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Publisher Correction: Accurate estimation of cell composition in bulk expression through robust integration of single-cell information

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Nature communications 2020年第1期11卷 2891页

作者： Brandon Jew Marcus Alvarez Elior Rahmani Zong Miao Arthur Ko Kristina M Garske Jae Hoon Sul Kirsi H Pietiläinen Päivi Pajukanta Eran Halperin Bioinformatics Interdepartmental Program UCLA Los Angeles CA 90095 USA. Department of Human Genetics David Geffen School ofMedicine at UCLA Los Angeles CA 90095 USA. Department of Computer Science School of Engineering UCLA Los Angeles CA 90095 USA. Department of Psychiatry and Biobehavioral Sciences UCLA Los Angeles CA 90095 USA. Obesity Research Unit Research Program for Clinical and Molecular Metabolism University of Helsinki Helsinki 00014 Finland. Obesity Center Endocrinology Abdominal Center Helsinki University Central Hospital and University of Helsinki Helsinki 00260 Finland. Bioinformatics Interdepartmental Program UCLA Los Angeles CA 90095 USA. ppajukanta@mednet.ucla.edu. Department of Human Genetics David Geffen School ofMedicine at UCLA Los Angeles CA 90095 USA. ppajukanta@mednet.ucla.edu. Institute for Precision Health School of Medicine UCLA Los Angeles CA 90095 USA. ppajukanta@mednet.ucla.edu. Department of Human Genetics David Geffen School ofMedicine at UCLA Los Angeles CA 90095 USA. ehalperin@cs.ucla.edu. Department of Computer Science School of Engineering UCLA Los Angeles CA 90095 USA. ehalperin@cs.ucla.edu. Department of Anesthesiology UCLA Health Los Angeles CA 90095 USA. ehalperin@cs.ucla.edu. Department of Computational Medicine School of Medicine UCLA Los Angeles CA 90095 USA. ehalperin@cs.ucla.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Genome-wide association study of long COVID

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Nature Genetics 2025年 1-16页

作者： Vilma Lammi Tomoko Nakanishi Samuel E. Jones Juha Karjalainen Martin Broberg Hele H. Haapaniemi Matti Pirinen Mari E. K. Niemi Mattia Cordioli Mark J. Daly Andrea Ganna Hanna M. Ollila J. Brent Richards Yukinori Okada Shea J. Andrews Beatriz Cortés Rafael de Cid Susana Iraola-Guzmán Natalia Blay Xavier Farré Heath E. O’Brien Thompson Hannah Patrick J. Short Ana Ochoa-Guzman Michelle Duran-Gomez Brian E. Fulton-Howard Masahiro Kanai Axel Schmidt Daniella Balla Julia Heggemann Sonja Schultz Pari Behzad Markus M. Nöthen Abigail Miller Kerstin U. Ludwig Ruth E. Mitchell George Davey Smith Nicholas J. Timpson Abdou Mousas Evangelos Evangelou Evangelia Ntzani Konstantinos K. Tsilidis Massimo Mangino Alicia Huerta-Chagoya Nasa Sinnott-Armstrong Elizabeth T. Cirulli Francisco Tanudjaja Efren Sandoval Nicole L. Washington Simon White Alexandre Bolze Kelly M. Schiabor Barrett Marc Vaudel Alex S. F. Kwong Amit K. Maiti Minttu M. Marttila Daniel C. Posner Alexis A. Rodriguez Chiara Batini Beatriz Guillen-Guio Olivia C. Leavy Anna L. Guyatt Catherine John Louise V. Wain Francesca Minnai Anna R. Dearman Benedict Hignell Meena Kumari C. A. Robert Warmerdam Lude H. Franke Celia B. Sequeros Søren Brunak David Westergaard Karina Banasik Thomas W. Winkler Iris M. Heid Daniel M. Jordan Ryan C. Thompson Alexander W. Charney Laura G. Sloofman Nicole W. Simons Noam D. Beckmann Raimonds Rešcenko Vita Rovite Peculis Raitis Monta Briviba Janis Klovinš Laura Ansone Lorenzo Miano Flora Peyvandi Francesco Malvestiti Nicola Montano Alessandra Bandera Francesco Bruno Arturo Blasi Jacqueline M. Lane Jakob M. Cherry Ryan K. Chung Laura Carvajal-Silva Kevin Aguilar-Valdés Leslie C. Cerpa Tamara V. Arévalo Eduardo Lamoza Alicia Colombo Ricardo A. Verdugo Erika Frangione Xu Xinyi Jennifer Taher Jordan Lerner-Ellis Lindsay Guare Shefali S. Verma Ekaterina Vergasova Michil Trofimov Layal Shaheen Nikolay Plotnikov Anna Kim Dmitrii Kharitonov Alexei Kamelin Alexander Rakitko Eirini Marouli Pasquale Striano Ummu Afeera Zainulabid Ashutosh Kumar Hajar Fa Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland Department of Human Genetics McGill University Montreal Quebec Canada Centre for Clinical Epidemiology Department of Medicine Lady Davis Institute Jewish General Hospital McGill University Montreal Quebec Canada Kyoto-McGill International Collaborative Program in Genomic Medicine Graduate School of Medicine Kyoto University Kyoto Japan Department of Genome Informatics Graduate School of Medicine the University of Tokyo Tokyo Japan Research Fellow Japan Society for the Promotion of Science Tokyo Japan Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA USA Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA USA Department of Mathematics and Statistics University of Helsinki Helsinki Finland Department of Public Health University of Helsinki Helsinki Finland Broad Institute Cambridge MA USA Analytical and Translational Genetics Unit Massachusetts General Hospital Harvard Medical School Boston MA USA Center for Genomic Medicine Massachusetts General Hospital Boston MA USA Anesthesia Critical Care and Pain Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Twin Research King’s College London London UK 5 Prime Sciences Inc Montreal Quebec Canada Department of Epidemiology Biostatistics and Occupational Health McGill University Montreal Quebec Canada Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan Laboratory for Systems Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Laboratory of Statistical Immunology Immunology Frontier Research Center (WPI-IFReC) Osaka University Suita Japan Departmen

