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International Conference on Information Management and Technology (ICIMTech)

作者： Bharuno Mahesworo Arif Budiarto Alam Ahmad Hidayat Haryono Soeparno Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia School of Computer Science Bina Nusantara University Jakarta Indonesia BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia

ISBN: (数字)9781728170718

ISBN: (纸本)9781728170725

Having good sleep is important to maintain physical and mental health. However, many young adults suffer poor sleep due to work or academic demands. Even more, sleep is associated with stress which is many young adults experienced it. To solve this problem, many epidemiologic studies suggest that exercise may improve sleep quality. On the other hand, several studies show that daily activity has no association with sleep quality. In this study, we tried to find more evidence of whether the daily activity has an association with sleep quality or not. We used a commercially available wearable device to capture the subject's heart rate, step count and deep sleep duration for 7 months. Then we used linear regression, XGBoost, and Long Short-Term Memory to find an association between these variables. The results show that there was no association between these variables.

关键词： Sleep Heart rate Biomedical monitoring computer science Predictive models Bioinformatics data science

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Temporal motifs in patent opposition and collaboration networks

arXiv

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arXiv 2021年

作者： Liu, Penghang Masuda, Naoki Kito, Tomomi Sarıyüce, Ahmet Erdem Department of Computer Science and Engineering State University of New York at Buffalo BuffaloNY United States Department of Mathematics State University of New York at Buffalo BuffaloNY United States Computational and Data-Enabled Science and Engineering Program State University of New York at Buffalo BuffaloNY United States Faculty of Science and Engineering Waseda University Tokyo Japan

Patents are intellectual properties that reflect innovative activities of companies and organizations. The literature is rich with the studies that analyze the citations among the patents and the collaboration relations among companies that own the patents. However, the adversarial relations between the patent owners are not as well investigated. One proxy to model such relations is the patent opposition, which is a legal activity in which a company challenges the validity of a patent. Characterizing the patent oppositions, collaborations, and the interplay between them can help better understand the companies’ business strategies. Temporality matters in this context as the order and frequency of oppositions and collaborations characterize their interplay. In this study, we construct a two-layer temporal network to model the patent oppositions and collaborations among the companies. We utilize temporal motifs to analyze the oppositions and collaborations from structural and temporal perspectives. We first characterize the frequent motifs in patent oppositions and investigate how often the companies of different sizes attack other companies. We show that large companies tend to engage in opposition with multiple companies. Then we analyze the temporal interplay between collaborations and oppositions. We find that two adversarial companies are more likely to collaborate in the future than two collaborating companies oppose each other in the future. © 2021, CC BY.

关键词： Patents and inventions

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A pretrained transformer model for decoding individual glucose dynamics from continuous glucose monitoring data

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National science Review 2025年第5期 362-381页

作者： Yurun Lu Dan Liu Zhongming Liang Rui Liu Pei Chen Yitong Liu Jiachen Li Zhanying Feng Lei M.Li Bin Sheng Weiping Jia Luonan Chen Huating Li Yong Wang Center for Excellence in Mathematical Sciences National Center for Mathematics and Interdisciplinary Sciences Hua Loo-Keng Center for Mathematical Sciences Key Laboratory of Management Decision and Information System Academy of Mathematics and Systems ScienceChinese Academy of Sciences School of Mathematics University of Chinese Academy of SciencesChinese Academy of Sciences Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Diabetes InstituteShanghai Clinical Center for Diabetes Shanghai Key Laboratory of Diabetes Mellitus Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences BGI-Research School of Mathematics South China University of Technology Department of Statistics Department of Biomedical Data Science Bio-X ProgramStanford University Department of Computer Science and Engineering Shanghai Jiao Tong University State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Guangdong Institute of Intelligence Science and Technology Pazhou Laboratory (Huangpu)

