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data Mining and Bioinformatics Approaches to Elucidate Bacterial Communities in the Extreme Environment

Data Mining and Bioinformatics Approaches to Elucidate Bacte...

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2023 International Conference on Informatics, Multimedia, Cyber and Information Systems, ICIMCIS 2023

作者： Trinugroho, Joko Pebrianto Hidayat, Alam Ahmad Nirwantono, Rudi Asadi, Faisal Pardamean, Bens Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia Bina Nusantara University School of Computer Science Bioinformatics and Data Science Research Center Mathematics Department Jakarta11480 Indonesia Bina Nusantara University Faculty of Engineering Bioinformatics and Data Science Research Center Biotechnology Department Jakarta11480 Indonesia Bina Nusantara University School of Computer Science Bioinformatics and Data Science Research Center Computer Science Department Jakarta11480 Indonesia Bina Nusantara University Binus Graduate Program Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9798350307306

Bacteria are microscopic organisms that can be found in many environments. They are abundant and have many roles in our life. Studying bacteria is essential so that we can identify the bacteria that are needed for many industrial applications. However, the main problem is that majority of the bacteria are unculturable, hampering the exploration of bacteria from different environments. Metagenomics approach which employs Next Generation Sequencing technology could help study bacteria by utilizing 16S rRNA marker gene. This study aims to demonstrate data mining and bioinformatics approaches to analyze 16S rRNA sequencing data. The raw sequencing data of 16S rRNA was collected from biological database. Then, the data were trimmed, denoised, and clustered to generate Amplicon Sequence Variants (ASVs). Diversity (alpha and beta) and taxonomic analyses were then conducted to elucidate the bacterial diversity and taxonomic profile of ASVs. The results of this work showed that Shannon and PD indices in China's hot spring were higher than Singapore and the USA. Furthermore, a significant difference was observed in the PD index. The unweighted UniFrac distance also showed there was a significant difference of the bacterial communities between the three locations. In addition, the taxonomic investigation unveiled prevalent bacterial groups in the ecosystem, namely Proteobacteria, Chloroflexi, Cyanobacteria, and Crenarchaeota. The research outcomes have the potential to serve as a foundational resource for subsequent bacterial metagenomic research, particularly the hot spring environment. © 2023 IEEE.

关键词： Bacteria

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Evaluating the Effectiveness of Transformer Models for Molecular Property Prediction: A Review 9

Evaluating the Effectiveness of Transformer Models for Molec...

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9th International Conference on Information Technology and Digital Applications, ICITDA 2024

作者： Imani, Alyssa Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Binus Graduate Program Bina Nusantara University Computer Science Departement Jakarta11480 Indonesia

ISBN: (纸本)9798331510732

Transformer models, originally successful in natural language processing, are now being applied to chemical and biological studies, excelling in areas such as molecular property prediction, material science, and drug discovery. BERT, a Transformer-based model, has become foundational in cheminformatics, particularly for QSAR (Quantitative Structure-Activity Relationship) modeling and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) evaluations in drug discovery. However, achieving higher accuracy often requires designing more complex models, which can compromise their interpretability. This posing a challenge for researchers who need to understand the reasoning behind the predictions. The trade-off between accuracy and interpretability presents a critical challenge in applying black box models to real-world problems in cheminformatics. This work compares Transformer-based models with traditional machine learning and deep learning approaches, focusing on both interpretability and performance. The goal is to highlight the strengths and limitations of each method, offering insights into their optimal use in drug discovery and material science. © 2024 IEEE.

关键词： Prediction models

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LDA Topic Modeling for Bioinformatics Terms in arXiv Documents 9th

LDA Topic Modeling for Bioinformatics Terms in arXiv Documen...

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9th International Conference on computer science and Computational Intelligence, ICCSCI 2024

作者： Karnyoto, Andrea Stevens Henry, Matthew Martianus Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program Bina Nusantara University Jakarta11480 Indonesia

A wide variety of disciplines contribute to bioinformatics research, including computer science, biology, chemistry, mathematics, and physics. This study determines the number of research articles published on arXiv classified as bioinformatics topics and the most frequently used bioinformatics terms using topic modeling, Latent Dirichlet Allocation (LDA). An algorithm based on LDA is used to discover topics hidden within large collections of documents through the use of statistical analysis. Our research examined 226453 articles on arXiv between January 2023 and January 2024. As a result, there are more than 10521 articles categorized into bioinformatics topics. Most commonly, 6352 documents are in the "Mathematical Physics" category. The second most popular category is "computer science," with 2950 documents. Accordingly, the terms 'RNA,' 'sequence,' 'tree,' and 'homology' are the three most commonly used terms in bioinformatics. The study of RNA plays a vital role in molecular biology;thus, the study of RNA is prevalent in bioinformatics. Sequential data refer to the order in which nucleotides or amino acids can be found in a DNA molecule or a protein. © 2024 The Authors.

