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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Eric Zettergren Dwayne Vickers Judith Runnels Charles P. Lin Mark J. Niedre Department of Electrical and Computer Engineering Northeastern University Department of Chemical Engineering Northeastern University Advanced Microscopy Program Center for Systems Biology and Wellman Center for Photomedicine Massachusetts General Hospital

ISBN: (纸本)9781424441211

Detection and quantification of rare circulating cells in biological tissues is an important problem and has many applications in biomedical research. Current methods normally involve extraction of blood samples and counting of cells ex vivo, or the use of microscopy-based fluorescence in vivo flow cytometry. The goal of this work is to develop an instrument for non-invasively enumerating very rare circulating cells in small animals with diffuse light with several orders of magnitude sensitivity improvement versus current approaches. In this work, we describe the design of our system and show that single, fluorescent microspheres can be detected in limb-mimicking optical flow phantoms with varying optical properties chosen to simulate in vivo conditions. Further, we demonstrate single cell counting capabilities using fluorescently (Vybrant-DiD) labeled Jurkat and Multiple Myeloma cells. Ongoing work includes in vivo testing and characterization of our system in mice.

关键词： Imaging Phantom Optic Flow Cell Count diffuse light in vivo test Optical properties TISSUES (BIOLOGY) EX-VIVO Fluorescence Myeloma cell blood specimen

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Improvement of LVRT capability of variable speed wind turbine generators using SMES unit

Improvement of LVRT capability of variable speed wind turbin...

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IEEE Innovative Smart Grid Technologies - Asia (ISGT Asia)

作者： A. M. Shiddiq Yunus A. Abu-Siada Mohammad A. S. Masoum Department of Mechanical Engineering Energy Conversion Study Program State of Polytechnic Ujung Pandang Makassar Indonesia Department of Electrical and Computer Engineering Curtin University of Technology Perth WA Australia

The ability of variable speed wind turbines technology to optimally tracking the power from wind energy has become the main reason of their popularity compared with the fixed speed wind turbines. In the earlier stage of connecting wind turbines (WTs) to the existing electricity grids, WTs were allowed to be disconnected from the grid in case of grid faults which might lead to the damage of the turbines. However, recently, the transmission system operators (TSOs) require to maintaining the connection of WTs with the grid to support the grid during fault and to assure the continuity of power supply. This requirement has been compiled in new grid codes in several countries. In this paper, super conducting magnetic energy storage (SMES) unit is used with two different types of variable speed wind turbine generators to comply with Spain grid codes. Results show that the low-voltage-ride-through (LVRT) of Type-3 and Type-4 wind turbine generators are significantly improved when SMES unit is connected to the system.

关键词： Wind turbines Coils Voltage fluctuations Generators Choppers Shafts Safety

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Erbium Emission from Silicon Based Photonic Bandgap Materials

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MRS Online Proceedings Library (OPL) 2011年第1期638卷 F17.2.1-F17.2.1页

作者： Herman A. Lopez J. Eduardo Lugo Selena Chan Sharon M. Weiss Christopher C. Striemer Philippe M. Fauchet Materials Science Program Electrical and Computer Engineering University of Rochester Rochester NY 14627 U.S.A Centro de Investigacion en Energia UNAM A.P. 34 C.P. 62580 Morelos Mexico Center for Future Health Electrical and Computer Engineering University of Rochester Rochester NY 14627 U.S.A Institute of Optics and Electrical and Computer Engineering University of Rochester Rochester NY 14627 U.S.A Department of Electrical and Computer Engineering University of Rochester Rochester NY 14627 U.S.A

Control over the 1.5 µm emission from erbium is desirable for communication and computational technologies because the erbium emission falls in the window of maximum transmission for silica based fiber optics. Tunable, narrow, directional, and enhanced erbium emission from silicon based 1-D photonic bandgap structures will be demonstrated. The structures are prepared by anodic etching of crystalline silicon and consist of two highly reflecting Bragg reflectors sandwiching an active layer. The cavities are doped by electro-migrating the erbium ions into the porous silicon matrix, followed by high temperature oxidation. By controlling the oxidation temperature, porosity, and thickness of the structure, the position of the erbium emission is tuned to emit in regions where the normal erbium emission is very weak. The erbium emission from the cavity is narrowed to a full width at half maximum (FWHM) of 12 nm with a cavity quality factor Q of 130, highly directional with a 20 degree emission cone around the normal axis, and enhanced by more than one order of magnitude when compared to its lateral emission. Erbium photoluminescence (PL) from porous silicon 2-D photonic bandgap structures is also demonstrated.