Continuous glucose monitoring(CGM) technology has grown rapidly to track real-time blood glucose levels and trends with improved sensor accuracy. The ease of use and wide availability of CGM will facilitate safe and effective decision making for diabetes management. Here, we developed an attention-based deep learning model, CGMformer, pretrained on a well-controlled and diverse corpus of CGM data to represent individual's intrinsic metabolic state and enable clinical applications. During pretraining, CGMformer encodes glucose dynamics including glucose level, fluctuation, hyperglycemia, and hypoglycemia into latent space with self-supervised learning. It shows generalizability in imputing glucose value across five external datasets with different populations and metabolic states(MAE = 3.7 mg/d L). We then fine-tuned CGMformer towards a diverse panel of downstream tasks in the screening of diabetes and its complications using task-specific data, which demonstrated a consistently boosted predictive accuracy over direct fine-tuning on a single task(AUROC = 0.914 for type 2 diabetes(T2D) screening and 0.741 for complication screening). By learning an intrinsic representation of an individual's glucose dynamics,CGMformer classifies non-diabetic individuals into six clusters with elevated T2D risks, and identifies a specific cluster with lean body-shape but high risk of glucose metabolism disorders, which is overlooked by traditional glucose measurements. Furthermore, CGMformer achieves high accuracy in predicting an individual's postprandial glucose response with dietary modelling(Pearson correlation coefficient = 0.763)and helps personalized dietary recommendations. Overall, CGMformer pretrains a transformer neural network architecture to learn an intrinsic representation by borrowing information from a large amount of daily glucose profiles, and demonstrates predictive capabilities fine-tuned towards a broad range of downstream applications, holding promise for the ear

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Application of expert system for oil palm smallholder-owned plantations

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AIP Conference Proceedings 2023年第1期2594卷

作者： A. Umami H. G. Mawandha D. D. Puruhito Purwadi T. Suparyanto D. Sudigyo B. Pardamean Department of Agrotechnology Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Departement of Agricultural Economics Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Departement of Agriculture Engineering Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta Indonesia 11480

Most of the oil palm smallholders operate independently. As a result of this lack of support and assistance, oil palm owned by independent smallholders has the lowest productivity compared to large private (corporation) plantations and large state plantations. In addition, smallholder-owned plantations often operate without paying attention to sustainability aspects. There is a need for an effective, efficient, and user-friendly mentoring tool for oil palm farmers that are accessed independently. The Android-based platform was developed by applying an expert system to support increased production of oil palm cultivation for smallholders. Several stages of the expert system implementation, including the identification of planters and land profiles, were carried out using the direct interview method. The expert system includes land preparation management, planting material selection, seeding, weeds control, pests and diseases, fertilization, harvesting and transport, plantation administration, chat platforms, and data scrapping from data providers. The type of expert system is a data-driven Decision Support System (DSS).

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Building Ramps and Pathways to data science in K-12, Minority-Serving Institutions, and Two-Year Colleges

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Scatterplot 2024年第1期1卷

作者： Rachel Saidi Helen Burn Ben Baumer Jason Black Debzani Deb Zarek Drozda a Math Statistics and Data Science Department Montgomery College – Rockville Campus Rockville MD USA b Mathematics Department Highline College Des Moines Washington Des Moines WA USA c Statistical and Data Sciences Department Smith College Northampton MA USA d School of Business and Interdisciplinary Center for Creativity and Innovation (ICCI) Florida A&M University Tallahassee FL USA e Computer Science Department Center for Applied Data Science (CADS) Winston-Salem State University Winston-Salem NC USA f Data Science 4 Everyone (DS4E) Program University of Chicago Chicago IL USA

Global demand for data scientists and analysts is on a trajectory of sustained growth, underscoring the need to expand enrollment of students in data science and data analytics courses and programs. This article explores diverse pathways to data science for various groups, including high school students, those in two-year colleges, and students in small colleges and minority-serving institutions. This article identifies opportunities and challenges associated with pursuing data science for students in these sectors, including factors such as building partnerships and awareness of the field and difficulties in establishing articulation agreements between institutions. The authors, representing various organizations participating in a panel discussion at the 2023 data science Leadership Summit of the Academic data science Alliance (ADSA), share insights into efforts to develop nontraditional pathways, serving as a resource for schools, colleges, and organizations contemplating creation of data science programs. The panelists’ combined experience spans work with a broad range of organizations including ADSA, American Mathematics Association of Two-Year Colleges, American Statistical Association, data science for Everyone, the Department of Education, HBCU data science Consortium, Mathematical Association of America, National Academies of science, Engineering, and Medicine, HBCU data science Consortium, National science Foundation, and StatPREP.

