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Search for the doubly charmed baryon Ω_(cc)^(+)

science China(Physics,Mechanics & Astronomy) 2021年第10期64卷 2-13页

作者： LHCb Collaboration Centro Brasileiro de Pesquisas Físicas (CBPF) Rio de Janeiro Brazil Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil Center for High Energy Physics Tsinghua University Beijing 100084 China Institute Of High Energy Physics (IHEP) Beijing 100039 China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100091 China University of Chinese Academy of Sciences Beijing 100086 China Institute of Particle Physics Central China Normal University Wuhan 430079 China CNRS IN2P3-LAPP Univ. Savoie Mont Blanc Annecy France CNRS/IN2P3 LPC Université Clermont Auvergne Clermont-Ferrand France CNRS/IN2P3 CPPM Aix Marseille Univ Marseille France CNRS/IN2P3 IJCLab Université Paris-Saclay Orsay France Laboratoire Leprince-Ringuet CNRS/IN2P3 Ecole Polytechnique Institut Polytechnique de Paris Palaiseau France LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS/IN2P3 Paris France I. Physikalisches Institut RWTH Aachen University Aachen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Max-Planck-Institut für Kernphysik (MPIK) Heidelberg Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany School of Physics University College Dublin Dublin Ireland INFN Sezione di Bari Bari Italy INFN Sezione di Bologna Bologna Italy INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Firenze Firenze Italy INFN Laboratori Nazionali di Frascati Frascati Italy INFN Sezione di Genova Genova Italy INFN Sezione di Milano Milano Italy INFN Sezione di Milano-Bicocca Milano Italy INFN Sezione di Cagliari Monserrato Italy Universita degli Studi di Padova Universita e INFN Padova Padova Italy INFN Sezione di Pisa Pisa Italy INFN Sezione di Roma La Sapienza Roma Italy INFN Sezione di Roma Tor Vergata Roma Italy Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Nikhef National Institute for Subatomic Physics and VU Unive

A search for the doubly charmed baryon ?cc+ with the decay mode c Ω_(cc)^(+)→ Ξc+K-π+ is performed using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the LHCb experiment from 2016 to 2018, corresponding to an integrated luminosity of 5.4 fb-1. No significant signal is observed within the invariant mass range of 3.6 to 4.0 GeV/c2. Upper limits are set on the ratio R of the production cross-section times the total branching fraction of the Ω_(cc)^(+)→ Ξc+K-π+ decay with respect to the Ξcc++→ Λc+K-π+π+ decay. Upper limits at 95% credibility level for R in the range 0.005 to 0.11 are obtained for diferent hypotheses on the ?cc+ mass and lifetime in the rapidity range from 2.0 to 4.5 and transverse momentum range from 4 to 15 GeV/c.

关键词： charmed baryons limits on production of particles charmed quarks experimental tests

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Search for the doubly heavy baryon Ξ_(bc)^(+)→ decaying to J/ψΞ_(c)^(+)

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Chinese Physics C 2023年第9期47卷 1-13页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.Agapopoulou C.A.Aidala S.Aiola Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev N.Bondar S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura L.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse M.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard deviations at masses of 6571 and 6694 MeV/c2, respectively. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relative to that of the B+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 TeV, in the Ξ+bc and in the B+c rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV/c, respectively. Upper limits are presented as a function of the Ξ+bc mass and lifetime.

