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114th Annual ASEE Conference and Exposition, 2007

作者： Jackson, Andrew Chin, Robert Coddington, Charles Petersen, Paul Hamid, Fonooni East Carolina University United States Department of Technology Systems College of Technology and Computer Science East Carolina University United States East Carolina University Indiana State University Graduate Faculties United States EDGJ Department of Technology Systems East Carolina University United States Faculty Senate East Carolina University United States Department of Technology East Carolina University College of Technology and Computer Science United States Cleveland State University Fenn College of Engineering United States Department of Technology Systems Science Occupational Safety Program East Carolina University Greenville NC United States Academic Practice Specialty Educational Standards Committee Task Force ASSE

The department of Technology Systems (TSYS) at East Carolina University has implemented a new faculty mentoring process to enable junior faculty members to learn from senior faculty members as they prepare for a career in academia. Five tenured professors and associate professors in the TSYS department have recently established a new process to mentor faculty members within the department who have begun not yet completed their initial tenure process at a major university. This process includes a series of workshops regarding academic performance expectations during the early stages of an academic career. Our commitment to new faculty takes on several related, yet distinct features. Examples of these initiatives include: 1) reduced workloads for new faculty for the first two years to enable them to generate individual and collaborative research activities, funded grants, and publications, 2) periodic university-wide training to learn policies and procedures that affect day-to-day activities on a college campus, 3) periodic workshops hosted by senior faculty mentors, and 4) one-on-one discussions between senior faculty members and junior faculty members to encourage candid dialogue between professional colleagues. Another feature of the mentorship philosophy is a proposal to the dean of the college to offer newly hired faculty a contractual start date of July 1steach year instead of starting their contract one week prior to the start of fall classes, normally in late August. This additional period of time will be used to train new faculty in essential policies and procedures, to complete a variety of administrative tasks on campus, to get a head start on preparing for classes in the fall, and cleaning up those supplemental tasks that accompany every move to a new location. The goal of this early commitment to new faculty is to reduce the stress associated with preparing for a new course, in a new environment, with a new set of operating procedures. This will also enab

关键词： Engineering education

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Non-Crosshybridizing Oligonucleotide Building Blocks for Accurate, Scalable Nanofabrication

Non-Crosshybridizing Oligonucleotide Building Blocks for Acc...

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IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

作者： Jin-woo Kim Ju Seok Lee Russell Deaton Cell and Molecular Biology Graduate Program University of Arkansas Fayetteville AR USA IEEE Senior Member Cell and Molecular Biology Graduate Program University of Arkansas Fayetteville AR 72701 USA. Department of Computer Science and Computer Engineering University of Arkansas Fayetteville AR 72701 USA.

The urgent need in the field of nanotechnology is functional, reliable, and scalable techniques for more complicated and controlled nanostructures in order to realize nanoscale materials and devices that have practical use and more capability than existing technologies. This paper addresses this need by presenting an in vitro protocol to select large non-crosshybridizing (NCH) libraries of oligonucleotides that provide a large address space of DNA sequences with which to increase both complexity and control in DNA-directed self-assembly processes. The selection protocol was experimentally verified and confirmed. The resultant large NCH libraries would allow self-assembling complex nanostructures with more precise control, leading to reliable, scaled-up, cost-effective manufacturing of nanoscale devices and systems.

关键词： Nanofabrication Nanostructures Nanostructured materials Nanoscale devices Space technology Protocols Libraries Self-assembly Nanotechnology Materials reliability

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DNA-Directed Self-Assembly of Microscopic 1-D Carbon Nanotube Wire

DNA-Directed Self-Assembly of Microscopic 1-D Carbon Nanotub...

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IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

作者： Jin-Woo Kim Nalinikanth Kotagiri Russell Deaton Steve Tung Cell and Molecular Biology Graduate Program University of Arkansas Fayetteville AR USA IEEE Senior Member Cell and Molecular Biology Graduate Program University of Arkansas Fayetteville AR 72701 USA. Department of Computer Science and Computer Engineering University of Arkansas Fayetteville AR 72701 USA. Department of Mechanical Engineering University of Arkansas Fayetteville AR USA

Molecular wire construction using DNA-directed self-assembly of multi-walled carbon nanotubes (MWNTs) has been attempted. MWNTs were selected owing to their exceptional electrical and structural properties. DNA, which possesses specific molecular recognition properties, served as the engine for the assembly. Non-crosshybridizing (NCH) sequences were designed to impart specificity and high throughput reaction. Stepwise manufacturing of the wire was accomplished by first functionalizing the NCH 20 base pair single-stranded sequences to the tips of MWNT using amide linkage. The adducts were then utilized to self-assemble 1D nanotube wire through DNA hybridization reactions between two complementary ssDNAs functionalized to the MWNT tips. TEM, epi-fluorescent microscopy and AFM analyses showed successful assemblies of micrometer-scale 1D MWNT-DNA wires, ranging from 2.7-20 mum. The results demonstrate great potentials of the DNA-guided self-assembly process, which would provide an uncomplicated, versatile and inexpensive way to manufacture micrometer-scale molecular wires.