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Application of SMES unit to improve the high-voltage-ride-through capability of DFIG-grid connected during voltage swell

Application of SMES unit to improve the high-voltage-ride-th...

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IEEE Innovative Smart Grid Technologies - Asia (ISGT Asia)

作者： A. M. Shiddiq Yunus A. Abu-Siada M. A. S. Masoum Department of Mechanical Engineering Energy Conversion Study Program State of Polytechnic Ujung Pandang Makassar Indonesia Department of Electrical and Computer Engineering Curtin University of Technology Perth WA Australia

The amount of wind turbine connected to the power grid has significantly increased during the last decade. This has resulted in essential need to establish grid codes. Previously, wind turbine generators (WTGs) were allowed to be disconnected from the network during any disturbance at the grid side to avoid WTGs from being damaged. However, lately, the transmission system operators (TSOs) require WTGs to be stayed connected to provide support to the grid during fault. This new requirement has been regulated in the new grid codes. In this paper, the super conducting magnetic energy storage (SMES) unit is used to enhance the high voltage ride through (HVRT) capability of DFIG based WTG during voltage swell events at the grid side. Two new grid codes are used to verify the ability of the SMES unit to avoid the WTG from being disconnected from the grid.

关键词： Coils Wind turbines Fuzzy logic Generators Reactive power Input variables Voltage fluctuations

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Multi-Tier Network Performance Analysis Using a Shotgun Cellular System

Multi-Tier Network Performance Analysis Using a Shotgun Cell...

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2011 IEEE Global Telecommunications Conference - GLOBECOM 2011

作者： Prasanna Madhusudhanan Juan G. Restrepo Youjian Liu Timothy X. Brown Kenneth R. Baker Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO USA Department of Applied Mathematics University of Colorado Boulder CO USA Department of Electrical Computer and Energy Engineering Interdisciplinary Telecommunications Program University of Colorado Boulder CO USA Interdisciplinary Telecommunications Program University of Colorado Boulder CO USA

This paper studies the carrier-to-interference ratio (CIR) and carrier-to-interference-plus-noise ratio (CINR) performance at the mobile station (MS) within a multi-tier network composed of M tiers of wireless networks, with each tier modeled as the homogeneous n-dimensional (n-D, n=1,2, and 3) shotgun cellular system, where the base station (BS) distribution is given by the homogeneous Poisson point process in n-D. The CIR and CINR at the MS in a single tier network are thoroughly analyzed to simplify the analysis of the multi-tier network. For the multi-tier network with given system parameters, the following are the main results of this paper: (1) semi-analytical expressions for the tail probabilities of CIR and CINR; (2) a closed form expression for the tail probability of CIR in the range [1,infinity); (3) a closed form expression for the tail probability of an approximation to CINR in the entire range [0,infinity); (4) a lookup table based approach for obtaining the tail probability of CINR, and (5) the study of the effect of shadow fading and BSs with ideal sectorized antennas on the CIR and CINR. Based on these results, it is shown that, in a practical cellular system, the installation of additional wireless networks (microcells, picocells and femtocells) with low power BSs over the already existing macrocell network will always improve the CINR performance at the MS.

