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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

BMC NEUROscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Oxidative Species-Induced Excitonic Transport in Tubulin Aromatic networks: Potential Implications for Neurodegenerative Disease

arXiv

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arXiv 2017年

作者： Kurian, P. Obisesan, T.O. Craddock, T.J.A. National Human Genome Center Howard University College of Medicine WashingtonDC20060 United States Department of Medicine Howard University College of Medicine WashingtonDC20060 United States Computational Physics Laboratory Howard University WashingtonDC20059 United States Georgetown-Howard Universities Center for Clinical and Translational Science Clinical Research Unit Howard University College of Medicine WashingtonDC20060 United States Departments of Psychology & Neuroscience Computer Science and Clinical Immunology Nova Southeastern University Fort LauderdaleFL33314 United States Clinical Systems Biology Group Institute for Neuro-Immune Medicine Nova Southeastern University Fort LauderdaleFL33328 United States

Oxidative stress is a pathological hallmark of neurodegenerative tauopathic disorders such as Alzheimer’s disease and Parkinson’s disease-related dementia, which are characterized by altered forms of the microtubule-associated protein (MAP) tau. MAP tau is a key protein in stabilizing the microtubule architecture that regulates neuron morphology and synaptic strength. When MAP tau is degraded in tauopathic disorders, neuron dysfunction results. The precise role of reactive oxygen species (ROS) in the tauopathic disease process, however, is poorly understood. Classically, mitochondrial dysfunction has been viewed as the major source of oxidative stress and has been shown to precede tau and amyloid pathology in various dementias, but the exact mechanisms are not clear. It is known that the production of ROS by mitochondria can result in ultraweak photon emission (UPE) within cells. While of low intensity, surrounding proteins within the cytosol can still absorb these energetic photons via aromatic amino acids (e.g., tryptophan and tyrosine). One likely absorber of these photons is the microtubule cytoskeleton, as it forms a vast network spanning neurons, is highly co-localized with mitochondria, and shows a high density of aromatic amino acids. Functional microtubule networks may traffic this ROS-generated endogenous photon energy for cellular signaling, or they may serve as dissipaters/conduits of such energy to protect the cell from potentially harmful effects. Experimentally, after in vitro exposure to exogenous photons, microtubules have been shown to reorient and reorganize in a dose-dependent manner with the greatest effect being observed around 280 nm, in the tryptophan and tyrosine absorption range. In this paper, recent modeling efforts based on ambient temperature experiment are presented, showing that tubulin polymers can feasibly absorb and channel these photoexcitations via resonance energy transfer, on the order of dendritic length scales and neuronal fi

关键词： Amino acids

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Assessing the benefits of search-based approaches when designing self-adaptive systems: a controlled experiment

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Journal of Software Engineering research and Development 2015年第1期3卷 1-27页

作者： Sandro S Andrade Raimundo J de A Macêdo Distributed Systems Laboratory (LaSiD) Federal University of Bahia (UFBa) Institute of Mathematics Department of Computer Science Salvador-BA Brazil GSORT Distributed Systems Group Federal Institute of Education Science and Technology of Bahia (IFBa) Department of Computer Science Salvador-BA Brazil

The well-orchestrated use of distilled experience, domain-specific knowledge, and well-informed trade-off decisions is imperative if we are to design effective architectures for complex software-intensive systems. In particular, designing modern self-adaptive systems requires intricate decision-making over a remarkably complex problem space and a vast array of solution mechanisms. Nowadays, a large number of approaches tackle the issue of endowing software systems with self-adaptive behavior from different perspectives and under diverse assumptions, making it harder for architects to make judicious decisions about design alternatives and quality attributes trade-offs. It has currently been claimed that search-based software design approaches may improve the quality of resulting artifacts and the productivity of design processes, as a consequence of promoting a more comprehensive and systematic representation of design knowledge and preventing design bias and false intuition. To the best of our knowledge, no empirical studies have been performed to provide sound evidence of such claim in the self-adaptive systems domain. This paper reports the results of a quasi-experiment performed with 24 students of a graduate program in distributed and Ubiquitous Computing. The experiment evaluated the design of self-adaptive systems using a search-based approach proposed by us, in contrast to the use of a non-automated approach based on architectural styles catalogs. The goal was to investigate to which extent the adoption of search-based design approaches impacts on the effectiveness and complexity of resulting architectures. In addition, we also analyzed the approach’s potential for leveraging the acquisition of distilled design knowledge. Our findings show that search-based approaches can improve the effectiveness of resulting self-adaptive systems architectures and reduce their design complexity. We found no evidence regarding the approach’s potential for leveraging the acqu

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Security modeling and analysis of an intrusion tolerant cloud data center 3

Security modeling and analysis of an intrusion tolerant clou...

