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Molecular architecture of mammalian pyruvate dehydrogenase complex

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Protein & Cell 2025年第1期16卷 72-78页

作者： Maofei Chen Yutong Song Sensen Zhang Yitang Zhang Xudong Chen Minghui Zhang Meng Han Xin Gao Sai Li Maojun Yang Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological StructureSchool of Life SciencesTsinghua UniversityBeijing 100084China Ministry of Education Key Laboratory of Protein Science Tsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology Tsinghua UniversityBeijing 100084China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesShenzhen University Health Science CenterShenzhen 518060China Protein Research Technology Center Protein Chemistry and Omics PlatformSchool of Life SciencesTsinghua UniversityBeijing 100084China Computer Science Program ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Computational Bioscience Research Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia Cryo-EM Facility Center Southern University of Science and TechnologyShenzhen 518055China Beijing Life Science Academy Beijing 102209China

Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), and dihydrolipoyl dehydrogenase(E3). These three enzymes perform distinct functions sequentially to catalyze the oxidative decarboxylation of pyruvate with formation of nicotinamide adenine dinucleotide(NADH) and acetyl-coenzyme A(Patel and Roche, 1990).

关键词： sequentially oxidative Dalton

Performance Analysis of Infrastructure Sharing Techniques in Cellular Networks: A Percolation Theory Approach

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IEEE Transactions on Vehicular Technology 2025年

作者： Lin, Hao Kishk, Mustafa A. Alouini, Mohamed-Slim King Abdullah University of Science and Technology (KAUST) Electrical and Computer Engineering Program Computer Electrical and Mathematical Sciences and Engineering Division (CEMSE) Thuwal 23955-6900 Saudi Arabia Maynooth University Department of Electronic Engineering Maynooth W23 F2H6 Ireland King Abdullah University of Science and Technology (KAUST) CEMSE Division Thuwal 23955-6900 Saudi Arabia

In the context of 5G, infrastructure sharing has been identified as a potential solution to reduce the investment costs of cellular networks. In particular, it can help low-income regions build 5G networks more affordably and further bridge the digital divide. There are two main kinds of infrastructure sharing: passive sharing (i.e., site sharing) and active sharing (i.e., access sharing), which require mobile network operators (MNOs) to share their non-electronic elements or electronic elements, respectively. Because co-construction and sharing can achieve broader coverage with lower investment, through percolation theory, we investigate how different sharing strategies can deliver large-scale continuous services. First, we examine the percolation characteristics in signal-to-interference-plus-noise ratio (SINR) coverage graphs and the necessary conditions for percolation. Second, we propose an ‘average coverage radius’ to approximate the SINR graph with a low base station (BS) density based on the Gilbert disk model. Finally, we estimate the critical conditions of BS densities of MNOs for different sharing strategies and compare the percolation probabilities under different infrastructure sharing strategies. © 1967-2012 IEEE.

关键词： Gilbert disk model graph theory Infrastructure sharing percolation theory stochastic geometry

Spectral Extremal Connectivity of Two-State Seizure Brain Waves

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arXiv 2025年

作者： Talento, Mara Sherlin D. Richards, Jordan Pinto-Orellana, Marco Huser, Raphael Ombao, Hernando C. Statistics Program Computer Electrical and Mathematical Science & Engineering Division King Abdullah University of Science and Technology 23955 - 6900 Saudi Arabia Neuro-AI Laboratory Computer Electrical and Mathematical Science & Engineering Division King Abdullah University of Science and Technology 23955 - 6900 Saudi Arabia School of Mathematics Maxwell Institute for Mathematical Sciences University of Edinburgh EdinburghEH9 3FD United Kingdom Department of Biomedical Engineering University of California Irvine92697 United States

