检索结果-内蒙古大学图书馆

The impact of sodium-glucose cotransporter-2 inhibitors on outcome of patients with diabetes mellitus and colorectal cancer

引用

Journal of Gastroenterology and Hepatology (Australia) 2024年第5期39卷 902-907页

作者： Chiang, Cho-Han Chiang, Cho-Hung Hsia, Yuan Ping Jaroenlapnopparat, Aunchalee Horng, Chuan-Sheng Wong, Kit Yee Wang, Shih-Syuan Chang, Yu-Cheng Chen, Brian Shiian Luan, Yu-Ze Wang, Chun-Hao Neilan, Tomas G. Chiang, Cho-Hsien Peng, Cheng-Ming Shiah, Her-Shyong Department of Medicine Mount Auburn Hospital Harvard Medical School Cambridge MA United States Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan Department of Family Medicine Taipei Tzu Chi Hospital Buddhist Tzu Chi Foundation New Taipei City Taiwan Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan Department of Anatomical and Cellular Pathology State Key Laboratory of Translational Oncology Prince of Wales Hospital The Chinese University of Hong Kong SAR Hong Kong Department of Neurology SUNY Downstate Medical Center Brooklyn NY United States Department of Medicine Danbury Hospital Danbury CT United States School of Medicine Chung Shan Medical University Taichung Taiwan Department of Medical Education National Taiwan University Hospital Taipei Taiwan Cardio-Oncology Program Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA United States Cardiovascular Imaging Research Center (CIRC) Division of Cardiology and Department of Radiology Massachusetts General Hospital Boston MA United States Department of Environmental and Occupational Medicine National Taiwan University Hospital Taipei Taiwan London School of Hygiene and Tropical Medicine London United Kingdom Da Vinci Minimally Invasive Surgery Center Chung Shan Medical University Hospital Taichung Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Hematology and Oncology Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei City Taiwan

Background and Aim: Patients with type 2 diabetes mellitus (T2DM) have a higher risk of colorectal cancer (CRC), and those with diagnosed CRC have a poorer prognosis compared with individuals with normal glucose levels. The inhibition of sodium-glucose cotransporter 2 (SGLT2) channels has been associated with a reduction in tumor proliferation in preclinical studies. We aimed to investigate the impact of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the outcome of T2DM patients with colorectal cancer. Methods: We performed a retrospective cohort study comprising adult patients with T2DM and colorectal adenocarcinoma. SGLT2i recipients were matched to non-SGLT2i recipients in a 1:1 ratio based on age, sex, and cancer stage. The primary outcome was overall survival (OS) and progression-free survival (PFS), and the secondary outcomes were previously reported serious adverse events associated with SGLT2i. Results: We identified 1347 patients with T2DM and colorectal adenocarcinoma, from which 92 patients in the SGLT2i cohort were matched to the non-SGLT2i cohort. Compared to non-SGLT2i recipients, SGLT2i recipients had a higher rate of 5-year OS (86.2% [95% CI: 72.0–93.5] vs 62.3% [95% CI: 50.9–71.8], P = 0.013) and 5-year PFS (76.6% [95% CI: 60.7–86.7] vs 57.0% [95% CI: 46.2–66.4], P = 0.021). In Cox proportional hazard analyses, SGLT2i were associated with a 50–70% reduction in all-cause mortality and disease progression. SGLT2i were not associated with an increased risk of serious adverse events. Conclusion: SGLT2i were associated with a higher rate of survival in T2DM patients with colorectal cancer. © 2024 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

关键词： Colorectal cancer Sodium-glucose cotransporter-2 inhibitors Survival

来源：评论

学校读者我要写书评

暂无评论

Liquid crystal torons in Poiseuille-like flows

arXiv

引用

arXiv 2024年

作者： Amaral, Guilherme N.C. Zhao, Hanqing Sedahmed, Mahmoud Campante, Tomás Smalyukh, Ivan I. Tasinkevych, Mykola Telo da Gama, Margarida M. Coelho, Rodrigo C.V. Centro de Física Teórica e Computacional Faculdade de Ciências Universidade de Lisboa Lisboa1749-016 Portugal Departamento de Física Faculdade de Ciências Universidade de Lisboa LisboaP-1749-016 Portugal Department of Physics Soft Materials Research Center University of Colorado BoulderCO80309 United States Department of Electrical Computer and Energy Engineering Materials Science and Engineering Program University of Colorado BoulderCO80309 United States Renewable and Sustainable Energy Institute National Renewable Energy Laboratory University of Colorado BoulderCO80309 United States International Institute for Sustainability with Knotted Chiral Meta Matter Hiroshima University Higashihiroshima739-8511 Japan SOFT Group School of Science and Technology Nottingham Trent University Clifton Lane NottinghamNG11 8NS United Kingdom

