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A query-based quantum eigensolver

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arXiv 2020年

作者： Jin, Shan Wu, Shaojun Zhou, Guanyu Li, Ying Li, Lvzhou Li, Bo Wang, Xiaoting Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Chengdu610051 China Graduate School of China Academy of Engineering Physics Beijing100193 China Institute of Computer Science Theory School of Data and Computer Science Sun Yat-sen University Guangzhou510006 China Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing100190 China

Solving eigenvalue problems is crucially important for both classical and quantum applications. Many well-known numerical eigensolvers have been developed, including the QR and the power methods for classical computers, as well as the quantum phase estimation(QPE) method and the variational quantum eigensolver for quantum computers. In this work, we present an alternative type of quantum method that uses fixed-point quantum search to solve Type II eigenvalue problems. It serves as an important complement to the QPE method, which is a Type I eigensolver. We find that the effectiveness of our method depends crucially on the appropriate choice of the initial state to guarantee a sufficiently large overlap with the unknown target eigenstate. We also show that the quantum oracle of our query-based method can be efficiently constructed for efficiently-simulated Hamiltonians, which is crucial for analyzing the total gate complexity. In addition, compared with the QPE method, our query-based method achieves a quadratic speedup in solving Type II problems. Copyright © 2020, The Authors. All rights reserved.

关键词： Eigenvalues and eigenfunctions

Natural remedies for post-inflammatory hyperpigmentation: Antibacterial and anti-melanogenesis properties of Thai herbs

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Pharmacological Research - Natural Products

Pharmacological Research - Natural Products 2025年 8卷

作者： Soontari Komkonekaew Wichuta Kamphuan Phattaraporn Paobthong Warinporn Anukoonrajchathon Pacharaporn Putthangkul Sarocha Sapcharoen Chanikan Sonklin Wiwat Klankaew Kanyanat Khongrin Kiattawee Choowongkomon Saranya Sedthananan Lueacha Tabtimmai Department of Biotechnology Faculty of Appiled Science King Mongkut’s University of Technology North Bangkok Bangkok Thailand Department of Industrial Chemistry Faculty of Appiled Science King Mongkut’s University of Technology North Bangkok Bangkok Thailand Interdisciplinary Program in genetic Engineering and Bioinformatics Graduate School Kasetsart University Bangkok Thailand Department of Biochemistry Faculty of Science Kasesart University Bangkok Thailand Center for Advanced Studies in Nanotechnology for Chemical Food and Agricultural Industries KU Institute for Advanced Studies Kasetsart University Bangkok Thailand Food and Agro-Industrial Research Center King Mongkut’s University of Technology North Bangkok Bangkok Thailand

Post-inflammatory hyperpigmentation (PIH) occurs when excess melanin is produced in response to skin irritation or injury, resulting in uneven pigmentation. This study evaluates the cosmeceutical potential of ethanolic extracts from eight Thai herbs— Curcuma xanthorrhiza (CX), Quercus infectoria (QI), Calophyllum inophyllum (CI), Caesalpinia sappan (CS), Garcinia hanburyi (GH), Punica granatum (PG), Cotylelobium lanceolatum (CL), and Strychnos nux-vomica (SN)—to treat PIH through antioxidant, anti-inflammatory, antibacterial, and anti-melanogenesis properties. Phytochemical analysis revealed that CX and QI contained high levels of phenolics and flavonoids, correlating with their strong antioxidant activity. CX also protected against hydrogen peroxide (H₂O₂)-induced oxidative stress in a yeast-based model and prevented DNA damage in vitro, helping to mitigate cellular injury that can lead to melanin overproduction. Anti-inflammatory assays showed that both CX and QI significantly reduced nitric oxide and interleukin-6 (IL-6) levels without causing cytotoxicity, supporting their role in treating inflammation-related PIH. The extracts also demonstrated selective antibacterial activity against Staphylococcus aureus (MSSA and MRSA) and Cutibacterium acnes , while sparing Staphylococcus epidermidis , an important member of the skin microbiome. CI and CX significantly inhibited C. acnes , a key contributor to acne-induced PIH. Finally, anti-melanogenesis assays revealed that QI and SN effectively inhibited α-MSH-induced melanin production. These findings suggest that CX, QI, and CI are promising natural cosmeceutical agents for addressing PIH by modulating oxidative stress, inflammation, microbial imbalance, and melanin overproduction, while maintaining skin microbiota integrity.

