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arXiv 2023年

作者： Lekadir, Karim Feragen, Aasa Fofanah, Abdul Joseph Frangi, Alejandro F. Buyx, Alena Emelie, Anais Lara, Andrea Porras, Antonio R. Chan, An-Wen Navarro, Arcadi Glocker, Ben Botwe, Benard O. Khanal, Bishesh Beger, Brigit Wu, Carol C. Cintas, Celia Langlotz, Curtis P. Rueckert, Daniel Mzurikwao, Deogratias Fotiadis, Dimitrios I. Zhussupov, Doszhan Ferrante, Enzo Meijering, Erik Weicken, Eva González, Fabio A. Asselbergs, Folkert W. Prior, Fred Krestin, Gabriel P. Collins, Gary S. Tegenaw, Geletaw S. Kaissis, Georgios Misuraca, Gianluca Tsakou, Gianna Dwivedi, Girish Kondylakis, Haridimos Jayakody, Harsha Woodruf, Henry C. Mayer, Horst Joachim Aerts, Hugo JWL Walsh, Ian Chouvarda, Ioanna Buvat, Irène Tributsch, Isabell Rekik, Islem Duncan, James Kalpathy-Cramer, Jayashree Zahir, Jihad Park, Jinah Mongan, John Gichoya, Judy W. Schnabel, Julia A. Kushibar, Kaisar Riklund, Katrine Mori, Kensaku Marias, Kostas Amugongo, Lameck M. Fromont, Lauren A. Maier-Hein, Lena Alberich, Leonor Cerdá Rittner, Leticia Phiri, Lighton Marrakchi-Kacem, Linda Donoso-Bach, Lluís Martí-Bonmatí, Luis Cardoso, M. Jorge Bobowicz, Maciej Shabani, Mahsa Tsiknakis, Manolis Zuluaga, Maria A. Bielikova, Maria Fritzsche, Marie-Christine Camacho, Marina Linguraru, Marius George Wenzel, Markus De Bruijne, Marleen Tolsgaard, Martin G. Ghassemi, Marzyeh Ashrafuzzaman, Md Goisauf, Melanie Yaqub, Mohammad Abadía, Mónica Cano Mahmoud, Mukhtar M.E. Elattar, Mustafa Rieke, Nicola Papanikolaou, Nikolaos Lazrak, Noussair Díaz, Oliver Salvado, Olivier Pujol, Oriol Sall, Ousmane Guevara, Pamela Gordebeke, Peter Lambin, Philippe Brown, Pieta Abolmaesumi, Purang Dou, Qi Lu, Qinghua Osuala, Richard Nakasi, Rose Zhou, S. Kevin Napel, Sandy Colantonio, Sara Albarqouni, Shadi Joshi, Smriti Carter, Stacy Klein, Stefan Petersen, Steffen E. Aussó, Susanna Awate, Suyash Raviv, Tammy Riklin Cook, Tessa Mutsvangwa, Tinashe E.M. Rogers, Wendy A. Niessen, Wiro J. Puig-Bosch, Xènia Zeng, Yi Mohammed, Yunusa G. Aquino, Yves Saint James Salahuddin, Zohaib Starmans, Martijn P.A. Department de Matemàtiques i Informàtica Universitat de Barcelona Barcelona Spain Barcelona Spain DTU Compute Technical University of Denmark Kgs Lyngby Denmark Department of Mathematics and Computer Science Faculty of Science and Technology Milton Margai Technical University Freetown Sierra Leone Center for Computational Imaging & Simulation Technologies in Biomedicine Schools of Computing and Medicine University of Leeds Leeds United Kingdom Cardiovascular Science and Electronic Engineering Departments KU Leuven Leuven Belgium Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Faculty of Engineering of Systems Informatics and Sciences of Computing Galileo University Guatemala City Guatemala Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Department of Medicine Women’s College Research Institute University of Toronto Toronto Canada Universitat Pompeu Fabra BarcelonaBeta Brain Research Center Barcelona Spain Department of Computing Imperial College London London United Kingdom School of Biomedical & Allied Health Sciences University of Ghana Accra Ghana Department of Midwifery & Radiography School of Health & Psychological Sciences City University of London United Kingdom Kathmandu Nepal European Heart Network Brussels Belgium Department of Thoracic Imaging University of Texas MD Anderson Cancer Center Houston United States IBM Research Africa Nairobi Kenya Departments of Radiology Medicine and Biomedical Data Science Stanford University School of Medicine Stanford United States Institute for AI and Informatics in Medicine Klinikum rechts der Isar Technical University Munich Munich Germany Department of Computing Imperial College London London United Kingdom Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania United Republic of Ioannina Greece Almaty AI Lab Almaty Kazakhstan

