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Intervention in biological phenomena modeled by S-systems: A model predictive control approach

Intervention in biological phenomena modeled by S-systems: A...

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作者： Meskin, N. Nounou, H. Nounou, M. Datta, A. Dougherty, E.R. Electrical Engineering Department Qatar University Doha Qatar Electrical and Computer Engineering Program Texas A and M University at Qatar Doha Qatar Chemical Engineering Program Texas A and M University at Qatar Doha Qatar Department of Electrical and Computer Engineering Texas A and M University College Station TX 77843 United States Translational Genomics Research Institute Phoenix AZ 85004 United States

ISBN: (纸本)9781457700804

Recent years have witnessed extensive research activity in modeling genetic regulatory networks (GRNs) as well as in developing therapeutic intervention strategies for such networks. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of GRNs, as well as that of biochemical pathways. In this paper, an intervention strategy is proposed for the S-system model. In this approach, a model predictive control algorithm is developed which guides the target variables to their desired values. The proposed intervention strategy is applied to the glycolytic-glycogenolytic pathway as well as a generic branched pathway and the simulation results presented demonstrate the effectiveness of the proposed scheme. © 2011 AACC American Automatic Control Council.

关键词： Model predictive control

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Adaptive resolution ADC array for an implantable neural sensor

Adaptive resolution ADC array for an implantable neural sens...

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作者： O'Driscoll, Stephen Shenoy, Krishna V. Meng, Teresa H. Department of Electrical and Computer Engineering University of California Davis CA 95161 United States Departments of Electrical Engineering and Bioengineering Neurosciences Program Stanford University Stanford CA 94305 United States Department of Electrical Engineering Stanford University Stanford CA 94305 United States

This paper describes an analog-to-digital converter (ADC) array for an implantable neural sensor which digitizes neural signals sensed by a microelectrode array. The ADC array consists of 96 variable resolution ADC base cells. The resolution of each ADC cell in the array is varied according to neural data content of the signal from the corresponding electrode. The resolution adaptation algorithm is essentially to periodically recalibrate the required resolution and this is done without requiring any additional ADC cells. The adaptation implementation and results are described. The base ADC cell is implemented using a successive approximation charge redistribution architecture. The choice of architecture and circuit design are presented. The base ADC has been implemented in 0.13 \mum CMOS as a 100 kS/s SAR ADC whose resolution can be varied from 3 to 8 bits with corresponding power consumption of 0.23 \muW to 0.90 \muW achieving an ENOB of 7.8 at the 8-bit setting. The energy per conversion step figure of merit is 48 fJ/step at the 8-bit setting. Resolution adaptation reduces power consumption by a factor of 2.3 for typical motor neuron signals while maintaining an effective 7.8-bit resolution across all channels. © 2011 IEEE.

关键词： Analog to digital conversion

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Adaptive rate transmission for spectrum sharing system with quantized channel state information

Adaptive rate transmission for spectrum sharing system with ...

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Annual Conference on Information Sciences and Systems

作者： Abdallah, Mohamed Salem, Ahmed Alouini, Mohamed-Slim Qaraqe, Khalid A. Electrical and Computer Engineering Texas A and M University at Qatar PO Box 23874 Doha Qatar Department of Electronics and Electrical Communication Cairo University Giza Egypt Electrical Engineering Program KAUST Thuwal Saudi Arabia

ISBN: (纸本)9781424498475

The capacity of a secondary link in spectrum sharing systems has been recently investigated in fading environments. In particular, the secondary transmitter is allowed to adapt its power and rate to maximize its capacity subject to the constraint of maximum interference level allowed at the primary receiver. In most of the literature, it was assumed that estimates of the channel state information (CSI) of the secondary link and the interference level are made available at the secondary transmitter via an infinite-resolution feedback links between the secondary/primary receivers and the secondary transmitter. However, the assumption of having infinite resolution feedback links is not always practical as it requires an excessive amount of bandwidth. In this paper we develop a framework for optimizing the performance of the secondary link in terms of the average spectral efficiency assuming quantized CSI available at the secondary transmitter. We develop a computationally efficient algorithm for optimally quantizing the CSI and finding the optimal power and rate employed at the cognitive transmitter for each quantized CSI level so as to maximize the average spectral efficiency. Our results give the number of bits required to represent the CSI sufficient to achieve almost the maximum average spectral efficiency attained using full knowledge of the CSI for Rayleigh fading channels. © 2011 IEEE.

关键词： Channel state information

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Frequency multiplexing tickle tones to determine harmonic coupling weights in nonlinear systems

Frequency multiplexing tickle tones to determine harmonic co...