关键词： arXiv bioinformatics Latent Dirichlet Allocation

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Indonesian Agricultural-crops Classification Using Transfer Learning Model 8

Indonesian Agricultural-crops Classification Using Transfer ...

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8th International Conference on computer science and Computational Intelligence, ICCSCI 2023

作者： Isnan, Mahmud Hidayat, Alam Ahmad Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Department of Mathematics School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta11480 Indonesia

Classification of Indonesian crops is a critical task in developing farming and getting more understanding of agriculture. However, there is no clear task in classifying types of crops in Indonesia. Transfer learning has been used successfully in a variety of image classification applications. Thus, in this paper, we collected images of Indonesian crops from the internet randomly and proposed a classification by using transfer learning of deep learning with four pre-trained models: EffficientNetB0, ResNet18, VGG19, and AlexNet. In the experiment, augmentation techniques such as random horizontal flip, random vertical flip, and random affine were utilized to prevent the network from overfitting. The result found that EfficientNet-B0 outperformed other models with an accuracy of 82.55. Then, the model struggled to distinguish between crops in the same family. According to the results, although transfer learning can work well to classify images of Indonesian agricultural crops, some improvements are still required to address existing issues. © 2023 The Authors. Published by Elsevier B.V.

关键词： Agriculture Classification Crop Deep Learning Transfer learning

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Count-data Mixed Models of Topical Tweets: A Case of Indonesia Flood Events 8

Count-Data Mixed Models of Topical Tweets: A Case of Indones...

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8th International Conference on computer science and Computational Intelligence, ICCSCI 2023

作者： Hidayat, Alam Ahmad Pardamean, Bens Mathematics Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta11480 Indonesia

Examining topic-level variability in modeling Twitter data can potentially yield more comprehensive insights into public perception during critical periods, thereby enhancing natural disaster mitigation and surveillance efforts. In this study, we utilized generalized linear mixed models (GLMMs) to illustrate the variability in tweet counts related to specific topics in Indonesia during the flood events that occurred in February 2021. The glmmTMB library in R was employed for this purpose. The data were assumed to follow two distinct exponential distributions: Poisson and Negative Binomial. To incorporate random effects, random intercepts and random slopes were introduced, allowing them to vary randomly across topics in the initial two models. Additionally, the final model addressed issues related to dispersion and zero-inflation. By evaluating the Akaike Information Criteria scores, we determined that a model based on the Negative Binomial distribution with random zero-inflation intercepts best fit the data. The chosen model formulation and the estimated parameters have the potential to forecast topic-specific trends in Indonesian flood-related Twitter data. © 2023 The Authors. Published by Elsevier B.V.

关键词： count data disaster surveillance floods mixed models Twitter

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Exploring Recurrent Neural Network Models for Depression Detection Through Facial Expressions: A Systematic Literature Review 6

Exploring Recurrent Neural Network Models for Depression Det...

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6th International Conference on computer and Informatics Engineering, IC2IE 2023

作者： Rumahorbo, Brilyan Nathanael Pardamean, Bens Elwirehardja, Gregorius Natanael Bina Nusantara University Binus Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia

ISBN: (纸本)9798350345162

Major Depressive Disorder (MDD) is a prevalent mental disorder, affecting a significant number of individuals, with estimates reaching 300 million cases worldwide. Currently, the diagnosis of this condition relies heavily on subjective assessments based on the experience of medical professionals. Therefore, researchers have turned to deep learning models to explore the detection of depression. The objective of this review is to gather information on detecting depression based on facial expressions in videos using deep learning techniques. Overall, this research found that RNN models achieved 7.22 MAE for AVEC2014. LSTM models produced 4.83 MAE for DAIC-WOZ, while GRU models achieved an accuracy of 89.77% for DAIC-WOZ. Features like Facial Action Units (FAU), eye gaze, and landmarks show great potential and need to be further analyzed to improve results. Analysis can include applying feature engineering techniques. Aggregation methods, such as mean calculation, are recommended as effective approaches for data processing. This Systematic Literature Review found that facial expressions do have relevant patterns related to MDD. © 2023 IEEE.

关键词： deep learning facial expression GRU LSTM major depressive disorder

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Long Short-Term Memory-based Models for Sleep Quality Prediction from Wearable Device Time Series data 8

Long Short-Term Memory-based Models for Sleep Quality Predic...