关键词： QCD B physics charm physics spectroscopy

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Cocreating the Visualization of Digital Mobility Outcomes: Delphi-Type Process With Patients

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JMIR Formative Research 2025年 9卷 e68782页

作者： Lumsdon, Jack Wilson, Cameron Alcock, Lisa Becker, Clemens Benvenuti, Francesco Bonci, Tecla van den Brande, Koen Brittain, Gavin Brown, Philip Buckley, Ellen Caruso, Marco Caulfield, Brian Cereatti, Andrea Delgado-Ortiz, Laura Del Din, Silvia Evers, Jordi Garcia-Aymerich, Judith Gaßner, Heiko Gur Arieh, Tova Hansen, Clint Hausdorff, Jeffrey M. Hiden, Hugo Hume, Emily Kirk, Cameron Maetzler, Walter Megaritis, Dimitrios Rochester, Lynn Scott, Kirsty Sharrack, Basil Sutton, Norman Vereijken, Beatrix Vogiatzis, Ioannis Yarnall, Alison Keogh, Alison Cantu, Alma Population Health Sciences Institute Faculty of Medical Sciences Newcastle University Newcastle Upon Tyne United Kingdom School of Clinical Medicine Department of Public Health and Primary Care University of Cambridge Cambridge United Kingdom Translational and Clinical Research Institute Faculty of Medical Sciences Newcastle University Newcastle Upon Tyne United Kingdom NIHR Newcastle Biomedical Research Centre Newcastle University The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne United Kingdom Robert Bosch Society for Medical Research Stuttgart Germany Digital Geriatrics Unit Medical Centre University of Heidelberg Heidelberg Germany Mobilise-D Patient and Public Advisory Group Newcastle Upon Tyne United Kingdom School of Mechanical Aerospace and Civil Engineering University of Sheffield Sheffield United Kingdom Insigneo Institute for Silico Medicine University of Sheffield Sheffield United Kingdom Department of Neuroscience Sheffield NIHR Translational Neuroscience BRC Sheffield Teaching Hospitals NHS Foundation Trust Sheffield United Kingdom Sheffield Institute for Translational Neuroscience University of Sheffield Sheffield United Kingdom The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne United Kingdom Division of Clinical Medicine University of Sheffield Sheffield United Kingdom Department of Electronics and Telecommunications Politecnico di Torino Turin Italy Insights Centre Data Analytics University College Dublin Dublin Ireland School of Public Health Physiotherapy and Sports Science University of College Dublin Dublin Ireland Barcelona Institute for Global Health Barcelona Spain Department of Medicine and Life Sciences Pompeu Fabra University Barcelona Spain Center for Biomedical Research Madrid Spain McRoberts BV The Hague Netherlands Department of Molecular Neurology University Hospital Erlangen Erlangen Germany Fraunhofer Institute for Integrated Circuits IIS Erlangen Germany Departmen

Background: Recent technological advances in wearable devices offer new potential for measuring mobility in real-world contexts. Mobilise-D has validated digital mobility outcomes to provide novel outcomes and end points in clinical research of 4 different long-term health conditions (Parkinson disease, multiple sclerosis, chronic obstructive pulmonary disease, and proximal femoral fracture). These outcomes also provide unique information that is important to patients;however, there is limited literature that explores the optimal methods to achieve this, such as the best way to visualize patients’ data. Objective: This study aimed to identify meaningful outcomes for each condition and how to best visualize them from the perspective of end users. Methods: Using a Delphi-type protocol with patients as subject matter experts, we gathered iterative feedback on the cocreation of visualizations through 3 rounds of questionnaires. An open-ended questionnaire was used in round 1 to understand what aspects of mobility were most influenced by their health condition. These responses were mapped onto relevant digital mobility outcomes and walking experiences and then prioritized for visualization. Using patient responses, we worked alongside researchers, clinicians, and a patient advisory group to develop visualizations that depicted a week of mobility data. During rounds 2 and 3, participants rated usefulness and ease of understanding on a 5-point Likert scale and provided unstructured feedback in comment boxes for each visualization. Visualizations were refined using the feedback from round 2 before receiving further feedback in round 3. Results: Participation varied across rounds 1 to 3 (n=48, n=79, and n=78, respectively). Round 1 identified important outcomes and contexts for each health condition, such as walking speed and stride length for people with Parkinson disease or multiple sclerosis and number of steps for people with chronic obstructive pulmonary disease or prox

