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arXiv 2024年

作者： Amaro, R. Åqvist, J. Bahar, I. Battistini, F. Bellaiche, A. Beltran, D. Biggin, P.C. Bonomi, M. Bowman, G.R. Bryce, R. Bussi, G. Carloni, P. Case, D. Cavalli, A. Chang, C.A. Cheatham, T.E. Cheung, M.S. Chipot, C. Chong, L.T. Choudhary, P. Cisneros, G.A. Clementi, C. Collepardo-Guevara, R. Coveney, P. Covino, R. Crawford, T.D. Dal Peraro, M. de Groot, B. Delemotte, L. De Vivo, M. Essex, J. Fraternali, F. Gao, J. Gelpí, J.L. Gervasio, F.L. Gonzalez-Nilo, F.D. Grubmüller, H. Guenza, M.G. Guzman, H.V. Harris, S. Head-Gordon, T. Hernandez, R. Hospital, A. Huang, N. Huang, X. Hummer, G. Iglesias-Fernández, J. Jensen, J.H. Jha, S. Jiao, W. Jorgensen, W.L. Kamerlin, S.C.L. Khalid, S. Laughton, C. Levitt, M. Limongelli, V. Lindahl, E. Lindorff-Larsen, K. Loverde, S. Lundborg, M. Luo, Y.L. Luque, F.J. Lynch, C.I. MacKerell, A. Magistrato, A. Marrink, S.J. Martin, H. McCammon, J.A. Merz, K. Moliner, V. Mulholland, A. Murad, S. Naganathan, A.N. Nangia, S. Noe, F. Noy, A. Oláh, J. O'Mara, M. Ondrechen, M.J. Onuchic, J.N. Onufriev, A. Osuna, S. Palermo, G. Panchenko, A.R. Pantano, S. Parish, C. Parrinello, M. Perez, A. Perez-Acle, T. Perilla, J.R. Pettitt, B.M. Pietropaolo, A. Piquemal, J.-P. Poma, A. Praprotnik, M. Ramos, M.J. Ren, P. Reuter, N. Roitberg, A. Rosta, E. Rovira, C. Roux, B. Röthlisberger, U. Sanbonmatsu, K. Schlick, T. Shaytan, A.K. Simmerling, C. Smith, J.C. Sugita, Y. Świderek, K. Taiji, M. Tao, P. Tikhonova, I.G. Tirado-Rives, J. Tuñón, I. Van Der Kamp, M.W. Van der Spoel, D. Velankar, S. Voth, G.A. Wade, R. Warshel, A. Welborn, V.V. Wetmore, S. Wong, C.F. Yang, L.-W. Zacharias, M. Orozco, M. Department of Molecular Biology University of California San DiegoCA United States Department of Cell and Molecular Biology Uppsala University Uppsala Sweden Laufer Center for Physical and Quantitative Biology Renaissance School of Medicine Stony Brook University Stony BrookNY United States Department of Biochemistry and Cell Biology Renaissance School of Medicine Stony Brook University Stony BrookNY United States Barcelona Spain European Molecular Biology Laboratory European Bioinformatics Institute Hinxton United Kingdom Structural Bioinformatics and Computational Biochemistry Department of Biochemistry University of Oxford Oxford United Kingdom Institut Pasteur Université Paris Cité CNRS UMR 3528 Computational Structural Biology Unit Paris France Department of Biochemistry and Biophysics University of Pennsylvania PhiladelphiaPA United States Division of Pharmacy and Optometry University of Manchester Manchester United Kingdom Scuola Internazionale Superiore di Studi Avanzati-SISSA Trieste Italy Computational Biomedicine Institute of Advanced Simulations IAS-5 Institute for Neuroscience and Medicine INM-9 Forschungszentrum Jülich GmbH Jülich Germany Department of Physics and Universitätsklinikum RWTH Aachen University Aachen Germany Department of Chemistry & Chemical Biology Rutgers University PiscatawayNJ United States Istituto Italiano di Tecnologia Drug Discovery and Development Bologna Italy Lausanne Switzerland Department of Chemistry University of California RiversideCA United States Department of Medicinal Chemistry College of Pharmacy University of Utah Salt Lake CityUT United States Department of Physics University of Washington SeattleWA United States Pacific Northwest National Laboratory RichlandWA United States LIA CNRS-UIUC UMR n°7019 Université de Lorraine Vandœuvre-lès-Nancy France Department of Physics University of Illinois at Urbana-Champaign UrbanaIL United States Department of Biochemistry and Molecular Biol