Three-dimensional (3D) simulations of the structure of liquid crystal (LC) torons, topologically protected distortions of the LC director field, under material flows are rare but essential in microfluidic applications. Here, we show that torons adopt a steady-state configuration at low flow velocity before disintegrating at higher velocities, in line with experimental results. Furthermore, we show that under partial slip conditions at the boundaries, the flow induces a reversible elongation of the torons, also consistent with the experimental observations. These results are in contrast with previous simulation results for 2D skyrmions under similar flow conditions, highlighting the need for a 3D description of this LC soliton in relation to its coupling to the material flow. These findings pave the way for future studies of other topological solitons, like hopfions and heliknotons, in flowing soft matter systems. Copyright © 2024, The Authors. All rights reserved.

关键词： Crystal structure

来源：评论

学校读者我要写书评

暂无评论

Inside Cover: A Photo- and Thermo-Driven Azoarene-Based Circularly Polarized Luminescence Molecular Switch in a Liquid Crystal Host (Angew. Chem. Int. Ed. 48/2023)

引用

Angewandte Chemie International Edition 2023年第48期62卷

作者： Wenxin Kang Yuqi Tang Xianyu Meng Siyang Lin Xinfang Zhang Prof. Jinbao Guo Prof. Quan Li Key Laboratory of Carbon Fibers and Functional Polymers Ministry of Education and College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast University Nanjing 211189 China Materials Science Graduate Program Kent State University Kent OH 44242 USA

来源：评论

学校读者我要写书评

暂无评论

Superior Performance of ZnGaO Solar-Blind Photodetectors by Implementing TFT Structure and Tunable ZNO Cycle Ratio

SSRN

引用

SSRN 2024年

作者： Fan, Hui-Chen Wang, Chen Xu, Yi-Hong Fan, Teng-Min Huang, Pao-Hsun Ruan, Yu-Jiao Wu, Tingzhu Kuo, Hao-Chung Wuu, Dong-Sing Lai, Feng-Min Lien, Shui-Yang Xiamen Key Laboratory of Development and Application for Advanced Semiconductor Coating Technology School of Opto-Electronic and Communication Engineering Xiamen University of Technology Xiamen361024 China School of Ocean Information Engineering Jimei University Jimei District Fujian Xiamen361021 China National Measurement and Testing Center for Flat Panel Display Industry Xiamen Institute of Measurement and Testing Xiamen361024 China National Integrated Circuit Industry and Education Integration Innovation Platform Department of Electronic Science Xiamen University Xiamen361005 China Department of Photonics Graduate Institute of Electro-Optical Engineering College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Department of Applied Materials and Optoelectronic Engineering National Chi Nan University Nantou54561 Taiwan Department of Biomedical Engineering Da-Yeh University Changhua51591 Taiwan

In this study, plasma enhanced atomic layer deposition was used to prepare ZnGaO thin films with different ZnO cycle ratios from 0% to 50%, which were employed to fabricate the MSM-type and TFT-type solar-blind photodetector. The properties of the films and the performance of the solar blind photodetector are greatly affected by the ZnO cycle ratio. Appropriate Zn doping content decreases the ratio of oxygen vacancies and Zn interstitials in Ga2O3, while excessive Zn doping degrades the quality of the film. Compared to MSM-type photodetector, an obviously improved performance of ZnGaO TFT-type photodetector has been observed due to its self-amplified photocurrent and the reduced dark current controlled by gate voltage. At a ZnO cycle ratio of 40%, a superior performance of TFT-type solar-blind photodetector with an ultra-low dark current ~4.5×10-13 A, an excellent light switching ratio ~2.2×107, and an outstandingly high sensitivity ~34.31 A/W has been obtained. These results demonstrate that the incorporation of Zn dopants can effectively modulate the performance of Ga2O3 TFT-type photodetector providing a great perspective for cost-effective and high-performance solar-blind PDs. © 2024, The Authors. All rights reserved.