Coherence analysis plays a vital role in the study of functional brain connectivity. However, coherence captures only linear spectral associations, and thus can produce misleading findings when ignoring variations of connectivity in the tails of the distribution. This limitation becomes important when investigating extreme neural events that are characterized by large signal amplitudes. The focus of this paper is to examine connectivity in the tails of the distribution, as this reveals salient information that may be overlooked by standard methods. We develop a novel notion of spectral tail association of periodograms to study connectivity in the network of electroencephalogram (EEG) signals of seizure-prone neonates. We further develop a novel non-stationary extremal dependence model for multivariate time series that captures differences in extremal dependence during different brain phases, namely burst-suppression and non-burst-suppression. One advantage of our proposed approach is its ability to identify tail connectivity at key frequency bands that could be associated with outbursts of energy which may lead to seizures. We discuss these novel scientific findings alongside a comparison of the extremal behavior of brain signals for epileptic and non-epileptic patients. © 2025, CC BY.

关键词： Electroencephalography

Correction: Materials laboratories of the future for alloys, amorphous, and composite materials (MRS Bulletin, (2025), 50, 2, (190-207), 10.1557/s43577-024-00846-y)

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MRS Bulletin 2025年 1-2页

作者： Banerjee, Sarbajit Meng, Y. Shirley Minor, Andrew M. Zhang, Minghao Zaluzec, Nestor J. Chan, Maria K.Y. Seidler, Gerald McComb, David W. Agar, Joshua Mukherjee, Partha P. Melot, Brent Chapman, Karena Guiton, Beth S. Klie, Robert F. McCue, Ian D. Voyles, Paul M. Robertson, Ian Li, Ling Chi, Miaofang Destino, Joel F. Devaraj, Arun Marquis, Emmanuelle A. Segre, Carlo U. Liu, Huinan H. Yang, Judith C. Momeni, Kasra Misra, Amit Abdolrahim, Niaz Medvedeva, Julia E. Cai, Wenjun Sehirlioglu, Alp Dizbay-Onat, Melike Mehta, Apurva Graham-Brady, Lori Maruyama, Benji Rajan, Krishna Warner, Jamie H. Taheri, Mitra L. Kalinin, Sergei V. Reeja-Jayan, B. Schwarz, Udo D. Simon, Sindee L. Brown, Craig M. Department of Chemistry and Department of Materials Science & Engineering Texas A & M University College Station United States Pritzker School of Molecular Engineering The University of Chicago Chicago United States Department of Materials Science & Engineering University of California Berkeley Berkeley United States National Center for Electron Microscopy Molecular Foundry Lawrence Berkeley National Laboratory Berkeley United States Center for Nanoscale Materials Argonne National Laboratory Lemont United States Department of Physics University of Washington Seattle United States Department of Materials Science & Engineering The Ohio State University Columbus United States Department of Mechanical Engineering and Mechanics Drexel University Philadelphia United States School of Mechanical Engineering Purdue University West Lafayette United States Department of Chemistry University of Southern California Los Angeles United States Department of Chemistry Stony Brook University The State University of New York Stony Brook United States Department of Chemistry University of Kentucky Lexington United States Department of Physics University of Illinois at Chicago Chicago United States Department of Materials Science & Engineering Northwestern University Evanston Bangladesh Department of Materials Science & Engineering University of Wisconsin–Madison Madison United States Department of Materials Science and Engineering University of Pennsylvania Philadelphia United States Department of Mechanical Engineering and Materials Science Duke University Durham United States Department of Chemistry Creighton University Omaha United States Physical and Computational Sciences Directorate Pacific Northwest National Laboratory Richland United States Department of Materials Science & Engineering University of Michigan–Ann Arbor Ann Arbor United States Department of Physics Illinois Institute of Technology Chicago United States Department of Bioengineering and the Mater

This article was updated to correct Minghao Zhang’s affiliation from "Pritzker School of Molecular engineering, The University of Chicago, Chicago, USA" to "Pritzker School of Molecular engineering, The University of Chicago, Chicago, USA;Argonne National Laboratory, Lemont, USA." Argonne National Laboratory was left off the original publication. © The Author(s) 2025.