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Modulus τ linking leptonic CP violation to baryon asymmetry in A4 modular invariant flavor model

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arXiv 2021年

作者： Okada, Hiroshi Shimizu, Yusuke Tanimoto, Morimitsu Yoshida, Takahiro Asia Pacific Center for Theoretical Physics Pohang37673 Korea Republic of Department of Physics Pohang University of Science and Technology Pohang37673 Korea Republic of Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Higashi-Hiroshima739-8526 Japan Core of Research for the Energetic Universe Hiroshima University Higashi-Hiroshima739-8526 Japan Department of Physics Niigata University Niigata950-2181 Japan

We propose an A4 modular invariant flavor model of leptons, in which both CP and modular symmetries are broken spontaneously by the vacuum expectation value of the modulus τ. The value of the modulus τ is restricted by the observed lepton mixing angles and lepton masses for the normal hierarchy of neutrino masses. The predictive Dirac CP phase δCP is in the ranges [0◦, 50◦], [170◦, 175◦] and [280◦, 360◦] for Re [τ] ◦, 80◦], [185◦, 190◦] and [310◦, 360◦] for Re [τ] > 0. The sum of three neutrino masses is predicted in [60, 84] meV, and the effective mass for the 0νββ decay is in [0.003, 3] meV. The modulus τ links the Dirac CP phase to the cosmological baryon asymmetry (BAU) via the leptogenesis. Due to the strong wash-out effect, the predictive baryon asymmetry YB can be at most the same order of the observed value. Then, the lightest right-handed neutrino mass is restricted in the range of M1 = [1.5, 6.5]×1013 GeV. We find the correlation between the predictive YB and the Dirac CP phase δCP. Only two predictive δCP ranges, [5◦, 40◦] (Re [τ] > 0) and [320◦, 355◦] (Re [τ] Copyright © 2021, The Authors. All rights reserved.

关键词： Neutrons

Database Management System Design with Time Series Modification for Child Growth and Malnutrition Monitoring in The Regency of Serdang Bedagai

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Database Management System Design with Time Series Modificat...

International Conference on Information Management and technology (ICIMTech)

作者： Reza Rahutomo Ika Nurlaila Anzaludin Samsinga Perbangsa Bens Pardamean Bioinformatics & Data Science Research Center Bina Nusantara University Jakarta Indonesia BINUS Online Learning Bina Nusantara University Jakarta Indonesia School of Information Systems Bina Nusantara University Jakarta Indonesia BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta Indonesia

ISBN: (数字)9781728170718

ISBN: (纸本)9781728170725

A poor data management has led zero stunting strategy in Indonesia moved nowhere. Some justifications on the demography and numbers of affected children remain a matter of plain assumptions without a clear supporting data. We hence develop a database system which enables time series monitoring on the expected increment of children's physical growth. At this initial step, our database system will be implemented at Public Health Office (Dinas Kesehatan) of Serdang Bedagai, South Celebes. This is a modification from Connoly and Begg's principles. Our database was built through 3-steps design started with conceptual followed by logical and at final step was normalizations-enriched physical design. By implementing this proposed system, the assigned healthcare workers will be able record every bit of superficial growth increase. Information obtained in the study is of essence for the efficient and effective intervention formula to achieve national zero stunting goal.

关键词： Pediatrics Monitoring Database systems Dictionaries Drugs Public healthcare

Sculpting liquid crystal skyrmions with external flows

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Physical Review Research 2023年第3期5卷 033210-033210页

作者： Rodrigo C. V. Coelho Hanqing Zhao Mykola Tasinkevych Ivan I. Smalyukh Margarida M. Telo da Gama Centro de Física Teórica e Computacional Faculdade de Ciências Universidade de Lisboa 1749-016 Lisboa Portugal Departamento de Física Faculdade de Ciências Universidade de Lisboa P-1749-016 Lisboa Portugal Department of Physics and Soft Materials Research Center University of Colorado Boulder Colorado 80309 USA SOFT Group School of Science and Technology Nottingham Trent University Clifton Lane Nottingham NG11 8NS United Kingdom International Institute for Sustainability with Knotted Chiral Meta Matter Hiroshima University Higashihiroshima 739-8511 Japan Department of Electrical Computer and Energy Engineering and Materials Science and Engineering Program University of Colorado Boulder Colorado 80309 USA Renewable and Sustainable Energy Institute National Renewable Energy Laboratory and University of Colorado Boulder Colorado 80309 USA

