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2019 International Conference on Biomedical Engineering, ICoBE 2019

作者： Abdullah, Azian Azamimi Aziz, Amira Najihah Abdul Kanaya, Shigehiko Ranjan Dash, Satya School of Mechatronic Engineering Universiti Malaysia Perlis Pauh Putra Campus Perlis-Arau02600 Malaysia Graduate School of Information Science Nara Institute of Science and Technology Ikoma Nara630-0192 Japan School of Computer Applications KIIT University India

Microorganism species can become pathogenic and cause bacterial infection, result from the imbalance in microbial ecosystem between host and microbe. Microorganisms emit secondary metabolites, known as volatile metabolites or organic compounds (VOCs) for various functions such as intra- or inter-species interactions, defense and attraction. Currently, VOCs are widely used as a biomarker for human diseases. This research is aimed to identify the relationship between microorganism species and volatile metabolite compound from the collected species and VOCs emitted organism data by using unsupervised machine learning approaches such as hierarchical clustering and graph-clustering method. Supervised machine learning methods also been used to classify the microorganism pathogenicity such as support vector machine (SVM) and random forest (RF). These data are collected from KNApSAcK and mVOC database where it provides most of the microorganism species and metabolites contents. From the collected data, there are in total of 1088 VOCs emitted by 517 microorganism species. As a result, the application of machine learning methods enable us to identify the relationship of species with their emitted VOCs and classify the microorganism species into their own pathogenicity. © 2019 IOP Publishing Ltd. All rights reserved.

关键词： Decision trees

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On-body non-invasive glucose monitoring sensor based on high figure of merit (FoM) surface plasmonic microwave resonator

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Scientific reports 2023年第1期13卷 17527页

作者： Farzad Soltanian Mehdi Nosrati Saleh Mobayen Chuan-Chun Li Telung Pan Ming-Ta Ke Paweł Skruch Department of Electrical Engineering University of Alberta Edmonton Canada. Department of Electrical Engineering Manhattan College New York USA. Department of Electrical Engineering University of Zanjan Zanjan Iran. mobayens@yuntech.edu.tw. Graduate School of Intelligent Data Science National Yunlin University of Science and Technology Douliou 640301 Yunlin Taiwan. mobayens@yuntech.edu.tw. National Taiwan University Hospital Yunlin Branch Yunlin Taiwan. a***@***. Bachelor Program in Interdisciplinary Studies College of Future National Yunlin University of Science and Technology Yunlin 64002 Taiwan. Graduate School of Intelligent Data Science National Yunlin University of Science and Technology Douliou 640301 Yunlin Taiwan. Department of Automatic Control and Robotics AGH University of Science and Technology 30-059 Kraków Poland.

High-figure of merit (FoM) plasmonic microwave resonator is researched as a non-invasive on-body sensor to monitor the human body's blood glucose variation rate in adults for biomedical applications, e.g., diabetic patients. The resonance frequencies of the proposed sensor are measured to be around [Formula: see text] GHz and [Formula: see text] GHz over the frequency band of DC to 6GHz which are suitable for monitoring interstitial fluid (ISF) changing rate. The [Formula: see text] sensor is experimentally wrapped on the human body arm to monitor the blood glucose changing rate via amplitude and frequency variations of the sensor. Amplitude variation and frequency shift are measured to be around 7 dB and 30 MHz, respectively. The measured results demonstrate the high precision of the proposed approach to depict a valid diagram for glucose changing rate due to good impedance matching of the designed microwave sensor and human body. The sensor is shown to enhance the sensitivity by a factor of 5 compared to the conventional ones.

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40.1-GHz sub-freezing 850-nm VCSEL: microwave extraction of cavity lifetimes and small-signal equivalent circuit modeling

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Optics express 2023年第7期31卷 11408-11422页

作者： Hao-Tien Cheng Cheng-Han Wu Milton Feng Chao-Hsin Wu Graduate Institute of Electronics Engineering National Taiwan Universityhttps://***/05bqach95 No. 1 Sec. 4 Roosevelt Rd. Taipei 106319 Taiwan Center for Quantum Science and Engineering National Taiwan Universityhttps://***/05bqach95 No. 1 Sec. 4 Roosevelt Rd. Taipei 106319 Taiwan Nick Holonyak Jr. Micro and Nanotechnology Laboratory Department of Electrical and Computer Engineering the University of Illinois at Urbana-Champaign 208 N. Wright St. Urbana IL 61801 USA Graduate School of Advanced Technology National Taiwan Universityhttps://***/05bqach95 No. 1 Sec. 4 Roosevelt Rd. Taipei 106319 Taiwan Graduate Institute of Photonics and Optoelectronics National Taiwan Universityhttps://***/05bqach95 No. 1 Sec. 4 Roosevelt Rd. Taipei 106319 Taiwan

