondria, potentially linked to oxidative stress. METHODS:The placental samples were collected from the Air Pollution on Pregnancy Outcome (APPO) cohort and were classified into two groups based on PM exposure levels: the High group (> 15μg/m³; n = 9) and the Low group (≤ 15μg/m³; n = 8). Transmission electron microscopy was used to assess the ultrastructure of the placenta, specifically the syncytiotrophoblast area. The structure of the mitochondria in the fetal capillaries was also analyzed. Malondialdehyde (MDA) and superoxide dismutase 2 (SOD2) were quantified by using enzyme-linked immunosorbent assays (ELISA). RESULTS:The High group placenta showed ultrastructural changes including microvilli loss, basement membrane thickening, vacuolation and swollen endoplasmic reticulum (ER). Microvilli were significantly shortened and lost in the High group (P < 0.005). Swollen vacuoles, ER stress, and basement membrane thickening were observed in High group syncytiotrophoblast (P < 0.005). Mitochondria in fetal capillaries from the High group were also damaged, showing disrupted double membranes and cristae (P < 0.05). MDA and SOD2 levels were significantly upregulated in the High group (P <0.05). CONCLUSION:Prenatal exposure to PM may be associated with alterations of placental ultrastructure and mitochondrial damage in fetal capillaries, potentially mediated by oxidative stress, as indicated by elevated levels of MDA and SOD2.

关键词： Mitochondrial damage Oxidative stress Particulate matter 2.5 Placenta Syncytiotrophoblast Transmission electron microscopy

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Hospital Admission Risks and Excess Costs for Neurological Symptoms Attributable to Long-Term Exposure to Fine Particulate Matter in New York State, USA

SSRN

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SSRN 2023年

作者： Min, Jieun Lee, Whanhee Bell, Michelle L. Kim, Yijun Heo, Seulkee Kim, Ga Eun Kim, Jee Hyun Yun, Ji Young Kim, Soo In Schwartz, Joel Ha, Eunhee Department of Environmental Medicine School of Medicine Ewha Womans University Seoul Korea Republic of Graduate Program in System Health Science and Engineering College of Medicine Ewha Womans University Seoul Korea Republic of Ewha Womans University College of Medicine Seoul Korea Republic of School of Biomedical Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan Korea Republic of Yale School of the Environment Yale University New HavenCT United States Department of Psychiatry Ewha Womans University Mokdong Hospital Ewha Womans University College of Medicine Seoul Korea Republic of Department of Neurology Ewha Womans University Seoul Hospital Ewha Womans University College of Medicine Seoul Korea Republic of Department of Environmental Health Harvard T H Chan School of Public Health BostonMA United States Department of Medical Science Ewha Womans University School of Medicine Ewha Medical Research Institute Seoul Korea Republic of

Background: Although emerging evidence suggests that PM2.5 is linked to neurological symptoms (NSs) via neuroinflammation, relevant studies are scarce. This study aimed to investigate the risks and excess costs of hospital admission for five NSs—fatigue, headache, dizziness, convulsion, and paralysis—attributable to long-term exposure to PM2.5 in New York State, ***: We analyzed the New York Statewide Planning and Research Cooperative system (SPARCS) from 2010 to 2016. A Bayesian hierarchical model with integrated nested Laplace approximations was performed to estimate the risks and excess costs of hospital admission for NSs due to long-term exposure to PM2.5 at the county ***: A 1 µg/m3 increase in lag 0–1 years PM2.5 was associated with an increased risk of headache and convulsion by 1.06 (1.01, 1.11) and 1.04 (1.01, 1.06), respectively. The excess hospital admission cost for five NSs attributable to lag 0–1 years PM2.5 above the new World health Organization guideline (annual standard: 5 µg/m3) was $200.24 (95% CI: 6.00, 376.96) million during 2011–2016, recording the highest for convulsion ($153.73 [95% CI: 63.61, 244.19] million).Conclusions: This study provides quantitative estimates of risks and excess costs for NSs attributable to long-term PM2.5 and suggests that policies that reduce long-term PM2.5 concentration in accordance with the new WHO air quality guidelines can yield substantial health and economic benefits related to NSs in the New York State population. © 2023, The Authors. All rights reserved.

关键词： Hierarchical systems

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