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Abstracts from the 15th International Myopia Conference

Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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Hydrodynamic interaction between overlapping domains during recurrence of registration within planar lipid bilayer membranes

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Physical Review E 2014年第3期89卷 032717-032717页

作者： Tao Han Trevor P. Bailey Mikko Haataja Department of Mechanical and Aerospace Engineering Princeton Institute for the Science and Technology of Materials (PRISM) and Program in Applied and Computational Mathematics (PACM) Princeton University Princeton New Jersey 08544 USA

Due to a thermodynamic coupling between the two leaflets comprising a lipid bilayer, compositional lipid domains residing within opposing leaflets are often found in registry. If the system is perturbed by displacing one domain relative to the other, diffusive and advective lipid fluxes are established to restore equilibrium and reestablish domain overlap. In this work, we focus on the advective part of the process, and first derive an analytical expression for the hydrodynamic drag coefficient associated with the advective flow for the special case of perfect domain overlap. The resulting expression identifies parameter regions where sliding friction between the leaflets dominates over viscous dissipation within the leaflets or vice versa. It is shown that in all practically relevant cases, sliding friction between the leaflets is the dominant factor. Finally, we investigate the domain separation dependence of the hydrodynamic drag coefficient via direct simulations of a continuum diffuse interface model, and provide useful empirical expressions for its behavior.

关键词： HYDRODYNAMICS BILAYER lipid membranes DRAG coefficient ENERGY dissipation SLIDING friction FLUX (Energy)

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Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

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Nature communications 2018年第1期9卷 4651页

作者： Suzana A Kahn Xin Wang Ryan T Nitta Sharareh Gholamin Johanna Theruvath Gregor Hutter Tej D Azad Lina Wadi Sara Bolin Vijay Ramaswamy Rogelio Esparza Kun-Wei Liu Michael Edwards Fredrik J Swartling Debashis Sahoo Gordon Li Robert J Wechsler-Reya Jüri Reimand Yoon-Jae Cho Michael D Taylor Irving L Weissman Siddhartha S Mitra Samuel H Cheshier Division of Pediatric Neurosurgery Lucile Packard Children's Hospital Stanford University School of Medicine Stanford 94305 California USA. suzanakahn@***. Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center Stanford University School of Medicine Stanford 94305 California USA. suzanakahn@***. Department of Neurosurgery Stanford University School of Medicine Stanford 94305 California USA. suzanakahn@***. Ludwig Institute for Cancer Research Stanford University School of Medicine Stanford 94305 California USA. suzanakahn@***. Division of Neurosurgery Arthur and Sonia Labatt Brain Tumor Research Centre Hospital for Sick Children University of Toronto Toronto M5G 0A4 Ontario Canada. Department of Neurosurgery Stanford University School of Medicine Stanford 94305 California USA. Division of Pediatric Neurosurgery Lucile Packard Children's Hospital Stanford University School of Medicine Stanford 94305 California USA. Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center Stanford University School of Medicine Stanford 94305 California USA. Computational Biology Program Ontario Institute for Cancer Research Toronto M5G 0A3 Ontario Canada. Department of Immunology Genetics and Pathology Science for Life Laboratory Rudbeck Laboratory Uppsala University Uppsala 75185 Sweden. Tumor Initiation and Maintenance Program Sanford Burnham Prebys Medical Discovery Institute 2880 Torrey Pines Scenic Drive La Jolla 92037 California USA. Ludwig Institute for Cancer Research Stanford University School of Medicine Stanford 94305 California USA. Department of Pediatrics and Department of Computer Science and Engineering University of California San Diego San Diego 92093 California USA. Department of Medical Biophysics University of Toronto Toronto M5G 1L7 Ontario Canada. Department of Pediatrics Children's Hospital Colorado University of Colorado School of Medicine Room No. P18-4114 Research

The original version of this Article omitted Suzana A. Kahn, Siddhartha S. Mitra & Samuel H. Cheshier as jointly supervising authors. This has now been corrected in both the PDF and HTML versions of the Article.