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association ofFOXP4with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID.

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Remembering the work of Phillip L. Geissler: A coda to his scientific trajectory

arXiv

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arXiv 2023年

作者： Bowman, Gregory R. Cox, Stephen J. Dellago, Christoph DuBay, Kateri H. Eaves, Joel D. Fletcher, Daniel A. Frechette, Layne B. Grünwald, Michael Klymko, Katherine Ku, JiYeon Omar, Ahmad K. Rabani, Eran Reichman, David R. Rogers, Julia R. Rosnik, Andreana M. Rotskoff, Grant M. Schneider, Anna R. Schwierz, Nadine Sivak, David A. Vaikuntanathan, Suriyanarayanan Whitelam, Stephen Widmer-Cooper, Asaph Bioengineering Biochemistry and Biophysics University of Pennsylvania PA19104 United States Yusuf Hamied Department of Chemistry University of Cambridge Lensfield Road CambridgeCB2 1EW United Kingdom Faculty of Physics University of Vienna Vienna1090 Austria Department of Chemistry University of Virginia CharlottesvilleVA22903 United States Department of Chemistry University of Colorado Boulder BoulderCO80309 United States Department of Bioengineering & Biophysics Program University of California Berkeley Berkeley United States Division of Biological Systems & Engineering Lawrence Berkeley National Laboratory Berkeley United States Chan Zuckerberg Biohub San Francisco United States Martin A. Fisher School of Physics Brandeis University WalthamMA02454 United States Department of Chemistry University of Utah Salt Lake City84112 United States Lawrence Berkeley National Lab BerkeleyCA94720 United States Co. Ltd Suwon16229 Korea Republic of Department of Materials Science and Engineering University of California BerkeleyCA94720 United States Materials Sciences Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Department of Chemistry University of California BerkeleyCA94720 United States Materials Sciences Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States The Raymond and Beverly Sackler Center Computational Molecular and Materials Science Tel Aviv University Tel Aviv69978 Israel Department of Chemistry Columbia University New YorkNY United States Department of Systems Biology Columbia University New YorkNY10032 United States Atomwise San FranciscoCA94103 United States Department of Chemistry Stanford University StanfordCA94305 United States Form Energy BerkeleyCA94710 United States Institute of Physics University of Augsburg Germany Department of Physics Simon Fraser University BurnabyBCV5A1S6 Canada Department of Chemistry University of Chicago ChicagoIL6063

Phillip L. Geissler made important contributions to the statistical mechanics of biological polymers, heterogeneous materials, and chemical dynamics in aqueous environments. He devised analytical and computational methods that revealed the underlying organization of complex systems at the frontiers of biology, chemistry, and materials science. In this retrospective, we celebrate his work at these frontiers. Copyright © 2023, The Authors. All rights reserved.