关键词： Zinc oxide

来源：评论

学校读者我要写书评

暂无评论

Community succession and protein enhancement in a mixed methanotroph-microalgae system with stepwise increase of ammonium loading - Inhibition and adaptation

引用

Water Research 2025年 284卷 123995页

作者： Baorui Zhang Liang Zhang Jianbo Liu Chen Cai Yan Zhou Interdisciplinary Graduate Program Nanyang Technological University 61 Nanyang Drive Singapore 637335 Singapore Nanyang Environment & Water Research Institute Nanyang Technological University 1 Cleantech Loop Singapore Singapore 637141 Singapore Guangdong Provincial Key Lab of Environmental Pollution Control and Remediation Technology School of Environmental Science and Engineering Sun Yat-Sen University Guangzhou China School of Civil and Environmental Engineering Nanyang Technological University 50 Nanyang Avenue Singapore Singapore 639798 Singapore CAS Key Laboratory of Urban Pollutant Conversion Department of Environmental Science and Engineering University of Science and Technology of China Hefei China

The integration of methanotrophs and microalgae in coculture systems presents a promising approach for sustainable biogas valorization and single-cell protein (SCP) production, offering dual benefits of greenhouse gas mitigation and nutrient recovery from waste streams. However, the resilience and metabolic interplay of these consortia under ammonium stress, common in industrial wastewater, remain poorly understood, limiting their scalability. This study systematically investigated the performance of a microalgae-methanotroph consortium under stepwise ammonium concentrations (130, 200 and 260 mg NH 4 + -N/L). The system demonstrated remarkable acclimation, achieving stable biogas conversion with 95.8 ± 5.3 mg CO 2 -C/(L·day) and 109.0 ± 11.4 mg CH 4 -C/(L·day) even at highest ammonium concentration. The SCP content increased from 32 % to over 52 % of cell dry weight with yield peaking at 90 mg/(L·day) under 200 mg N/L. A microbial community shift from Methylosinus to ammonia-tolerant Methylococcus dominance underpinned functional stability. Metagenomic analyses revealed ammonium-driven metabolic adaptations: extracellular substance secretion reprograms under stress, nitrogen assimilation was enhanced via glutamine synthetase, and antioxidant defenses were activated. Network analysis highlighted intensified competition (31 % negative correlations) under stress, yet key synergies within coculture system sustained carbon and nitrogen metabolism. These findings resolve knowledge gaps in ammonium-stressed consortia dynamics and provide insights for engineering systems to advancing the circular bioeconomy.

关键词： Ammonium inhibition and recovery Metabolic adaption Methanotroph-microalgae coculture system

来源：评论

学校读者我要写书评

暂无评论

Chiral central charge from a single bulk wave function

arXiv

引用

arXiv 2021年

作者： Kim, Isaac H. Shi, Bowen Kato, Kohtaro Albert, Victor V. Department of Computer Science University of California Davis DavisCA United States Centre for Engineered Quantum Systems School of Physics University of Sydney SydneyNSW Australia Department of Physics University of California at San Diego San DiegoCA United States Center for Quantum Information and Quantum Biology Osaka University Osaka Japan Graduate School of Informatics Nagoya University Nagoya Japan Joint Center for Quantum Information and Computer Science National Institute of Standards and Technology University of Maryland College ParkMD United States

A (2 + 1)-dimensional gapped quantum many-body system can have a topologically protected energy current at its edge. The magnitude of this current is determined entirely by the temperature and the chiral central charge, a quantity associated with the effective field theory of the edge. We derive a formula for the chiral central charge that, akin to the topological entanglement entropy, is completely determined by the many-body ground state wave function in the bulk. According to our formula, nonzero chiral central charge gives rise to a topological obstruction that prevents the ground state wave function from being real-valued in any local product basis. © 2021, CC BY.

关键词： Ground state

来源：评论

学校读者我要写书评

暂无评论

Design of a Highly Reliable SRAM Cell with Advanced Self-Recoverability from Soft Errors

Design of a Highly Reliable SRAM Cell with Advanced Self-Rec...

