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computer AIDS FOR SHIP DESIGN, INTEGRATION AND CONTROL

NAVAL ENGINEERS JOURNAL 1980年第2期92卷 73-87页

作者： CARLSON, CM JOHNSON, RA HELMING, FW Mr. Craig M. Carlson received his B.S. degree in Naval Architecture and Marine Engineering from the University of Michigan in 1970 and began his career with the Department of the Navy at the Naval Ship Engineering Center (NAVSEC). In 1972. he returned to the University of Michigan under the NAVSEC Long Term Training Program and received his M.S. degree in Naval Architecture and Marine Engineering. After returning to the Ship Arrangements Branch at NAVSEC. he was assigned as Task Leader for General Arrangements for the PGG PCG PHM. and MCM ship designs and was awarded Outstanding Performance Awards in 1974 and 1975. In addition he was Manager of the Arrangement Subsystem of the Navy's Computer-Aided Ship Design and Construction Program (CASDAC). In October 1979. he became Manager of the CASDAC Hull Design System. Currently. he also is enrolled in the M.S. of Computer Science Program at Johns Hopkins University. Mr. Carlson previously has presented technical papers at ASNE Day 1974 and 1978 as well as at the 1979 DOD Manufacturing Technology Advisory Group Conference. Besides ASNE. which he joined in 1972. he is a member of SNAME. ASE. and the U.S. Naval Institute. Mr. Robert A. Johnson is a Naval Architect in Surface Combatants Design (SEA 03D3). Ship Design Integration Directorate Naval Sea Systems Command. He received an Associate in Engineering degree in Drafting and Design Technology in 1959. his B.S. degree in Aerospace Engineering in 1965. and his M.S. degree in Engineering Mechanics in 1970. all from the Pennsylvania State University. In 1973. he was selected for the NA VSEC Hull Division s Long Term Training Program at the University of Michigan subsequently receiving his M.S.E. degree in Naval Architecture in 1974. Mr. Johnson began his career with the Ordnance Research Laboratory at Pennsylvania State University in 1959 where he worked. on the design of hydroelastic submarine models and conducted research in the area of flow induced structural vibrations. In 1967 he joined HRB-Singer at State Colle

This paper presents an integrated approach to computer-Aided Ship Design for U.S. Navy preliminary and contract design. An integrated Hull Design System (HDS), currently under development by the Hull Group of the Naval Sea Systems Command (NAVSEA 32). is the vehicle for the discussion. This paper is directed toward practicing ship design professionals and the managers of the ship design process. Primary emphasis of this paper, and of the development effort currently under way, is on aiding ship design professionals in their work. Focus is on integration and management control of the extremely complex set of processes which make up naval ship design. The terminology of the Ship Designer and Design Manager is used. The reader needs no familiarity with the technologies of computer science.

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A Machine Learning-Based Approach for Classification of Alzheimer’s Disease and its Risk Prediction

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Alzheimer's & Dementia 2022年第S11期18卷

作者： Payam Hosseinzadeh Kasani Jung-Kyeom Kim Peyman Hosseinzadeh Kassani Yeshin Kim Jeong-Ah Kim Chihyun Park Cheol-Heui Yun Seong Hye Choi Sang-Ah Lee Seo-Young Lee Jae-Won Jang Department of Neurology Kangwon National University Hospital Chuncheon Korea Republic of (South) Interdisciplinary Graduate Program in Medical Bigdata Convergence Kangwon National University Chuncheon Korea Republic of (South) Department of Neurology and Neurological Sciences Stanford University Stanford CA USA College of Medicine Kangwon National University Chuncheon Korea Republic of (South) Department of Ophthalmology Kangwon National University Hospital Chuncheon Korea Republic of (South) Department of Computer Science and Engineering Kangwon National University Chuncheon Korea Republic of (South) Department of Agricultural Biotechnology Seoul National University Seoul Korea Republic of (South) Research Institute of Agriculture and Life Sciences Seoul National University Seoul Korea Republic of (South) Department of Neurology Inha University School of Medicine Incheon Korea Republic of (South) Department of Preventive Medicine Kangwon National University School of Medicine Chuncheon Korea Republic of (South)