The communities that embraced data archiving efforts decades ago are now, in the era of data-driven biology, those gaining the most from the AI revolution. The structural biology community was a pioneer in this regard by establishing the Protein data Bank (PDB) in 1971 and making data accessible using the FAIR (Findable, Accessible, Interoperable and Reusable) principles even before these were articulated [1, 2]. The genomics/bioinformatics community has followed the example, establishing many widely used databases [3, 4]. By contrast, molecular simulation has been anchored in usage paradigms dating back to the seventies, when molecular dynamics (MD) simulation was first applied to study biomacromolecules [5]. At that time, MD was used by theoretical physicists and chemists in "proof of concept" simulations. Still, fifty years later, MD has evolved into a cornerstone molecular biology technique that can provide accurate quantitative analysis and property prediction. MD is now employed by tens of thousands of researchers worldwide, accounting for roughly 15% of global supercomputer usage. Unfortunately, these rich and costly data are not systematically maintained, and when further analyses are required, simulations have to be rerun-an unacceptable situation from scientific, environmental and sustainability standpoints. In this letter, we argue for a collaborative endeavor to archive MD simulation data and describe ongoing efforts to establish cost-effective and sustainable data archiving strategies. © 2024, CC BY-NC-SA.

关键词： Biotic

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Author Correction: Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision

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Nature methods 2025年第2期22卷 448页

作者： Marieke Vromman Jasper Anckaert Stefania Bortoluzzi Alessia Buratin Chia-Ying Chen Qinjie Chu Trees-Juen Chuang Roozbeh Dehghannasiri Christoph Dieterich Xin Dong Paul Flicek Enrico Gaffo Wanjun Gu Chunjiang He Steve Hoffmann Osagie Izuogu Michael S Jackson Tobias Jakobi Eric C Lai Justine Nuytens Julia Salzman Mauro Santibanez-Koref Peter Stadler Olivier Thas Eveline Vanden Eynde Kimberly Verniers Guoxia Wen Jakub Westholm Li Yang Chu-Yu Ye Nurten Yigit Guo-Hua Yuan Jinyang Zhang Fangqing Zhao Jo Vandesompele Pieter-Jan Volders OncoRNALab Cancer Research Institute Ghent (CRIG) Department of Biomolecular Medicine Ghent University Ghent Belgium. Department of Molecular Medicine University of Padova Padova Italy. Genomics Research Center Academia Sinica Taipei City Taiwan. Institute of Crop Science and Institute of Bioinformatics Zhejiang University Zhejiang China. Department of Biomedical Data Science and of Biochemistry Stanford University Stanford CA USA. Klaus Tschira Institute for Integrative Computational Cardiology Department of Internal Medicine III University Hospital Heidelberg German Center for Cardiovascular Research (DZHK) Heidelberg Germany. School of Basic Medical Science Department of Medical Genetics Wuhan University Wuhan China. EMBL-EBI Hinxton UK. Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine School of Artificial Intelligence and Information Technology Nanjing University of Chinese Medicine Nanjing China. Computational Biology Group Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) Jena Germany. Biosciences Institute Faculty of Medical Sciences Newcastle University Newcastle UK. Translational Cardiovascular Research Center University of Arizona - College of Medicine Phoenix Phoenix AZ USA. Sloan Kettering Institute New York NY USA. Bioinformatics Group Department of Computer Science and Interdisciplinary Center for Bioinformatics Universität Leipzig Leipzig Germany. Data Science Institute I-Biostat Hasselt University Hasselt Belgium. State Key Laboratory of Bioelectronics School of Biological Sciences and Medical Engineering Southeast University Nanjing China. Department of Biochemistry and Biophysics National Bioinformatics Infrastructure Sweden Science for Life Laboratory Stockholm University Stockholm Sweden. Center for Molecular Medicine Children's Hospital Fudan University and Shanghai Key Laboratory of Medical Epigenetics International Laboratory of Medical Epigenetics and Metab