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Abstracts from the 3rd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects

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Molecular Cytogenetics 2017年第2期10卷 77-94页

作者： Athel Cornish-Bowden David Rasnick Henry H. Heng Steven Horne Batoul Abdallah Guo Liu Christine J. Ye Mathew Bloomfield Mark D. Vincent C. Marcelo Aldaz Jenny Karlsson Anders Valind Caroline Jansson David Gisselsson Jennifer A. Marshall Graves Aleksei A. Stepanenko Svitlana V. Andreieva Kateryna V. Korets Dmytro O. Mykytenko Stanislav S. Avdieiev Nataliya L. Huleyuk Vladimir P. Baklaushev Oksana A. Kovaleva Vladimir P. Chekhonin Yegor S. Vassetzky Bjorn Bakker Aaron S. Taudt Mirjam E. Belderbos David Porubsky Diana C. J. Spierings Tristan V. de Jong Nancy Halsema Hinke G. Kazemier Karina Hoekstra-Wakker Victor Guryev Peter M. Lansdorp Maria Colomé Tatché Floris Foijer Allan Bradley Eveline S. J. M. de Bont Anke van den Berg Thomas Liehr Nicolaas C. Baudoin Joshua M. Nicholson Kimberly Soto Daniela Cimini Isabel Quintanilla Jordi Camps M. Dürrbaum N. Donnelly V. Passerini C. Kruse Z. Storchová B. Habermann Daniele Mandrioli Fiorella Belpoggi Ellen K Silbergeld Melissa J Perry Rolf I. Skotheim Marthe Løvf Bjarne Johannessen Andreas M. Hoff Sen Zhao Jonas M. SveeStrømme Anita Sveen Ragnhild A. Lothe R. Hehlmann A. Voskanyan A. Fabarius Alfred Böcking Stefan Biesterfeld Leonid Berynskyy Christof Börgermann Rainer Engers Josef Dietz A. Fritz N. Page C. Tye G. Stein J. Stein N. Sehgal R. Berezney J. Vecerova B. Stojkovicz H. Ding J. Xu S. Bhattacharya Xue Gong Sarah Grasedieck Julian Swoboda Jonathan R. Pollack Frank G. Rücker Lars Bullinger Fani-Marlen Roumelioti Maria Chiourea Christina Raftopoulou Sarantis Gagos Peter Duesberg Mat Bloomfield Sunyoung Hwang Hans Tobias Gustafsson Ciara O’Sullivan Aracelli Acevedo-Colina Eduardo M. Torres Xinhe Huang Robert C. Dickson Christian Klose Andrej Schevchenko Paola Cavaliere Noah Dephoure Martha R. Stampfer Mark A. LaBarge James C. Garbe Lukas Vrba Bernard Futscher Yi-Hong Zhou Andrew L. Trinh Michelle Digman Directeur de Recherche (Émérite) Centre National de la Recherche Scientifique (CNRS) Marseilles France 549 Fairbanks Ave. Oakland California 94610 USA Wayne State University School of Medicine Detroit MI USA University of Michigan School of Medicine Ann Arbor MI USA Department of Molecular and Cell Biology UC Berkeley Donner Lab Berkeley CA USA Department of Natural Sciences and Mathematics Dominican University of California San Rafael CA USA Department of Medical Oncology London Regional Cancer Program London Ontario N6A 4L6 Canada Department of Epigenetics and Molecular Carcinogenesis University of Texas M.D. Anderson Cancer Center Science Park Smithville TX 78957 USA Department of Laboratory Medicine Division of Clinical Genetics Lund University Lund SE221 84 Sweden Department of Clinical Sciences Division of Oncology and Pathology Lund University Lund SE221 85 Sweden Skåne Regional and Univeristy Laboratories Department of Pathology Lund SE221 85 Sweden School of Life Sciences La Trobe University Melbourne Vic 3168 Australia Department of Functional Genomics Institute of Molecular Biology and Genetics Kyiv 03680 Ukraine Institute of Hereditary Pathology National Academy of Medical Sciences of Ukraine Lviv 79008 Ukraine Federal Research and Clinical Center FMBA of Russia Moscow 115682 Russia R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology Kyiv 03022 Ukraine V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology Ministry of Health of the Russian Federation Moscow 119034 Russia Department of Medicinal Nanobiotechnology Pirogov Russian State Medical University Moscow 117997 Russia CNRS UMR8126 Université Paris-Sud 11 Institut de Cancérologie Gustave Roussy Villejuif 94805 France European Research Institute for the Biology of Ageing University of Groningen University Medical Center Groningen A. Deusinglaan 1 NL-9713 AV Groningen The Netherlands Department of Paediatrics University