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Bayesian Inference for Non-Synchronously Observed Diffusions

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arXiv 2025年

作者： Jasra, Ajay Kamatani, Kengo Wu, Amin School of Data Science The Chinese University of Hong Kong Shenzhen Shenzhen China Institute of Statistical Mathematics Tokyo190-0014 Japan Statistics Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia

We consider the problem of Bayesian inference for bi-variate data observed in time but with observation times which occur non-synchronously. In particular, this occurs in a wide variety of applications in finance, such as high-frequency trading or crude oil futures trading. We adopt a diffusion model for the data and formulate a Bayesian model with priors on unknown parameters along with a latent representation for the the so-called missing data. We then consider computational methodology to fit the model using Markov chain Monte Carlo (MCMC). We have to resort to time-discretization methods as the complete data likelihood is intractable and this can cause considerable issues for MCMC when the data are observed in low frequencies. In a high frequency observation frequencies we present a simple particle MCMC method based on an Euler–Maruyama time discretization, which can be enhanced using multilevel Monte Carlo (MLMC). In the low frequency observation regime we introduce a novel bridging representation of the posterior in continuous time to deal with the issues of MCMC in this case. This representation is discretized and fitted using MCMC and MLMC. We apply our methodology to real and simulated data to establish the efficacy of our methodology. © 2025, CC BY.

关键词： Crude oil

The growing memristor industry

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Nature 2025年第8059期640卷 613-622页

作者： Lanza, Mario Pazos, Sebastian Aguirre, Fernando Sebastian, Abu Le Gallo, Manuel Alam, Syed M. Ikegawa, Sumio Yang, J. Joshua Vianello, Elisa Chang, Meng-Fan Molas, Gabriel Naveh, Ishai Ielmini, Daniele Liu, Ming Roldan, Juan B. Department of Materials Science and Engineering National University of Singapore Singapore Singapore Institute for Functional Intelligent Materials National University of Singapore Singapore Singapore Centre for Advanced 2D Materials (CA2DM) National University of Singapore Singapore Singapore Materials Science and Engineering Program Physical Science and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia Intrinsic Semiconductor Technologies London United Kingdom IBM Research – Zurich Rüschlikon Switzerland Everspin Technologies Chandler AZ United States Department of Electrical and Computer Engineering University of Southern California Los Angeles CA United States CEA-Leti Université Grenoble Alpes Grenoble France Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan Weebit Nano Hod Hasharon Israel Dipartimento di Elettronica Informazione e Bioingegneria (DEIB) Politecnico di Milano and *** Milano Italy Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing China Departamento de Electrónica y Tecnología de Computadores Universidad de Granada Facultad de Ciencias Granada Spain

The semiconductor industry is experiencing an accelerated transformation to overcome the scaling limits of the transistor and to adapt to new requirements in terms of data storage and computation, especially driven by artificial intelligence applications and the Internet of Things. In this process, new materials, devices, integration strategies and system architectures are being developed and optimized. Among them, memristive devices and circuits—memristors are two-terminal memory devices that can also mimic some basic bioelectronic functions—offer a potential approach to create more compact, energy-efficient or better-performing systems. The memristor industry is growing quickly, raising abundant capital investment, creating new jobs and placing advanced products in the market. Here we analyse the status and prospects of the memristor industry, focusing on memristor-based products that are already commercially available, prototypes with a high technological readiness level that might affect the market in the near future, and discuss obstacles and pathways to their implementation. © Springer Nature Limited 2025.