关键词： Self-assembly Carbon nanotubes Wire Atomic force microscopy Transmission electron microscopy DNA Assembly Sequences Engines Throughput

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Information-Theoretic Variable Selection in Neural Networks

Information-Theoretic Variable Selection in Neural Networks

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IEEE Symposium on Foundations of Computational Intelligence, FOCI

作者： Ryotaro Kamimura Fumihiko Yoshida Yamashita Toshie Ryozo Kitajima Information Technology Center Information Science Laboratory Japan Department of Media Studies Tokai University Hiratsuka Kanagawa Japan Graduate Program in Computer Sciences Tokai University Hiratsuka Kanagawa Japan

In this paper, we propose a new type of information-theoretic approach to variable selection. Many approaches have been proposed in estimating the importance of input variables. The majority of these approaches have focused upon output errors. We here introduce an approach concerning internal representations. First, we delete an input unit with corresponding connection weights. Then, by examining some change in hidden unit activation with and without a input variable, we can extract an important variable. We apply this method to an artificial data in which the number of hidden units is redundantly increased so as to clearly show improved performance and the stability of our method. Then, we apply the method to the cabinet approval ratings in which better interpretation of input variables can be given

关键词： Input variables Neural networks Computational intelligence computer networks Information theory Data mining Standards development Measurement units Information science Laboratories

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The constraints of the valuation distribution for solving a class of games by using a best response algorithm

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International Journal of Manufacturing Technology and Management 2007年第4期12卷 327-341页

作者： Gangshu, Cai Jie, Zhong Wurman, Peter R. Management Information Systems and Decision Sciences Texas A and M International University Laredo TX 78041 United States Management Information Systems and Decision Sciences Department Texas A and M International University United States Operations Research and Computer Science North Carolina State University Raleigh NC 27695-7535 United States SAS Institute Cary United States Operations Research and Computer Science Graduate Program North Carolina State University United States Computer Science Department North Carolina State University United States

Infinite games with incomplete information are common in practice. First-price, sealed-bid auctions are a prototypical example. To solve this kind of infinite game, a heuristic approach is to discretise the strategy spaces and enumerate to approximate the equilibrium strategies. However, an approximate algorithm might not be guaranteed to converge. This paper discusses the utilisation of a best response algorithm in solving infinite games with incomplete information. We show the constraints of the valuation distributions define the necessary conditions of the convergence of the best response algorithm for several classes of infinite games, including auctions. A salient feature of the necessary convergence conditions lies in that they can be employed to compute the exact Nash equilibria without discretising the strategy space if the best response algorithm converges. Copyright © 2007 Inderscience Enterprises Ltd.

关键词： Game theory

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The generation challenge programme platform: Semantic standards and workbench for crop science

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International Journal of Plant Genomics 2008年第1期2008卷 369601页