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Ground and excited state properties of high performance anthocyanidin dyes-sensitized solar cells in the basic solutions

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AIP Conference Proceedings 2015年第1期1677卷

作者： Eka Cahya Prima Brian Yuliarto Suyatman Hermawan Kresno Dipojono 1Advanced Functional Material Laboratory Engineering Physics Institut Teknologi Bandung Indonesia 2Computational Material Design and Quantum Engineering Laboratory Engineering Physics Institut Teknologi Bandung Indonesia 3International Program on Science Education Universitas Pendidikan Indonesia Indonesia

The aglycones of anthocyanidin dyes were previously reported to form carbinol pseudobase, cis-chalcone, and trans-chalcone due to the basic levels. The further investigations of ground and excited state properties of the dyes were characterized using density functional theory with PCM(UFF)/B3LYP/6-31+G(d,p) level in the basic solutions. However, to the best of our knowledge, the theoretical investigation of their potential photosensitizers has never been reported before. In this paper, the theoretical photovoltaic properties sensitized by dyes have been successfully investigated including the electron injections, the ground and excited state oxidation potentials, the estimated open circuit voltages, and the light harvesting efficiencies. The results prove that the electronic properties represented by dyes’ LUMO-HOMO levels will affect to the photovoltaic performances. Cis-chalcone dye is the best anthocyanidin aglycone dye with the electron injection spontaneity of −1.208 eV, the theoretical open circuit voltage of 1.781 V, and light harvesting efficiency of 56.55% due to the best HOMO-LUMO levels. Moreover, the ethanol solvent slightly contributes to the better cell performance than the water solvent dye because of the better oxidation potential stabilization in the ground state as well as in the excited state. These results are in good agreement with the known experimental report that the aglycones of anthocyanidin dyes in basic solvent are the high potential photosensitizers for dye-sensitized solar cell.

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High-order continuum kinetic method for modeling plasma dynamics in phase space

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AIP Conference Proceedings 2014年第1期1639卷 146-149页

作者： G. V. Vogman P. Colella U. Shumlak Applied Science & Technology Program University of California Berkeley Berkeley CA 94720 USA Computational Research Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA and Department of Electrical Engineering & Computer Science University of California Berkeley CA 94720 USA Aerospace & Energetic Research Program University of Washington Seattle WA 98195 USA

Continuum methods offer a high-fidelity means of simulating plasma kinetics. While computationally intensive, these methods are advantageous because they can be cast in conservation-law form, are not susceptible to noise, and can be implemented using high-order numerical methods. Advances in continuum method capabilities for modeling kinetic phenomena in plasmas require the development of validation tools in higher dimensional phase space and an ability to handle non-cartesian geometries. To that end, a new benchmark for validating Vlasov-Poisson simulations in 3D (x,vx,vy) is presented [1]. The benchmark is based on the Dory-Guest-Harris instability and is successfully used to validate a continuum finite volume algorithm. To address challenges associated with non-cartesian geometries, unique features of cylindrical phase space coordinates are described. Preliminary results of continuum kinetic simulations in 4D (r,z,vr,vz) phase space are presented.

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A web-based, hospital-wide health care-associated bloodstream infection surveillance and classification system: Development and evaluation

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JMIR Medical Informatics 2015年第3期3卷 e31页

作者： Tseng, Yi-Ju Wu, Jung-Hsuan Lin, Hui-Chi Chen, Ming-Yuan Ping, Xiao-Ou Sun, Chun-Chuan Shang, Rung-Ji Sheng, Wang-Huei Chen, Yee-Chun Lai, Feipei Chang, Shan-Chwen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Computational Health Informatics Program Boston Children's Hospital Boston MA United States Department of Electrical Engineering National Taiwan University Taipei Taiwan Center for Infection Control National Taiwan University Hospital Taipei Taiwan National Taiwan University Hospital Information Systems Office Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan Department of Internal Medicine National Taiwan University Hospital and College of Medicine Taipei Taiwan National Health Research Institutes National Institute of Infectious Diseases and Vaccinology Miaoli Taiwan