Background Dementia, a clinical syndrome with progressive neurodegenerative disease, is one of the inevitable aging consequences. Alzheimer’s disease (AD) is the most common cause of dementia. Accurate detection and classification of Alzheimer’s disease alongside its conversion from Mild Cognitive Impairment (MCI) to AD at an early stage is of significant clinical importance. However, a reliable diagnosis with a multi-label classification approach remains a challenging task. This study aimed to measure the effectiveness of machine learning algorithm integrated with feature importance techniques to constitutes a multi-label classification of AD prediction for clinical practice. Method The machine learning algorithms are validated using a nationwide cohort dataset, the Korean Brain Aging Study for the early diagnosis and prediction of AD (KBASE) to identify the most important risk factors, where a database is classified into three classes namely, normal cognition (NC, n = 91), mild cognitive impairment (MCI, n = 61), and Alzheimer’s disease (AD, n = 49). Applying eight state-of-the-art supervised machine learning algorithms namely Support Vector Machine, Naive Bayes, XGBoost, Decision Tree, Logistic Regression, Random Forest, Bagging, and AdaBoost. A stratified 10-fold cross-validation was used for every train/test split and several performance measures, including accuracy, precision, recall and f1-score were used to compare the classifier performances. Result Based on the performance evaluation, the XGBoost classifier significantly outperformed all other models and achieved 82.55% accuracy followed by the Bagging classifier (81%). According to the XGBoost model, calculating risk factors to predict performance, the Consortium to Establish a Registry for AD (CERAD) subsets is among the highest ranked feature. It was intriguing that the parameters including job, job levels and retirement achieved a minimal, if any, impact in the final performance. Conclusion Collectivel

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Author Correction: Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance

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Nature neuroscience 2023年第12期26卷 2250页

作者： Kyungchul Noh Woo-Hyun Cho Byung Hun Lee Dong Wook Kim Yoo Sung Kim Keebum Park Minkyu Hwang Ellane Barcelon Yoon Kyung Cho C Justin Lee Bo-Eun Yoon Se-Young Choi Hye Yoon Park Sang Beom Jun Sung Joong Lee Department of Physiology and Neuroscience Dental Research Institute Seoul National University School of Dentistry Seoul Republic of Korea. Department of Physics and Astronomy Seoul National University Seoul Republic of Korea. Department of Molecular Biology Dankook University Cheonan Republic of Korea. Department of Electronic and Electrical Engineering Ewha Womans University Seoul Republic of Korea. Center for Cognition and Sociality Institute for Basic Science (IBS) Daejeon Republic of Korea. Department of Electrical and Computer Engineering University of Minnesota Minneapolis MN USA. Graduate Program in Smart Factory Ewha Womans University Seoul Republic of Korea. Department of Brain & Cognitive Sciences Ewha Womans University Seoul Republic of Korea. Department of Physiology and Neuroscience Dental Research Institute Seoul National University School of Dentistry Seoul Republic of Korea. sjlee87@snu.ac.kr.

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Abstracts and Workshops 7th National Spinal Cord Injury Conference November 9-11, 2017 Fallsview Casino Resort Niagara Falls, Ontario, Canada Abstracts

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JOURNAL OF SPINAL CORD MEDICINE 2017年第6期40卷 813-869页