引用

International Test Conference in Asia (ITC-Asia)

作者： Zhengda Dou Albin Yan Jun Zhou Yuanjie Hu Yan Chen Tianming Ni Jie Cui Patrick Girard Xiaoqing Wen School of Computer Science and Technology Anhui University/Anhui Engineering Laboratory of IoT Security Technologies Hefei China College of Electrical Engineering Anhui Polytechnic University Wuhu China Laboratory of Informatics Robotics and Microelectronics of Montpellier University of Montpellier/CNRS Montpellier France Graduate School of Computer Science and Systems Engineering Kyushu Institute of Technology Fukuoka Japan

ISBN: (数字)9781728189444

ISBN: (纸本)9781728189451

In this paper, a highly reliable SRAM cell, namely SESRS cell, is proposed. Since the cell has a special feedback mechanism among its internal nodes and has more access transistors compared to a standard SRAM cell, the SESRS cell provides the following advantages: (1) it can self-recover from single node upsets (SNUs) and double-node upsets (DNUs); (2) it can reduce power consumption by 49.78% and silicon area by 7.92%, compared with the only existing SRAM cell which can self-recover from all possible DNUs. Simulation results validate the robustness of the proposed SESRS cell. Moreover, compared with the state-of-the-art hardened SRAM cells, the proposed SESRS cell can reduce read access time by 61.93% on average.

关键词： SRAM cells Transistors Integrated circuit reliability Logic gates Standards Robustness Reliability engineering

来源：评论

学校读者我要写书评

暂无评论

Online Game Marketplace for Online Game Virtual Item Transaction 8

Online Game Marketplace for Online Game Virtual Item Transac...

引用

8th IIAI International Congress on Advanced Applied Informatics, IIAI-AAI 2019

作者： Rachmadi, Randy Chairullah, Rafid Levina, Vania Pambudi, Muchamad Rilo Warnars, Harco Leslie Hendric Spits Matsuo, Tokuro Computer Science Department School of Computer Science Bina Nusantara University Jakarta 11480 Indonesia Departement of IT Consultant PT Parkland World Indonesia Jl. Raya Serang 68 Km. Desa Nambo llir Cikande Serang Banten Indonesia Graduate School of Industrial Technology Advanced Institute of Industrial Technology Tokyo Japan

ISBN: (纸本)9781728126272

This paper trying to create something new regarding the online game marketplace for producing an integrated marketplace with several combined genre and categories of games. The primary purpose of this research is to develop e-commerce for online games and explain the benefit that people can get from it. This research focuses on building an online marketplace based on a website that can provide an opportunity to do it transaction related to a specific game. Mainly, the online games marketplace quality will be based on user satisfaction and user recommendation from the previous research. Meanwhile, these satisfaction level include four dimensions that decide the perceived value of the user reason for purchasing an online games item, which are functional value, emotional value, monetary value, and social value. From that information, we build a marketplace for online games item to satisfy the user requirement and also benefiting with its advantages. We also provide the difference between e-commerce mainly with our proposed e-commerce for online games item. The results will be a full-fledged web-based application for online games item marketplace. This paper will be an opportunity to further development of online games marketplace for the growth of online games transaction. © 2019 IEEE.

关键词： Electronic commerce

来源：评论

学校读者我要写书评

暂无评论

Identification of secondary metabolites, antioxidant potential, total phenolic and flavonoids of three red algae from Hari Island waters, Southeast Sulawesi, Indonesia

引用

AIP Conference Proceedings 2023年第1期2704卷

作者： Sernita Firdaus I. Sahidin Nunuk Hariani Soekamto Doctoral Program of Chemistry Science Graduate School Hasanuddin University Makassar 90245 Indonesia Department of Medical Laboratory Technology Politeknik Bina Husada Kendari Kendari 93117 Indonesia Department of Chemistry Faculty Mathematics and Natural Science University of Hasanuddin Makassar 90245 Indonesia Department of Pharmacology Faculty of Pharmacy University of Halu Oleo Kendari 93232 Indonesia