Background: Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. In recent years, concerns have been raised about the clinical, technical, ethical and legal risks associated with healthcare AI. To increase adoption in the real world, it is essential that AI technologies are trusted and accepted by patients, clinicians, health organisations and authorities. This paper describes the FUTURE-AI framework as the first international consensus guideline for trustworthy AI in healthcare. Methods: The FUTURE-AI consortium was founded in 2021 and now comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two-year period, the consortium established guiding principles and best practices for trustworthy and deployable AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. Findings: The FUTURE-AI framework was established based on six guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 30 best practices were defined, addressing technical, clinical, socio-ethical and legal dimensions of trustworthy AI. The recommendations cover the entire lifecycle of healthcare AI, from design, development and validation to regulation, deployment, and monitoring. Interpretation: FUTURE-AI is a structured, risk-informed framework which provides guidance for constructing healthcare AI tools that will be trusted, deployed and adopted in real-world clinical practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of healthcare AI. Copyright © 2023, The Authors. All rights

关键词： Clinical research

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Bicycle flow dynamics on wide roads: Experiment and modeling

arXiv

引用

arXiv 2019年

作者： Guo, Ning Jiang, Rui Wong, S.C. Hao, Qing-Yi Xue, Shu-Qi Hu, Mao-Bin School of Automotive and Transportation Engineering Hefei University of Technology Hefei230009 China Key Lab. of Transport Industry of Big Data Application Technologies for Comprehensive Transport Ministry of Transport Beijing Jiaotong University Beijing100044 China Department of Civil Engineering University of Hong Kong Pokfulam Road Hong Kong School of Mathematics and Computational Science Anqing Normal University Anqing246133 China School of Engineering Science University of Science and Technology of China Hefei230026 China

Cycling is a green transportation mode, and is promoted by many governments to mitigate traffic congestion. However, studies concerning the traffic dynamics of bicycle flow are very limited. This study experimentally investigated bicycle flow dynamics on a wide road, modeled using a 3-m-wide track. The results showed that the bicycle flow rate remained nearly constant across a wide range of densities, in marked contrast to single-file bicycle flow, which exhibits a unimodal fundamental diagram. By studying the weight density of the radial locations of cyclists, we argue that this behavior arises from the formation of more lanes with the increase of global density. The extra lanes prevent the longitudinal density from increasing as quickly as in single-file bicycle flow. When the density is larger than 0.5 bicycles/m2, the flow rate begins to decrease, and stop-and-go traffic emerges. A cognitive-science-based model to reproduce bicycle dynamics is proposed, in which cyclists apply simple cognitive procedures to adapt their target directions and desired riding speeds. To incorporate differences in acceleration, deceleration, and turning, different relaxation times are used. The model can reproduce the experimental results acceptably well and may also provide guidance on infrastructure design. Copyright © 2019, The Authors. All rights reserved.

关键词： Traffic congestion

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English verb regularization in books and tweets

arXiv

引用

arXiv 2018年

作者： Gray, Tyler J. Reagan, Andrew J. Dodds, Peter Sheridan Danforth, Christopher M. Vermont Complex Systems Center Computational Story Lab Department of Mathematics & Statistics University of Vermont BurlingtonVT05401 MassMutual Data Science AmherstMA01002

The English language has evolved dramatically throughout its lifespan, to the extent that a modern speaker of Old English would be incomprehensible without translation. One concrete indicator of this process is the movement from irregular to regular (-ed) forms for the past tense of verbs. In this study we quantify the extent of verb regularization using two vastly disparate datasets: (1) Six years of published books scanned by Google (2003{2008), and (2) A decade of social media messages posted to Twitter (2008{2017). We find that the extent of verb regularization is greater on Twitter, taken as a whole, than in English Fiction books. Regularization is also greater for tweets geotagged in the United States relative to American English books, but the opposite is true for tweets geotagged in the United Kingdom relative to British English books. We also find interesting regional variations in regularization across counties in the United States. However, once differences in population are accounted for, we do not identify strong correlations with socio-demographic variables such as education or income. Copyright © 2018, The Authors. All rights reserved.

