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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018)

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NATURE GENETICS 2018年第12期50卷 1755-1755页

作者： Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Karaman, Ibrahim Fu Liang Ng Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Magi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stephanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Theriault, Sebastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renee Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Noordam, Raymond Pare, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Goncalo Amin, Najaf Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C. Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco, Fabiola M. Demirkale, Cumhur Yusuf Dorr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Franberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen Department of Epidemiology and Biostatistics Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK National Institute for Health Research Barts Cardiovascular Biomedical Research Center Queen Mary University of London London UK MRC-PHE Centre for Environment and Health Imperial College London London UK Department of Mathematics Imperial College London London UK Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Tennessee Valley Healthcare System (626)/Vanderbilt University Nashville TN USA Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Department of Obstetrics and Gynecology Vanderbilt University Medical Center Tennessee Valley Health Systems VA Nashville TN USA Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA Division of Aging Department of Medicine Brigham and Women’s Hospital Department of Medicine Harvard Medical School Boston MA USA Atlanta VAMC and Emory Clinical Cardiovascular Research Institute Atlanta GA USA VA Palo Alto Health Care System Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Nephrology Section Memphis VA Medical Center and University of Tennessee Health Science Center Memphis TN USA Estonian Genome Center University of Tartu Tartu Estonia Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Department Clinical Sciences Malmö Lund University Malmö Sweden MRC Human Genetics Un

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

关键词： Cardiovascular diseases Genome informatics Genome-wide association studies

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Control and Notification Automatic Water Pump with Arduino and SMS Gateway

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IOP Conference Series: Materials science and Engineering 2018年第1期407卷

作者： R Ratnadewi H Nurdiyanto A Najmurrokhman C Prabowo R Idmayanti H Eteruddin C A Sugianto N Kurniasih H K Siburian D Nababan R Rahim Electrical Engineering Universitas Kristen Maranatha Bandung Indonesia Department of Informatics STMIK Dharma Wacana Metro Lampung Indonesia Department of Electrical Engineering Universitas Jenderal Achmad Yani Cimahi Indonesia Department of Information Technology Politeknik Negeri Padang Padang Indonesia Department of Electrical Universitas Lancang Kuning Pekanbaru Indonesia Departement of Informatics Politeknik TEDC Bandung Bandung Indonesia Library and Information Science Program Universitas Padjadjaran Bandung Indonesia Department of Informatics Sekolah Tinggi Manajemen Informatika dan Komputer Medan Indonesia Department of Information System Universitas Pelita Harapan Medan Medan Indonesia School of Computer and Communication Engineering Universiti Malaysia Perlis Kubang Gajah Malaysia

This paper aims to facilitate the owner to control water pump machine from the vacuum, and the condition of the water is it full or not in house or apartment. The current control system still has many limitations in controlling the water pump machine at home or apartment. The water machine control system was designed with device that has a smart surveillance system that can be accessed with Android smartphone and all information from or to machine control system will command by using SMS, this device create a development of Arduino UNO microcontroller technology that allows the reading of the GSM Module and connected with SMS Gateway. Experiment results facilitate real-time water control and much easy for the owner to control water tank.

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Reinforcement Learning with Multiple Shared Rewards

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Procedia computer science 2016年 80卷 855-864页

作者： Douglas M. Guisi Richardson Ribeiro Marcelo Teixeira Andre P. Borges Fabricio Enembreck Department of Informatics Federal University of Technology of Paraná Pato Branco Brazil Department of Informatics Federal University of Technology of Paraná Ponta Grossa Brazil Graduate Program in Computer Science Pontifical Catholic University of Paraná Curitiba Brazil

A major concern in multi-agent coordination is how to select algorithms that can lead agents to learn together to achieve certain goals. Much of the research on multi-agent learning relates to reinforcement learning (RL) techniques. One element of RL is the interaction model, which describes how agents should interact with each other and with the environment. Discrete, continuous and objective-oriented interaction models can improve convergence among agents. This paper proposes an approach based on the integration of multi-agent coordination models designed for reward-sharing policies. By taking the best features from each model, better agent coordination is achieved. Our experimental results show that this approach improves convergence among agents even in large state-spaces and yields better results than classical RL approaches.