We present an 850-nm vertical-cavity surface-emitting laser (VCSEL) constructed for a wide operating temperature range from 25°C to -50°C sub-freezing temperature, demonstrating 40.1-GHz at -50°C. The optical spectra, junction temperature, and microwave equivalent circuit modeling of a sub-freezing 850-nm VCSEL between -50°C and 25°C are also discussed. Reduced optical losses, higher efficiencies, and shorter cavity lifetimes at sub-freezing temperatures are the leading causes of the improved laser output powers and bandwidths. The e-h recombination lifetime and the cavity photon lifetime are shortened to 113 and 4.1 ps, respectively. Could potentially supercharge VCSEL-based sub-freezing optical links for applications in frigid weather, quantum computing, sensing, aerospace, etc.

关键词： Astronomical telescopes Optical interconnects Quantum computing Quantum efficiency Semiconductor lasers Vertical cavity surface emitting lasers

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Nonlocal Flat Optics for Size-Selective Image Processing and Denoising

Research Square

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Research Square 2025年

作者： Chamoli, Sandeep Kumar Jin, Chunqi Fan, Yandong Kiani, Mehdi Goh, Heedong Huang, Chen Guo, Shuyu Wang, Yuntong Zhu, Fei Xing, Guohua Li, Bo Bai, Tian Alù, Andrea Li, Wei GPL Photonics Laboratory State Key Laboratory of Luminescence Science and Technology Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Jilin Changchun130033 China University of Chinese Academy of Sciences Beijing100049 China Photonics Initiative Advanced Science Research Center City University of New York New YorkNY10031 United States Physics Program Graduate Center of the City University of New York New YorkNY10016 United States College of Computer Science and Technology Jilin University Changchun130012 China

All-optical image processing based on metasurfaces is a swiftly advancing field of technology, due to its high speed, large integrability and inherently low energy requirements. So far, the proposed devices have been focusing on canonical operations, such as differentiations to perform edge detection across all objects in a complex scene. Yet, undesired background noise and clutter can hinder such operations, requiring target selection with digital post-processing which inherently limits the overall accuracy, efficiency and speed. Here, we introduce an optical solution for real-time size-selective image processing and experimentally demonstrate the concept with a metal-dielectric-metal film performing a spatial band-pass filter in momentum space. We show high-resolution (~ 0.9 μm) edge detection and real-time dynamic denoising, ideally suited for bio-imaging applications and target recognitions. This innovative k-space analog operation expands the scope of nonlocal flat optics for analog image processing, ushering in opportunities for ultra-compact and multifunctional image processors. © 2025, CC BY.

关键词： Image denoising

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In silico identification of a novel Cdc2-like kinase 2 (CLK2) inhibitor in triple negative breast cancer

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Protein science 2024年第6期33卷 e5004页

作者： Huang, Cheng-Chiao Hsu, Chia-Ming Chao, Min-Wu Hsu, Kai-Cheng Lin, Tony Eight Yen, Shih-Chung Tu, Huang-Ju Pan, Shiow-Lin Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taiwan Division of General Surgery Department of Surgery Taipei Medical University Hospital Taipei Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan School of Medicine College of Medicine National Sun Yat-sen University Kaohsiung Taiwan Institute of Biopharmaceutical Sciences College of Medicine National Sun Yat-sen University Kaohsiung Taiwan The Doctoral Program of Clinical and Experimental Medicine College of Medicine National Sun Yat-sen University Kaohsiung Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan TMU Research Center of Drug Discovery Taipei Medical University Taipei Taiwan Warshel Institute for Computational Biology The Chinese University of Hong Kong (Shenzhen) Guangdong Shenzhen China

Dysregulation of RNA splicing processes is intricately linked to tumorigenesis in various cancers, especially breast cancer. Cdc2-like kinase 2 (CLK2), an oncogenic RNA-splicing kinase pivotal in breast cancer, plays a significant role, particularly in the context of triple-negative breast cancer (TNBC), a subtype marked by substantial medical challenges due to its low survival rates. In this study, we employed a structure-based virtual screening (SBVS) method to identify potential CLK2 inhibitors with novel chemical structures for treating TNBC. Compound 670551 emerged as a novel CLK2 inhibitor with a 50% inhibitory concentration (IC₅₀) value of 619.7 nM. Importantly, Compound 670551 exhibited high selectivity for CLK2 over other protein kinases. Functionally, this compound significantly reduced the survival and proliferation of TNBC cells. Results from a cell-based assay demonstrated that this inhibitor led to a decrease in RNA splicing proteins, such as SRSF4 and SRSF6, resulting in cell apoptosis. In summary, we identified a novel CLK2 inhibitor as a promising potential treatment for TNBC therapy. © 2024 The Authors. Protein science published by Wiley Periodicals LLC on behalf of The Protein Society.