Background: Surveillance of health care-associated infections is an essential component of infection prevention programs, but conventional systems are labor intensive and performance dependent. Objective: To develop an automatic surveillance and classification system for health care-associated bloodstream infection (HABSI), and to evaluate its performance by comparing it with a conventional infection control personnel (ICP)-based surveillance system. Methods: We developed a Web-based system that was integrated into the medical information system of a 2200-bed teaching hospital in Taiwan. The system automatically detects and classifies HABSIs. Results: In this study, the number of computer-detected HABSIs correlated closely with the number of HABSIs detected by ICP by department (n=20;r=.999 P<.001) and by time (n=14;r=.941;P<.001). Compared with reference standards, this system performed excellently with regard to sensitivity (98.16%), specificity (99.96%), positive predictive value (95.81%), and negative predictive value (99.98%). The system enabled decreasing the delay in confirmation of HABSI cases, on average, by 29 days. Conclusions: This system provides reliable and objective HABSI data for quality indicators, improving the delay caused by a conventional surveillance system. © 2020 JMIR Publications Inc. All rights reserved.

关键词： Health care-associated infection Infection control Information systems Surveillance Web-based services

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Toward the Multi-scale Simulation for a Human Body Using the Next-generation Supercomputer

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Procedia IUTAM 2014年 10卷 193-200页

作者： Yoichiro Matsumoto Satoshi Ii Seiji Shiozaki Kazuyasu Sugiyama Shu Takagi School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Department of Mechanical Science and Bioengineering Osaka University 1-1 Machikaneyama Toyonaka Osaka 560-0043 Japan Computational Science Research Program RIKEN 2-1 Hirosawa Wako Saitama 351-0198 Japan

We have developed novel numerical methods for fluid-structure and fluid-membrane interaction problems. The basic equation set is formulated in a full Eulerian framework. The method is based on the finite difference volume-of-fluid scheme with fractional step algorithm. It is validated through a numerical solution to a deformable vesicle problem, and applied to blood flows including red blood cells (RBCs) and platelets. Further, to gain insight into the mechanism of thrombus formation, a stochastic Monte Carlo model to describe the platelet-vessel wall interaction is incorporated into the Eulerian method. The effect of the RBCs on the platelet motion is discussed.

关键词： Eulerian method fluid-structure interaction blood flow stochastic Monte Carlo method

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Discrete time optimal control applied to pest control problems

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Involve 2014年第4期7卷 479-489页

作者： Ding, Wandi Hendon, Raymond Cathey, Brandon Lancaster, Evan Germick, Robert Department of Mathematical Sciences Middle Tennessee State University Murfreesboro 37132 TN United States Computational Science Program Middle Tennessee State University Murfreesboro 37132 TN United States Department of Physics and Astronomy University of Tennessee Knoxville Knoxville 37996 TN United States Department of University Studies Middle Tennessee State University Murfreesboro 37132 TN United States Department of Electrical Engineering University of Tennessee Knoxville 37996 TN United States

We apply discrete time optimal control theory to the mathematical modeling of pest control. Two scenarios: biological control and the combination of pesticide and biological control are considered. The goal is maximizing the “valuable” population, minimizing the pest population and the cost to apply the control strategies. Using the extension of Pontryagin’s maximum principle to discrete system, the adjoint systems and the characterization of the optimal pest controls are derived. Numerical simulations of various cases are provided to show the effectiveness of our methods. © 2014 Mathematical sciences Publishers.

关键词： biological pest control discrete model optimal control pesticide

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Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

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BMC pharmacology & toxicology 2017年第SUPPL 1期18卷 64-64页