关键词： Adaptive Agents Shared Rewards Interaction Learning Coordination.

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Retraction: The Effect of Mixed Pertamax with Tuak Nias (Tuonifaro) on Fuel Consumption at 125CC Machine and Its Dissemination Using Website (J. Phys.: Conf. Ser. 1114 012075)

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Journal of Physics: Conference Series 2018年第1期1114卷

作者： Kristian Tarigan Erianto Ongko H Hartono Dahlan Abdullah Cut Ita Erliana Nurmawati Sulfikar Sallu S Sriadhi Akbar Iskandar Nuning Kurniasih GS Achmad Daengs Ricardo Freedom Nanuru A A Saleh Muhammad Ikhsan Setiawan Wiwien Hadikurniawati Edy Winarno Department of Mechanical Engineering Universitas Darma Agung Medan Indonesia Department of Informatics Akademi Teknologi Industri ImmanuelIndonesia Department of Computer Science STMIK IBBI Medan Indonesia Department of Informatics Universitas Malikussaleh Aceh Indonesia Department of Industrial Engineering Universitas Malikussaleh Aceh Indonesia Faculty of Industry Technique University of 45 Surabaya Indonesia Faculty Of Information Technology Universitas Sembilan Belas November Kolaka Sulawesi Tenggara Indonesia Department of Electrical Engineering Universitas Negeri Medan Indonesia Department of Informatics STMIK AKBA Makassar Indonesia Faculty of Communication Sciences Library and Information Science Program Universitas Padjadjaran Bandung Indonesia Department of Management Universitas 45 Surabaya Indonesia Universitas Kristen Indonesia Maluku. Ambon Indonesia Statistics Financial & Social Sciences Research Group Indonesia Department of Civil Engineering Narotama University Surabaya Indonesia Faculty of Information Technology Universitas Stikubank Semarang Indonesia

This paper was retracted by IOP Publishing on 12 December 2018. This paper was published due to a technical error and was not intended to be included in this journal. Retraction published: 8 February 2019

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Student perceptions of faculty support: Do class size or institution type matter? 123

Student perceptions of faculty support: Do class size or ins...

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123rd ASEE Annual Conference and Exposition

作者： Allendoerfer, Cheryl Wilson, Denise Plett, Melani Bates, Rebecca A. Smith, Tamara Floyd Veilleux, Nanette M. University of Washington College of Engineering United States University of Washington Department of Electrical Engineering Seattle United States Seattle Pacific University United States Minnesota State University Department of Integrated Engineering Program Mankato United States Tuskegee University Department of Chemical Engineering United States Simmons College Computer Science and Informatics Program BostonMA United States

In the context of Tinto's Model of Institutional Departure, faculty support is critical to academic integration, which in turn is an essential element of persistence in college. Thus, understanding students' perceptions of faculty support in varied settings can provide insight into student satisfaction, performance, and persistence in engineering programs. In this study, focus groups were conducted with 175 students from five different institutions and a variety of engineering and computer science majors. The institutions in this study included a small women's college, a historically black university, a small private university, a medium size teaching university, and a large public research university. Focus group transcripts were coded and analyzed qualitatively. Findings from this analysis show that in some settings, despite a perceived lack of formal, in-class faculty support, students are still able to find faculty support outside the classroom, while in other settings this informal support is also perceived as lacking. In general, smaller environments with smaller student-to-faculty ratios appear to support stronger perceptions of support, although through different pathways. A small class size does not guarantee that students will perceive greater faculty support in that class. Large class sizes are not automatically detrimental for students, but they can be if students in those classes feel a lack of faculty support or availability both in and out of the classroom. With regard to institution type, the notion that undergraduates perceive lower levels of faculty support at research institutions holds true. This study has not verified whether the level of faculty support is actually less at research institutions, but only that students' self-reported perceptions of that support were lower at the research-focused institution when compared to teaching-focused institutions in this study. Regardless, given the importance of faculty support in persistence and other a