Seaweed from the red algae class (Rhodophyceae) ranks the highest in the number that grows in Indonesian marine waters. Red algae have various antibacterial, antioxidant, anti-inflammatory, antiviral, anticancer, antidiabetic, and antihyperlipidemic activities. The red algae collected from the Waters of Hari Island Southeast Sulawesi are Gracilaria sp, Gracilaria spp, and Kappaphycus alvarezii. There have been no reports of red algae’s chemical content and biological activity from the waters of the Hari Islands in Southeast Sulawesi. Gracilaria sp, Gracilaria spp, and Kappaphycus alvarezii were extracted using methanol and antioxidant activity using the ABTS method, total phenolic and flavonoid using colorimetric methods, and identification of secondary metabolites using LC-MS/MS. Methanol extracts of Gracilaria sp, Gracilaria spp, and Kappaphycus alvarezii showed antioxidant properties with IC50 values of 43.33±0.94 mg/L, 87.97±1.45 mg/L, and 72.54±1.57 mg/L. Total phenolic content of methanolic extracts of Gracilaria sp, Gracilaria spp, and Kappaphycus alvarezii was 40.99±0.66 mgGAE/g eks, 0.99 ±0.40 mgGAE/g eks, and 0.73±0.32 mgGAE/g eks. The total flavonoid content of methanolic extracts of Gracilaria sp, Gracilaria spp, and Kappaphycus alvarezii was 1.96±0.12 mgQE/g eks, 0.72 ±0.09 mgQE/g eks, and 0.22±0.23 mgQE/g eks. The methanol extracts of Gracilaria sp, Gracilaria spp, and Kappaphycus alvarezii contain alkaloids, steroids, terpenoids, phenolics, and flavonoids. The compounds detected in the methanol extract of Gracilaria sp were digiprolactone, 3-Tert-butyl-4-methoxyphenol, the methanol extract of Gracilaria spp, and Kappaphycus alvarezii were 3-Tert-butyl-4-methoxyphenol. Red algae Gracilaria sp, Gracilaria spp, and Kappaphycus alvarezii contain compounds that are thought to play a role in antioxidant activity and total phenol and flavonoid content.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Structural, Electronic, Optical, and Potassium Anodic Electrochemical Characteristics of 2-Dimensional Silicane: A Density Functional Theory Investigation

SSRN

引用

SSRN 2022年

作者： Peng, Qiong Rehman, Javed Aziz, Saadullah G. Laref, Amel Albaqami, Munirah D. Alotabi, Reham Ghazi Dinh, Van An Shibl, Mohamed F. Institution of Condensed Physics College of Physics and Electronics Engineering Hengyang Normal University Hengyang421002 China Department of Physics National University of Defense Technology Hunan Changsha410073 China Baluchistan Quetta87300 Pakistan Chemistry Department Faculty of Science King Abdulaziz University Jeddah21589 Saudi Arabia Department of Physics and Astronomy College of Science King Saud University Riyadh11451 Saudi Arabia Chemistry Department College of Science King Saud University Riyadh11451 Saudi Arabia Department of Precision Engineering Graduate School of Engineering Osaka University 2-1 Yamadaoka Osaka Suita565-0871 Japan Renewable Energy Program Center for Sustainable Development College of Arts and Sciences Qatar University Doha2713 Qatar

Two-dimensional (2D) graphene-like materials have attracted tremendous interest due to their remarkable properties in nanoelectronics. To understand and characterize the various physical properties of silicane relevant to optoelectronic and battery applications, various characteristics of 2D silicane Si2H2 are investigated using the density-functional theory. It is disclosed that the structure of 2D Si2H2 is stable, which corroborates its experimental feasibility based on the computational outcomes. With absorption coefficients of about 73.08 (104/cm) and 158.86 (104/cm) at 7.63 eV and 7.66 eV, respectively, it is pertinent to optoelectronic devices. 2D silicane is an exemplary K anodic material, owing to its lesser average open-circuit voltage (OCV) (0.23) and superior theoretical capacity (506 mAhg-1). Afterward, we procured the lowest activation barrier (40 meV) for K migration, which implies the swift charge/discharge mechanism for potassium ion batteries (PIBs). These concomitant findings reinforce the pertinence of silicane material in solar and K anodic utilizations. © 2022, The Authors. All rights reserved.

关键词： Open circuit voltage

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：