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78th ARFTG Microwave Measurement Conference: High Power RF Measurement Techniques, ARFTG 2011

作者： Baylis, Charles Marks II, Robert J. Wireless and Microwave Circuits and Systems Program Department of Electrical and Computer Engineering Baylor University Waco TX 76798 United States

ISBN: (纸本)9781467302814

Obtaining the Jacobian parameters for a nonlinear system, such as in X-parameter or S-function measurement, requires excitation of tickle tones either on or slightly off of the main harmonic frequencies. Traditional off-frequency measurements involve simultaneous excitation with tickle tones both slightly above and/or below a single harmonic frequency at a time. This paper describes a multiplexing technique for the excitation of the system with perturbations at all harmonics simultaneously. This technique requires both frequency and cross-frequency noninterference for successful results from the measurements. If these conditions exist for the nonlinear system, the off-frequency multiplexing technique for tickle tones can reduce the measurements necessary to find the Jacobian matrices by a factor equal to the number of harmonics considered in the polyharmonic distortion. These methods provide exact results for memoryless polynomial nonlinearities. © 2011 IEEE.

关键词： Nonlinear systems

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Enhancing the entrepreneurial mindset of freshman engineers

Enhancing the entrepreneurial mindset of freshman engineers

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118th ASEE Annual Conference and Exposition

作者： Reid, Kenneth Ferguson, Daniel Michael Department in Electrical and Computer Engineering Ohio Northern University United States Engineering Education Program Purdue University West Lafayette United States

On page 1 of Educating the Engineer of 2020: Adapting engineering Education to the New Century cites the most critical task of engineering educators: "first and foremost, engineering education must produce technically excellent and innovative graduates." This report further states "it is agreed that innovation is the key and engineering is essential to the task of helping the United States maintain its economic leadership and its share of high technology jobs." The goal of our research is to benchmark and identify creativity and innovation skill sets in first-year engineering students, which are included among necessary entrepreneurial skill sets, and understand how and why these skill sets change over their undergraduate matriculation. Our research will report on an initial study of the impact of first-year engineering courses on the changes in entrepreneurial mindsets of first year engineering students. Entrepreneurial mindset in our study is operationally defined as a more growth orientated mindset versus a fixed orientated mindset. This operational definition and the accompanying mindset measurement instrument was developed and validated by Carol Dweck of Stanford University. Based on Dweck's research results we assume a growth mindset is a reasonable surrogate for a student engineer's creative and innovative or entrepreneurial skills. Mindset of student engineers are benchmarked at the beginning of the freshman year and then again at the end of the freshman year, soon after completion of a team based poverty alleviation freshman capstone project. Two pre and post control samples of freshman engineer mindsets are being collected from similar sized engineering program. at comparable colleges in our geographic vicinity. Initial beginning-of-year testing results indicate a statistically significant tilt toward a fixed mindset in freshman engineering students compared to a growth mindset observed in an opportunity sample of freshman business students. We are trackin

关键词： engineering education

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The experimental determination of the onset of electrical and thermal conductivity percolation thresholds in carbon nanotube-polymer composites

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2010 MRS Fall Meeting

作者： Kim, Byung-Wook Pfeifer, Steven Park, Sung-Hoon Bandaru, Prabhakar R. Department of Electrical and Computer Engineering University of California San Diego CA United States Materials Science Program Department of Mechanical Engineering University of California San Diego CA United States

ISBN: (纸本)9781605112893

We show evidence of electrical and thermal conductivity percolation in polymer based carbon nanotube (CNT) composites, which follow power law variations with respect to the CNT concentrations in the matrix. The experimentally obtained percolation thresholds, i.e., ∼ 0.074 vol % for single walled CNTs and ∼ 2.0 vol % for multi-walled CNTs, were found to be aspect ratio dependent and in accordance with those determined theoretically from excluded volume percolation theory. A much greater enhancement, over 10 orders of magnitude, was obtained in the electrical conductivity at the percolation threshold, while a smaller increase of ∼ 100% was obtained in the thermal conductivity values. Such a difference is qualitatively explained on the basis of the respective conductivity contrast between the CNT filler and the polymer matrix. © 2011 Materials Research Society.

关键词： Aspect ratio

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A parallel Ray Tracing architecture suitable for application-specific hardware and GPGPU implementations

A parallel Ray Tracing architecture suitable for application...