关键词： Statistical mechanics

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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Author Correction: T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control

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Nature immunology 2023年第4期24卷 729页

作者： Maria M Steele Abhinav Jaiswal Ines Delclaux Ian D Dryg Dhaarini Murugan Julia Femel Sunny Son Haley du Bois Cameron Hill Sancy A Leachman Young H Chang Lisa M Coussens Niroshana Anandasabapathy Amanda W Lund Ronald O. Perelman Department of Dermatology NYU Grossman School of Medicine New York University Langone Health New York NY USA. Department of Cell Developmental and Cancer Biology and Knight Cancer Institute Oregon Health and Science University Portland OR USA. Department of Dermatology Microbiology and Immunology Meyer Cancer Center Englander Institute of Precision Medicine Weill Cornell Medicine New York NY USA. Applied Bioinformatics Laboratories NYU Langone Health New York NY USA. Department of Dermatology Oregon Health and Science University Portland OR USA. Department of Biomedical Engineering and Computational Biology Program Oregon Health and Science University Portland OR USA. OHSU Center for Spatial Systems Biomedicine Oregon Health and Science University Portland OR USA. Ronald O. Perelman Department of Dermatology NYU Grossman School of Medicine New York University Langone Health New York NY USA. amanda.lund@***. Department of Cell Developmental and Cancer Biology and Knight Cancer Institute Oregon Health and Science University Portland OR USA. amanda.lund@***. Department of Pathology NYU Grossman School of Medicine New York University Langone Health New York NY USA. amanda.lund@***. Laura and Isaac Perlmutter Cancer Center NYU Grossman School of Medicine New York University Langone Health New York NY USA. amanda.lund@***.

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Concurrent starbursts in molecular gas disks within a pair of colliding galaxies at z = 1.52

arXiv

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arXiv 2018年

作者： Silverman, J.D. Daddi, E. Rujopakarn, W. Renzini, A. Mancini, C. Bournaud, F. Puglisi, A. Rodighiero, G. Liu, D. Sargent, M. Arimoto, N. Béthermin, M. Fensch, J. Hayward, C.C. Kartaltepe, J. Kashino, D. Koekemoer, A. Magdis, G. McCracken, H.J. Nagao, T. Sheth, K. Smolčić, V. Valentino, F. Kavli Institute for the Physics and Mathematics of the Universe University of Tokyo Kashiwa277-8583 Japan Laboratoire AIM CEA/DSM-CNRS-Universite Paris Diderot Irfu/Service d'Astrophysique CEA Saclay Department of Physics Faculty of Science Chulalongkorn University 254 Phayathai Road Pathumwan Bangkok10330 Thailand Don Kaeo Mae Rim Chiang Mai50180 Thailand Kavli Institute for the Physics and Mathematics of the Universe Todai Institutes for Advanced Study University of Tokyo Kashiwa277-8583 Japan Instituto Nazionale de Astrofisica Osservatorio Astronomico di Padova v.co dell'Osservatorio 5 PadovaI-35122 Italy Dipartimento di Fisica e Astronomia Universita di Padova vicolo Osservatorio 3 Padova35122 Italy Astronomy Centre Department of Physics and Astronomy University of Sussex BrightonBN1 9QH United Kingdom Astronomy Program Department of Physics and Astronomy Seoul National University 599 Gwanak-ro Gwanak-gu Seoul151-742 Korea Republic of Subaru Telescope 650 North A'ohoku Place Hilo Hawaii96720 United States European Southern Observatory Karl-Schwarzschild-Str. 2 Garching85748 Germany European Southern Observatory Karl-Schwarzschild-Str. 2 Garching bei München85748 Germany Center for Computational Astrophysics Flatiron Institute 162 Fifth Avenue New YorkNY10010 United States School of Physics and Astronomy Rochester Institute of Technology 84 Lomb Memorial Drive RochesterNY14623 United States Institute of Astronomy ETH Zürich Wolfgang-Pauli-Strasse 27 ZürichCH-8093 Switzerland Space Telescope Science Institute 3700 San Martin Drive BaltimoreMD21218 United States Cosmic DAWN Centre Niels Bohr Institute University of Copenhagen Juliane Mariesvej 30 Copenhagen2100 Denmark Institut d'Astrophysique de Paris CNRS UMR 7095 and UPMC 98bis boulevard Arago ParisF-75014 France Graduate School of Science and Engineering Ehime University 2-5 Bunkyo-cho Matsuyama790-8577 Japan NASA Headquaters 300 E. St SW WashingtonDC2054