We investigate, using experiments and numerical simulations, the distortions and the alignment of skyrmions in liquid crystal under external flows for a range of average flow velocities. The simulations are based on the Landau-de Gennes Q tensor theory both for isolated as well as for systems with many skyrmions. We found striking flow-driven elongation of an isolated skyrmion and flow alignment of skyrmions in the many-skyrmion system, both of which are also observed in the experiments. In the simulations, particular attention was given to the dissipation rate and to the various dissipation channels for a single skyrmion under external flow. This analysis provides insight on the observed scaling regime of the elongation of isolated flowing skyrmions and revealed a surprising plastic response at very short times, which may be relevant in applications based on the alignment of soft structures such as liquid crystal skyrmions.

关键词： Complex fluids Living matter & active matter Lattice-Boltzmann methods Optical microscopy Photoluminescence

TiEMPO: Open-source time-dependent end-to-end model for simulating ground-based submillimeter astronomical observations

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arXiv 2021年

作者： Huijten, Esmee Roelvink, Yannick Brackenhoff, Stefanie A. Taniguchi, Akio Bakx, Tom J.L.C. Marthi, Kaushal B. Zaalberg, Stan Baselmans, Jochem J.A. Chin, Kah Wuy Huiting, Robert Karatsu, Kenichi Laguna, Alejandro Pascual Tamura, Yoichi Takekoshi, Tatsuya Yates, Stephen J.C. van Hoven, Maarten Endo, Akira Faculty of Electrical Engineering Mathematics and Computer Science Delft University of Technology Mekelweg 4 Delft2628 CD Netherlands Kavli Institute of NanoScience Faculty of Applied Sciences Delft University of Technology Lorentzweg 1 Delft2628 CJ Netherlands Division of Particle and Astrophysical Science Graduate School of Science Nagoya University Aichi464-8602 Japan Kapteyn Astronomical Institute University of Groningen P.O. Box 800 Groningen9700 AV Netherlands SRON—Netherlands Institute for Space Research Sorbonnelaan 2 Utrecht3584 CA Netherlands National Astronomical Observatory of Japan Mitaka Tokyo181-8588 Japan Department of Astronomy School of Science University of Tokyo Bunkyo Tokyo113-0033 Japan Institute of Astronomy Graduate School of Science The University of Tokyo 2-21-1 Osawa Mitaka Tokyo181-0015 Japan SRON—Netherlands Institute for Space Research Landleven 12 Groningen9747 AD Netherlands

The next technological breakthrough in millimeter-submillimeter astronomy is 3D imaging spectrometry with wide instantaneous spectral bandwidths and wide fields of view. The total optimization of the focal-plane instrument, the telescope, the observing strategy, and the signal-processing software must enable efficient removal of foreground emission from the Earth’s atmosphere, which is time-dependent and highly nonlinear in frequency. Here we present TiEMPO: Time-dependent End-to-end Model for Post-process Optimization of the DESHIMA spectrometer. TiEMPO utilizes a dynamical model of the atmosphere and parametrized models of the astronomical source, the telescope, the instrument, and the detector. The output of TiEMPO is a timestream of sky brightness temperature and detected power, which can be analyzed by standard signal-processing software. We first compare TiEMPO simulations with an on-sky measurement by the wideband DESHIMA spectrometer, and find good agreement in the noise power spectral density and sensitivity. We then use TiEMPO to simulate the detection of the line emission spectrum of a high-redshift galaxy using the DESHIMA 2.0 spectrometer in development. The TiEMPO model is open source. Its modular and parametrized design enables users to adapt it to design and optimize the end-to-end performance of spectroscopic and photometric instruments on existing and future telescopes. Copyright © 2021, The Authors. All rights reserved.

