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Workshop on Requirements and Validation, Verification, and Testing

作者： Neto, Arilo Claudio Dias De Freitas Rodrigues, Rosiane Travassos, Guilherme Horta Post-graduation Program In Informatics Computer Science Department Federal University of Amazonas Manaus AM Brazil Systems Engineering and Computer Science Program COPPE Federal University of Rio De Janeiro Rio De Janeiro RJ Brazil

ISBN: (纸本)9780769543451

The combination of testing techniques is considered an effective strategy to evaluate a software product. However, the selection of which techniques to combine in a software project has been an interesting challenge in the Software Engineering field. This paper presents a proposal extending an approach developed to support the combined selection of model-based testing (MBT) techniques, named Porantim, applying Multiobjective Combinatorial Optimization strategy by determining the smallest dominating set in a bipartite and weighted graph. Thus, a local search strategy algorithm is proposed generating solutions aiming at maximizing the coverage of software project characteristics and skills required by the testing team to use the techniques and minimizing the eventual effort to construct models used for test cases generation. A preliminary evaluation analyzes this new approach when compared to the Porantim's original version, and the results indicate improvements in the MBT techniques selection. © 2011 IEEE.

关键词： Software testing

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An extensible architecture for DTV middleware 11

An extensible architecture for DTV middleware

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Proceedings of the 9th European Conference on Interactive TV and Video

作者： Ghisi, Bruno Cavaler Siqueira, Frank Graduate Program in Computer Science - PPGCC Department of Informatics and Statistics - INE Federal University Os Santa Catarina - UFSC Florianópolis Brazil

ISBN: (纸本)9781450306027

The currently adopted specifications for Digital Television (DTV) middleware do not define the internal characteristics of their architecture. As a result, the existing middleware implementations are not as flexible, extensible and adaptable as they should be due to the adoption of a closely-coupled architecture. This paper proposes a modular architecture for DTV middleware, which allows easy extension and updating, providing a simple way to add new features to the middleware. This architecture is based on the OSGi framework and its software components, called bundles. A categorization of these bundles was proposed, based on different usage scenarios that were identified, according to industry time-to-market and innovation needs. Prototypes of the architecture and of bundles have been implemented, and tests performed with these prototypes show the feasibility of this approach. © 2011 ACM.

关键词： Digital television

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Minimum maximum-degree publish-subscribe overlay network design

Minimum maximum-degree publish-subscribe overlay network des...

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作者： Onus, Melih Richa, Andréa W. Department of Computer Engineering Bilkent University Ankara 06560 Turkey Computer Science and Engineering Program School of Computing Informatics and Decision Systems Engineering Arizona State University Tempe AZ 85281 United States

Designing an overlay network for publish/subscribe communication in a system where nodes may subscribe to many different topics of interest is of fundamental importance. For scalability and efficiency, it is important to keep the degree of the nodes in the publish/subscribe system low. It is only natural then to formalize the following problem: Given a collection of nodes and their topic subscriptions, connect the nodes into a graph that has least possible maximum degree in such a way that for each topic t, the graph induced by the nodes interested in t is connected. We present the first polynomial-time logarithmic approximation algorithm for this problem and prove an almost tight lower bound on the approximation ratio. Our experimental results show that our algorithm drastically improves the maximum degree of publish/subscribe overlay systems. We also propose a variation of the problem by enforcing that each topic-connected overlay network be of constant diameter while keeping the average degree low. We present three heuristics for this problem that guarantee that each topic-connected overlay network will be of diameter 2 and that aim at keeping the overall average node degree low. Our experimental results validate our algorithms, showing that our algorithms are able to achieve very low diameter without increasing the average degree by much. © 2011 IEEE.

关键词： Overlay networks

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A Study of NetCDF as an Approach for High Performance Medical Image Storage

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Journal of Physics: Conference Series 2012年第1期341卷

作者： Marcone Magnus Thiago Coelho Prado Aldo von Wangenhein Douglas D J de Macedo M A R Dantas Post-graduate Program in Computer Science Department of Informatics and Statistic Federal University of Santa Catarina Florianópolis SC - Brasil Post-graduate Program in Knowledge Engineering and Managemet Department of Knowledge Engineering Federal University of Santa Catarina Florianópolis SC - Brasil

The spread of telemedicine systems increases every day. The systems and PACS based on DICOM images has become common. This rise reflects the need to develop new storage systems, more efficient and with lower computational costs. With this in mind, this article discusses a study for application in NetCDF data format as the basic platform for storage of DICOM images. The study case comparison adopts an ordinary database, the HDF5 and the NetCDF to storage the medical images. Empirical results, using a real set of images, indicate that the time to retrieve images from the NetCDF for large scale images has a higher latency compared to the other two methods. In addition, the latency is proportional to the file size, which represents a drawback to a telemedicine system that is characterized by a large amount of large image files.