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3rd IEEE World Conference on Complex systems, WCCS 2015

作者： Mir, Iman El Kim, Dong Seong Haqiq, Abdelkrim Computer Networks Mobility and Modeling Laboratory FST Hassan 1 University Settat Morocco Department of Computer Science and Software Engineering University of Canterbury New Zealand E-NGN Research Group Africa and Middle East Morocco

ISBN: (纸本)9781467396691

It is important to protect a Cloud Data Center even if there are attacks by an adversary. In order to improve the security of a Cloud Data Center (CDC) in particular, system availability, a proactive approach named SCIT (Self-Cleansing Intrusion Tolerance) may be adopted to the CDC. In this paper, we present a general analytic model of the SCIT approach for the CDC. We first introduce an architecture and its flow of an intrusion tolerant CDC. We focus on a SCIT approach for a virtual machine (VM) in a CDC. We model and implement the SCIT in SHARPE (Symbolic Hierarchical Automated Reliability and Performance Evaluator) and carry out numerical analysis. Our numerical results show that the SCIT approach can increase the system availability. © 2015 IEEE.

关键词： Virtualization

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Security modeling and analysis of a self-cleansing intrusion tolerance technique 11

Security modeling and analysis of a self-cleansing intrusion...

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11th International Conference on Information Assurance and Security, IAS 2015

ISBN: (纸本)9781467387156

Since security is increasingly the principal concern in the conception and implementation of software systems, it is very important that the security mechanisms are designed so as to protect the computer systems against cyber attacks. An Intrusion Tolerance systems play a crucial role in maintaining the service continuity and enhancing the security compared with the traditional security. In this paper, we propose to combine a preventive maintenance with existing intrusion tolerance system to improve the system security. We use a semi-Markov process to model the system behavior. We quantitatively analyze the system security using the measures such as system availability, Mean Time To Security Failure and cost. The numerical analysis is presented to show the feasibility of the proposed approach. © 2015 IEEE.

关键词： Preventive maintenance

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A novel collaborative approach for sinkhole detection in MANETs 13

A novel collaborative approach for sinkhole detection in MAN...

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13th International Conference on Ad-hoc networks and Wireless, ADHOC-NOW 2014 accompanied by 2nd International Workshop on Emerging Technologies for Smart Devices, ETSD 2014, 2nd International Workshop on Marine Sensors and systems, MARSS 2014, Multimedia Wireless ad hoc networks, MWaoN 2014, Security in Ad Hoc networks, SecAN 2014, 2nd Smart Sensor Protocols and Algorithms, SSPA 2014 and 8th International Workshop on Wireless Sensor, Actuator and Robot networks, WiSARN 2014

作者： Sánchez-Casado, Leovigildo Maciá-Fernández, Gabriel García-Teodoro, Pedro Aschenbruck, Nils Department of Signal Theory Telematics and Communications School of Computer Science and Telecommunications CITIC-UGR University of Granada C/Periodista Daniel Saucedo Aranda S/n Granada18071 Spain Distributed Systems Group Institute of Computer Science University of Osnabrück Albrechtstr. 28 Osnabrück49076 Germany

ISBN: (纸本)9783662463376

This paper presents a novel approach intended to detect sinkholes in MANETs running AODV. The study focuses on the detection of thewell-known sinkhole attack, devoted to attractmost of the surrounding network traffic by providing fake routes, and thus, invalidating alternative legitimate routes and disrupting the normal network *** detection approach relies on the existence of "contamination borders", formed by legitimate nodes under the influence of the sinkhole attack and, at the same time, neighbors of non-contaminated legitimate nodes. Thus, by collecting the routing information of the neighbors, these nodes are likely to be able to properly detect *** evaluate our approach in a simulation framework and the experimental results show the promising nature of this approach in terms of detection capabilities. © Springer-Verlag Berlin Heidelberg 2015.

关键词： Intrusion detection

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MASAT: Model-based automated security assessment tool for cloud computing 11

MASAT: Model-based automated security assessment tool for cl...