关键词： CLK2 drug discovery kinase inhibitor structure-based virtual screening triple-negative breast cancer

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Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway

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生物化学与生物物理学报（英文版） 2019年第1期51卷 31-40页

作者： Tao Li Qili Li Weiguo Wu Yong Li De-xing Hou Hua Xu Baodong Zheng Shaoxiao Zeng Yang Shan Xiangyang Lu Fangming Deng Si Qin Core Research Program 1515 Key Laboratory for Food Science and Biotechnology of Hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China Hunan Agricultural Product Processing Institute Hunan Academy of Agricultural Sciences Changsha 410125 China Core Research Program 1515 Key Laboratory for Food Science and Biotechnology of Hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China The United Graduate School of Agricultural Sciences Faculty of Agriculture Kagoshima University Kagoshima 890-0065Japan Department of Pediatrics Steele Children's Research Center University of Arizona Tucson 85724 USA Department of Food Safety College of Food Science Fujian Agriculture and Forestry University Fuzhou 350002 China Core Research Program 1515 Key Laboratory for Food Science and Biotechnology of Hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China The United Graduate School of Agricultural Sciences Faculty of Agriculture Kagoshima University Kagoshima 890-0065Japan Department of Pediatrics Steele Children's Research Center University of Arizona Tucson 85724 USA

Lotus seed is well known as traditional food and medicine,but its skin is usually *** studies have shown that lotus seed skin contains a high concentration of proanthocyanidins that have multi-functions,such as antioxidation,anti-inflammation,and anti-cancer *** the present study,we aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation,identify their chemical structures by HPLC-MS-MS and NMR,and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in *** results showed that PMR mainly contained oligomeric proanthocyanidins,especially dimeric procyanidin B1 (PB1),procyanidin B2 and procyanidin *** it had limited ability to directly scavenge radicals in vitro,PMR could significantly enhance the expressions of antioxidant proteins via activation of nuclear factor-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in HepG2 *** data revealed that PB1,a major component in PMR,stabilized Nrf2 by inhibiting the ubiquitination of Nrf2,which led to subsequent activation of the Nrf2-ARE pathway,including the enhancements of Nrf2 nuclear translocation,Nrf2-ARE binding and ARE transcriptional ***,the in vivo results in high fat diet-induced mice further verified the powerful antioxidant property of *** results revealed that lotus seed skin is a promising resource for functional food development.

关键词： lotus seed skin extract proanthocyanidin Nrf2-ARE pathway antioxidant activity

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The Quantum Internet (Technical Version)

arXiv

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arXiv 2025年

作者： Rohde, Peter P. Huang, Zixin Ouyang, Yingkai Huang, He-Liang Su, Zu-En Devitt, Simon Ramakrishnan, Rohit Mantri, Atul Tan, Si-Hui Liu, Nana Harrison, Scott Radhakrishnan, Chandrashekar Brennen, Gavin K. Baragiola, Ben Q. Dowling, Jonathan P. Byrnes, Tim Munro, William J. Centre for Quantum Software and Information Faculty of Engineering and Information Technology University of Technology Sydney SydneyNSW Australia Hearne Institute for Theoretical Physics Louisiana State University Baton Rouge United States School of Mathematical and Physical Sciences Macquarie University NSW2109 Australia School of Mathematical and Physical Sciences University of Sheffield SheffieldS3 7RH United Kingdom Henan Key Laboratory of Quantum Information and Cryptography Henan Zhengzhou450000 China Hefei National Laboratory for Physical Sciences at Microscale Department of Modern Physics University of Science & Technology of China Hefei China CAS Centre for Excellence and Synergetic Innovation Centre in Quantum Information & Quantum Physics University of Science & Technology of China Hefei China CAS-Alibaba Quantum Computing Laboratory Shanghai China InstituteQ Aalto University Espoo02150 Finland Indian Institute of Science Bangalore India Singapore University of Technology & Design Singapore Centre for Quantum Technologies National University of Singapore Singapore Horizon Quantum Ireland 24 Fitzwilliam Place Dublin 2 D02 T296 Ireland Institute of Natural Sciences Shanghai Jiao Tong University Shanghai200240 China School of Mathematical Sciences Shanghai Jiao Tong University Shanghai200240 China Ministry of Education Key Laboratory in Scientific and Engineering Computing Shanghai Jiao Tong University Shanghai200240 China Shanghai Artificial Intelligence Laboratory Shanghai China University of Michigan Shanghai Jiao Tong University Joint Institute Shanghai200240 China Leibniz Institute for Research & Information in Education Frankfurt am Main Germany Department of Computer Science and Engineering NYU Shanghai 567 West Yangsi Road Shanghai200124 China Centre of Excellence in Engineered Quantum Systems Macquarie University NSW Australia Centre for Quantum Computation and Communication Technology School of Science RMIT University VIC