关键词： Social networking (online)

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Why is the Winner the Best?

Why is the Winner the Best?

引用

Conference on Computer Vision and Pattern Recognition (CVPR)

作者： M. Eisenmann A. Reinke V. Weru M. D. Tizabi F. Isensee T. J. Adler S. Ali V. Andrearczyk M. Aubreville U. Baid S. Bakas N. Balu S. Bano J. Bernal S. Bodenstedt A. Casella V. Cheplygina M. Daum M. De Bruijne A. Depeursinge R. Dorent J. Egger D. G. Ellis S. Engelhardt M. Ganz N. Ghatwary G. Girard P. Godau A. Gupta L. Hansen K. Harada M. Heinrich N. Heller A. Hering A. Huaulmé P. Jannin A. E. Kavur O. Kodym M. Kozubek J. Li H. Li J. Ma C. Martín-Isla B. Menze A. Noble V. Oreiller N. Padoy S. Pati K. Payette T. Rädsch J. Rafael-Patiño V. Singh Bawa S. Speidel C. H. Sudre K. Van Wijnen M. Wagner D. Wei A. Yamlahi M. H. Yap C. Yuan M. Zenk A. Zia D. Zimmerer D. Aydogan B. Bhattarai L. Bloch R. Brüngel J. Cho C. Choi Q. Dou I. Ezhov C. M. Friedrich C. Fuller R. R. Gaire A. Galdran Á. García Faura M. Grammatikopoulou S. Hong M. Jahanifar I. Jang A. Kadkhodamohammadi I. Kang F. Kofler S. Kondo H. Kuijf M. Li M. Luu T. Martinčič P. Morais M. A. Naser B. Oliveira D. Owen S. Pang J. Park S. Park S. Płotka E. Puybareau N. Rajpoot K. Ryu N. Saeed A. Shephard P. Shi D. Štepec R. Subedi G. Tochon H. R. Torres H. Urien J. L. Vilaça K. A. Wahid H. Wang J. Wang L. Wang X. Wang B. Wiestler M. Wodzinski F. Xia J. Xie Z. Xiong S. Yang Y. Yang Z. Zhao K. Maier-Hein P. F. Jäger A. Kopp-Schneider L. Maier-Hein Division of Intelligent Medical Systems German Cancer Research Center (DKFZ) Heidelberg Germany Helmholtz Imaging German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Division of Biostatistics German Cancer Research Center (DKFZ) Heidelberg Germany Division of Medical Image Computing German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Engineering and Physical Sciences School of Computing University of Leeds Leeds UK Institute of Informatics School of Management HES-SO Valais-Wallis University of Applied Sciences and Arts Western Switzerland Sierre Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University Hospital Lausanne Switzerland Technische Hochschule Ingolstadt Ingolstadt Germany Center for Artificial Intelligence and Data Science for Integrated Diagnostics (AI2D) and Center for Biomedical Image Computing and Analytics (CBICA) University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology University of Washington Seattle WA USA Department of Computer Science Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) University College London London UK Universitat Autònoma de Barcelona & Computer Vision Center Barcelona Spain Division of Translational Surgical Oncology National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany Department of Advanced Robotics Istituto Italiano di Tecnologia Italy Department of Electronics Information and Bioengineering Politecnico di Milano Milan Italy IT University of Copenhagen Copenhagen Denmark Department of General Visceral and Transplantation Surgery Heidelberg University Hospital Heidelberg Germany Department of Radiology and Nuc

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and post-processing (66%). The “typical” lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work.

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SN2023ixf in Messier 101: A Variable Red Supergiant as the Progenitor Candidate to a Type II Supernova