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8th International Conference on computer science and Computational Intelligence, ICCSCI 2023

作者： Hidayat, Alam Ahmad Budiarto, Arif Pardamean, Bens Mathematics Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta11480 Indonesia

Several studies suggest that sleep quality is associated with physical activities. Moreover, deep sleep time can be used to determine the sleep quality of an individual. In this work, we aim to find the association between physical activities and deep sleep time by modeling the time series data such as heart rate and a number of steps captured from a commercial wearable device. Our previous study demonstrates that deep learning-based time series modeling is well suited for our problem since the temporal patterns in the two physical parameters need to be captured to obtain more accurate results. We first preprocess our series data to have a time-step size of 10 minutes. To improve our previous effort in this modeling, we compare four different variants of Long Short-Term Memory (LSTM)-based models, ranging from single input to dual input models. Our result shows that the simple stacked LSTM model performs better for our data because the remaining models suffer from overfitting due to a larger number of the trained parameters. © 2023 The Authors. Published by Elsevier B.V.

关键词： deep learning forecasting sleep quality time series wearable devices

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PentaPen: Combining Penalized Models to Identify Important SNPs on Whole-genome Arabidopsis thaliana data 24

PentaPen: Combining Penalized Models to Identify Important S...

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16th International Conference on Bioinformatics and Biomedical Technology, ICBBT 2024

作者： Kohli, Nikita Tomal, Jabed H. Lin, Wenjun Yan, Yan Program of Data Science Thompson Rivers University KamloopsBC Canada Department of Mathematics and Statistics Thompson Rivers University KamloopsBC Canada School of Computer Science and Technology Algoma University BramptonON Canada School of Computer Science University of Guelph GuelphON Canada

ISBN: (纸本)9798400717666

In the rapidly advancing field of genomics, the identification of Single Nucleotide Polymorphisms (SNPs) plays a crucial role in understanding complex phenotypic *** study introduces "PentaPen", an innovative computational workflow which combines the strengths of five penalized models to achieve improved accuracy in SNP *** compare the performance of PentaPen with existing models, highlighting its advantages in solving problems arising from when the number of predictors exceeds the number of *** model comparison, we provide insights into PentaPen's effectiveness in utilizing all SNPs as input, streamlines data pre-processing, and leverages parallel computation, enabling the workflow a considerable stride in SNP ***, a thorough evaluation and comparison of computational complexities signifies competitive edge of the workflow over individual penalized *** future research directions, we propose applications of PentaPen to plant-specific characteristics and suggest further explorations to assess the robustness of its *** summary, this manuscript presents the genomics community with a tool that combines computational efficiency with high-precision SNP detection, making a strong contribution to the field of genomic research. © 2024 Copyright held by the owner/author(s).

关键词： Genome

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Systematic Literature Review on Statistics and Machine Learning Predictive Models for Rice Phenotypes 8

Systematic Literature Review on Statistics and Machine Learn...

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8th International Conference on computer science and Computational Intelligence, ICCSCI 2023

作者： Dominic, Nicholas Cenggoro, Tjeng Wawan Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta11480 Indonesia

Predicting the best-quality of rice phenotypes is the priority among agricultural researchers to fulfill worldwide food security. Trend development of predictive models from statistics to machine learning is the subject of this review. Gathered from the Google Scholar database, 14 appropriate papers (2016-2020) related to the rice phenotypes prediction were selected through title and abstract content filtering. The outputs show that Support Vector Machine, Multi-layer Perceptron, and regression are the most used models, while yield is the priority prediction point besides tiller, panicle, and 1000-grain weight of rice. However, finding the accurate predictor is invariably challenging due to distinct rice varieties in the world and high confounding factors. Thus, developing an advanced deep learning model that accommodates these needs is worth considering further. © 2023 The Authors. Published by Elsevier B.V.

关键词： machine learning rice phenotypes prediction statistics

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Prior-Guided Parallel Residual Bi-Fusion Network in USV Obstacle Detection

Prior-Guided Parallel Residual Bi-Fusion Network in USV Obst...

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2023 International Conference on Consumer Electronics - Taiwan, ICCE-Taiwan 2023

作者： Hsu, Chih-Chung Yang, Sophia Hou, Xiu-Yu Jhang, Yu-An Institute of Data Science National Cheng Kung University Taiwan National Tsing Hua University Interdisciplinary Program of Electrical Engineering and Computer Science Taiwan

ISBN: (纸本)9798350324174

In this paper, we propose a novel Prior-Guided Parallel Residual Bi-Fusion Feature Pyramid Network (PPRB-FPN) for accurate obstacle detection in unmanned surface vehicle (USV) sailing. Our method tackles the challenge of detecting small objects, which are prone to information vanishing. To the end, we leverage the PRB-FPN for small object detection and YOLOv7 as a single-stage object detector to effectively identify obstacles. Our experimental results on the Obstacle Detection Challenge dataset at the 1st Workshop on Maritime computer Vision (MaCVi) demonstrate that our method outperforms both Mask R-CNN (mrcnn) and YOLOv7, achieving an F-avg score of 0.514. © 2023 IEEE.

关键词： Unmanned surface vehicles

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