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High-Throughput computational Studies in Catalysis and Materials Research, and their Impact on Rational Design

arXiv

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arXiv 2019年

作者： Afzal, Mohammad Atif Faiz Hachmann, Johannes Schrödinger Inc. PortlandOR97204 United States Department of Chemical and Biological Engineering University at Buffalo State University of New York BuffaloNY14260 United States Computational and Data-Enabled Science and Engineering Graduate Program University at Buffalo The State University of New York BuffaloNY14260 United States New York State Center of Excellence in Materials Informatics BuffaloNY14203 United States

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An Early Stage Researcher's Primer on Systems Medicine Terminology

Network and Systems Medicine

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Network and Systems Medicine 2021年第1期4卷 2-50页

作者： Zanin, Massimiliano Aitya, Nadim A.A. Basilio, José Baumbach, Jan Benis, Arriel Behera, Chandan K. Bucholc, Magda Castiglione, Filippo Chouvarda, Ioanna Comte, Blandine Dao, Tien-Tuan Ding, Xuemei Pujos-Guillot, Estelle Filipovic, Nenad Finn, David P. Glass, David H. Harel, Nissim Iesmantas, Tomas Ivanoska, Ilinka Joshi, Alok Boudjeltia, Karim Zouaoui Kaoui, Badr Kaur, Daman Maguire, Liam P. McClean, Paula L. McCombe, Niamh De Miranda, João Luís Moisescu, Mihnea Alexandru Pappalardo, Francesco Polster, Annikka Prasad, Girijesh Rozman, Damjana Sacala, Ioan Sanchez-Bornot, Jose M. Schmid, Johannes A. Sharp, Trevor Solé-Casals, Jordi Spiwok, Vojtěch Spyrou, George M. Stalidzans, Egils Stres, Blaa Sustersic, Tijana Symeonidis, Ioannis Tieri, Paolo Todd, Stephen Van Steen, Kristel Veneva, Milena Wang, Da-Hui Wang, Haiying Wang, Hui Watterson, Steven Wong-Lin, Kongfatt Yang, Su Zou, Xin Schmidt, Harald H.H.W. Centro de Tecnología Biomédica Universidad Politécnica de Madrid Madrid Spain Intelligent Systems Research Centre School of Computing Engineering and Intelligent Systems Ulster University Ulster United Kingdom Center for Physiology and Pharmacology Institute of Vascular Biology and Thrombosis Research Medical University of Vienna Vienna Austria TUM School of Life Sciences Weihenstephan Technical University of Munich Freising Germany Holon Israel CNR National Research Council IAC Institute for Applied Computing Rome Italy Lab of Computing Medical Informatics and Biomedical Imaging Technologies School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece Université Clermont Auvergne INRAE UNH Plateforme d'Exploration du Métabolisme MetaboHUB Clermont Clermont-Ferrand France Université de Technologie de Compiègne Compiègne France Labex MS2T Control of Technological Systems-of-Systems CNRS and Université de Technologie de Compiègne Compiègne France Faculty of Engineering University of Kragujevac Kragujevac Serbia Kragujevac Serbia Steinbeis Advanced Risk Technologies Institute Doo Kragujevac Kragujevac Serbia Pharmacology and Therapeutics School of Medicine Galway Neuroscience Centre National University of Ireland Galway Ireland School of Computing Ulster University Ulster United Kingdom Holon Israel Department of Mathematics and Natural Sciences Kaunas University of Technology Kaunas Lithuania Faculty of Computer Science and Engineering Ss. Cyril and Methodius University Skopje Macedonia Medicine Faculty Université Libre de Bruxelles CHU de Charleroi Charleroi Belgium Northern Ireland Centre for Stratified Medicine Biomedical Sciences Research Institute Ulster University Ulster United Kingdom Escola Superior de Tecnologia e Gestão Instituto Politécnico de Portalegre Portalegre Portugal Instituto Superior Técnico Universidade de Lisboa Lisboa Portugal Faculty of Automatic Control and Computers University Politehnica of B

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. These include both modeling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. Results: This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for digging into the topic. © Massimiliano Zanin et al., 2021;Published by Mary Ann Liebert, Inc. 2021.