作者： Bruskiewich, Richard Senger, Martin Davenport, Guy Ruiz, Manuel Rouard, Mathieu Hazekamp, Tom Takeya, Masaru Doi, Koji Satoh, Kouji Costa, Marcos Simon, Reinhard Balaji, Jayashree Akintunde, Akinnola Mauleon, Ramil Wanchana, Samart Shah, Trushar Anacleto, Mylah Portugal, Arllet Ulat, Victor Jun Thongjuea, Supat Braak, Kyle Ritter, Sebastian Dereeper, Alexis Skofic, Milko Rojas, Edwin Martins, Natalia Pappas, Georgios Alamban, Ryan Almodiel, Roque Barboza, Lord Hendrix Detras, Jeffrey Manansala, Kevin Mendoza, Michael Jonathan Morales, Jeffrey Peralta, Barry Valerio, Rowena Zhang, Yi Gregorio, Sergio Hermocilla, Joseph Echavez, Michael Yap, Jan Michael Farmer, Andrew Schiltz, Gary Lee, Jennifer Casstevens, Terry Jaiswal, Pankaj Meintjes, Ayton Wilkinson, Mark Good, Benjamin Wagner, James Morris, Jane Marshall, David Collins, Anthony Kikuchi, Shoshi Metz, Thomas McLaren, Graham Van Hintum, Theo Crop Research Informatics Laboratory International Rice Research Institute (IRRI) DAPO Box 7777 Metro Manila Philippines Crop Research Informatics Laboratory International Maize and Wheat Improvement Center (CIMMYT) DF 06600 Mexico Apdo. Postal 6-641 Mexico Centre International de Recherche Agronomique Pour le Développement (CIRAD) 34398 Montpellier Cedex 5 Avenue Agropolis France Bioversity International 00057 Maccarese (Fiumicino) Rome Via dei Tre Denari 472/a Italy National Institute for Agrobiological Sciences (NIAS) Tsukuba Ibaraki 305-8602 Kannondai 2-1-2 Japan Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA) Brasilia DF 70770-900 Parque Estaçao Biologia Final W5 Norte Brazil Centro Internacional de la Papa (CIP) Lima 12 Avenida La Molina 1895 La Molina Peru International Crops Research Institute for the Semi-Arid Tropics Patancheru Andhra Pradesh 502324 India International Center for Agricultural Research in the Dry Areas Aleppo P.O. Box 5466 Syrian Arab Republic National Center for Genetic Engineering and Biotechnology 113 Thailand Science Park Klong Luang Pathumthani 12120 Phahonyothin Road Klong 1 Thailand Institute of Computer Science College of Arts and Sciences University of the Philippines Los Banos Laguna 4031 Philippines Department of Computer Science University of the Philippines Melchor Hall Diliman Quezon City 1101 Philippines National Center for Genome Resources Santa Fe NM 87505 2935 Rodeo Park Drive East United States Scottish Crop Research Institute Invergowrie Dundee DD2 5DA United Kingdom Department of Plant Breeding Cornell University Ithaca NY 14853 United States African Centre for Gene Technologies Lynnwood Ridge 0040 P.O. Box 75011 South Africa Department of Medical Genetics Faculty of Medicine University of British Columbia Vancouver BC V6T 1Z3 Canada School of Computing Science Simon Fraser Universtiy Burnaby BC V5A 1S6 8888 University Drive Canada Bioinformatics Graduate Program Genome Sciences Centre BC

The Generation Challenge programme (GCP) is a global crop research consortium directed toward crop improvement through the application of comparative biology and genetic resources characterization to plant breeding. A key consortium research activity is the development of a GCP crop bioinformatics platform to support GCP research. This platform includes the following: (i) shared, public platform-independent domain models, ontology, and data formats to enable interoperability of data and analysis flows within the platform;(ii) web service and registry technologies to identify, share, and integrate information across diverse, globally dispersed data sources, as well as to access high-performance computational (HPC) facilities for computationally intensive, high-throughput analyses of project data;(iii) platform-specific middleware reference implementations of the domain model integrating a suite of public (largely open-access/-source) databases and software tools into a workbench to facilitate biodiversity analysis, comparative analysis of crop genomic data, and plant breeding decision making.

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Contributors to the Lab on a Chip cell and tissue engineering in microsystems special issue

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Lab on a Chip 2007年第6期7卷 667-671页

作者： Bhatia, Sangeeta N. Chen, Christoper Bashir, Rashid Beebe, David J. Desai, Tejal Gottwald, Eric Khademhosseini, Ali Langer, Robert S. Piel, Matthieu Takayama, Shuichi Thorsen, Todd Tien, Joe Voldman, Joel Vunjak-Novakovic, Gordana Wu, Mingming Yu, Hanry Massachusetts Institute of Technology Harvard-MIT Division of Health Sciences and Technology Department of Electrical Engineering and Computer Science United States Laboratory for Multiscale Regenerative Technologies United States Department of Innovation University of Pennsylvania Department of Bioengineering United States Cell Biology and Physiology Program Cell Growth and Cancer Program Tissue Microfabrication Laboratory Department of Electrical and Computer Engineering and Biomedical Engineering Purdue University United States Department of Electronics University of Glasgow United Kingdom Department of Physiology and Bioengineering University of California San Francisco CA United States California Institute for Quantitative Biomedical Research UCSF/UC Berkeley Graduate Group in Bioengineering United States Laboratory of Therapeutic Micro and Nanotechnology Institute for Biological Interfaces Germany 3D-Cell Culture Techniques Group Institute for Biological Interfaces Germany Department of Medicine and Health Sciences and Technology Massachusetts Institute of Technology (MIT) United States Institut Curie UMR 144 IC/CNRS France Biomedical Engineering Department University of Michigan United States Department of Biomedical Engineering Macromolecular Science and Engineering Program United States Sibley School of Mechanical and Aerospace Engineering School of Chemical and Molecular Engineering Cornell University United States National University of Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR Singapore

A graphical abstract is available for this content

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Computational Techniques for Accompaniment and Measuring of Otology Pathologies

Computational Techniques for Accompaniment and Measuring of ...