作者： [Anonymous] a NET Team Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. fo Neural Engineering and Therapeutic Team Lyndhurst Centre Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. c Rick Hansen Institute Vancouver BC Canada. ev Rick Hansen Institute Vancouver BC Canada. fc Stan Cassidy Hospital University of New Brunswick Fredericton NB Canada. fd Dalhousie University Halifax NS Canada. e University of Saskatchewan Saskatoon SK Canada. aa University of Calgary Calgary AB Canada. y Dalhousie University Halifax NS Canada. fa Health Sciences Centre Winnipeg MB Canada. fb University of Manitoba Winnipeg MB Canada. h University of Alberta Edmonton AB Canada. i Universite Laval Quebe c City QC Canada. bd Rick Hansen Institute Vancouver BC Canada. fz Clinician Investigator Lyndhurst Centre Toronto Rehabilitation Institute University Health Network and Assistant Professor Department of Medicine Division of Physical Medicine and Rehabilitation University of Toronto. v University of Toront o Toronto ON Canada. n Institute of Biomaterials and Biomedical Engineering University of Toronto Toronto ON Canada. o Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. ga Clinical Scientist Lyndhurst Centre Toronto Rehabilitation Institute University Health Network and Assistant Professor Department of Physical Therapy University of Toronto. dx Department of Electrical and Computer Engineering University of Toronto Toronto ON Canada. fm Lawson Health Research Institute London ON Canada. r Parkwood Institute London ON Canada. bi Parkwood Institute London ON Canada. s University of British Columbia Vancouver BC Canada. t Simon Fraser University Burnaby BC Canada. u DeltaQuest Foundation Concord MA USA. z Institut national d'excellence en santé et en services sociaux (INESSS) Quebec City QC Ca

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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The generation challenge programme platform: Semantic standards and workbench for crop science

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International Journal of Plant Genomics 2008年第1期2008卷 369601页

作者： Bruskiewich, Richard Senger, Martin Davenport, Guy Ruiz, Manuel Rouard, Mathieu Hazekamp, Tom Takeya, Masaru Doi, Koji Satoh, Kouji Costa, Marcos Simon, Reinhard Balaji, Jayashree Akintunde, Akinnola Mauleon, Ramil Wanchana, Samart Shah, Trushar Anacleto, Mylah Portugal, Arllet Ulat, Victor Jun Thongjuea, Supat Braak, Kyle Ritter, Sebastian Dereeper, Alexis Skofic, Milko Rojas, Edwin Martins, Natalia Pappas, Georgios Alamban, Ryan Almodiel, Roque Barboza, Lord Hendrix Detras, Jeffrey Manansala, Kevin Mendoza, Michael Jonathan Morales, Jeffrey Peralta, Barry Valerio, Rowena Zhang, Yi Gregorio, Sergio Hermocilla, Joseph Echavez, Michael Yap, Jan Michael Farmer, Andrew Schiltz, Gary Lee, Jennifer Casstevens, Terry Jaiswal, Pankaj Meintjes, Ayton Wilkinson, Mark Good, Benjamin Wagner, James Morris, Jane Marshall, David Collins, Anthony Kikuchi, Shoshi Metz, Thomas McLaren, Graham Van Hintum, Theo Crop Research Informatics Laboratory International Rice Research Institute (IRRI) DAPO Box 7777 Metro Manila Philippines Crop Research Informatics Laboratory International Maize and Wheat Improvement Center (CIMMYT) DF 06600 Mexico Apdo. Postal 6-641 Mexico Centre International de Recherche Agronomique Pour le Développement (CIRAD) 34398 Montpellier Cedex 5 Avenue Agropolis France Bioversity International 00057 Maccarese (Fiumicino) Rome Via dei Tre Denari 472/a Italy National Institute for Agrobiological Sciences (NIAS) Tsukuba Ibaraki 305-8602 Kannondai 2-1-2 Japan Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA) Brasilia DF 70770-900 Parque Estaçao Biologia Final W5 Norte Brazil Centro Internacional de la Papa (CIP) Lima 12 Avenida La Molina 1895 La Molina Peru International Crops Research Institute for the Semi-Arid Tropics Patancheru Andhra Pradesh 502324 India International Center for Agricultural Research in the Dry Areas Aleppo P.O. Box 5466 Syrian Arab Republic National Center for Genetic Engineering and Biotechnology 113 Thailand Science Park Klong Luang Pathumthani 12120 Phahonyothin Road Klong 1 Thailand Institute of Computer Science College of Arts and Sciences University of the Philippines Los Banos Laguna 4031 Philippines Department of Computer Science University of the Philippines Melchor Hall Diliman Quezon City 1101 Philippines National Center for Genome Resources Santa Fe NM 87505 2935 Rodeo Park Drive East United States Scottish Crop Research Institute Invergowrie Dundee DD2 5DA United Kingdom Department of Plant Breeding Cornell University Ithaca NY 14853 United States African Centre for Gene Technologies Lynnwood Ridge 0040 P.O. Box 75011 South Africa Department of Medical Genetics Faculty of Medicine University of British Columbia Vancouver BC V6T 1Z3 Canada School of Computing Science Simon Fraser Universtiy Burnaby BC V5A 1S6 8888 University Drive Canada Bioinformatics Graduate Program Genome Sciences Centre BC