关键词： Fading Noise Approximation methods Random variables Closed-form solutions Macrocell networks Femtocells

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Integration of Multilayers in Er-Doped Porous Silicon Structures and Advances in 1.5 μm Optoelectronic Devices

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MRS Online Proceedings Library 2011年第1期536卷 135-140页

作者： H. A. Lopez S. Chan L. Tsybeskov H. Koyama V. P. Bondarenko P. M. Fauchet Materials Science Program University of Rochester Rochester USA Department of Electrical and Computer Engineering University of Rochester Rochester USA Belarusian State University of Informatics and Radioelectronics Minsk Belarus

Infrared photoluminescence (PL) and electroluminescence (EL) from erbium-doped porous silicon (PSi) structures are studied. The PL and EL from the Er-doped PSi structures and the absence of silicon band edge recombination, point defect, and dislocation luminescence bands suggest that the Er-complex centers are the most efficient recombination sites. PSi multilayers with very high reflectivity (R ≥ 90%) in the 1.5 gim range have been incorporated in the structures resulting in a PL enhancement of over 100%. Stable and intense EL is obtained from the Er-doped structures. The EL spectrum is similar to that of the PL, but shifted towards higher energy. The unexpected shift in emission opens up the possibility for erbium related luminescence to encompass a larger part of the optimal wavelength window for fiber optic communications.

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282

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Cytokine 2013年第3期63卷 310-310页

作者： Elia D. Tait Wojno Mario Noti Brian S. Kim Mark C. Siracusa Paul R. Giacomin Meera G. Nair Alain J. Benitez Kathryn R. Ruymann Amanda B. Muir David A. Hill Kudakwashe R. Chikwava Amin E. Moghaddam Quentin J. Sattentau Aneesh Alex Chao Zhou Paul Menard-Katcher Masato Kubo Kazushige Obata-Ninomiya Hajime Karasuyama Michael R. Comeau David Artis Department of Microbiology University of Pennsylvania Philadelphia PA USA Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine James Cook University Cairns Australia Division of Gastroenterology Hepatology and Nutrition Children’s Hospital of Philadelphia Philadelphia PA USA Department of Pediatrics Division of Allergy and Immunology Children’s Hospital of Philadelphia Philadelphia PA USA Department of Pathology and Laboratory Medicine Children’s Hospital of Philadelphia Philadelphia PA USA The Sir William Dunn School of Pathology The University of Oxford Oxford UK Department of Electrical and Computer Engineering Lehigh University Bethlehem PA USA Center for Photonics and Nanoelectronics Lehigh University BethlehemPA USA Bioengineering Program Lehigh University Bethlehem PA USA Division of Gastroenterology Hospital of the University of Pennsylvania Philadelphia PA USA Laboratory for Signal Network Research Center for Allergy and Immunology RIKEN Yokohama Institute Yokohama Japan Division of Molecular Pathology Research Institute for Biological Science Tokyo University of Science Chiba Japan Department of Immune Regulation Tokyo Medical and Dental University Graduate School Tokyo Japan JST CREST Tokyo Medical and Dental University Graduate School Tokyo Japan Inflammation Research Amgen Inc. Seattle WA USA Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA USA

Eosinophilic esophagitis (EoE) is a food allergy-associated disease characterized by esophageal eosinophilia and associated inflammation. EoE has become increasingly common in industrialized countries. However, current management strategies, such as treatment with swallowed steroids and dietary restrictions, are nonspecific or negatively impact the quality of life of EoE patients. In addition, use of more specific therapies that target immunoglobulin E (IgE) and interleukin (IL)-5 have been largely unsuccessful in ameliorating EoE. Thus, there is an urgent need to identify novel, specific immunological pathways that underlie the pathogenesis of EoE that could be targeted to treat this disease. Recently, a genome-wide association study identified that EoE is associated with a gain-of-function polymorphism in the gene that encodes thymic stromal lymphopoietin (TSLP). TSLP is an IL-7 family member cytokine that promotes allergic inflammation by eliciting T helper type 2 cytokine responses, IgE production, and the expansion of a distinct population of basophils . However, whether TSLP directly promotes allergic inflammation in the esophagus and the mechanisms by which TSLP might contribute to the pathogenesis of EoE remain unknown. Here, we describe a new murine model of experimental EoE-like disease that was used to investigate the role of TSLP in allergic inflammation of the esophagus. Murine experimental EoE-like disease developed independently of IgE but was dependent on TSLP-elicited basophils. Critically, therapeutic antibody-mediated neutralization of TSLP or depletion of basophil populations ameliorated established EoE-like disease in mice. Finally, elevated TSLP levels and exaggerated basophil responses were observed in esophageal biopsies from EoE patients, and a gain-of-function polymorphism in TSLP correlated with increased basophil responses in patients with EoE. Together, these data indicate that TSLP-elicited basophil responses may play a key role in medi