arXiv

引用

arXiv 2023年

作者： Kilpatrick, Charles D. Foley, Ryan J. Jacobson-Galán, Wynn V. Piro, Anthony L. Smartt, Stephen J. Drout, Maria R. Gagliano, Alexander Gall, Christa Hjorth, Jens Jones, David O. Mandel, Kaisey S. Margutti, Raffaella Ramirez-Ruiz, Enrico Ransome, Conor L. Villar, V. Ashley Coulter, David A. Gao, Hua Matthews, David Jacob Taggart, Kirsty Zenati, Yossef Department of Physics and Astronomy Northwestern University EvanstonIL60208 United States Department of Astronomy and Astrophysics University of California Santa CruzCA95064 United States Department of Astronomy and Astrophysics University of California BerkeleyCA94720 United States The Observatories of the Carnegie Institution for Science 813 Santa Barbara St. PasadenaCA91101 United States Astrophysics Research Centre School of Mathematics and Physics Queen's University Belfast BelfastBT7 1NN United Kingdom Department of Physics University of Oxford Denys Wilkinson Building Keble Road OxfordOX1 3RH United Kingdom David A. Dunlap Department of Astronomy and Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada Department of Astronomy University of Illinois 1002 W. Green St. Urbana-ChampaignIL61801 United States Center for Astrophysical Surveys National Center for Supercomputing Applications UrbanaIL61801 United States DARK Niels Bohr Institute University of Copenhagen Jagtvej 128 Copenhagen2200 Denmark Gemini Observatory NSF's NOIRLab 670 N. A'ohoku Place HiloHI96720 United States Institute of Astronomy Kavli Institute for Cosmology Madingley Road CambridgeCB3 0HA United Kingdom Department of Astronomy and Astrophysics The Pennsylvania State University Davey Lab State College PA16802 United States Institute for Computational & Data Sciences The Pennsylvania State University University ParkPA United States Institute for Gravitation and the Cosmos The Pennsylvania State University University ParkPA16802 United States Institute for Astronomy University of Hawaii 2680 Woodlawn Drive HonoluluHI96822 United States Department of Physics and Astronomy The Johns Hopkins University BaltimoreMD21218 United States ISEF International Fellowship

We present pre-explosion optical and infrared (IR) imaging at the site of the type II supernova (SN II) 2023ixf in Messier 101 at 6.9 Mpc. We astrometrically registered a ground-based image of SN 2023ixf to archival Hubble Space Telescope (HST), Spitzer Space Telescope (Spitzer), and ground-based near-IR images. A single point source is detected at a position consistent with the SN at wavelengths ranging from HST R-band to Spitzer 4.5 µm. Fitting to blackbody and red supergiant (RSG) spectral-energy distributions (SEDs), we find that the source is anomalously cool with a significant mid-IR excess. We interpret this SED as reprocessed emission in a 8600 R☉ circumstellar shell of dusty material with a mass ∼5×10−5 M☉ surrounding a log(L/L☉) = 4.74 ±0.07 and Teff = 3920+200−160 K RSG. This luminosity is consistent with RSG models of initial mass 11 M☉, depending on assumptions of rotation and overshooting. In addition, the counterpart was significantly variable in pre-explosion Spitzer 3.6 µm and 4.5 µm imaging, exhibiting ∼70% variability in both bands correlated across 9 yr and 29 epochs of imaging. The variations appear to have a timescale of 2.8 yr, which is consistent with κ-mechanism pulsations observed in RSGs, albeit with a much larger amplitude than RSGs such as α Orionis (Betelgeuse). © 2023, CC BY.

关键词： Supernovae

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Learning from learning machines: A new generation of AI technology to meet the needs of science

arXiv

引用

arXiv 2021年

作者： Pion-Tonachini, Luca Bouchard, Kristofer Martin, Hector Garcia Peisert, Sean Holtz, W. Bradley Aswani, Anil Dwivedi, Dipankar Wainwright, Haruko Pilania, Ghanshyam Nachman, Benjamin Marrone, Babetta L. Falco, Nicola Prabhat Arnold, Daniel Wolf-Yadlin, Alejandro Powers, Sarah Climer, Sharlee Jackson, Quinn Carlson, Ty Sohn, Michael Zwart, Petrus Kumar, Neeraj Justice, Amy Tomlin, Claire Jacobson, Daniel Micklem, Gos Gkoutos, Georgios V. Bickel, Peter J. Cazier, Jean-Baptiste Müller, Juliane Webb-Robertson, Bobbie-Jo Stevens, Rick Anderson, Mark Kreutz-Delgado, Ken Mahoney, Michael W. Brown, James B. Pattern Computer Inc. Friday HarborWA98250 United States Biosciences Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Computational Research Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Helen Wils Neuroscience Institute Redwood Center for Theoretical Neuroscience Uc Berkeley BerkeleyCA94720 United States Doe Agile BioFoundry Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Joint BioEnergy Institute Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Bcam Basque Center for Applied Mathematics Bilbao48009 Spain Computer Science University of California Davis DavisCA95616 United States Cenic La MiradaCA90638 United States Health Informatics University of California Davis School of Medicine SacramentoCA95817 United States Berkeley Institute for Data Science University of California Berkeley BerkeleyCA94720 United States Industrial Engineering and Operations Research University of California Berkeley BerkeleyCA94720 United States Environmental & Earth Sciences Area Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Nuclear Engineering University of California Berkeley BerkeleyCA94720 United States Materials Science and Technology Division Los Alamos National Laboratory Los AlamosNM87545 United States Physics Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Bioscience Division Los Alamos National Laboratory Los AlamosNM87545 United States Earth and Environmental Sciences Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Energy Technologies Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Computing and Computational Sciences Oak Ridge National Laboratory Oak RidgeTN37831 United States Industrial & Systems Engineering The University of Tennessee KnoxvilleTN37996 United States Department of Computer Science University of Missouri-Saint Louis St. LouisMO63121 United