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A Conceptual Exploration of Generative AI-Induced Cognitive Dissonance and its Emergence in University-Level Academic Writing

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arXiv 2025年

作者： Seran, Carl Errol Tan, Myles Joshua Toledo Karim, Hezerul Abdul AlDahoul, Nouar Biology Program College of Arts and Sciences University of St. La Salle Bacolod Philippines Department of Natural Sciences College of Arts and Sciences University of St. La Salle Bacolod Philippines Faculty of Education University of the Philippines Open University Los Baños Philippines Department of Electrical and Computer Engineering Herbert Wertheim College of Engineering University of Florida GainesvilleFL United States Department of Epidemiology College of Public Health and Health Professions College of Medicine University of Florida GainesvilleFL United States Department of Chemical Engineering College of Engineering and Technology University of St. La Salle Bacolod Philippines Department of Electronics Engineering College of Engineering and Technology University of St. La Salle Bacolod Philippines Yo-Vivo Corporation Bacolod Philippines Faculty of Engineering Multimedia University Persiaran Multimedia Cyberjaya Malaysia Department of Computer Science Division of Science New York University Abu Dhabi Abu Dhabi United Arab Emirates

The integration of Generative Artificial Intelligence (GenAI) intouniversity-level academic writing presents both opportunities and challenges,particularly in relation to cognitive dissonance (CD). This work explores howGenAI serves as both a trigger and amplifier of CD, as students navigateethical concerns, academic integrity, and self-efficacy in their writingpractices. By synthesizing empirical evidence and theoretical insights, weintroduce a hypothetical construct of GenAI-induced CD, illustrating thepsychological tension between AI-driven efficiency and the principles oforiginality, effort, and intellectual ownership. We further discuss strategiesto mitigate this dissonance, including reflective pedagogy, AI literacyprograms, transparency in GenAI use, and discipline-specific task *** approaches reinforce critical engagement with AI, fostering a balancedperspective that integrates technological advancements while safeguarding humancreativity and learning. Our findings contribute to ongoing discussions on AIin education, self-regulated learning, and ethical AI use, offering aconceptual framework for institutions to develop guidelines that align AIadoption with academic values. © 2025, CC BY.

关键词： Generative adversarial networks

Unbiased Parameter Estimation for Bayesian Inverse Problems

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arXiv 2025年

作者： Chada, Neil K. Jasra, Ajay Maama, Mohamed Tempone, Raul Department of Mathematics City University of Hong Kong China School of Data Science The Chinese University of Hong Kong Shenzhen CN Shenzhen China Applied Mathematics and Computational Science Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia

In this paper we consider the estimation of unknown parameters in Bayesian inverse problems. In most cases of practical interest, there are several barriers to performing such estimation, This includes a numerical approximation of a solution of a differential equation and, even if exact solutions are available, an analytical intractability of the marginal likelihood and its associated gradient, which is used for parameter estimation. The focus of this article is to deliver unbiased estimates of the unknown parameters, that is, stochastic estimators that, in expectation, are equal to the maximizer of the marginal likelihood, and possess no numerical approximation error. Based upon the ideas of [4] we develop a new approach for unbiased parameter estimation for Bayesian inverse problems. We prove unbiasedness and establish numerically that the associated estimation procedure is faster than the current state-of-the-art methodology for this problem. We demonstrate the performance of our methodology on a range of problems which include a PDE and ODE. Copyright © 2025, The Authors. All rights reserved.

关键词： Markov processes

650 nm emitting InGaN red micro-LEDs with ITO n-electrodes

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Applied Physics Express 2025年第6期18卷 061001-061001页

作者： Cesur Altinkaya Rawan S. Jalmood Mohammed A. Najmi Daisuke Iida Kazuhiro Ohkawa Material Science and Engineering Program Physical Sciences and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia Electrical and Computer Engineering Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia

InGaN red micro-LEDs were fabricated with indium tin oxide (ITO) and metal n-electrode designs. Micro-LEDs with ITO electrodes achieved a peak on-wafer external quantum efficiency of 2.1% (at 1.25 A cm⁻²) and wall-plug efficiency of 1.7% (at 0.64 A cm⁻²), representing 1.6 times and 1.5 times improvements compared to metal-based electrodes. Improved performance was attributed to the transparency of ITO, enabling light extraction, while metal electrodes block emission. Both configurations achieved a low leakage current density (≤ 10^–7 A cm⁻²) and a high peak emission wavelength around 650 nm. These results represent a strong potential for low-power consumption required/area-limited AR/VR applications.

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