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作者： Ellery, Alex Barnes, Dave Buckland, Rodney Welch, Chris Garry, James Zarnecki, John Gebbie, Jonathan Green, Ashley Smith, Mark Hall, David McInnes, Colin Winfield, Alan Nehmzow, Ulrich Ball, Andrew School of Engineering Kingston University London United Kingdom Dept. of Computer Science Aberystwyth University of Wales United Kingdom Dept. of Design and Innovation Open University Milton Keynes United Kingdom Space and Defence Division Logica London United Kingdom Earth Observation Navigation and Science Directorate Astrium Ltd. Stevenage United Kingdom British National Space Centre London United Kingdom Dept. of Aerospace Engineering University of Glasgow United Kingdom Intelligent Autonomous Systems Laboratory University of West of England Bristol United Kingdom Dept of Computer Science University of Essex Colchester United Kingdom Planetary and Space Sciences Research Institute Open University Milton Keynes United Kingdom

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Learning Cellular Objectives from Fluxes by Inverse Optimization

Learning Cellular Objectives from Fluxes by Inverse Optimiza...

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IEEE Annual Conference on Decision and control

作者： Qi Zhao Arion Stettner Ed Reznik Daniel Segre Ioannis Ch. Paschalidis Dept. of Electrical and Computer Eng. and Division of Systems Engineering Boston University Department of Biomedical Engineering Boston University Bioinformatics Program Department of Biology and Department of Biomedical Engineering Boston University

ISBN: (纸本)9781479978878

Flux Balance Analysis (FBA) is a widely used approach for studying biochemical networks, and in particular the genome-scale metabolic network reconstructions. It formulates the problem of predicting a cell's chemical reaction fluxes as the linear optimization problem of maximizing a cellular objective (e.g., growth) subject to constraints capturing stoichiometry mass balances of the metabolic network and bounds that reflect the composition of the growth medium. In practice, however, reaction fluxes of the cells under specific growth conditions are available to be measured, but the primal FBA objective function is not necessarily known. Understanding its structure can elucidate the cellular metabolic control mechanisms and infer important information regarding an organism's evolution. To that end, we have developed an Inverse Flux Balance Analysis (InvFBA) method which is a novel inverse optimization-based framework for inferring metabolic objective functions. Within this framework, we present three different forms of objective functions: linear, quadratic, and non-parametric. We show that in all cases, the inverse problem is tractable and can be solved efficiently. We provide several numerical examples to show that the inference of the objective function is consistent with simulated flux data and actual measurements.

关键词： Linear programming Kernel Optimization Biochemistry Biomass Biomedical measurement

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Application of running quantities for control of an adaptive hybrid compensator

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EUROPEAN TRANSACTIONS ON ELECTRICAL POWER 1996年第5期6卷 337-344页

作者： Czarnecki, LS Chen, G Staroszczyk, Z [?]Leszek S. Czarnecki (1939) received the M.Sc. and PbD. degrees in electrical engineering and Habil. Dr. degree from the Silesian Technical University Poland in 1%3 1%9and 1984 respectively where he was employed as an Assistant Professor. Since 1984 he worked for two years at the Power Engineering Section Division of Electrical Engineering National Research Council of Canada as a Visiting Research Officer. In 1987 he joined the Electrical Engineering Dept. at Zielona Gora Technical University. In 1989 he joined the Electrical and Computer Engineering Dept. of the Louisiana State University (LSU) Baton Rouge NSA as an Associate Professor. For developing a power theory of asymmetrical three-phase systems with non-sinusoidal waveforms he was elected to the grade of Fellow IEEE in 1996. His research interests include network analysis and synthesis power flow in non-sinusoidal systems compensation and powerquality improvement in non-sinusoidal unbalanced systems and power electronics. (Electrical and Computer Eng. Louisiana State University Baton Rouge/USA Louisiana 70803 T + 15 0413 88-52 41 Fax + 15 0413 88-52 00 Internet page: http://www.geoci tie coml Cape Canavera 4739)

A control algorithm for a hybrid compensator based on a concept of running complex RMS values of the fundamental harmonic of voltages and currents is presented in the paper. The hybrid compensator is composed of an adaptive passive balancing compensator controlled in the frequency-domain, and a current source, controlled in the time-domain. The algorithm used for the compensator control is rooted in a new approach to the power theory of electrical systems with quasi-periodic waveforms. it is based on the concept of running quantities and a forward extrapolation of the power properties of a time-variant load. Experimental results obtained using such an algorithm for controlling a laboratory prototype of the hybrid compensator are presented in the paper.

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Comet - A fast component placer 80

Comet - A fast component placer

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17th Annual ACM IEEE Design Automation Conference, DAC 1980

作者： Smith, Valerie K. Smith, Robert J. Preston, Phil A. V-R information Systems 4120 Edwards Mountain Drive AustinTX78731 United States Electrical Engineering Dept. University of Texas AustinTX78712 United States Telex Computer Products 6422 E. 41st Street TulsaOK74135 United States

ISBN: (纸本)0897910206

Classical Unconnected Set (UCS) and other iterative placement improvement algorithms may converge slowly toward desirable component arrangements. This paper discusses mechanisms that inhibit convergence, then proposes techniques for accelerating rate of improvement. A placer incorporating these procedures is described, and experimental results demonstrating effectiveness of the approach are given. © 1980 ACM.