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2011 14th Euromicro Conference on Digital System Design: Architectures, Methods and Tools, DSD 2011

作者： Nery, Alexandre S. Nedjah, Nadia Franca, Felipe M.G. Jozwiak, Lech LAM - Computer Architecture and Microelectronics Laboratory Systems Engineering and Computer Science Program COPPE Universidade Federal Rio de Janeiro Brazil Department of Electronics Engineering and Telecommunications Faculty of Engineering Universidade do Estado Rio de Janeiro Brazil Department of Electrical Engineering - Electronic Systems Eindhoven University of Technology Netherlands

ISBN: (纸本)9780769544946

The Ray Tracing rendering algorithm can produce high-fidelity images of 3-D scenes, including shadow effects, as well as reflections and transparencies. This is currently done at a processing speed of at most 30 frames per second. Therefore, actual implementations of the algorithm are not yet suitable for interactive real-time rendering, which is required in games and virtual reality based applications. Fortunately, the algorithm allows for massive parallelization of its computations. In this paper, we present a parallel architecture for ray tracing based on a uniform spatial subdivision of the scene and exploiting an embedded computation of ray-triangle intersections. This approach allows for a significant acceleration of intersection computations, as well as, a reduction of the total number of the required intersections checks. Furthermore, it allows for these checks to be performed in parallel and in advance for each ray. In this paper we discuss and analyze an ASIP-based implementation using FPGAs and a GPGPU-based parallel implementation of the proposed architecture. The performance of both implementations are reported and compared." © 2011 IEEE.

关键词： Ray tracing

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A compton scattering suppression based image reconstruction method for digital breast tomosynthesis

A compton scattering suppression based image reconstruction ...

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2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11

作者： Xu, Shiyu Chen, Ying Department of Electrical and Computer Engineering Southern Illinois University Carbondale IL 62901 United States Biomedical Engineering Graduate Program Southern Illinois University Carbondale IL 62901 United States

ISBN: (纸本)9781467304900

In this paper, we present a novel statistical reconstruction method based on Compton noise suppression for Digital Breast Tomosynthesis. The physical modeling for X-ray's interaction with tissues was investigated. A Compton noise based statistical model with a conjugate prior was introduced. Results from our proposed method, Backprojection (BP) method, Simultaneous Algebraic Reconstruction Technique (SART) and Maximum Likelihood with Convex Algorithm (MLCA) were compared based on image quality analysis. Compared with other algorithms, our proposed method shows comparable performance. It also produces even better results in the Contrast to Noise Ratio (CNR) evaluation. ©2011 IEEE.

关键词： Image reconstruction

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Effects of slice thickness filter in filtered backprojection reconstruction with the parallel breast tomosynthesis imaging configuration

Effects of slice thickness filter in filtered backprojection...

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2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11

作者： Cong, Linlin Chen, Ying Zhou, Weihua Biomedical Engineering Graduate Program Southern Illinois University Carbondale IL 62901 United States Department of Electrical and Computer Engineering Southern Illinois University Carbondale IL 62901 United States

ISBN: (纸本)9781467304900

Digital breast tomosynthesis is a novel breast cancer detection technique by allowing the reconstruction of arbitrary planes in the breast from a set of limited-angle projection images acquired at different view angles with a particular tube geometry setup. In this paper, filtered backprojection (FBP) was optimized as the reconstruction method with a parallel imaging breast tomosynthesis system. The slice thickness filter (profile filter) with task-adapted parameters was applied to computer simulated data, in order to investigate the main effects of this kind of filter regarding spatial resolution and artifacts in the reconstructed results. ©2011 IEEE.

关键词： Medical imaging

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Autonomous passive light tracking utilizing single-wall carbon nanotube enhanced opto-thermo-mechanical elastomer actuators

Autonomous passive light tracking utilizing single-wall carb...

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International Solid-State Sensors, Actuators and Microsystems Conference

作者： Liu, Ye Li, Chensha Lo, Chi-Wei Jiang, Hongrui Electrical and Computer Engineering Department University of Wisconsin Madison WI United States Materials Science Program University of Wisconsin Madison WI United States

ISBN: (纸本)9781457701573

We have developed novel opto-thermo-mechanical actuators by effectively distributing a significant amount of single-wall carbon nanotube (SWCNT, up to 0.7%w/w) into liquid crystal elastomer (LCE) matrices. These SWCNT/LCE actuators exhibit a great potential to be utilized in MEMS applications, as they respond to a wide spectrum of visible/near-infrared light, and possess a large reversible compressive strain (up to 35%) when stimulated. Autonomous and passive light tracking is demonstrated here as one of the applications. With a simple design, the actuators are able to adaptively tilt a solar cell towards the light source by a degree of ∼15° (with an incident light intensity of 1.6 kW/m2). As a result, the photocurrent output of the solar cell is significantly enhanced (up to 247.10%) without any other control system or external energy source. © 2011 IEEE.

关键词： Yarn

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