The Generation Challenge programme (GCP) is a global crop research consortium directed toward crop improvement through the application of comparative biology and genetic resources characterization to plant breeding. A key consortium research activity is the development of a GCP crop bioinformatics platform to support GCP research. This platform includes the following: (i) shared, public platform-independent domain models, ontology, and data formats to enable interoperability of data and analysis flows within the platform;(ii) web service and registry technologies to identify, share, and integrate information across diverse, globally dispersed data sources, as well as to access high-performance computational (HPC) facilities for computationally intensive, high-throughput analyses of project data;(iii) platform-specific middleware reference implementations of the domain model integrating a suite of public (largely open-access/-source) databases and software tools into a workbench to facilitate biodiversity analysis, comparative analysis of crop genomic data, and plant breeding decision making.

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape

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Nature immunology 2024年第6期25卷 1123页

作者： Noah Gamble Alexandra Bradu Jason A Caldwell Joshua McKeever Olubusayo Bolonduro Ebru Ermis Caroline Kaiser YeEun Kim Benjamin Parks Sandy Klemm William J Greenleaf Gerald R Crabtree Andrew S Koh Department of Pathology University of Chicago Chicago IL USA. Graduate Program in Biophysical Sciences University of Chicago Chicago IL USA. Committee on Molecular Metabolism and Nutrition University of Chicago Chicago IL USA. Committee on Genetics Genomics Systems Biology University of Chicago Chicago IL USA. Department of Human Genetics University of Chicago Chicago IL USA. Immunology Program Stanford University Stanford CA USA. Department of Genetics Stanford University Stanford CA USA. Department of Computer Science Stanford University Stanford CA USA. Department of Applied Physics Stanford University Stanford CA USA. Chan Zuckerberg Biohub San Francisco CA USA. Department of Pathology Stanford University Stanford CA USA. Department of Developmental Biology Stanford University Stanford CA USA. Department of Pathology University of Chicago Chicago IL USA. akoh@uchicago.edu. Institute for Biophysical Dynamics University of Chicago Chicago IL USA. akoh@uchicago.edu.

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Erratum: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins

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Nature communications 2017年第1期8卷 1298页

作者： Song Li Chwee Tat Koe Su Ting Tay Angie Lay Keng Tan Shenli Zhang Yingjie Zhang Patrick Tan Wing-Kin Sung Hongyan Wang Neuroscience and Behavioural Disorders Program Duke-NUS Medical School 8 College Road Singapore 169857 Singapore. Cancer and Stem Cell Biology Program Duke-NUS Medical School 8 College Road Singapore 169857 Singapore. NUS Graduate School for Integrative Sciences and Engineering National University of Singapore 28 Medical Drive Singapore 117456 Singapore. Cellular and Molecular Research National Cancer Centre Singapore 169610 Singapore. Cancer Science Institute of Singapore National University of Singapore Singapore 119074 Singapore. Genome Institute of Singapore 60 Biopolis Street Genome 02-01 Singapore 138672 Singapore. Department of Computer Science National University of Singapore Singapore 117417 Singapore. Neuroscience and Behavioural Disorders Program Duke-NUS Medical School 8 College Road Singapore 169857 Singapore. hongyan.wang@duke-nus.edu.sg. NUS Graduate School for Integrative Sciences and Engineering National University of Singapore 28 Medical Drive Singapore 117456 Singapore. hongyan.wang@duke-nus.edu.sg. Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore. hongyan.wang@duke-nus.edu.sg.

A correction to this article has been published and is linked from the HTML version of this article.

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