关键词： Semantics

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An extreme test case for planet formation: a close-in Neptune orbiting an ultracool star

arXiv

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arXiv 2023年

作者： Stefánsson, Guðmundur Mahadevan, Suvrath Miguel, Yamila Robertson, Paul Delamer, Megan Kanodia, Shubham Cañas, Caleb Winn, Joshua Ninan, Joe Terrien, Ryan Holcomb, Rae Ford, Eric Zawadzki, Brianna Bowler, Brendan P. Bender, Chad Cochran, William Diddams, Scott Endl, Michael Fredrick, Connor Halverson, Samuel Hearty, Fred Hill, Gary J. Lin, Andrea Metcalf, Andrew Monson, Andrew Ramsey, Lawrence Roy, Arpita Schwab, Christian Wright, Jason Zeimann, Gregory Princeton University Department of Astrophysical Sciences United States Department of Astronomy & Astrophysics The Pennsylvania State University United States Center for Exoplanets and Habitable Worlds The Pennsylvania State University United States ETH Zurich Institute for Particle Physics & Astrophysics Switzerland Leiden Observatory University of Leiden Netherlands SRON Netherlands Institute for Space Research Netherlands Department of Physics & Astronomy University of California Irvine United States Earth and Planets Laboratory Carnegie Institution for Science United States NASA Goddard Space Flight Center United States Department of Astronomy & Astrophysics Tata Institute of Fundamental Research India Carleton College United States Center for Astrostatistics The Pennsylvania State University United States Institute for Computational & Data Sciences The Pennsylvania State University United States Department of Astronomy The University of Texas at Austin AustinTX78712 United States Steward Observatory The University of Arizona United States Center for Planetary Systems Habitability and McDonald Observatory UT Austin United States Electrical Computer and Energy Engineering University of Colorado United States National Institute of Standards & Technology United States Department of Physics University of Colorado United States Jet Propulsion Laboratory California Institute of Technology United States McDonald Observatory UT Austin United States Space Vehicles Directorate Air Force Research Laboratory United States Space Telescope Science Institute United States Department of Physics and Astronomy Johns Hopkins University United States School of Mathematical and Physical Sciences Macquarie University Australia Penn State Extraterrestrial Intelligence Center The Pennsylvania State University United States Hobby-Eberly Telescope University of Texas Austin AustinTX78712 United States

In current theories of planet formation, close-orbiting planets as massive as Neptune are expected to be very rare around low-mass stars. We report the discovery of a Neptune-mass planet orbiting the 'ultracool' star LHS 3154, which is nine times less massive than the Sun. The planet's orbital period is 3.7 days and its minimum mass is 13.2 Earth masses, giving it the largest known planet-to-star mass ratio among short-period planets ( Copyright © 2023, The Authors. All rights reserved.

关键词： Planets

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Cooperator-driven and defector-driven punishments: How do they influence cooperation?

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Physical Review E 2019年第5期100卷 052304-052304页

作者： Pengbi Cui (崔鹏碧) Zhi-Xi Wu Tao Zhou Xiaojie Chen School of Astronautics Northwestern Polytechnical University Xi'an 710072 People's Republic of China National Key Laboratory of Aerospace Flight Dynamics Xi'an 710072 People's Republic of China School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu 610054 China Institute of Computational Physics and Complex Systems Lanzhou University Lanzhou Gansu 730000 China and Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou University Lanzhou Gansu 730000 China Institute of Fundamental and Frontier Science University of Electronic Science and Technology of China Chengdu 610073 China Big Data Research Center University of Electronic Science and Technology of China Chengdu 611731 China School of Mathematical Sciences University of Electronic Science and Technology of China Chengdu 611731 China