We report on the discovery of a merger-driven starburst at z = 1:52, PACS-787, based on high signal-to-noise ALMA observations. CO(5-4) and continuum emission (850μm) at a spatial resolution of 0.3" reveal two compact (r1/2 ∼ 1 kpc) and interacting molecular gas disks at a separation of 8.6 kpc thus indicative of an early stage in a merger. With a SFR of 991 Mo yr-1, this starburst event should occur closer to final coalescence, as usually seen in hydrodynamical simulations. From the CO size, inclination, and velocity profile for both disks, the dynamical mass is calculated through a novel method that incorporates a calibration using simulations of galaxy mergers. Based on the dynamical mass, we measure (1) the molecular gas mass, independent from the CO luminosity, (2) the ratio of the total gas mass and the CO(1 - 0) luminosity (αCO ≡ Mgas/L'CO1-0), and (3) the gas-to-dust ratio, with the latter two being lower than typically assumed. We find that the high star formation, triggered in both galaxies, is caused by a set of optimal conditions: a high gas mass/fraction, a short depletion time (τdepl = 85 and 67 Myrs) to convert gas into stars, and the interaction of likely counter-rotating molecular disks that may accelerate the loss of angular momentum. The state of interaction is further established by the detection of di_use CO and continuum emission, tidal debris that bridges the two nuclei and is associated with stellar emission seen by HST/WFC3. This observation demonstrates the power of ALMA to study the dynamics of galaxy mergers at high redshift. Copyright © 2018, The Authors. All rights reserved.

关键词： Galaxies

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Mapping the Human Body at Cellular Resolution -- The NIH Common Fund Human BioMolecular Atlas program