关键词： Class size Engineering Faculty support Faculty-student interactions Institution type

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The Effect of Mixed Pertamax with Tuak Nias (Tuonifaro) on Fuel Consumption at 125CC Machine and Its Dissemination Using Website

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Journal of Physics: Conference Series 2018年第1期1114卷

The purpose of this research is to know how influence of mixture of pertamax with Tuak Nias (Tuonifaro) to fuel consumption at 125 cc engine To prove that Tuak Nias or Tuonifaro can be used as fuel mixture on motorcycle and examine how big influence of mix between Tuak Nias or Tuonifaro with Pertamax, conducting research by literature study method or literature study. Many authors use various supporting / input factors and supporting books related to the titles discussed. because Tuak Nias or tuonifaro contain low 4-5% ethanonic elements and contain 90% alcoholic elements so that the fuel easily burns easily in the combustion chamber and produces great power. The results of this research will be disseminated using the website

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Multi-level computational methods for interdisciplinary research in the hathi trust digital library

arXiv

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arXiv 2017年

作者： Murdock, Jaimie Allen, Colin Borner, Katy Light, Robert McAlister, Simon Ravenscroft, Andrew Rose1, Robert Rose, Doori Otsuka, Jun Bourget, David Lawrence, John Reed, Chris Program in Cognitive Science Indiana University BloomingtonIN United States School of Informatics and Computing Indiana University BloomingtonIN United States Department of History and Philosophy of Science and Medicine Indiana University BloomingtonIN United States Indiana University Network Science Institute IUNI BloomingtonIN United States User-Centered Social Media Department of Computer Science and Applied Cognitive Science University of Duisburg-Essen Duisburg Germany International Centre for Public Pedagogy ICPuP Cass School of Education and Communities University of East London London Department of Mathematics Indiana University BloomingtonIN United States Department of Philosophy Kyoto University Kyoto Japan Department of Philosophy University of Western Ontario LondonON Canada Centre for G Technology University of Dundee Dundee United Kingdom

We show how faceted search using a combination of traditional classification sys-tems and mixed-membership topic models can go beyond keyword search to inform re-source discovery, hypothesis formulation, and argument extraction for interdisciplinary research. Our test domain is the history and philosophy of scientific work on animal mind and cognition. The methods can be generalized to other research areas and ul-timately support a system for semi-automatic identification of argument structures. We provide a case study for the application of the methods to the problem of identi-fying and extracting arguments about anthropomorphism during a critical period in the development of comparative psychology. We show how a combination of classifi-cation systems and mixed-membership models trained over large digital libraries can inform resource discovery in this domain. Through a novel approach of \drill-down" topic modeling|simultaneously reducing both the size of the corpus and the unit of analysis|we are able to reduce a large collection of fulltext volumes to a much smaller set of pages within six focal volumes containing arguments of interest to historiansand philosophers of comparative psychology. The volumes identified in this way did not appear among the first ten results of the keyword search in the HathiTrust digital library and the pages bear the kind of \close reading" needed to generate original in-terpretations that is the heart of scholarly work in the humanities. Zooming back out, we provide a way to place the books onto a map of science originally constructed from very different data and for different purposes. The multilevel approach advances un-derstanding of the intellectual and societal contexts in which writings are interpreted. Copyright © 2017, The Authors. All rights reserved.