The desire to share and unite remote digital assets motivated the development of the classical internet, the enabler of the entire 21st century economy and our modern way of life. As we enter the quantum era, it is to be expected there will be a similar demand for networking quantum assets, motivating a global quantum internet for bringing together the world's quantum resources, leveraging off their exponential trajectory in capability. We present models for quantum networking, how they might be applied in the future, and the implications they will have. Socially, economically, politically and geostrategically, the upcoming era of quantum supremacy will be as significant for the 21st century as the transistor was for the 20th. The inherently different scaling in the computational power of quantum computers fundamentally changes the dynamics of how they will operate in the future. Given their high expected initial cost, a client/server model for outsourcing computation will be essential for enabling the accessibility and proliferation of this technology, and ensuring its economic viability. We therefore anticipate the emergence of cloud quantum computing, a model for outsourcing quantum computations to the network. We argue that economic efficiency will mandate that all future quantum computers be united into a single global virtual quantum computer, offering exponentially more power to all network participants than if they were to keep their resources to themselves. This model for the allocation of computational resources is uniquely quantum, with no classical analogue, completely altering the economic landscape for the future of computation. Given the sensitivity of much of the data to which future quantum computers are going to foreseeably be applied, protocols for encrypted quantum computation will be essential - the outsourcing of computations that neither an eavesdropper nor even the server performing the computation can spy upon. This will enable new models fo

关键词： Outsourcing

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Ramadhan short-term electric load: A hybrid model of cycle spinning wavelet and group method data handling (CSW-GMDH)

IAENG International Journal of Computer Science

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IAENG International Journal of computer science 2019年第4期46卷

作者： Caraka, Rezzy Eko Chen, Rung Ching Toharudin, Toni Pardamean, Bens Bakar, Sakhinah Abu Yasin, Hasbi College of Informatics Chaoyang University of Technology Taichung City41349 Taiwan Department of Statistics Padjadjaran University Bandung Indonesia College of Informatics Chaoyang University of Technology Taichung City41349 Indonesia Bioinformatics Data Science Research Center Bina Nusantara University Indonesia BINUS Graduate Program-Master of Computer Science Bina Nusantara University. Indonesia School of Mathematical Sciences FST The National University of Malaysia Malaysia Department of Statistics Diponegoro University Semarang Indonesia

In general, performing a nonlinearity time series analysis in the modeling of data can reach a robust and increase the quality of the results. Wavelet methods have successfully been applied in a great variety of applications for modeling also forecasting. Wavelet Transform divided into two categories. There is continuous wavelet (CWT) and a discrete wavelet transform (DWT). Cycle spinning unlike the discrete wavelet transform (DWT), is highly redundant, non-orthogonal, also defined naturally for all sample sizes. There is a Group Method of Data Handling (GMDH) algorithm, which is a multivariate analysis method can be used in modeling and identifying uncertainty on linear also nonlinearity systems. In this paper, we aim to explain the combination of A-Trous wavelet transforms applied on cycle spinning and group method of data handling (GMDH) in data of short-term electric load holy month of Ramadhan from 2014 to 2015. © 2019, International Association of Engineers.