关键词： cocreation data visualization digital mobility outcomes mobility wearable devices

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DPHL:A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham Tim Schelfhorst Richard R.G.D.Haas Irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang Mo Hu Yue Zhou Winan J.Van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic Franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan N.M.Ijzermans John W.M.Martens Renske D.M.Steenbergen Nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta Mantoo Sze S.Lee Serene J.Y.Yeow Syed M.F.Alkaff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang Man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan Meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry Lam Ding Ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREMEN)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus MC University Medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of Medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by *** data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： Data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma

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Constraints on the photon polarisation in b → sγ transitions using Bs0→ ϕe⁺e⁻ decays

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Journal of High Energy Physics 2025年第3期2025卷 1-23页

作者： Aaij, R. Abdelmotteleb, A.S.W. Abellan Beteta, C. Abudinén, F. Ackernley, T. Adefisoye, A.A. Adeva, B. Adinolfi, M. Adlarson, P. Agapopoulou, C. Aidala, C.A. Ajaltouni, Z. Akar, S. Akiba, K. Albicocco, P. Albrecht, J. Alessio, F. Alexander, M. Aliouche, Z. Alvarez Cartelle, P. Amalric, R. Amato, S. Amey, J.L. Amhis, Y. An, L. Anderlini, L. Andersson, M. Andreianov, A. Andreola, P. Andreotti, M. Andreou, D. Anelli, A. Ao, D. Archilli, F. Argenton, M. Arguedas Cuendis, S. Artamonov, A. Artuso, M. Aslanides, E. Ataíde Da Silva, R. Atzeni, M. Audurier, B. Bacher, D. Bachiller Perea, I. Bachmann, S. Bachmayer, M. Back, J.J. Baladron Rodriguez, P. Balagura, V. Baldini, W. Balzani, L. Bao, H. Baptista de Souza Leite, J. Barbero Pretel, C. Barbetti, M. Barbosa, I.R. Barlow, R.J. Barnyakov, M. Barsuk, S. Barter, W. Bartolini, M. Bartz, J. Basels, J.M. Bashir, S. Bassi, G. Batsukh, B. Battista, P.B. Bay, A. Beck, A. Becker, M. Bedeschi, F. Bediaga, I.B. Behling, N.A. Belin, S. Bellee, V. Belous, K. Belov, I. Belyaev, I. Benane, G. Bencivenni, G. Ben-Haim, E. Berezhnoy, A. Bernet, R. Bernet Andres, S. Bertolin, A. Betancourt, C. Betti, F. Bex, J. Bezshyiko, Ia. Bhom, J. Bieker, M.S. Biesuz, N.V. Billoir, P. Biolchini, A. Birch, M. Bishop, F.C.R. Bitadze, A. Bizzeti, A. Blake, T. Blanc, F. Blank, J.E. Blusk, S. Bocharnikov, V. Boelhauve, J.A. Boente Garcia, O. Boettcher, T. Bohare, A. Boldyrev, A. Bolognani, C.S. Bolzonella, R. Bondar, N. Bordelius, A. Borgato, F. Borghi, S. Borsato, M. Borsuk, J.T. Bouchiba, S.A. Bovill, M. Bowcock, T.J.V. Boyer, A. Bozzi, C. Brea Rodriguez, A. Breer, N. Brodzicka, J. Brossa Gonzalo, A. Brown, J. Brundu, D. Buchanan, E. Buonaura, A. Buonincontri, L. Burke, A.T. Burr, C. Butter, J.S. Buytaert, J. Byczynski, W. Cadeddu, S. Cai, H. Caillet, A.C. Calabrese, R. Calderon Ramirez, S. Calefice, L. Cali, S. Calvi, M. Calvo Gomez, M. Camargo Magalhaes, P. Cambon Bouzas, J.I. Campana, P. Campora Perez, D.H. Campoverde Quezada, A.F. Capelli, S. Capriotti, L. Caravaca-Mora, R. Carbone, A. Carcedo Salgad School of Physics and Astronomy Monash University Melbourne Australia Centro Brasileiro de Pesquisas Físicas (CBPF) Rio de Janeiro Brazil Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil Department of Engineering Physics Tsinghua University Beijing China Institute Of High Energy Physics (IHEP) Beijing China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China University of Chinese Academy of Sciences Beijing China Institute of Particle Physics Central China Normal University Hubei Wuhan China Consejo Nacional de Rectores (CONARE) San Jose Costa Rica Université Savoie Mont Blanc CNRS IN2P3-LAPP Annecy France Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France Université Paris-Saclay Centre d’Etudes de Saclay (CEA) IRFU Saclay France Gif-Sur-Yvette France Aix Marseille Univ CNRS/IN2P3 CPPM Marseille France Université Paris-Saclay CNRS/IN2P3 IJCLab Orsay France Laboratoire Leprince-Ringuet CNRS/IN2P3 Ecole Polytechnique Institut Polytechnique de Paris Palaiseau France LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS/IN2P3 Paris France I. Physikalisches Institut RWTH Aachen University Aachen Germany Universität Bonn — Helmholtz-Institut für Strahlen und Kernphysik Bonn Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Physikalisches Institut Albert-Ludwigs-Universität Freiburg Freiburg Germany Max-Planck-Institut für Kernphysik (MPIK) Heidelberg Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany School of Physics University College Dublin Dublin Ireland INFN Sezione di Bari Bari Italy INFN Sezione di Bologna Bologna Italy INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Firenze Firenze Italy INFN Laboratori Nazionali di Frascati Frascati Italy INFN Sezione di Genova Genova Italy INFN Sezione di Milano Milano Italy INFN Sezione di Milano-Bicocca Milano Italy INFN