作者： Todd Milne, G. Sandner, Peter Lincoln, Kathleen A. Harrison, Paul C. Chen, Hongxing Wang, Hong Clifford, Holly Qian, Hu Sheng Wong, Diane Sarko, Chris Fryer, Ryan Richman, Jeremy Reinhart, Glenn A. Boustany, Carine M. Pullen, Steven S. Andresen, Henriette Moltzau, Lise Román Cataliotti, Alessandro Levy, Finn Olav Lukowski, Robert Frankenreiter, Sandra Friebe, Andreas Calamaras, Timothy Baumgartner, Robert McLaughlin, Angela Aronovitz, Mark Baur, Wendy Wang, Guang-Rong Kapur, Navin Karas, Richard Blanton, Robert Hell, Stefan Waldman, Scott A. Lin, Jieru E. Colon-Gonzalez, Francheska Kim, Gilbert W. Blomain, Erik S. Merlino, Dante Snook, Adam Erdmann, Jeanette Wobst, Jana Kessler, Thorsten Schunkert, Heribert Walter, Ulrich Pagel, Oliver Walter, Elena Gambaryan, Stepan Smolenski, Albert Jurk, Kerstin Zahedi, Rene Klinger, James R. Benza, Raymond L. Corris, Paul A. Langleben, David Naeije, Robert Simonneau, Gérald Meier, Christian Colorado, Pablo Chang, Mi Kyung Busse, Dennis Hoeper, Marius M. Masferrer, Jaime L. Jacobson, Sarah Liu, Guang Sarno, Renee Bernier, Sylvie Zhang, Ping Flores-Costa, Roger Currie, Mark Hall, Katherine Möhrle, Dorit Reimann, Katrin Wolter, Steffen Wolters, Markus Mergia, Evanthia Eichert, Nicole Geisler, Hyun-Soon Ruth, Peter Feil, Robert Zimmermann, Ulrike Koesling, Doris Knipper, Marlies Rüttiger, Lukas Tanaka, Yasutake Okamoto, Atsuko Nojiri, Takashi Kumazoe, Motofumi Tokudome, Takeshi Miura, Koichi Hino, Jun Hosoda, Hiroshi Miyazato, Mikiya Kangawa, Kenji Kapil, Vikas Ahluwalia, Amrita Paolocci, Nazareno Eaton, Philip Campbell, James C. Henning, Philipp Franz, Eugen Sankaran, Banumathi Herberg, Friedrich W. Kim, Choel Wittwer, M. Luo, Q. Kaila, V. Dames, S. A. Tobin, Andrew Alam, Mahmood Rudyk, Olena Krasemann, Susanne Hartmann, Kristin Prysyazhna, Oleksandra Zhang, Min Zhao, Lan Weiss, Astrid Schermuly, Ralph Moyes, Amie J. Chu, Sandy M. Baliga, Reshma S. Hobbs, Adrian J. Michalakis, Stylianos Mühlfriedel, Regine Schön, Christian Fischer, Dominik M. Wilhelm, Barbara Zobor, Ditta Kohl, Ironwood Pharmaceuticals Cambridge USA Bayer AG Drug Discovery - Cardiovascular Research Wuppertal Germany Department of Cardiometabolic Diseases Research Boehringer Ingelheim Pharmaceuticals Ridgefield USA Department of Small Molecule Drug Research Boehringer Ingelheim Pharmaceuticals Ridgefield USA Department of Pharmacology University of Oslo and Oslo University Hospital Oslo Norway Institute of Experimental Medical Research University of Oslo and Oslo University Hospital Oslo Norway Center for Heart Failure Research University of Oslo and Oslo University Hospital Oslo Norway Department of Pharmacology Toxicology and Clinical Pharmacy Institute of Pharmacy University of Tuebingen Tuebingen Germany Physiologisches Institut Universität Würzburg Würzburg Germany Molecular Cardiology Research Institute Tufts Medical Center Boston USA Present Affiliation: Division of Cardiology University of Pittsburgh Medical Center Pittsburgh USA Present Affiliation: Department of Medicine Brown University School of Medicine Providence USA Division of Cardiology Tufts Medical Center Boston USA Max Planck Institute for Biophysical Chemistry Göttingen and German Cancer Research Center (DKFZ) Heidelberg Germany Department of Pharmacology and Experimental Therapeutics Thomas Jefferson University Philadelphia USA Institut für Kardiogenetik and Universitäres Herzzentrum Lübeck Universität zu Lübeck Lübeck Germany & DZHK e.V. (German Center for Cardiovascular Research) Partner Site Hamburg/Kiel/Lübeck Lübeck Germany Deutsches Herzzentrum München Klinik für Herz- und Kreislauferkrankungen Technische Universität München Munich Germany Center for Thrombosis & Hemostasis Universitätsklinikum der Johannes Gutenberg-Universität Mainz Mainz Germany Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V Dortmund Germany Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences St. Petersburg Russia UCD Conway Institute UCD School of Medicine

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