关键词： Digital libraries

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Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

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Scientific data 2021年第1期8卷 242页

作者： Julien Cohen-Adad Eva Alonso-Ortiz Mihael Abramovic Carina Arneitz Nicole Atcheson Laura Barlow Robert L Barry Markus Barth Marco Battiston Christian Büchel Matthew Budde Virginie Callot Anna J E Combes Benjamin De Leener Maxime Descoteaux Paulo Loureiro de Sousa Marek Dostál Julien Doyon Adam Dvorak Falk Eippert Karla R Epperson Kevin S Epperson Patrick Freund Jürgen Finsterbusch Alexandru Foias Michela Fratini Issei Fukunaga Claudia A M Gandini Wheeler-Kingshott Giancarlo Germani Guillaume Gilbert Federico Giove Charley Gros Francesco Grussu Akifumi Hagiwara Pierre-Gilles Henry Tomáš Horák Masaaki Hori James Joers Kouhei Kamiya Haleh Karbasforoushan Miloš Keřkovský Ali Khatibi Joo-Won Kim Nawal Kinany Hagen H Kitzler Shannon Kolind Yazhuo Kong Petr Kudlička Paul Kuntke Nyoman D Kurniawan Slawomir Kusmia René Labounek Maria Marcella Laganà Cornelia Laule Christine S Law Christophe Lenglet Tobias Leutritz Yaou Liu Sara Llufriu Sean Mackey Eloy Martinez-Heras Loan Mattera Igor Nestrasil Kristin P O'Grady Nico Papinutto Daniel Papp Deborah Pareto Todd B Parrish Anna Pichiecchio Ferran Prados Àlex Rovira Marc J Ruitenberg Rebecca S Samson Giovanni Savini Maryam Seif Alan C Seifert Alex K Smith Seth A Smith Zachary A Smith Elisabeth Solana Y Suzuki George Tackley Alexandra Tinnermann Jan Valošek Dimitri Van De Ville Marios C Yiannakas Kenneth A Weber Ii Nikolaus Weiskopf Richard G Wise Patrik O Wyss Junqian Xu NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. jcohen@polymtl.ca. Functional Neuroimaging Unit CRIUGM Université de Montréal Montreal QC Canada. jcohen@polymtl.ca. Mila - Quebec AI Institute Montreal QC Canada. jcohen@polymtl.ca. NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. Department of Radiology Swiss Paraplegic Centre Nottwil Switzerland. Centre for Advanced Imaging The University of Queensland Brisbane Australia. Department of Radiology University of British Columbia Vancouver BC Canada. Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Charlestown MA USA. Department of Radiology Harvard Medical School Boston MA USA. Harvard-Massachusetts Institute of Technology Health Sciences & Technology Cambridge MA USA. School of Information Technology and Electrical Engineering The University of Queensland Brisbane Australia. NMR Research Unit Queen Square MS Centre UCL Queen Square Institute of Neurology Faculty of Brain Sciences University College London London UK. Department of Systems Neuroscience University Medical Center Hamburg-Eppendorf Hamburg Germany. Department of Neurosurgery Medical College of Wisconsin Milwaukee WI USA. Aix-Marseille Univ CNRS CRMBM Marseille France. APHM Hopital Universitaire Timone CEMEREM Marseille France. Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center Nashville TN USA. Department of Computer and Software Engineering Polytechnique Montreal Montreal Canada. CHU Sainte-Justine Research Centre Montreal QC Canada. Centre de Recherche CHUS CIMS Sherbrooke Canada. Sherbrooke Connectivity Imaging Lab (SCIL) Computer Science department Université de Sherbrooke Sherbrooke Canada. Université de Strasbourg CNRS ICube Strasbourg France. UHB - University Hospital Brno and Masaryk University Department of Radiology and Nuclear

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Supporting Software Architecture Learning Using Runtime Visualization

Supporting Software Architecture Learning Using Runtime Visu...