An angular analysis of the Bs0→ ϕe+e− decay is performed using the proton-proton collision dataset collected between 2011 and 2018 by the LHCb experiment, corresponding to an integrated luminosity of 9 fb−1 at centre... 详细信息

An angular analysis of the Bs0→ ϕe⁺e⁻ decay is performed using the proton-proton collision dataset collected between 2011 and 2018 by the LHCb experiment, corresponding to an integrated luminosity of 9 fb⁻¹ at centre-of-mass energies of 7, 8 and 13 TeV. The analysis is performed in the very low dielectron invariant mass-squared region between 0.0009 and 0.2615 GeV²/c⁴. The longitudinal polarisation fraction of the ϕ meson is measured to be less than 11.5% at 90% confidence level. The ATReCP observable, which is related to the lepton forward-backward asymmetry, is measured to be 0.116 ± 0.155 ± 0.006, where the first uncertainty is statistical and the second systematic. The transverse asymmetries, AT2 and ATImCP, which are sensitive to the virtual photon polarisation, are found to be −0.045 ± 0.235 ± 0.014 and 0.002 ± 0.247 ± 0.016, respectively. The results are consistent with Standard Model predictions. © The Author(s) 2025.

关键词： B Physics Flavour Changing Neutral Currents Hadron-Hadron Scattering Rare Decay

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Design, Synthesis and Evaluation the Bioactivites of Novel Quinazoline Derivatives as Immune Checkpoint Inhibitors

