The pharmaceutical drug industry faces considerable challenges in supply chain management, particularly in regard to tracking and tracing medications. Counterfeit drugs pose a significant global threat, and existing s...
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With the growing technological advancements in the Internet and advanced functionalities in vehicular networks, it becomes crucial to execute tasks quickly and efficiently. However, the limited onboard computational c...
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Drug discovery is an expensive and risky process. To combat the challenges in drug discovery, an increasing number of researchers and pharmaceutical companies recognize the benefits of utilizing computational techniqu...
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Drug discovery is an expensive and risky process. To combat the challenges in drug discovery, an increasing number of researchers and pharmaceutical companies recognize the benefits of utilizing computational techniques. Evolutionary computation (EC) offers promise as most drug discovery problems are essentially complex optimization problems beyond conventional optimization algorithms. EC methods have been widely applied to solve these complex optimization problems especially in lead com-pound generation and molecular virtual evaluation, substantially speeding up the process of drug discovery and development. This article presents a comprehensive survey of EC-based drug discovery methods. Particularly, a new taxonomy of the methods is provided and the advantages and limitations of the methods are reviewed. In addition, the potential future directions of EC-based drug discovery are discussed and the publicly available resources including databases and computational tools are compiled for the convenience of researchers seeking to pursue this field. IEEE
Conspiracy theories propose that significant events are orchestrated by secretive, powerful groups, gaining traction especially during social upheaval and spreading rapidly via social media. These theories have real-w...
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In the domain of autonomous industrial manipulators,precise positioning and appropriate posture selection in path planning are pivotal for tasks involving obstacle avoidance,such as handling,heat sealing,and *** Multi...
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In the domain of autonomous industrial manipulators,precise positioning and appropriate posture selection in path planning are pivotal for tasks involving obstacle avoidance,such as handling,heat sealing,and *** Multi-Degree-of-Freedom(MDOF)manipulators offer kinematic redundancy,aiding in the derivation of optimal inverse kinematic solutions to meet position and posture requisites,their path planning entails intricate multiobjective optimization,encompassing path,posture,and joint motion *** satisfactory results in practical scenarios remains *** response,this study introduces a novel Reverse Path Planning(RPP)methodology tailored for industrial *** approach commences by conceptualizing the manipulator’s end-effector as an agent within a reinforcement learning(RL)framework,wherein the state space,action set,and reward function are precisely defined to expedite the search for an initial collision-free *** enhance convergence speed,the Q-learning algorithm in RL is augmented with ***,we formulate the cylindrical bounding box of the manipulator based on its Denavit-Hartenberg(DH)parameters and propose a swift collision detection ***,the motion performance of the end-effector is refined through a bidirectional search,and joint weighting coefficients are introduced to mitigate motion in high-power *** efficacy of the proposed RPP methodology is rigorously examined through extensive simulations conducted on a six-degree-of-freedom(6-DOF)manipulator encountering two distinct obstacle configurations and target *** results substantiate that the RPP method adeptly orchestrates the computation of the shortest collision-free path while adhering to specific posture constraints at the target ***,itminimizes both posture angle deviations and joint motion,showcasing its prowess in enhancing the operational performance of MDOF industrial manipulators.
Public service websites have become an integral part of people's everyday existence. And the proliferation of mobile devices has further facilitated access to these websites. These websites not only have formal di...
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Fiber materials are key materials that have changed human history and promoted the progress of human civilization. In ancient times, humans used feathers and animal skins for clothing, and later they widely employed n...
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Fiber materials are key materials that have changed human history and promoted the progress of human civilization. In ancient times, humans used feathers and animal skins for clothing, and later they widely employed natural fibers such as cotton, hemp, silk and wool to make fabrics(Fig. 1a). Chinese ancestors had mastered the art of natural fiber weaving as early as the Neolithic *** thousand years ago, people were already familiar with and adept at techniques for spinning natural fibers [1].
Increasingly popular decentralized applications (dApps) with complex application logic incur significant overhead for executing smart contract transactions, which greatly limits public block chain performance. Pre-exe...
The increasing occurrence of extreme weather events is challenging power grid operation. For extreme weather events, the system operator is responsible for estimating the power outages and scheduling the restoration r...
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In today’s digital landscape, social media platforms have become important areas for disseminating information, ranging from legitimate discourse to misinformation, especially on critical topics such as Climate Chang...
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