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Conference on Software Engineering Education & Training (CSEE&T)

作者： John C. Georgas James D. Palmer Michael J. McCormick Informatics and Computing Program Northern Arizona University Flagstaff Arizona Department of Electrical Engineering and Computer Science Northern Arizona University Flagstaff Arizona

Static diagrams are the most prevalent artifact used in visualizing component-and-connector architectures and supporting software architecture learning. The use of such artifacts exhibits a fundamental disconnect from the dynamic nature of software systems, deemphasizes the importance of architectural interactions with a focus on static structure, and does not support a high degree of learner engagement. This paper presents our work in addressing these challenges by developing runtime visualization techniques that better support learning through the use of visual vocabularies that leverage insights from computer graphics and human perception. We also present evaluative data drawn from user studies and associated insights, which provide positive indicators that our work is effective in supporting our target learning outcomes.

关键词： Visualization Unified modeling language Software architecture computer architecture Runtime Object oriented modeling Software systems

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Proceedings of the 16th Annual UT-KBRIN Bioinformatics Summit 2016: bioinformatics

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BMC Bioinformatics 2017年第9期18卷 1-9页

作者： Eric C. Rouchka Juw Won Park Julia H. Chariker David A. Tieri Shreedharkumar Rajurkar Vikas Singh Nishchal K. Verma Yan Cui Mark Farman Bradford Condon Jolanta Jaromczyk Neil Moore Jerzy Jaromczyk Daniel Harris Patrick Calie Eun Kyong Shin Robert L. Davis Arash Shaban-Nejad Joshua M. Mitchell Hunter N. B. Moseley Robert M. Flight Qing Jun Wang Richard M. Higashi Teresa W-M Fan Andrew N. Lane Liangqun Lu Bernie J Daigle Jr. Xi Chen Andrey Smelter Jerzy W. Jaromczyk Bailey K. Phan Nathaniel J. Serpico Ethan G. Toney Li Chen Caroline E. Melton Jennifer R. Mandel Bernie J. Daigle Jr. Hao Chen Kazi I. Zaman Ramin Homayouni Patrick J. Trainor Andrew P. DeFilippis Samantha M. Carlisle Shesh N. Rai Department of Computer Engineering and Computer Science University of Louisville Duthie Center for Engineering Louisville KY 40292 USA Kentucky Biomedical Research Infrastructure (KBRIN) Bioinformatics Core 522 East Gray Street Louisville KY 40292 USA Department of Psychological and Brain Sciences University of Louisville Louisville KY 40292 USA Department of Anatomical Sciences and Neurobiology University of Louisville Louisville KY 40292 USA Department of Electrical Engineering IIT Kanpur India Department of Microbiology Immunology and Biochemistry University of Tennessee Health Science Center Memphis TN 38103 USA Center for Integrative and Translational Genomics University of Tennessee Health Science Center Memphis TN 38103 USA Department of Plant Pathology University of Kentucky Lexington KY 40546 USA UK Healthcare Genomics University of Kentucky Lexington KY 40536 USA Department of Entomology & Plant Pathology University of Tennessee Knoxville TN 37996 USA Department of Forestry University of Kentucky Lexington KY 40506 USA Department of Computer Science University of Kentucky Lexington KY 40506 USA Department of Computer Science University of Kentucky Lexington KY 40508 USA Department of Biological Sciences Eastern Kentucky University Richmond KY 40475 USA University of Tennessee Health Science Center – Oak-Ridge National Lab (UTHSC-ORNL) Center for Biomedical Informatics Department of Pediatrics Memphis TN 38103 USA Department of Molecular & Cellular Biochemistry University of Kentucky Lexington KY 40536 USA Markey Cancer Center University of Kentucky Lexington KY 40536 USA Center for Environmental and Systems Biochemistry University of Kentucky Lexington KY 40536 USA Institute for Biomedical Informatics University of Kentucky Lexington KY 40536 USA Department of Molecular and Cellular Biochemistry University of Kentucky Lexington KY 40536 USA Department of Statistics University of Kentucky Louisville KY

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