We outline emerging opportunities and challenges to enhance the utility of AI for scientific discovery. The distinct goals of AI for industry versus the goals of AI for science create tension between identifying patterns in data versus discovering patterns in the world from data. If we address the fundamental challenges associated with "bridging the gap" between domain-driven scientific models and data-driven AI learning machines, then we expect that these AI models can transform hypothesis generation, scientific discovery, and the scientific process itself. © 2021, CC BY.

关键词： Learning systems

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Computing integrals involved the gaussian function with a small standard deviation

arXiv

引用

arXiv 2018年

作者： Ma, Yunyun Ma, Yunyun Xu, Yuesheng Xu, Yuesheng School of Computer Science and Network Security Dongguan University of Technology Dongguan523808 China Department of Mathematics and Statistics Old Dominion University NorfolkVA23529 United States School of Data and Computer Science Guangdong Province Key Lab of Computational Science Sun Yat-sen University Guangzhou510275 China

We develop efficient numerical integration methods for computing an integral whose integrand is a product of a smooth function and the Gaussian function with a small standard deviation. Traditional numerical integration methods applied to the integral normally lead to poor accuracy due to the rapid change in high order derivatives of its integrand when the standard deviation is small. The proposed quadrature schemes are based on graded meshes designed according to the standard deviation so that the quadrature errors on the resulting subintervals are approximately equal. The integral in each subinterval is then computed by considering the Gaussian function as a weight function and interpolating the smooth factor of the integrand at the Chebyshev points of the first kind. For a finite order differentiable factor, we design a quadrature scheme having accuracy of a polynomial order and for an infinitely differentiable factor of the integrand, we design a quadrature scheme having accuracy of an exponential order. Numerical results are presented to confirm the accuracy of these proposed quadrature schemes. Copyright © 2018, The Authors. All rights reserved.

关键词： Statistics

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An Early Stage Researcher's Primer on Systems Medicine Terminology