Economic studies have shown that there are two types of regulation schemes which can be considered as a vital part of today's global economy: self-regulation enforced by self-regulation organizations to govern industry practices and government regulation which is considered as another scheme to sustain corporate adherence. An outstanding problem of particular interest is to understand quantitatively the role of these regulation schemes in evolutionary dynamics. Typically, punishment usually occurs for enforcement of regulations. Taking into account both types of punishments to influence the regulations, we develop a game model where six evolutionary situations with corresponding combinations of strategies are considered. Furthermore, a semianalytical method is developed to allow us to give accurate estimations of the boundaries between the phases of full defection and nondefection. We find that, associated with the evolutionary dynamics, for an infinite well-mixed population, the mix of both punishments performs better than one punishment alone in promoting public cooperation, but for a networked population the cooperator-driven punishment turns out to be a better choice. We also reveal the monotonic facilitating effects of the synergy effect, punishment fine, and feedback sensitivity on the public cooperation for an infinite well-mixed population. Conversely, for a networked population an optimal intermediate range of feedback sensitivity is needed to best promote punishers' populations. Overall, a networked structure is overall more favorable for punishers and further for public cooperation, because of both network reciprocity and mutualism between punishers and cooperators who do not punish defectors. We provide physical understandings of the observed phenomena, through a detailed statistical analysis of frequencies of different strategies and spatial pattern formations in different evolution situations. These results provide valuable insights into how to select

关键词： Collective behavior in networks Competition Fitness Population dynamics Collective dynamics Evolutionary games Lattices Mean field theory Monte Carlo methods

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Differential Evolution Based High-order Peak Filter Design with Application to Compensation of Contact-induced Vibration in HDD Servo Systems

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International Journal of Automation and computing 2017年第1期14卷 45-56页

作者： Deqing Huang Jian-Xin Xu Xin Deng Venkatakrishnan Venkataramanan The Cat Tuong Huynh Institute of Systems Science and Technology School of Electrical Engineering Southwest Jiaotong University Department of Electrical and Computer Engineering National University of Singapore Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and Telecommunications Data Storage Institute Agency for Science Technology and Research

Sensitivity loop shaping using add-on peak filters is a simple and effective method to reject narrow-band disturbances in hard disk drive （HDD） servo systems. The parallel peak filter is introduced to provide high-gain magnitude in the concerned frequency range of open-loop transfer function. Different from almost all the known peak filters that possess second-order structures, we explore in this paper bow high-order peak filters can be designed to improve the loop shaping performance. The main idea is to replace some of the constant coefficients of common second-order peak filter by frequency-related transfer functions, and then differential evolution （DE） algorithm is adopted to perform optimal design. We creatively introduce chromosome coding and fitness function design, which are original and the key steps that lead to the success of DE applications in control system design. In other words, DE is modified to achieve a novel design for hard disk drive control. Owing to the remarkable searching ability of DE, the expected shape of sensitivity function can be achieved by incorporating the resultant high-order peak filter in parallel with baseline feedback controller. As a result, a seventh-order peak filter is designed to compensate for contact-induced vibration in a high-density HDD servo system, where the benefits of high-order filter are clearly demonstrated.

关键词： Differential evolution （DE） contact-induced vibration peak filter optimization sensitivity loop shaping hard disk drive（HDD）.

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Mutual clustering on comparative texts via heterogeneous information networks

arXiv

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arXiv 2019年

作者： Cao, Jianping Wang, Senzhang Wen, Danyan Peng, Zhaohui Yu, Philip S. Wang, Fei-yue Research Center for Military Computational Experiments and Parallel Systems Technology National University of Defense Technology Changsha410073 China Ministry of Industry and Information Technology Nanjing211106 China School of Economics & Management Nanjing University of Science and Technology Nanjing210094 China School of Computer Science and Technology Shandong University Qingdao China Department of Computer Science University of Illinois at Chicago Chicago60607 United States Institute for Data Science Tsinghua University Beijing100084 China Beijing China Qingdao Academy of Intelligent Industries Qingdao266000 China Institute of Systems Engineering Macau University of Science and Technology Macau999078 China