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Epileptic Seizure Prediction Using Variational Mixture of Gaussians

Epileptic Seizure Prediction Using Variational Mixture of Ga...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Ali Shahidi Zandi Guy A. Dumont Manouchehr Javidan Reza Tafreshi Department of Electrical & Computer Engineering at The University of British Columbia MD FRCPC Division of Neurology Department of Medicine at The University of British Columbia Mechanical Engineering Program at Texas A&M University at Qatar

ISBN: (纸本)9781424441211

We propose a novel patient-specific method for predicting epileptic seizures by analysis of positive zero-crossing intervals in scalp electroencephalogram (EEG). In real-time analysis, the histogram of these intervals for the current EEG epoch is computed, and the values which correspond to the bins discriminating between interictal and preictal references are selected as an observation. Then, the set of observations from the last 5 min is compared with two reference sets of data points (interictal and preictal) using a variational Gaussian mixture model (GMM) of the data, and a combined index is computed. Comparing this index with a patient-specific threshold, an alarm sequence is produced for each channel. Finally, a seizure prediction alarm is generated according to channel-based information. The proposed method was evaluated using ～40.3 h of scalp EEG recordings from 6 patients with total of 28 partial seizures. A high sensitivity of 95% was achieved with a false prediction rate of 0.134/h and an average prediction time of 22.8 min for the test dataset.

关键词： epileptic seizure Gauss Scalp EEG Dataset Alarm Bins Electroencephalography

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SYSTEMS BIOLOGY IN BARLEY POWDERY MILDEW INTERACTIONS

SYSTEMS BIOLOGY IN BARLEY POWDERY MILDEW INTERACTIONS

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The 13th International Cereal Rusts and Powdery Mildews Conference(第13届国际禾谷类锈病与白粉病大会)

作者： Roger WISE Priyanka SURANA Greg FUERST Ruo XU Dan NETTLETON Divya MISTRY Julie DICKERSON Lin WANG Tom BRUTNELL Department of Plant Pathology and Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Department of Statistics Iowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011USA Department of Plant Pathology and MicrobiologyCenter for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Crop and Insect Genetics Genomicsand Informatics Research UnitU.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011USA Department of Plant Pathology and Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Department of StatisticsIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011USA Crop and Insect GeneticsGenomicsand Informatics Research UnitU.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011USA Department of Electrical and Computer Engineering Iowa State UniversityAmesIowa 50011USA Boyce Thompson Institute for Plant ResearchCornell UniversityIthacaNY

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Frame coherence and sparse signal processing

Frame coherence and sparse signal processing

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IEEE International Symposium on Information Theory

作者： Dustin G. Mixon Waheed U. Bajwa Robert Calderbank Program in Applied and Computational Mathematics Princeton University Princeton NJ USA Department of Electrical and Computer Engineering Duke University Durham NC USA

The sparse signal processing literature often uses random sensing matrices to obtain performance guarantees. Unfortunately, in the real world, sensing matrices do not always come from random processes. It is therefore desirable to evaluate whether an arbitrary matrix, or frame, is suitable for sensing sparse signals. To this end, the present paper investigates two parameters that measure the coherence of a frame: worst-case and average coherence. We first provide several examples of frames that have small spectral norm, worst-case coherence, and average coherence. Next, we present a new lower bound on worst-case coherence and compare it to the Welch bound. Later, we propose an algorithm that decreases the average coherence of a frame without changing its spectral norm or worst-case coherence. Finally, we use worst-case and average coherence, as opposed to the Restricted Isometry Property, to garner near-optimal probabilistic guarantees on both sparse signal detection and reconstruction in the presence of noise. This contrasts with recent results that only guarantee noiseless signal recovery from arbitrary frames, and which further assume independence across the nonzero entries of the signal-in a sense, requiring small average coherence replaces the need for such an assumption.

关键词： Coherence Signal processing algorithms Noise Harmonic analysis Noise measurement Geometry

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