SSRN

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SSRN 2023年

作者： Vo, Tam Thuy Lu Hoang, Van-Hai Dung, Phan Thi Phuong Nguyen, Tiep K. Ngo, Son Tung Nguyen, Yen Thi Kim Nguyen, Thanh Xuan Hien, Tran Thi Thu Hoang, Tham H. Thi Do, Yen Seo, Ji Hae Tran, Phuong-Thao Department of Biochemistry Keimyung University School of Medicine Daegu42601 Korea Republic of Faculty of Pharmacy and Nursing Tay Do University 68 Lo Hau Thanh My Can Tho900000 Viet Nam Faculty of Pharmacy PHENIKAA University Hanoi12116 Viet Nam PHENIKAA University Yen Nghia Hadong Hanoi12116 Viet Nam Hanoi University of Pharmacy 13-15 Le Thanh Tong Hanoi100000 Viet Nam Laboratory of Biophysics Institute for Advanced Study in Technology Ton Duc Thang University Ho Chi Minh City72915 Viet Nam Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City72915 Viet Nam Research Institute of Pharmaceutical Sciences College of Pharmacy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Department of Neurosurgery Viet-Duc University Hospital Hanoi100000 Viet Nam Vietnam University of Traditional Medicine 2 Tran Phu Ha Dong Hanoi100000 Viet Nam Center for Biomedical Informatics Vingroup Big Data Institute 458 Minh Khai Street Hai Ba Trung Hanoi100000 Viet Nam College of Engineering and Computer Science VinUniversity Vinhomes Ocean Park Gia Lam Hanoi100000 Viet Nam

Indoleamine 2,3-dioxygenase (IDO1) has emerged as a critical immune checkpoint with profound implications in numerous types of cancer. Dysregulation of IDO1 has prompted considerable interest in IDO1 as a target in immuno-oncology therapy. Herein, we report novel quinazoline derivatives specifically designed to target IDO1. Based on the active site of apo-IDO1 and a clinical trial cadidate, linrodostat, we designed novel, selectively targeting cancer cell derivatives with micromolar IC50 values. Via docking study, we confirm the robust binding affinity of these quinazoline compounds to apo-IDO, firmly establishing their potential as IDO1 targeted agents. We also uncover that these compounds suppress immuno-oncology target PD-L1 in addition to IDO1. Intriguingly, compound V-d emerges as a stand out, triggering cell death through caspase-dependent and caspase-independent manners. More importantly, V-d presents it ability to hinder tumor sphere formation and re-sensitized cisplatin-resistant A2780 cells to cisplatin treatment. These findings suggest that compound V-d emerges as a promising lead candidate for the future development of immuno anticancer agents. Our study offers exciting prospects for enhanced cancer therapy. © 2023, The Authors. All rights reserved.

关键词： Oncology

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Quantum Simulation for High-Energy Physics

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PRX Quantum 2023年第2期4卷 027001-027001页

作者： Christian W. Bauer Zohreh Davoudi A. Baha Balantekin Tanmoy Bhattacharya Marcela Carena Wibe A. de Jong Patrick Draper Aida El-Khadra Nate Gemelke Masanori Hanada Dmitri Kharzeev Henry Lamm Ying-Ying Li Junyu Liu Mikhail Lukin Yannick Meurice Christopher Monroe Benjamin Nachman Guido Pagano John Preskill Enrico Rinaldi Alessandro Roggero David I. Santiago Martin J. Savage Irfan Siddiqi George Siopsis David Van Zanten Nathan Wiebe Yukari Yamauchi Kübra Yeter-Aydeniz Silvia Zorzetti Physics Division Lawrence Berkeley National Laboratory Berkeley California 94720 USA Department of Physics Maryland Center for Fundamental Physics and the NSF Institute for Robust Quantum Simulation University of Maryland College Park Maryland 20742 USA Department of Physics University of Wisconsin Madison Wisconsin 53706 USA T-2 Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Fermi National Accelerator Laboratory Batavia Illinois 60510 USA Enrico Fermi Institute University of Chicago Chicago Illinois 60637 USA Kavli Institute for Cosmological Physics University of Chicago Chicago Illinois 60637 USA Department of Physics University of Chicago Chicago Illinois 60637 USA Department of Physics and Illinois Center for the Advanced Study of the Universe and Illinois Quantum Information Science and Technology Center University of Illinois Urbana Illinois 61801 USA QuEra Computing Inc Boston Massachusetts 02135 USA Department of Mathematics University of Surrey Guildford Surrey GU2 7XH United Kingdom Center for Nuclear Theory Department of Physics and Astronomy Stony Brook University New York 11794-3800 USA Department of Physics Brookhaven National Laboratory Upton New York 11973 USA Peng Huanwu Center for Fundamental Theory Hefei Anhui 230026 China Interdisciplinary Center for Theoretical Study University of Science and Technology of China Hefei Anhui 230026 China Pritzker School of Molecular Engineering Chicago Quantum Exchange and Kadanoff Center for Theoretical Physics University of Chicago Illinois 60637 USA qBraid Co. Harper Court 5235 Chicago Illinois 60615 USA Department of Physics Harvard University Cambridge Massachusetts 02138 USA Department of Physics and Astronomy University of Iowa Iowa City Iowa 52242 USA Duke Quantum Center Duke University Durham North Carolina 27701 USA Department of Electrical and Computer Engineering Duke University Durham North Carolina 27708 USA Department of Physics Duke University