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An Approach Using Parallel Architecture to Storage DICOM Images in Distributed File System

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Journal of Physics: Conference Series 2012年第1期341卷

作者： Tiago S Soares Thiago C Prado M A R Dantas Douglas D J de Macedo Michael A Bauer Informatics and Statistic Department Federal University of Santa Catarina Florianpolis Brazil Post-Graduate Program of Knowledge Engineering and Management Federal University of Santa Catarina Florianpolis Brazil Department of Computer Science University of Western Ontario UWO London Canada

Telemedicine is a very important area in medical field that is expanding daily motivated by many researchers interested in improving medical applications. In Brazil was started in 2005, in the State of Santa Catarina has a developed server called the CyclopsDCMServer, which the purpose to embrace the HDF for the manipulation of medical images (DICOM) using a distributed file system. Since then, many researches were initiated in order to seek better performance. Our approach for this server represents an additional parallel implementation in I/O operations since HDF version 5 has an essential feature for our work which supports parallel I/O, based upon the MPI paradigm. Early experiments using four parallel nodes, provide good performance when compare to the serial HDF implemented in the CyclopsDCMServer.

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Missing Data Imputation for Remote CHF Patient Monitoring Systems

Missing Data Imputation for Remote CHF Patient Monitoring Sy...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Myung-kyung Suh Jonathan Woodbridge Mars Lan Alex Bui Lorraine S. Evangelista Majid Sarrafzadeh Computer Science Department University of California Medical Imaging Informatics Group Department of Radiological Sciences University of California Program of Nursing Science University of California

ISBN: (纸本)9781424441211

Congestive heart failure (CHF) is a leading cause of death in the United States. WANDA is a wireless health project that leverages sensor technology and wireless communication to monitor the health status of patients with CHF. The first pilot study of WANDA showed the system's effectiveness for patients with CHF. However, WANDA experienced a considerable amount of missing data due to system misuse, nonuse, and failure. Missing data is highly undesirable as automated alarms may fail to notify healthcare professionals of potentially dangerous patient conditions. In this study, we exploit machine learning techniques including projection adjustment by contribution estimation regression (PACE), Bayesian methods, and voting feature interval (VFI) algorithms to predict both non-binomial and binomial data. The experimental results show that the aforementioned algorithms are superior to other methods with high accuracy and recall. This approach also shows an improved ability to predict missing data when training on entire populations, as opposed to training unique classifiers for each individual.

关键词： missing data Congestive Heart Failure Health Status system effectiveness Cause of Death Patient Monitoring System CARRIER SYSTEM Health Personnel

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Dynamic mortality simulation model incorporating risk indicators for cardiovascular diseases 11

Dynamic mortality simulation model incorporating risk indica...

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Simulation Winter Conference

作者： Jocimara S. Ferranti Paulo J. de Freitas Filho Postgraduate Program in Computer Science Department of Informatics and Statistics Federal University of Santa Catarina Florianopolis Santa Catarina Brazil

This article describes a dynamic-fuzzy simulation model and proposes an extension to it. The model represents a person's physiological capacity throughout life and simulates the occurrence of risk events from birth until death, including a representation of the process of recovering health after it has been impacted by a risk event. The expanded model incorporates cardiovascular risk factors in order to reproduce curves plotted from real mortality data from a specific population whose cause of death was cardiovascular diseases. By adjusting the parameters, it proved possible to reproduce mortality curves from populations with specific characteristics such as hypertension, obesity and physical activity levels. A simulation model that is capable of focusing on specific populations makes it possible to test alternative intervention designed to reduce the mortality caused by specific diseases, thereby contributing to improved quality-of-life for populations and to cost savings for both public and private health care systems.

关键词： Aging Mathematical model Equations Computational modeling Diseases Radio frequency

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Integration of Multilayers in Er-Doped Porous Silicon Structures and Advances in 1.5 μm Optoelectronic Devices

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MRS Online Proceedings Library 2011年第1期536卷 135-140页

作者： H. A. Lopez S. Chan L. Tsybeskov H. Koyama V. P. Bondarenko P. M. Fauchet Materials Science Program University of Rochester Rochester USA Department of Electrical and Computer Engineering University of Rochester Rochester USA Belarusian State University of Informatics and Radioelectronics Minsk Belarus

Infrared photoluminescence (PL) and electroluminescence (EL) from erbium-doped porous silicon (PSi) structures are studied. The PL and EL from the Er-doped PSi structures and the absence of silicon band edge recombination, point defect, and dislocation luminescence bands suggest that the Er-complex centers are the most efficient recombination sites. PSi multilayers with very high reflectivity (R ≥ 90%) in the 1.5 gim range have been incorporated in the structures resulting in a PL enhancement of over 100%. Stable and intense EL is obtained from the Er-doped structures. The EL spectrum is similar to that of the PL, but shifted towards higher energy. The unexpected shift in emission opens up the possibility for erbium related luminescence to encompass a larger part of the optimal wavelength window for fiber optic communications.