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Annual IEEE Symposium on computer-Based Medical Systems

作者： V. Heck A.v. Wangenheim D.D. Abdala E. Comunello S.S. Costa C.C. Dornelles Computer Science and Statistics Department Universidade Federal de Santa Catarina Florianópolis Santa Catarina Brazil Cyclops Group – Laboratory of Image Processing and Virtual Reality Universidade Federal de Santa Catarina Florianópolis Santa Catarina Brazil Graduate Program in Applied Computer Science Universidade do Vale do Itajaí Florianópolis Santa Catarina Brazil Otitis Media Center of Brazil Universidade Federal do Rio Grande do Sul - Medical School Porto Alegre Rio Grande do Sul Brazil

The following article presents a computational methodology to assist the assessment of tympanic pathologies, particularly chronic otitis media, based on digital otoscopic images. A computational system which implements the methodology is described. This approach does not impose additional effort to the acquisition protocol and diagnosis of tympanic pathologies. In preliminary tests, it has shown precision and easiness of use. The presented methodology and system were tested by the Otitis Media Center of Brazil (***) with a case base of 660 patients, resulting in 1320 bilateral tympanic images.

关键词： Pathology Laboratories Image processing Virtual reality computer science Statistics Biomedical imaging Medical diagnostic imaging Area measurement Protocols

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Decision Fusion of Circulating Markers for Breast Cancer Detection in Premenopausal Women

Decision Fusion of Circulating Markers for Breast Cancer Det...

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IEEE Symposium on Bioinformatics and Bioengineering (BIBE)

作者： Jonathan L. Jesneck Sayan Mukherjee Loren W. Nolte Anna E. Lokshin Jeffrey R. Marks Joseph Lo Duke Advanced Imaging Labs Institute for Genome Sciences and Policy Department of Computer Science Duke University USA Department of Electrical and Computer Engineering Division of Hematology/Oncology University of Pittsburgh School of Medicine Pittsburgh PA USA Division of Hematology/Oncology University of Pittsburgh Cancer Institute Pittsburgh PA USA Division of Hematology/Oncology University of Pittsburgh Cancer Institute Pittsburgh PA Institute for Genome Sciences and Policy Department of Experimental Surgery Medical Center Duke University USA Department of Experimental Surgery Duke University Medical Center Medical Physics Graduate Program Duke University Durham NC USA

Current mammographic screening for breast cancer is less effective for younger women. To complement mammography for premenopausal women, we investigated the feasibility screening test using 98 blood serum proteins. Because the data set was very noisy and contained only weak features, we used a classifier designed for noisy data: decision fusion. Decision fusion outperformed both a support vector machine (SVM) and linear regression with forward stepwise feature selection on all three two-class classification tasks: normal tissue vs. cancer, normal tissue vs. benign lesions, and benign lesions vs. cancer. Decision fusion detected cancer moderately well (AUC=0.84 on normal vs. cancer), demonstrating promise as a screening tool. Decision fusion also detected benign lesions similarly well (AUC=0.83 on normal vs. benign lesions) and was the only classifier to achieve any success in separating benign from malignant lesions (AUC=0.64 on benign vs. cancer). The classification results suggest that the assayed proteins are more indicative of a secondary effect, such as immune response, rather than specific for breast cancer. In conclusion, the decision fusion classifier demonstrated some promise in detecting breast lesions and outperformed other classifiers, especially for the very noisy classification problem of distinguishing benign from malignant lesions.

关键词： Breast cancer Cancer detection Lesions Proteins Support vector machines Support vector machine classification Mammography Testing Blood Linear regression

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Order-computable sets

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Notre Dame Journal of Formal Logic 2007年第3期48卷 317-347页

作者： Hirschfeldt, Denis Miller, Russell Podzorov, Sergei Department of Mathematics University of Chicago Chicago IL 60637 5734 S University Ave United States Department of Mathematics Queens College-CUNY Flushing NY 11367 65-30 Kissena Blvd United States Ph.D. Program in Computer Science Graduate Center of CUNY New York NY 10016 365 Fifth Avenue United States Department of Mechanics and Mathematics Novosibirsk State University Novosibirsk 630090 Pirogova St 2 Russian Federation

We give a straightforward computable-model-theoretic definition of a property of Δ02 sets called order-computability. We then prove various results about these sets which suggest that, simple though the definition is... 详细信息

We give a straightforward computable-model-theoretic definition of a property of Δ⁰₂ sets called order-computability. We then prove various results about these sets which suggest that, simple though the definition is, the property defies any easy characterization in pure computability theory. The most striking example is the construction of two computably isomorphic ce. sets, one of which is order-computable and the other not. © 2007 University of Notre Dame.

关键词： Computable model theory Limitwise-monotonic functions Order-computability

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