It is for the first time that quantum simulation for high-energy physics (HEP) is studied in the U.S. decadal particle-physics community planning, and in fact until recently, this was not considered a mainstream topic in the community. This fact speaks of a remarkable rate of growth of this subfield over the past few years, stimulated by the impressive advancements in quantum information sciences (QIS) and associated technologies over the past decade, and the significant investment in this area by the government and private sectors in the U.S. and other countries. High-energy physicists have quickly identified problems of importance to our understanding of nature at the most fundamental level, from tiniest distances to cosmological extents, that are intractable with classical computers but may benefit from quantum advantage. They have initiated, and continue to carry out, a vigorous program in theory, algorithm, and hardware co-design for simulations of relevance to the HEP mission. This Roadmap is an attempt to bring this exciting and yet challenging area of research to the spotlight, and to elaborate on what the promises, requirements, challenges, and potential solutions are over the next decade and beyond.

关键词： Quantum simulation

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Network Resiliency Against Earthquakes

Network Resiliency Against Earthquakes

引用

International Workshop on Reliable Networks Design and Modeling (RNDM)

作者： Alessandro Valentini Balázs Vass Jorik Oostenbrink Levente Csák Fernando Kuipers Bruno Pace David Hay János Tapolcai University of Study “G.d'Annunzio” of Chieti-Pescara Chieti Italy MTA-BME Future Internet Research Group High-Speed Networks Laboratory (HSNLab) Budapest University of Technology and Economics Delft University of Technology Delft the Netherlands School of Engineering and Computer Science Hebrew University Jerusalem Israel

Guaranteeing a high availability of network services is a crucial part of network management. In this study, we show how to compute the availability of network services under earthquakes, by using empirical data. We take a multi-disciplinary approach and create an earthquake model based on seismological research and historical data. We then show how to integrate this empirical disaster model into existing network resiliency models to obtain the vulnerability and availability of a network under earthquakes. While previous studies have applied their models to ground shaking hazard models or earthquake scenarios, we compute (1) earthquake activity rates and (2) a relation between magnitude and disaster area, and use both as input data for our modeling. This approach is more in line with existing network resiliency models: it provides better information on the correlation between link failures than ground shaking hazard models and a more comprehensive view than a fixed set of scenarios.

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Search for the doubly heavy baryons Ω^(0)_(bc) and E^(0)_(bc) decaying to Λ^(+)_(c)π^(-) and E^(+)_(c)π^(-)

引用

Chinese Physics C 2021年第9期45卷 10-21页

作者： R.Aaij C.Abelian Beteta T.Ackernley B.Adeva M.Adinolfi H.Afshamia C.A.Aidala S.Aiola Z.Ajaltouni S.Aka J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelie S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Beminghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.Bjorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Camiti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo J.Dalseno C.D'Ambrosi Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University ofChinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universite Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/FN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kemphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKr

The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the E^(0)_(bc)baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and E^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ω^(0)_(bc)and E^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(E^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(E^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence *** upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(E^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→E^(+)_(c)π^(-)(E^(0)_(bc)→E^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(E^(0)_(bc))baryon.