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BioN∅T: A searchable database of biomedical negated sentences

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BMC Bioinformatics 2011年第1期12卷 1-7页

作者： Agarwal, Shashank Yu, Hong Kohane, Issac Medical Informatics College of Engineering and Applied Sciences University of Wisconsin-Milwaukee 3200 N. Cramer St. Milwaukee WI 53201-0784 United States Department of Computer Science and Electrical Engineering College of Engineering and Applied Sciences University of Wisconsin-Milwaukee 3200 N. Cramer St. Milwaukee WI 53201-0784 United States Department of Health Sciences College of Health Science University of Wisconsin-Milwaukee 2400 E. Hartford Ave. Milwaukee WI 53211 United States Children's Hospital Informatics Program Children's Hospital 300 Longwood Ave. Enders-6 Boston MA 02115 United States

Background: Negated biomedical events are often ignored by text-mining applications;however, such events carry scientific significance. We report on the development of BioN∅T, a database of negated sentences that can be used to extract such negated ***: Currently BioN∅T incorporates ≈32 million negated sentences, extracted from over 336 million biomedical sentences from three resources: ≈2 million full-text biomedical articles in Elsevier and the PubMed Central, as well as ≈20 million abstracts in PubMed. We evaluated BioN∅T on three important genetic disorders: autism, Alzheimer's disease and Parkinson's disease, and found that BioN∅T is able to capture negated events that may be ignored by ***: The BioN∅T database can be a useful resource for biomedical researchers. BioN∅T is freely available at http://***/. In future work, we will develop semantic web related technologies to enrich BioN∅T. © 2011 Agarwal et al;licensee BioMed Central Ltd.

关键词： Database systems

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Detecting Drug Interactions From Adverse-Event Reports: Interaction Between Paroxetine and Pravastatin Increases Blood Glucose Levels (vol 90, pg 133, 2011)

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CLINICAL PHARMACOLOGY & THERAPEUTICS 2011年第3期90卷 480-480页

作者： Tatonetti, N. P. Denny, J. C. Murphy, S. N. Fernald, G. H. Krishnan, G. Castro, V. Yue, P. Tsao, P. S. Kohane, I. Roden, D. M. Altman, R. B. 1Biomedical Informatics Training Program Stanford University Stanford California USA 2Department of Bioengineering Stanford University Stanford California USA 3Department of Genetics Stanford University Stanford California USA 4Department of Biomedical Informatics Vanderbilt University Nashville Tennessee USA 5Department of Medicine Vanderbilt University Nashville Tennessee USA 6Laboratory of Computer Science Massachusetts General Hospital Boston Massachusetts USA 7Harvard Medical School Boston Massachusetts USA 8Stanford Center for Clinical Informatics Stanford University Stanford California USA 9Department of Medicine/ Cardiovascular Medicine Stanford University Stanford California USA 10Children's Hospital Boston Massachusetts USA 11Brigham and Women's Hospital Boston MassachusettsUSA

The lipid-lowering agent pravastatin and the antidepressant paroxetine are among the most widely prescribed drugs in the world. Unexpected interactions between them could have important public health implications. We mined the US Food and Drug Administration's (FDA's) Adverse Event Reporting System (AERS) for side-effect profiles involving glucose homeostasis and found a surprisingly strong signal for comedication with pravastatin and paroxetine. We retrospectively evaluated changes in blood glucose in 104 patients with diabetes and 135 without diabetes who had received comedication with these two drugs, using data in electronic medical record (EMR) systems of three geographically distinct sites. We assessed the mean random blood glucose levels before and after treatment with the drugs. We found that pravastatin and paroxetine, when administered together, had a synergistic effect on blood glucose. The average increase was 19 mg/dl (1.0 mmol/l) overall, and in those with diabetes it was 48 mg/dl (2.7 mmol/l). In contrast, neither drug administered singly was associated with such changes in glucose levels. An increase in glucose levels is not a general effect of combined therapy with selective serotonin reuptake inhibitors (SSRIs) and statins.

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