Network and Systems Medicine

引用

Network and Systems Medicine 2021年第1期4卷 2-50页

作者： Zanin, Massimiliano Aitya, Nadim A.A. Basilio, José Baumbach, Jan Benis, Arriel Behera, Chandan K. Bucholc, Magda Castiglione, Filippo Chouvarda, Ioanna Comte, Blandine Dao, Tien-Tuan Ding, Xuemei Pujos-Guillot, Estelle Filipovic, Nenad Finn, David P. Glass, David H. Harel, Nissim Iesmantas, Tomas Ivanoska, Ilinka Joshi, Alok Boudjeltia, Karim Zouaoui Kaoui, Badr Kaur, Daman Maguire, Liam P. McClean, Paula L. McCombe, Niamh De Miranda, João Luís Moisescu, Mihnea Alexandru Pappalardo, Francesco Polster, Annikka Prasad, Girijesh Rozman, Damjana Sacala, Ioan Sanchez-Bornot, Jose M. Schmid, Johannes A. Sharp, Trevor Solé-Casals, Jordi Spiwok, Vojtěch Spyrou, George M. Stalidzans, Egils Stres, Blaa Sustersic, Tijana Symeonidis, Ioannis Tieri, Paolo Todd, Stephen Van Steen, Kristel Veneva, Milena Wang, Da-Hui Wang, Haiying Wang, Hui Watterson, Steven Wong-Lin, Kongfatt Yang, Su Zou, Xin Schmidt, Harald H.H.W. Centro de Tecnología Biomédica Universidad Politécnica de Madrid Madrid Spain Intelligent Systems Research Centre School of Computing Engineering and Intelligent Systems Ulster University Ulster United Kingdom Center for Physiology and Pharmacology Institute of Vascular Biology and Thrombosis Research Medical University of Vienna Vienna Austria TUM School of Life Sciences Weihenstephan Technical University of Munich Freising Germany Holon Israel CNR National Research Council IAC Institute for Applied Computing Rome Italy Lab of Computing Medical Informatics and Biomedical Imaging Technologies School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece Université Clermont Auvergne INRAE UNH Plateforme d'Exploration du Métabolisme MetaboHUB Clermont Clermont-Ferrand France Université de Technologie de Compiègne Compiègne France Labex MS2T Control of Technological Systems-of-Systems CNRS and Université de Technologie de Compiègne Compiègne France Faculty of Engineering University of Kragujevac Kragujevac Serbia Kragujevac Serbia Steinbeis Advanced Risk Technologies Institute Doo Kragujevac Kragujevac Serbia Pharmacology and Therapeutics School of Medicine Galway Neuroscience Centre National University of Ireland Galway Ireland School of Computing Ulster University Ulster United Kingdom Holon Israel Department of Mathematics and Natural Sciences Kaunas University of Technology Kaunas Lithuania Faculty of Computer Science and Engineering Ss. Cyril and Methodius University Skopje Macedonia Medicine Faculty Université Libre de Bruxelles CHU de Charleroi Charleroi Belgium Northern Ireland Centre for Stratified Medicine Biomedical Sciences Research Institute Ulster University Ulster United Kingdom Escola Superior de Tecnologia e Gestão Instituto Politécnico de Portalegre Portalegre Portugal Instituto Superior Técnico Universidade de Lisboa Lisboa Portugal Faculty of Automatic Control and Computers University Politehnica of B

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. These include both modeling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. Results: This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for digging into the topic. © Massimiliano Zanin et al., 2021;Published by Mary Ann Liebert, Inc. 2021.

关键词： Semantics

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Algebraic multigrid methods for saddle point systems arising from mortar contact formulations

arXiv

引用

arXiv 2019年

作者： Wiesner, Tobias A. Mayr, Matthias Popp, Alexander Gee, Michael W. Wall, Wolfgang A. Leica Geosystems AG Heinrich-Wild-Strasse 201 Heerbrugg9435 Switzerland Institute for Mathematics and Computer-Based Simulation University of the Bundeswehr Munich Werner-Heisenberg-Weg 39 NeubibergD-85577 Germany Data Science & Computing Lab University of the Bundeswehr Munich Werner-Heisenberg-Weg 39 NeubibergD-85577 Germany Mechanics & High Performance Computing Group Technical University of Munich Parkring 35 GarchingD-85748 Germany Institute for Computational Mechanics Technical University of Munich Boltzmannstr. 15 GarchingD-85748 Germany

In this paper, a fully aggregation-based algebraic multigrid strategy is developed for nonlinear contact problems of saddle point type using a mortar finite element approach. While the idea of extending multigrid methods to saddle point systems can already be found, e.g., in the context of Stokes and Oseen equations in literature, the main contributions of this work are (i) the development and open-source implementation of an interface aggregation strategy specifically suited for generating Lagrange multiplier aggregates that are required for coupling structural equilibrium equations with contact constraints and (ii) a review of saddle point smoothers in the context of constrained interface problems. The new interface aggregation strategy perfectly fits into an aggregation-based multigrid framework and can easily be combined with segregated transfer operators, which allow to preserve the saddle point structure on the coarse levels. Further analysis provides insight into saddle point smoothers applied to contact problems, while numerical experiments illustrate the robustness of the new method. We have implemented the proposed algorithm within the MueLu package of the open-source Trilinos project. Numerical examples demonstrate the robustness of the proposed method in complex dynamic contact problems as well as its scalability up to 23.9 million unknowns on 480 MPI ranks. Copyright © 2019, The Authors. All rights reserved.