关键词： B physics quarkonium spectroscopy heavy quark production

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Galaxy clusters at z∼1 imaged by ALMA with the Sunyaev-Zel’dovich effect

arXiv

引用

arXiv 2022年

作者： Kitayama, Tetsu Ueda, Shutaro Okabe, Nobuhiro Akahori, Takuya Hilton, Matt Hughes, John P. Ichinohe, Yuto Kohno, Kotaro Komatsu, Eiichiro Lin, Yen-Ting Miyatake, Hironao Oguri, Masamune Sifón, Cristóbal Takakuwa, Shigehisa Takizawa, Motokazu Tsutsumi, Takahiro van Marrewijk, Joshiwa Wollack, Edward J. Department of Physics Toho University Chiba Funabashi274-8510 Japan No. 1 Section 4 Roosevelt Road Taipei10617 Taiwan Institute of Astronomy National Tsing Hua University Hsinchu30013 Taiwan Department of Physics Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8526 Japan Astrophysical Science Center Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8526 Japan Core Research for Energetic Universe Hiroshima University Department of Physics Hiroshima University 1-3-1 1-3-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8526 Japan Physics Program Graduate School of Advanced Science and Engineering Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8526 Japan Mizusawa VLBI observatory National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Operation Division SKA Observatory Jodrell Bank Lower Withington MacclesfieldSK11 9DL United Kingdom Astrophysics Research Centre University of KwaZulu-Natal Westville Campus Durban4041 South Africa School of Mathematics Statistics & Computer Science University of KwaZulu-Natal Westville Campus Durban4041 South Africa Wits Centre for Astrophysics School of Physics University of the Witwatersrand Private Bag 3 Johannesburg2050 South Africa Department of Physics and Astronomy Rutgers The State University of New Jersey PiscatawayNJ08854-8019 United States Department of Physics Rikkyo University 3-34-1 Nishi-Ikebukuro Toshima-ku Tokyo171-8501 Japan Institute of Astronomy School of Science The University of Tokyo 2-21-1 Osawa Mitaka Tokyo181-0015 Japan Research Center for the Early Universe School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan Max-Planck-Institut für Astrophysik Karl-Schwarzschild Str. 1 GarchingD-85741 Germany The University of Tokyo Institutes for Advanced Study The University of Tokyo 5-1-5 Kashiwanoha Chiba277-8583 Japan Nagoya University Nagoya464-8

We present high angular-resolution measurements of the thermal Sunyaev-Zel’dovich effect (SZE) toward two galaxy clusters, RCS J2319+0038 at z = 0.9 and HSC J0947−0119 at z = 1.1, by the Atacama Large Millimeter/submillimeter Array (ALMA) in Band 3. They are supplemented with available Chandra X-ray data, optical data taken by Hyper Suprime-Cam on Subaru, and millimeter-wave SZE data from the Atacama Cosmology Telescope. Taking into account departures from spherical symmetry, we have reconstructed non-parametrically the inner pressure profile of two clusters as well as electron temperature and density profiles for RCS J2319+0038. This is one of the first such measurements for an individual cluster at z >∼ 0.9. We find that the inner pressure profile of both clusters is much shallower than that of local cool-core clusters. Our results consistently suggest that RCS J2319+0038 hosts a weak cool core, where radiative cooling is less significant than in local cool cores. On the other hand, HSC J0947−0119 exhibits an even shallower pressure profile than RCS J2319+0038 and is more likely a non-cool-core cluster. The SZE centroid position is offset by more than 140 h−170kpc from the peaks of galaxy distribution in HSC J0947−0119, suggesting a stronger influence of mergers in this cluster. We conclude that these distant clusters are at a very early stage of developing the cool cores typically found in clusters at lower redshifts. Copyright © 2022, The Authors. All rights reserved.

关键词： Millimeter waves

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