Recent advancements in Artificial Intelligence have been fueled by vast datasets, powerful computing resources, and sophisticated algorithms. However, traditional Machine Learning models face limitations in handling s...
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Artificial intelligence (AI) is revolutionizing the field of drug development, particularly in addressing key challenges such as drug response prediction, drug combination design, drug repositioning, and drug molecule...
Artificial intelligence (AI) is revolutionizing the field of drug development, particularly in addressing key challenges such as drug response prediction, drug combination design, drug repositioning, and drug molecule generation. Traditional drug discovery is hindered by long timelines, high costs, and low success rates, necessitating innovative technologies to accelerate the process. AI technologies, such as deep learning, graph neural networks, and generative models, have demonstrated significant potential in enhancing the accuracy of drug response predictions, optimizing drug combination strategies,identifying opportunities for drug repositioning, and generating drug molecules with specific biological activities. These advancements not only accelerate the drug development process but also open up new possibilities for precision *** review discusses the latest applications and developments of AI in drug discovery, highlighting the breakthroughs and challenges AI addresses in drug development. By summarizing the current research progress, this study provides theoretical support and practical guidance for further applications of AI in drug development.
Nanofibrous acoustic energy harvesters(NAEHs)have emerged as promising wearable platforms for efficient noise-to-electricity conversion in distributed power energy systems and wearable sound amplifiers for assistive l...
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Nanofibrous acoustic energy harvesters(NAEHs)have emerged as promising wearable platforms for efficient noise-to-electricity conversion in distributed power energy systems and wearable sound amplifiers for assistive listening ***,their reallife efficacy is hampered by low power output,particularly in the low-frequency range(<1 kHz).This study introduces a novel approach to enhance the performance of NAEHs by applying machine learning(ML)techniques to guide the synthesis of electrospun polyvinylidene fluoride(PVDF)/polyurethane(PU)nanofibers,optimizing their application in wearable *** use a feed-forward neural network along with solving an optimization problem to find the optimal input values of the electrospinning(applied voltage,nozzle-collector distance,electrospinning time,and drum rotation speed)to generate maximum output performance(acoustic-to-electricity conversion efficiency).We first prepared a dataset to train the network to predict the output power given the input variables with high *** introducing the neural network,we fix the network and then solve an optimization problem using a genetic algorithm to search for the input values that lead to the maximum energy harvesting *** ML-guided wearable PVDF/PU NAEH platform can deliver a maximal acoustoelectric power density output of 829μW/cm^(3) within the surrounding noise *** addition,our system can function stably in a broad frequency(0.1-2 kHz)with a high energy conversion efficiency of 66%.Sound recognition analysis reveals a robust correlation exceeding 0.85 among lexically akin terms with varying sound intensities,contrasting with a diminished correlation below 0.27 for words with disparate semantic ***,this work provides a previously unexplored route to utilize ML in advancing wearable NAEHs with excellent practicability.
The majorizing measure theorem of Fernique and Talagrand is a fundamental result in the theory of random processes. It relates the boundedness of random processes indexed by elements of a metric space to complexity me...
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With the prevalence of pre-training-fine-tuning paradigm, how to efficiently adapt the pre-trained model to the downstream tasks has been an intriguing issue. Parameter-Efficient Fine-Tuning (PEFT) methods have been p...
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With the prevalence of pre-training-fine-tuning paradigm, how to efficiently adapt the pre-trained model to the downstream tasks has been an intriguing issue. Parameter-Efficient Fine-Tuning (PEFT) methods have been proposed for low-cost adaptation. Although PEFT has demonstrated effectiveness and been widely applied, the underlying principles are still unclear. In this paper, we adopt the PAC-Bayesian generalization error bound, viewing pre-training as a shift of prior distribution which leads to a tighter bound for generalization error. We validate this shift from the perspectives of oscillations in the loss landscape and the quasi-sparsity in gradient distribution. Based on this, we propose a gradient-based sparse finetuning algorithm, named Sparse Increment Fine-Tuning (SIFT), and validate its effectiveness on a range of tasks including the GLUE Benchmark and Instruction-tuning. The code is accessible at https://***/song-wx/SIFT. Copyright 2024 by the author(s)
A long-standing question in the evolutionary multi-objective (EMO) community is how to generate a good initial population for EMO algorithms. Intuitively, as the starting point of optimization, a good initial populati...
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Advancements in communication have boosted digital image sharing but also heightened security risks due to easy manipulation. Therefore, authentication techniques are crucial for securing medical images. This paper pr...
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The present work strives to investigate the effect of using dimensionality reduction techniques (DRTs) on breast cancer (BC) classification problem. Primarily, we focused on the following five (DRTs): Auto-Encoders (A...
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Wireless power transfer (WPT) systems using magnetic resonant coupling (MRC) have made significant progress recently, leading to various optimization methods in scenarios involving multiple-input multiple-output (MIMO...
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To ensure the safety and fluidity of air traffic, the air traffic controller applies a set of rules dictated by the ICAO, called separation rules. For this, the controller must first undergo training based in part on ...
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