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11th International Conference on Information Assurance and Security, IAS 2015

作者： Mjihil, Oussama Kim, Dong Seong Haqiq, Abdelkrim Computer Networks Mobility and Modeling Laboratory FST Hassan 1st University Settat Morocco Department of Computer Science and Software Engineering University of Canterbury New Zealand E-NGN Research Group Africa and Middle East South Africa

ISBN: (纸本)9781467387156

Security assessment and mitigation have gained considerable attention over the recent years according to the information technology evolution and its broad adoption. Organizations are more aware of their data security, and they also have become more exigent in terms of extensibility and flexibility of their Information Technology infrastructures. Cloud computing is introduced as an evolution of information technology that offers major solutions and techniques to meet the evolving requirements of both tenants and clients. Therefore, extensibility and dynamic adjustment, which are among the most essential Cloud advantages, can make the security analysis a very hard task. There have been many approaches to analyze automatically the cyber security of traditional IT infrastructures without taking into account the new Cloud features, such as the nested virtualization. Until now, there is a few work to assess the security of Cloud computing. In this paper, we propose a novel approach to design and develop Model-based Automated Security Assessment Tool named MASAT. © 2015 IEEE.

关键词： Virtualization

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curlX: A middleware to enforce access control policies within a cloud environment

curlX: A middleware to enforce access control policies withi...

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IEEE Conference on Communications and Network Security (CNS)

作者： Meryeme Ayache Mohammed Erradi Bernd Freisleben Networking & Distributed Systems Research Group Mohammed V University Rabat Morocco Department of Mathematics & Computer Science University of Marburg Germany

Today cloud security and privacy concerns pose significant challenges. One particular challenge consists in how to take into consideration the user's security policies while accessing the outsourced data. In fact, for a given application, we may have a set of rules, as high level security policy, which needs to hold prior to any query execution. Therefore, the main problem that we tackle in this ongoing project is how to enforce this high level security policy in the cloud storage layer without conflicts. To address this challenges, we propose a middleware denoted curlX which consists of two main processes: the security policy enforcement process and the verification process.

关键词： Cloud computing Access control Data privacy Virtual machining Electronic mail

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Utilizing reconfigurable hardware to optimizeworkflows in networked nodes: Deploying partial reconfiguration to optimize load and dependability in constrained networks

IFIP Advances in Information and Communication Technology

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IFIP Advances in Information and Communication Technology 2015年 231卷 373-386页

作者： Murr, Dominik Mühlbauer, Felix Dressler, Falko Bobda, Christophe Self-Organizing Embedded Systems Group Department of Computer Science Kaiserslautern University of Technology Germany Computer Networks and Communication Systems Department of Computer Science Friedrich-Alexander University Erlangen-Nuremberg Germany

ISBN: (纸本)9780387722573

This work investigates the use of reconfigurable devices as computing platform for self-organizing embedded systems. Those usually consist of a set of distributed, autonomous nodes interacting with each other in order to solve a given problem. Several aspects of hardware-software co-design as well as partial reconfiguration are presented in order to enforce adaptivity of a node. One targeted application field for this kind of system are sensor networks in which reconfigurable devices, in this case FPGAs, can be used as computation nodes to provide services that require more computation power. To manage the available hardware resources as a whole we suggest a market-economy-like system of supply and demand. Requests, built up out of several tasks, can be po © Springer-Verlag Berlin Heidelberg 2015.

关键词： Field programmable gate arrays (FPGA)

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Experimental evaluation of RF-based indoor localization algorithms under RF interference

Experimental evaluation of RF-based indoor localization algo...

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International Conference on Localization and GNSS (ICL-GNSS)

作者： Filip Lemic Vlado Handziski Adam Wolisz Timotheos Constambeys Christos Laoudias Stephan Adler Simon Schmitt Yuan Yang Telecommunication Networks Group Technische Universität Berlin Department of Computer Science University of Cyprus KIOS Research Center for Intelligent Systems and Networks University of Cyprus Department of Mathematics and Computer Science Freie Universität Berlin

In the current practice, the performance evaluation of RF-based indoor localization solutions is typically realized in non-standardized environments and following ad-hoc procedures, which hampers objective comparison and does not provide clear insight into their intrinsic properties. Many evaluation procedures also neglect important environmental factors like RF interference, diminishing the real-world value of the obtained results. Localization competitions, in which different solutions are evaluated along a set of standardized metrics under unified and representative conditions, can play an important role in mitigating these problems, but their organization is cost and labor intensive. In this paper we report on the design, execution and results from an online localization competition in which several different RF-based indoor localization algorithms have been evaluated with the help of a remotely accessible and automated testbed infrastructure, that reduces these overheads. The competing algorithms have been evaluated following a combination of precision, latency and sensitivity metrics, under four different benchmarking scenarios, resulting in 28 different benchmarking experiments. The obtained results provide strong indication that specific types of RF-interference noticeably degrade the localization performance.

关键词： Interference Benchmark testing Accuracy IEEE 802.11 Standard Sensitivity Robots

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