arXiv

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arXiv 2019年

作者： Snyder, Michael P. Lin, Shin Posgai, Amanda Atkinson, Mark Regev, Aviv Rood, Jennifer Rozenblatt-Rosen, Orit Gaffney, Leslie Hupalowska, Anna Satija, Rahul Gehlenborg, Nils Shendure, Jay Laskin, Julia Harbury, Pehr Nystrom, Nicholas A. Bar-Joseph, Ziv Zhang, Kun Börner, Katy Lin, Yiing Conroy, Richard Procaccini, Dena Roy, Ananda L. Pillai, Ajay Brown, Marishka Galis, Zorina S. Cai, Long Shendure, Jay Trapnell, Cole Lin, Shin Jackson, Dana Snyder, Michael P. Nolan, Garry Greenleaf, William James Lin, Yiing Plevritis, Sylvia Ahadi, Sara Lee, Hayan Nevins, Stephanie Esplin, Ed Horning, Aaron Bahmani, Amir Zhang, Kun Sun, Xin Jain, Sanjay Hagood, James Kharchenko, Peter Atkinson, Mark Bodenmiller, Bernd Brusko, Todd Clare-Salzler, Michael Nick, Harry Otto, Kevin Posgai, Amanda Wasserfall, Clive Maffioletti, Sergio Caprioli, Richard M. Spraggins, Jeffrey M. Gutierrez, Danielle Patterson, Nathan Heath Neumann, Elizabeth K. Harris, Raymond deCaestecker, Mark de Plas, Raf Van Lau, Ken Cai, Long Yuan, Guo-Cheng Zhu, Qian Dries, Ruben Yin, Peng Saka, Sinem K. Kishi, Jocelyn Y. Wang, Yu Goldaracena, Isabel Laskin, Julia Ye, DongHye Burnum-Johnson, Kristin E. Piehowski, Paul D. Ansong, Charles Zhu, Ying Harbury, Pehr Desai, Tushar Mulye, Jay Chou, Peter Nagendran, Monica Bar-Joseph, Ziv Teichmann, Sarah A. Paten, Benedict Murphy, Robert F. Ma, Jian Kiselev, Vladimir Yu Kingsford, Carl Ricarte, Allyson Ruffalo, Matthew Gehlenborg, Nils Kharchenko, Peter Vella, Margaret McCallum, Chuck Börner, Katy Cross, Leonard E. Friedman, Samuel H. Heiland, Randy Herr, Bruce Macklin, Paul Quardokus, Ellen M. Record, Lisel Sluka, James P. Weber, Griffin M. Nystrom, Nicholas A. Silverstein, Jonathan C. Blood, Philip D. Ropelewski, Alexander J. Shirey, William E. Mabee, Paula Lenhardt, W. Christopher Robasky, Kimberly Michailidis, Stavros Satija, Rahul Marioni, John Regev, Aviv Butler, Andrew Stuart, Tim Fisher, Eyal Ghazanfar, Shila Rood, Jennifer Gaffney, Leslie Ersalan, Gokcen Biancalani, Tommaso Conroy, Richard Procaccini, Dena Roy, Anan School of Medicine Stanford University 300 Pasteur Drive United States Department of Genetics Stanford School of Medicine StanfordCA94305 United States Department of Medicine University of Washington SeattleWA98195 United States Department of Pathology University of Florida Diabetes Institute GainesvilleFL32610 United States Klarman Cell Observatory Broad Institute of MIT and Harvard CambridgeMA02142 United States Howard Hughes Medical Institute Koch Institute of Integrative Cancer Research Department of Biology Massachusetts Institute of Technology CambridgeMA02140 United States New York Genome Center New York CityNY10013 United States New York University New YorkNY10012 United States Department of Biomedical Informatics Harvard Medical School BostonMA02115 United States Department of Genome Sciences University of Washington SeattleWA98105 United States Department of Chemistry Purdue University West LafayetteIN47907 United States Department of Biochemistry Stanford University School of Medicine StanfordCA94305 United States Pittsburgh Supercomputing Center Carnegie Mellon University PittsburghPA15213 United States Department of Computational Biology School of Computer Science Carnegie Mellon University PittsburghPA15213 United States Department of Bioengineering University of California San Diego La JollaCA92093 United States Department of Intelligent Systems Engineering School of Informatics Computing and Engineering Indiana University BloomingtonIN47408 United States Department of Surgery Washington University School of Medicine St LouisMO63110 United States Division of Program Coordination Planning and Strategic Initiatives National Institutes of Health BethesdaMD20892 United States National Human Genome Research Institute National Institutes of Health BethesdaMD20892 United States National Heart Lung and Blood Institute National Institutes of Health BethesdaMD20892 United States Caltech-UW TMC Departmen

Transformative technologies are enabling the construction of three dimensional (3D) maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, consortia, and the biomedical research community at large towards the shared vision of a comprehensive, accessible 3D molecular and cellular atlas of the human body, in health and various disease settings. Copyright © 2019, The Authors. All rights reserved.

关键词： Mapping

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Erratum for Wang et al., "Clinically Applicable System for Rapidly Predicting Enterococcus faecium Susceptibility to Vancomycin"

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Microbiology spectrum 2022年第1期10卷 e0261021页