关键词： Iterative methods

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Nonlinear fuzzy control of human heart rate during aerobic endurance training with respect to significant model variations

Nonlinear fuzzy control of human heart rate during aerobic e...

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International Conference on System Theory, control, and Computing (ICSTCC)

作者： Adrian Pătraşcu Monica Patrascu Iacob Hantiu Faculty of Physical Education and Sport Babeş-Bolyai University Cluj-Napoca Romania Automatic Control and Systems Engineering Dept. University Politehnica of Bucharest Bucharest Romania

In the field of physical activity a significant importance is held by aerobic endurance training, which is a relatively low intensity exercise that depends primarily on aerobic energy generating processes. This type of training is used for the overall endurance and fitness of the body by engaging all the major systems of the body and pushing the limits of their functions with the ultimate goal of adapting these structures to the stress of the physical effort and thus improving the performance output. However, using classic training methods, it is often impossible to ensure the necessary operating points in order to obtain the desired results. The human heart rate model with respect to the velocity of walking or running presents inherent nonlinearities that are required to be taken into account when designing computer integrated training aids. This paper implements such a tool using a fuzzy control system for human heart rate during aerobic endurance training. The controller is tested and validated using two nonlinear human-on-treadmill models, and it presents robustness to significant model variations, as well as uncertainties in the model parameters and white noise type of disturbances. The designed control system ensures desired heart rate profiles, finding its usefulness in supporting the training configuration process by specialized professionals.

关键词： Heart rate Training control systems Fuzzy logic Mathematical model Adaptation models Computational modeling

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AN INTELLIGENT TUTORING SYSTEM BASED ON A DOMAIN ONTOLOGY FOR THE DESIGN OF LEAD-LAG controlLERS

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IFAC Proceedings Volumes 2006年第6期39卷 105-110页

作者： Isaías García Carmen Benavides José R. Villar Francisco Rodríguez Héctor Aláiz Ángel Alonso Systems Engineering and Control Group Electrical and Electronic Engineering University of León Edificio Tecnológico Campus de Vegazana s/n 24071 León (SPAIN) Science and Artificial Intelligence Group Dept. of Computer Science Edificio departamental 1 Campus de Viesques s/n 33204 Gijón Asturias (SPAIN)

The modeling of domains is today a technique with growing acceptance into the software community. Domain models allow the information to be represented in the computer at higher abstraction levels than in the usual applications, so improving the human to machine and machine to machine interactions. This paper deals with the application of such modeling paradigm to the control engineering education field, showing how the knowledge of this domain can be represented in a conceptual structure called ontology which is used as the base for building an Intelligent Tutoring System, a software tool used in the emerging field of e-learning.

关键词： Intelligent Tutoring systems ontologies conceptual modeling control engineering education

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A simple and quick approximation algorithm for traveling salesman problem in the plane 11th

A simple and quick approximation algorithm for traveling sal...

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11th Annual International Symposium on Algorithms and Computation, ISAAC 2000

作者： Kubo, Norihiro Muramoto, Katsuhiro Shimozono, Shinichi School of Computer Science and Systems Enginieering Kyushu Inst. of Tech Iizuka820-8502 Japan FAD Iwashita Engineering Inc Nakahara Shinmachi 2-3 Tobata-ku Kitakyushu804-0003 Japan Dept. of Artificial Intelligence Kyushu Inst. of Tech Iizuka820-8502 Japan

ISBN: (纸本)3540412557

We present a quite simple, fast and practical algorithm to find a short cyclic tour that visits a set of points distributed on the plane. The algorithm runs in O(n log n) time with O(n) space, and is simple enough to easily implement on resource restricted machines. It constructs a tour essentially by axis-sorts of the points and takes a kind of the ‘fixed dissection strategy,’ though it neither tries to find best tours in subregions nor optimizes the order among subregions. As well as the worst-case approximation ratio of produced tours, we show that the algorithm is a ‘probabilistic’ constant-ratio approximation algorithm for uniform random distributions. We made computational comparisons of our algorithm, Karp’s partitioning algorithm, Lin-Kernighan local search, Arora’s randomized PTAS, etc. The results indicate that in running time our algorithm overwhelms existing ones, and the average approximation ratio is better or competitive. © Springer-Verlag Berlin Heidelberg 2000.