关键词： data science pathways access K-12 minority-serving institution two-year college

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Learning management system for oil palm smallholder-owned plantations

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AIP Conference Proceedings 2023年第1期2594卷

作者： E. Firmansyah D. Nurjannah S. I. Dinarti D. Sudigyo T. Suparyanto B. Pardamean Department of Agrotechnology Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Departement of Agricultural Economics Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Departement of Agriculture Engineering Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta Indonesia 11480

The production gap between oil palm smallholder-owned plantations and corporations shows a real problem in the national palm oil industry. To reduce the gap, user-friendly assistance for smallholder-owned plantations is needed for the cultivation of sustainable palm oil production. Android-based software can be a platform for bridging the transfer of knowledge and technology, transfer of problems, and transfer of solutions between planters and experts. The platform development was formulated in five stages which began with Learning Management System (LMS) application development, identification of Good Agricultural Practices (GAP) and Best Management Practices (BMP) materials, development of digital contents, uploading the digital content to the LMS server, and dissemination. The curriculum in the application platform was prepared based on the needs of the growers according to the identification results of the farmers' profiles. The curriculum consists of GAP and BMP material blocks. Each block was divided into discussion topics. The digital contents related to GAP and BMP were set in the LMS, which was built using Moodle platform.

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Scientific discovery in the age of artificial intelligence

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NATURE 2023年第7978期621卷 E33-E33页

作者： Wang, Hanchen Fu, Tianfan Du, Yuanqi Gao, Wenhao Huang, Kexin Liu, Ziming Chandak, Payal Liu, Shengchao Van Katwyk, Peter Deac, Andreea Anandkumar, Anima Bergen, Karianne Gomes, Carla P. Ho, Shirley Kohli, Pushmeet Lasenby, Joan Leskovec, Jure Liu, Tie-Yan Manrai, Arjun Marks, Debora Ramsundar, Bharath Song, Le Sun, Jimeng Tang, Jian Velickovic, Petar Welling, Max Zhang, Linfeng Coley, Connor W. Bengio, Yoshua Zitnik, Marinka Department of Engineering University of Cambridge Cambridge UK Department of Computing and Mathematical Sciences California Institute of Technology Pasadena CA USA NVIDIA Santa Clara CA USA Department of Computational Science and Engineering Georgia Institute of Technology Atlanta GA USA Department of Computer Science Cornell University Ithaca NY USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Department of Computer Science Stanford University Stanford CA USA Department of Physics Massachusetts Institute of Technology Cambridge MA USA Harvard-MIT Program in Health Sciences and Technology Cambridge MA USA Mila – Quebec AI Institute Montreal Quebec Canada Université de Montréal Montreal Quebec Canada HEC Montréal Montreal Quebec Canada CIFAR AI Chair Toronto Ontario Canada Department of Earth Environmental and Planetary Sciences Brown University Providence RI USA Data Science Institute Brown University Providence RI USA Center for Computational Astrophysics Flatiron Institute New York NY USA Department of Astrophysical Sciences Princeton University Princeton NJ USA Department of Physics Carnegie Mellon University Pittsburgh PA USA Department of Physics and Center for Data Science New York University New York NY USA Google DeepMind London UK Department of Computer Science and Technology University of Cambridge Cambridge UK Microsoft Research Beijing China Department of Biomedical Informatics Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Harvard Data Science Initiative Cambridge MA USA Kempner Institute for the Study of Natural and Artificial Intelligence Harvard University Cambridge MA USA Department of Systems Biology Harvard Medical School Boston MA USA Deep Forest Sciences Palo Alto CA USA BioMap Beijing China Mo

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Exploration of Dark Chemical Genomics Space via Portal Learning: Applied to Targeting the Undruggable Genome and COVID-19 Anti-Infective Polypharmacology

Research Square

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Research Square 2021年

作者： Cai, Tian Xie, Li Chen, Muge Liu, Yang He, Di Zhang, Shuo Mura, Cameron Bourne, Philip E. Xie, Lei Ph.D. Program in Computer Science The Graduate Center The City University of New York New York10016 United States Department of Computer Science Hunter College The City University of New York New York10065 United States Master Program in Computer Science Courant Institute of Mathematical Sciences New York University United States School of Data Science Department of Biomedical Engineering University of Virginia VA22903 United States Helen and Robert Appel Alzheimer’s Disease Research Institute Feil Family Brain & Mind Research Institute Weill Cornell Medicine Cornell University New York10021 United States