作者： Hsin-Yao Wang Chia-Ru Chung Chao-Jung Chen Ko-Pei Lu Yi-Ju Tseng Tzu-Hao Chang Min-Hsien Wu Wan-Ting Huang Ting-Wei Lin Tsui-Ping Liu Tzong-Yi Lee Jorng-Tzong Horng Jang-Jih Lu Department of Laboratory Medicine Chang Gung Memorial Hospitalgrid.413801.f at Linkou Taoyuan City Taiwan. Ph.D. Program in Biomedical Engineering Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Computer Science and Information Engineering National Central Universitygrid.37589.30 Taoyuan City Taiwan. Graduate Institute of Integrated Medicine China Medical Universitygrid.254145.3 Taichung Taiwan. Proteomics Core Laboratory China Medical Universitygrid.254145.3 Hospital Taichung Taiwan. Graduate Program in Biomedical Information Yuan-Ze University Taoyuan City Taiwan. Department of Information Management Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Graduate Institute of Biomedical Informatics Taipei Medical University Taipei City Taiwan. Clinical Big Data Research Center Taipei Medical University Hospital Taipei City Taiwan. Graduate Institute of Biomedical Engineering Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Division of Haematology/Oncology Department of Internal Medicine Chang Gung Memorial Hospitalgrid.413801.f at Linkou Taoyuan City Taiwan. Biosensor Group Biomedical Engineering Research Center Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Pathology Kaohsiung Chang Gung Memorial Hospitalgrid.413801.f and Chang Gung University College of Medicine Kaohsiung Taiwan. School of Life and Health Sciences The Chinese University of Hong Kong Shenzhen China. Warshel Institute for Computational Biology The Chinese University of Hong Kong Shenzhen China. Department of Bioinformatics and Medical Engineering Asia University Taichung City Taiwan. School of Medicine Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Medical Biotechnology and Laboratory Science Chang Gung Universitygrid.145695.a Taoyuan City Taiwan.

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A molecular single-cell lung atlas of lethal COVID-19 (vol 595, pg 114, 2021)

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NATURE 2021年第7882期598卷 E2-E2页

作者： Melms, Johannes C. Biermann, Jana Huang, Huachao Wang, Yiping Nair, Ajay Tagore, Somnath Katsyv, Igor Rendeiro, Andre F. Amin, Amit Dipak Schapiro, Denis Frangieh, Chris J. Luoma, Adrienne M. Filliol, Aveline Fang, Yinshan Ravichandran, Hiranmayi Clausi, Mariano G. Alba, George A. Rogava, Meri Chen, Sean W. Ho, Patricia Montoro, Daniel T. Kornberg, Adam E. Han, Arnold S. Bakhoum, Mathieu F. Anandasabapathy, Niroshana Suarez-Farinas, Mayte Bakhoum, Samuel F. Bram, Yaron Borczuk, Alain Guo, Xinzheng V. Lefkowitch, Jay H. Marboe, Charles Lagana, Stephen M. Del Portillo, Armando Tsai, Emily J. Zorn, Emmanuel Markowitz, Glen S. Schwabe, Robert F. Schwartz, Robert E. Elemento, Olivier Saqi, Anjali Hibshoosh, Hanina Que, Jianwen Izar, Benjamin Department of Medicine Division of Hematology/Oncology Columbia University Irving Medical Center New York NY USA Columbia Center for Translational Immunology Columbia University Irving Medical Center New York NY USA Herbert Irving Comprehensive Cancer Center Columbia University Irving Medical Center New York NY USA Program for Mathematical Genomics Columbia University New York NY USA Columbia Center for Human Development Columbia University Irving Medical Center New York NY USA Division of Digestive and Liver Diseases Columbia University Irving Medical Center New York NY USA Department of Medicine Columbia University Irving Medical Center New York NY USA Institute of Human Nutrition Columbia University New York NY USA Department of Systems Biology Columbia University Irving Medical Center New York NY USA Department of Pathology and Cell Biology Columbia University Irving Medical Center New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Caryl and Israel Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA WorldQuant Initiative for Quantitative Prediction Weill Cornell Medicine New York NY USA Department of Physiology and Biophysics Weill Cornell Medical College New York NY USA Department of Dermatology Weill Cornell Medical College New York NY USA Meyer Cancer Center Weill Cornell Medical College New York NY USA Laboratory of Systems Pharmacology Harvard Medical School Boston MA USA Klarman Cell Observatory Broad Institute of MIT and Harvard Cambridge MA USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Department of Cancer Immunology and Virology Dana-Farber Cancer Center Boston MA USA Human Immune Monitoring Core Columbia University Irving Medical Center New York NY USA Department of Medicine Division of Pulmonary and Critical Care Massachusetts General Hospital Boston MA USA Cell Circu

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