关键词： Deformation

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The EXPRES Stellar-Signals Project II. State of the Field in Disentangling Photospheric Velocities

arXiv

引用

arXiv 2022年

作者： Zhao, Lily L. Fischer, Debra A. Ford, Eric B. Wise, Alex Cretignier, Michaël Aigrain, Suzanne Barragan, Oscar Bedell, Megan Buchhave, Lars A. Camacho, João D. Cegla, Heather M. Cisewski-Kehe, Jessi Cameron, Andrew Collier de Beurs, Zoe L. Dodson-Robinson, Sally Dumusque, Xavier Faria, João P. Gilbertson, Christian Haley, Charlotte Harrell, Justin Hogg, David W. Holzer, Parker John, Ancy Anna Klein, Baptiste Lafarga, Marina Lienhard, Florian Maguire-Rajpaul, Vinesh Mortier, Annelies Nicholson, Belinda Palumbo, Michael L. Delgado, Victor Ramirez Shallue, Christopher J. Vanderburg, Andrew Viana, Pedro T.P. Zhao, Jinglin Zicher, Norbert Cabot, Samuel H.C. Henry, Gregory W. Roettenbacher, Rachael M. Brewer, John M. Llama, Joe Petersburg, Ryan R. Szymkowiak, Andrew E. Department of Astronomy Yale University 52 Hillhouse Ave. New HavenCT06511 United States Center for Computational Astrophysics Flatiron Institute Simons Foundation 162 Fifth Avenue New YorkNY10010 United States CCA Team Department of Astronomy & Astrophysics 525 Davey Laboratory The Pennsylvania State University University ParkPA16802 United States Center for Exoplanets and Habitable Worlds 525 Davey Laboratory The Pennsylvania State University University ParkPA16802 United States Institute for Computational & Data Sciences The Pennsylvania State University University ParkPA16802 United States Institute for Advanced Sciences PennState Team Astronomy Department University of Geneva 51 Chemin de Pegasi 51 Versoix1290 Switzerland Geneva Team Sub-department of Astrophysics Department of Physics University of Oxford OxfordOX1 3RH United Kingdom OxBridGen Team DTU Space National Space Institute Technical University of Denmark Elektrovej 328 Kgs. Lyngby DK-2800 Denmark Instituto de Astrofísica e Ciências do Espaço Universidade do Porto CAUP Rua das Estrelas Porto4150-762 Portugal Departamento de Física e Astronomia Faculdade de Ciências Universidade do Porto Rua do Campo Alegre 687 Porto4169-007 Portugal Porto Team Department of Physics University of Warwick Gibbet Hill Road CoventryCV4 7AL United Kingdom Centre for Exoplanets and Habitability University of Warwick CoventryCV4 7AL United Kingdom Warwick Team Department of Statistics University of Wisconsin-Madison 1300 University Ave. MadisonWI53706 United States University of St Andrews Centre for Exoplanet Science SUPA School of Physics & Astronomy North Haugh St AndrewsKY16 9SS United Kingdom St. Andrews Team Department of Earth Atmospheric and Planetary Sciences Massachusetts Institute of Technology 77 Massachusetts Avenue 54-918 CambridgeMA02139 United States Department of Astronomy University of Texas at Austin 2515 Speedway AustinTX78712 United States ML EPRVs Team Dep

Measured spectral shifts due to intrinsic stellar variability (e.g., pulsations, granulation) and activity (e.g., spots, plages) are the largest source of error for extreme precision radial velocity (EPRV) exoplanet detection. Several methods are designed to disentangle stellar signals from true center-of-mass shifts due to planets. The EXPRES Stellar Signals Project (ESSP) presents a self-consistent comparison of 22 different methods tested on the same extreme-precision spectroscopic data from EXPRES. Methods derived new activity indicators, constructed models for mapping an indicator to the needed RV correction, or separated out shape- and shift-driven RV components. Since no ground truth is known when using real data, relative method performance is assessed using the total and nightly scatter of returned RVs and agreement between the results of different methods. Nearly all submitted methods return a lower RV RMS than classic linear decorrelation, but no method is yet consistently reducing the RV RMS to sub-meter-per-second levels. There is a concerning lack of agreement between the RVs returned by different methods. These results suggest that continued progress in this field necessitates increased interpretability of methods, high-cadence data to capture stellar signals at all timescales, and continued tests like the ESSP using consistent data sets with more advanced metrics for method performance. Future comparisons should make use of various well-characterized data sets—such as solar data or data with known injected planetary and/or stellar signals—to better understand method performance and whether planetary signals are preserved. Copyright © 2022, The Authors. All rights reserved.

关键词： Spectrometers

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