Advances in biomedicine are largely fueled by exploring uncharted territories of human biology. Machine learning can both enable and accelerate discovery, but faces a fundamental hurdle when applied to unseen data with distributions that differ from previously observed ones—a common dilemma in scientific inquiry. We have developed a new deep learning framework, called Portal Learning, to explore dark chemical and biological space. Three key, novel components of our approach include: (i) end-to-end, step-wise transfer learning, in recognition of biology’s sequence-structure-function paradigm, (ii) out-of-cluster meta-learning, and (iii) stress model selection. Portal Learning provides a practical solution to the out-of-distribution (OOD) problem in statistical machine learning. Here, we have implemented Portal Learning to predict chemical-protein interactions on a genome-wide scale. Systematic studies demonstrate that Portal Learning can effectively assign ligands to unexplored gene families (unknown functions), versus existing state-of-the-art methods. Compared with AlphaFold2-based protein-ligand docking, Portal Learning significantly improved the performance by 79% in PR-AUC and 27% in ROC-AUC, respectively. The superior performance of Portal Learning allowed us to target previously "undruggable" proteins and design novel polypharmacological agents for disrupting interactions between SARS-CoV-2 and human proteins. Portal Learning is general-purpose and can be further applied to other areas of scientific inquiry. © 2021, CC BY.

关键词： Coronavirus

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Exploration of dark chemical genomics space via portal learning: Applied to targeting the undruggable genome and COVID-19 anti-infective polypharmacology

arXiv

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arXiv 2021年

Advances in biomedicine are largely fueled by exploring uncharted territories of human biology. Machine learning can both enable and accelerate discovery, but faces a fundamental hurdle when applied to unseen data with distributions that differ from previously observed ones—a common dilemma in scientific inquiry. We have developed a new deep learning framework, called Portal Learning, to explore dark chemical and biological space. Three key, novel components of our approach include: (i) end-to-end, step-wise transfer learning, in recognition of biology’s sequence-structure-function paradigm, (ii) out-of-cluster meta-learning, and (iii) stress model selection. Portal Learning provides a practical solution to the out-of-distribution (OOD) problem in statistical machine learning. Here, we have implemented Portal Learning to predict chemical-protein interactions on a genome-wide scale. Systematic studies demonstrate that Portal Learning can effectively assign ligands to unexplored gene families (unknown functions), versus existing state-of-the-art methods, thereby allowing us to target previously "undruggable" proteins and design novel polypharmacological agents for disrupting interactions between SARS-CoV-2 and human proteins. Portal Learning is general-purpose and can be further applied to other areas of scientific *** Codes 68T07 © 2021, CC BY.

关键词： Genes

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Automatic detection of large-scale flux ropes and their geoeffectiveness with a machine learning approach

arXiv

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arXiv 2024年

作者： Pal, Sanchita dos Santos, Luiz F.G. Weiss, Andreas J. Narock, Thomas Narock, Ayris Nieves-Chinchilla, Teresa Jian, Lan K. Good, Simon W. NASA Postdoctoral Program Fellow NASA Goddard Space Flight Center GreenbeltMD20771 United States SETI Institute Mountain ViewCA94043 United States Center for Natural Computer and Data Sciences Goucher College BaltimoreMD United States ADNET Systems Inc. 7515 Mission Drive LanhamMD20706 United States Heliophysics Science Division NASA Goddard Space Flight Center GreenbeltMD20771 United States Department of Physics University of Helsinki P.O. Box 64 HelsinkiFI-00014 Finland

Detecting large-scale flux ropes (FRs) embedded in interplanetary coronal mass ejections (ICMEs) and assessing their geoeffectiveness are essential since they can drive severe space weather. At 1 au, these FRs have an average duration of 1 day. Their most common magnetic features are large, smoothly rotating magnetic fields. Their manual detection has become a relatively common practice over decades, although visual detection can be time-consuming and subject to observer bias. Our study proposes a pipeline that utilizes two supervised binary-classification machine learning (ML) models trained with solar wind magnetic properties to automatically detect large-scale FRs and additionally determine their geoeffectiveness. The first model is used to generate a list of auto-detected FRs. Using the properties of southward magnetic field the second model determines the geoeffectiveness of FRs. Our method identifies 88.6% and 80% large-scale ICMEs (duration ≥ 1 day) observed at 1 au by Wind and Sun Earth Connection Coronal and Heliospheric Investigation (STEREO) mission, respectively. While testing with a continuous solar wind data obtained from Wind, our pipeline detected 56 of the 64 large-scale ICMEs during 2008 - 2014 period (recall= 0.875) but many false positives (precision= 0.56) as we do not take into account any additional solar wind properties than the magnetic properties. We found an accuracy of 0.88 when estimating the geoeffectiveness of the auto-detected FRs using our method. Thus, in space weather now-casting and forecasting at L1 or any planetary missions, our pipeline can be utilized to offer a first-order detection of large-scale FRs and geoeffectiveness. © 2024, CC BY.

关键词： Magnetic fields

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