Currently, many intelligence systems contain the texts from multi-sources, e.g., bulletin board system (BBS) posts, tweets and news. These texts can be "comparative" since they may be semantically correlated and thus provide us with different perspectives toward the same topics or events. To better organize the multi-sourced texts and obtain more comprehensive knowledge, we propose to study the novel problem of Mutual Clustering on Comparative Texts (MCCT), which aims to cluster the comparative texts simultaneously and collaboratively. The MCCT problem is difficult to address because 1) comparative texts usually present different data formats and structures and thus they are hard to organize, and 2) there lacks an effective method to connect the semantically correlated comparative texts to facilitate clustering them in an unified way. To this aim, in this paper we propose a Heterogeneous Information Network-based Text clustering framework HINT. HINT first models multi-sourced texts (e.g. news and tweets) as heterogeneous information networks by introducing the shared "anchor texts" to connect the comparative texts. Next, two similarity matrices based on HINT as well as a transition matrix for cross-text-source knowledge transfer are constructed. Comparative texts clustering are then conducted by utilizing the constructed matrices. Finally, a mutual clustering algorithm is also proposed to further unify the separate clustering results of the comparative texts by introducing a clustering consistency constraint. We conduct extensive experimental on three tweets-news datasets, and the results demonstrate the effectiveness and robustness of the proposed method in addressing the MCCT problem. Copyright © 2019, The Authors. All rights reserved.

关键词： Clustering algorithms

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Advances in Machine Learning for the Behavioral sciences

arXiv

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arXiv 2019年

作者： Kliegr, Tomáš Bahník, Štěpán Fürnkranz, Johannes Department of Information and Knowledge Engineering Faculty of Informatics and Statistics University of Economics Prague Czech Republic Department of Management Faculty of Business Administration University of Economics Prague Czech Republic Computational Data Analytics Group Department of Computer Science Johannes Kepler Universität Linz Altenbergerstraße 66B Linz4040 Austria

The areas of machine learning and knowledge discovery in databases have considerably matured in recent years. In this article, we briefly review recent developments as well as classical algorithms that stood the test of time. Our goal is to provide a general introduction into different tasks such as learning from tabular data, behavioral data, or textual data, with a particular focus on actual and potential applications in behavioral sciences. The supplemental appendix to the article also provides practical guidance for using the methods by pointing the reader to proven software implementations. The focus is on R, but we also cover some libraries in other programming languages as well as systems with easy-to-use graphical interfaces. Copyright © 2019, The Authors. All rights reserved.

关键词： data mining

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Cooperator-driven and defector-driven punishments: How do they influence cooperation?

arXiv

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arXiv 2019年

作者： Cui, Pengbi Wu, Zhi-Xi Zhou, Tao Chen, Xiaojie School of Astronautics Northwestern Polytechnical University Xi’an710072 China School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu610054 China Institute of Computational Physics and Complex Systems Lanzhou University Lanzhou Gansu730000 China Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou University Lanzhou Gansu730000 China Big Data Research Center University of Electronic Science and Technology of China Chengdu611731 China Institute of Fundamental and Frontier Science University of Electronic Science and Technology of China Chengdu610073 China School of Mathematical Sciences University of Electronic Science and Technology of China Chengdu611731 China

Economic studies have shown that there are two types of regulation schemes which can be considered as a vital part of today’s global economy: self-regulation enforced by self-regulation organizations to govern industry practices, and government regulation which is considered as another scheme to sustain corporate adherence. An outstanding problem of particular interest is to understand quantitatively the role of these regulation schemes in evolutionary dynamics. Typically, punishment usually occurs for enforcement of regulations. Taking into account both types of punishments to curve the regulations, we develop a game model where six evolutionary situations with corresponding combinations of strategies are considered. Furthermore, a semi-analytical method is developed to allow us to give an accurate estimations of the boundaries between the phases of full defection and nondefection. We find that, associated with the evolutionary dynamics, for infinite well-mixed population, the mix of both punishments performs better than one punishment alone in promoting public cooperation, but for networked population the cooperator-driven punishment turns out to be a better choice. We also uncover monotonous facilitating effects of synergy effect, punishment fine and feedback sensitivity on the public cooperation for infinite well-mixed population. Conversely, for networked population an optimal intermediate range of feedback sensitivity is needed to best promote punishers’ populations. Overall, networked structure is overall more favorable for punishers and further for public cooperation, because of both network reciprocity and mutualism between punishers and cooperators who do not punish defectors. We provide physical understandings of the observed phenomena, through a detailed statistical analysis of frequencies of different strategies and spatial pattern formations in different evolution situations. These results provide valuable insights into how to select and enforce suitab

关键词： Deregulation

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