Operating a smart city is intricate and requires comprehensive management. Implementing a decision model is one effective and efficient method to address this complexity. This study seeks to systematically review arti...
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The assessment of cryptocurrency performance has been subject to criticism due to the lack of a standardized approach, leaving the evaluation process without clear guidance. In this research, an innovative object-driv...
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Detecting fake news in the digital era is challenging due to the proliferation of misinformation. One of the crucial is-sues in this domain is the inherent class imbalance, where genuine news articles significantly ou...
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Code-mixed language is ubiquitous. Having been commonly practiced among bilingual communities, code-mixed language has emerged as a common language among social media users. Despite its popularity, the analysis of a c...
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This study investigates emotion detection on tweets written in the Indonesian language, using the IndoBERT model that has been trained for 50 epochs. The examination conducted in this study provides a comprehensive an...
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This study discusses the development of smart precision farming systems using big data and cloud-based intelligent decision support systems. Big data plays an important role in collecting, storing, and analyzing large...
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Since cloud computing becoming the trend, the way servers being implemented slowly moves to the cloud. Companies did not need to buy a physical server machine to deploy an app. Having a private server on cloud infrast...
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Automation testing is essential to carry out functional testing quickly and precisely. Software testing is beneficial for testers doing many testing processes according to the existing scenarios. So, there is an urgen...
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Membership function (MF) in process of fuzzy logic is very meaningful. It depicts the core of model. It can be adopted from the expert judgment and also coming from the configuration of data behavior. The study is an ...
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Background Rare diseases can be difficult to diagnose due to limited patient data and broad genetic diversity. Despite the advances in variant prioritization tools, many rare disease cases remain undiagnosed. While la...
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Background Rare diseases can be difficult to diagnose due to limited patient data and broad genetic diversity. Despite the advances in variant prioritization tools, many rare disease cases remain undiagnosed. While large language models (LLMs) have performed well in medical exams, their accuracy in diagnosing rare genetic diseases has not yet been evaluated. Methods To identify causal genes for genetic diseases, we benchmarked various LLMs for gene prioritization. We employed multi-agent and Human Phenotype Ontology (HPO) classification approaches to identify patient case groups based on phenotypes categorizing them into different levels of solvability. To address LLM limitations in ranking large gene sets, we used a divide-and-conquer strategy to break down the ranking task into smaller subsets. Mini-batching inputs and limiting the number of generated tokens improved efficiency. Results In its vanilla form, GPT-4 consistently outperformed the other LLMs with an accuracy around 30%. Multi-agent and HPO classification approaches aided us in distinguishing between confidently-solved and challenging cases. In addition, we observed bias towards well-studied genes and input order sensitivity which are drawbacks of LLMs in disease-causal gene prioritization. Our divide-and-conquer strategy enhanced accuracy by overcoming positional and gene frequency biases in literature. This framework, based on benchmarking insights and novel techniques, significantly optimizes the overall process when identifying disease-causal genes for genetic diseases when compared to our baseline evaluation, and thereby better enables the development of targeted diagnostic and therapeutic interventions. Conclusions Using HPO classification and our novel multi-agent techniques, and our LLM divide-and-conquer strategy (1) highlighted the importance of accounting for differences in patient case solvability and (2) yielded improved performance in identifying causal genes for rare diseases when compare
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