关键词： Approximation algorithms

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Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity

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Antiviral Chemistry and Chemotherapy 2003年第4期14卷 183-194页

作者： Manfredini, Stefano Solaroli, Nicola Angusti, Angela Nalin, Federico Durini, Elisa Vertuani, Silvia Pricl, Sabrina Ferrone, Marco Spadari, Silvio Focher, Federico Verri, Annalisa De Clercq, Erik Balzarini, Jan Dept. of Pharmaceutical Sciences University of Ferrara Ferrara Italy Computer-aided Systems Laboratory Department of Chemical Engineering University of Trieste Trieste Italy Istituto di Genetica Molecolare CNR Pavia Italy Division of Clinical Virology Huddinge University Hospital Huddinge/Stockholm Sweden Rega Institute for Medical Research Katholieke Universiteit Leuven Leuven Belgium

Continuing our investigations on inhibitors of ribonucleotide reductase (RNR), the crucial enzyme that catalyses the reduction of ribonucleotides to deoxyribonucleotides, we have now prepared and evaluated 5′ -phosphonoacetic acid, amide and ester analogues of adenosine, uridine and cytidine with the aim to verify both substrate specificity and contribution to biological activity of diphosphate mimic moieties. A molecular modelling study has been conducted on the RNR R1 subunit, in order to verify the possible interaction of the proposed bioisosteric moieties. The study compounds were finally tested on the recombinant murine RNR showing a degree of inhibition that ranged from 350 μM for the UDP analogue 5′-deoxy-5′ -N-(phosphon-acetyl)uridine sodium salt (amide) to 600 μM for the CDP analogue 5′-O-[(diethyl-phosphon)acetyl]cytidine (ester). None of the tested compounds displayed noteworthy cytostatic activity at 100-500 μM concentrations, whereas ADP analogue 5′-N-[(diethyl-phosphon) acetyl]adenosine (amide) and 5′-deoxy-5′ -N-(phosphon-acetyl)adenosine sodium salt (amide) showed a moderate inhibitory activity (EC₅₀: 48 μM) against HSV-2 and a modest inhibitory activity (EC₅₀: 110 μM) against HIV-1, respectively.

关键词： Cytostatic and antiviral activity Diphosphate isosters Molecular modelling Phoshonoacetic ester and amide RNR inhibitors Synthesis

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Dynamic on-line measurement of equivalent parameters of three-phase systems for harmonic frequencies - Reply

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EUROPEAN TRANSACTIONS ON ELECTRICAL POWER 1996年第5期6卷 336-336页

作者： Czarnecki, LS [?]Leszek S. Czarnecki (1939) received the M.Sc. and Ph.D. degrees in electrical engineering and Habil. Dr. degree from the Silesian Technical University Poland in 1963 1969 and 1984 respectively where he was employed as an Assistant Professor. Since 1984 he worked for two years at the Power Engineering Section Division of Electrical Engineering National Research Council of Canada as a Visiting Research Officer. In 1987 he joined the Electrical Engineering Dept. at Zielona Gora Technical University. In 1989 he joined the Electrical and Computer Engineering Dept. of the Louisiana State University (LSU) Baton Rouge NSA. as an Associate Professor. Fordeveloping a power theory of asymmetrical three-phase systems with non-sinusoidal waveforms he was elected to the grade of Fellow IEEE in 1996. His research interests include network analysis and synthesis power flow in non-sinusoidal systems compensation and power-quality improvement in non-sinusoidd unbalanced systems and power electronics. (Electrical and Computer Eng. Louisiana State University Baton Rouge/ USA Louisiana 70803 T + 1504888-5241 Fax + 1504/388-5200 Internet page: http:/***/Cape Canavera U4739)

A method of an on-line measurement of equivalent parameters for harmonic frequencies of a three-phase distribution system with harmonic generating loads is discussed in the paper. The impedances of the supply and the load, the complex RMS (CRMS) values of the load generated current harmonics, and the CRMS values of the distribution voltage harmonics are the subject of the measurement. It is shown that the on-line measurement of these parameters requires that the line voltages and currents are measured at least in three different states of the system. These states of the tested system are changed by disturbing the system with a current harmonics generating device, built in a form of a fast thyristor switch. The method is illustrated with measurements in a physical system.

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Evolution of Metallic Connection Technologies of Busbar in Silicon Solar Cells: Brief Review

Evolution of Metallic Connection Technologies of Busbar in S...

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IEEE/IAS International Conference on Industry Applications (INDUSCON)

作者： A.M.C. Silveira M.R.M. Neves R. Garcia H. Alvarez M.G. Villalva F.C. Marques L.C. Kretly Communications Department DECOM School of Electrical and Computer Engineering Campinas Brazil Dept. of Systems and Energy DSE School of Electrical and Computer Engineering Campinas Brazil Dept. Research and Development - R&D Build Your Dreams Company - BYD Campinas Brazil Dept. of Applied Physics DFA Institute of Physics Gleb Wataghin Campinas Brazil

This work consists of presenting a brief review of the evolution of metallic connection technologies in busbars applied to the front and rear of solar cells, thus demonstrating their fundamentals, materials and essential manufacturing processes that impact on improving the energy efficiency of solar modules. In this brief review, one can follow the technical limitations that led to the evolution of metallic connection technologies in busbars over time and their impacts on the photovoltaic market. Contributing to a broad understanding of the resistive components of solar cells that consists of the series resistance parameter.

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