关键词： Discrete wavelet transforms

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Integrability of Goldilocks quantum cellular automata

arXiv

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arXiv 2024年

作者： Hillberry, Logan E. Piroli, Lorenzo Vernier, Eric Halpern, Nicole Yunger Prosen, Tomaž Carr, Lincoln D. Department of Physics The University of Texas at Austin AustinTX78712 United States Dipartimento di Fisica e Astronomia Università di Bologna INFN Sezione di Bologna via Irnerio 46 BolognaI-40126 Italy Laboratoire de Probabilités Statistique et Modélisation CNRS Université Paris Cité Sorbonne Université Paris France Joint Center for Quantum Information and Computer Science NIST University of Maryland College ParkMD20742 United States Institute for Physical Science and Technology University of Maryland College ParkMD20742 United States Faculty of Mathematics and Physics University of Ljubljana Jadranska 19 LjubljanaSI-1000 Slovenia Institute of Mathematics Physics and Mechanics Jadranska 19 LjubljanaSI-1000 Slovenia Quantum Engineering Program Colorado School of Mines GoldenCO80401 United States Department of Physics Colorado School of Mines GoldenCO80401 United States Department of Applied Mathematics and Statistics Colorado School of Mines GoldenCO80401 United States

Goldilocks quantum cellular automata (QCA) have been simulated on quantum hardware and produce emergent small-world correlation networks. In Goldilocks QCA, a single-qubit unitary is applied to each qubit in a one-dimensional chain subject to a balance constraint: a qubit is updated if its neighbors are in opposite basis states. Here, we prove that a subclass of Goldilocks QCA—including the one implemented experimentally—map onto free fermions and therefore can be classically simulated efficiently. We support this claim with two independent proofs, one involving a Jordan–Wigner transformation and one mapping the integrable six-vertex model to QCA. We compute local conserved quantities of these QCA and predict experimentally measurable expectation values. These calculations can be applied to test large digital quantum computers against known solutions. In contrast, typical Goldilocks QCA have equilibration properties and quasienergy-level statistics that suggest nonintegrability. Still, the latter QCA conserve one quantity useful for error mitigation. Our work provides a parametric quantum circuit with tunable integrability properties with which to test quantum hardware. © 2024, CC BY.

关键词： Qubits

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Benzyl 2-Naphthyl Ether, a Sensitizer in Paper Recycling Effluent, Exerts Dioxin-Like Effects on Zebrafish ( Danio Rerio) Via Aryl Hydrocarbon Receptors

SSRN

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SSRN 2023年

作者： Takeda, Kazuki Sarata, Aoi Terasaki, Masanori Kubota, Akira Shimizu, Keita Kamata, Ryo Laboratory of Toxicology School of Veterinary Medicine Kitasato University 35-1 Higashi 23-bancho Towada-shi Aomori034-8628 Japan Department of Computer Science Tokyo Institute of Technology 4259-J3-1818 Nagatsuta-cho Midori-ku Yokohama-shi Kanagawa226–0026 Japan Environmental Chemistry Laboratory Graduate School of Arts and Sciences Iwate University 3-18-34 Ueda Morioka City Iwate020-8550 Japan Laboratory of Toxicology Department of Veterinary Medicine Obihiro University of Agriculture and Veterinary Medicine 2-11 Inada-cho Nishi Hokkaido Obihiro080-8555 Japan

Aromatic sensitizers and related substances (SRCs), crucial in the paper industry for facilitating color-forming and color-developing chemical reactions, inadvertently contaminate effluents during paper recycling. Owing to their structural resemblance to endocrine-disrupting aromatic organic compounds, concerns have arisen about potential adverse effects on aquatic organisms. In this study, we focused on SRC effects via the aryl hydrocarbon receptor (AHR), employing molecular docking simulations and zebrafish (Danio rerio) embryo exposure assessments. Molecular docking revealed heightened binding affinity between certain SRCs in the paper recycling effluents and zebrafish Ahr2 and human AHR, which are pivotal components in the SRC toxicity mechanism. Zebrafish fertilized eggs were exposed to SRCs up to 96 h postfertilization, and among these substances, benzyl 2-naphthyl ether (BNE) caused morphological abnormalities, such as pericardial edema and shortened body length, at relatively low concentrations (1 μM) during embryogenesis. BNE also significantly increased cyp1a and ahr2 gene expression. Co-exposure to the AHR antagonist CH-223191 only partially mitigated BNE’s phenotypic effects, despite the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin being relatively well-restored by CH-223191, indicating BNE’s AHR-independent toxic mechanisms. Furthermore, some SRCs, including BNE, exhibited in silico binding affinity to the estrogen receptor and upregulation of cyp19a1b gene expression. Therefore, additional insights into the toxicity of SRCs and their mechanisms are essential. Nevertheless, the present findings provide important information on SRCs and other papermaking chemicals that could help minimize the environmental impact of the paper industry. © 2023, The Authors. All rights reserved.

关键词： Ethers

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