关键词： Millimeter waves

Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk (vol 54, pg 804, 2022)

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NATURE GENETICS 2022年第8期54卷 1259-1259页

作者： Turner, Adam W. Hu, Shengen Shawn Mosquera, Jose Verdezoto Ma, Wei Feng Hodonsky, Chani J. Wong, Doris Auguste, Gaelle Song, Yipei Sol-Church, Katia Farber, Emily Kundu, Soumya Kundaje, Anshul Lopez, Nicolas G. Ma, Lijiang Ghosh, Saikat Kumar B. Onengut-Gumuscu, Suna Ashley, Euan A. Quertermous, Thomas Finn, Aloke V. Leeper, Nicholas J. Kovacic, Jason C. Bjorkegren, Johan L. M. Zang, Chongzhi Miller, Clint L. Center for Public Health Genomics University of Virginia Charlottesville VA USA Department of Biochemistry and Molecular Genetics University of Virginia Charlottesville VA USA Medical Scientist Training Program University of Virginia Charlottesville VA USA Department of Pathology University of Virginia Charlottesville VA USA Robert M. Berne Cardiovascular Research Center University of Virginia Charlottesville VA USA Genome Analysis & Technology Core University of Virginia Charlottesville VA USA Genome Sciences Laboratory University of Virginia Charlottesville VA USA Department of Genetics Stanford University School of Medicine Stanford CA USA Department of Computer Science Stanford University Stanford CA USA Division of Vascular Surgery Department of Surgery Stanford University Stanford CA USA Department of Genetics and Genomic Sciences Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA CVPath Institute Gaithersburg MD USA Department of Public Health Sciences University of Virginia Charlottesville VA USA Division of Cardiovascular Medicine Department of Medicine Stanford University Stanford CA USA Cardiovascular Research Institute Icahn School of Medicine at Mount Sinai New York NY USA Victor Chang Cardiac Research Institute Darlinghurst New South Wales Australia St. Vincent’s Clinical School University of New South Wales Sydney New South Wales Australia Integrated Cardio Metabolic Centre Department of Medicine Karolinska Institutet Huddinge Sweden

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across cell types. Genome-wide association studies have identified over 200 loci associated with CAD, where the majority of risk variants reside in noncoding DNA sequences impacting cis-regulatory elements. Here, we applied single-nucleus assay for transposase-accessible chromatin with sequencing to profile 28,316 nuclei across coronary artery segments from 41 patients with varying stages of CAD, which revealed 14 distinct cellular clusters. We mapped ~320,000 accessible sites across all cells, identified cell-type-specific elements and transcription factors, and prioritized functional CAD risk variants. We identified elements in smooth muscle cell transition states (for example, fibromyocytes) and functional variants predicted to alter smooth muscle cell- and macrophage-specific regulation of MRAS (3q22) and LIPA (10q23), respectively. We further nominated key driver transcription factors such as PRDM16 and TBX2. Together, this single-nucleus atlas provides a critical step towards interpreting regulatory mechanisms across the continuum of CAD risk.

关键词： Atherosclerosis Epigenomics Gene regulation

Deep learning inter-atomic potential for thermal and phonon behaviour of silicon carbide with quantum accuracy

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arXiv 2021年

作者： Fu, Baoqin Sun, Yandong Zhang, Linfeng Wang, Han Xu, Ben Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and Technology Sichuan University Chengdu610064 China Graduate School China Academy of Engineering Physics Beijing100193 China Program in Applied and Computational Mathematics Princeton University PrincetonNJ United States Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics Beijing100088 China

Silicon carbide (SiC) is an essential material for next generation semiconductors and components for nuclear plants. It’s applications are strongly dependent on its thermal conductivity, which is highly sensitive to microstructures. Molecular dynamics (MD) simulation is the most used methods to address thermal transportation mechanisms in devices or microstructures of nano-meters. However, the implementation of MD is limited in SiC because of lacking accurate inter-atomic potentials. In this work, using the Deep Potential (DP) methodology, we developed two inter-atomic potentials (DP-*Corresponding author. IAPs) for SiC based on two adaptively generated datasets within the density functional approximations at the local density and the generalized gradient levels. These two DP-IAPs manifest their speed with quantum accuracy in lattice dynamics simulations as well as scattering rate analysis of phonon transportation. Combining with molecular dynamics simulations, the thermal transport and mechanical properties were systematically investigated. The presented methodology and the inter-atomic potentials pave the way for a systematic approach to model heat transport in SiC related devices using multiscale modelling. Copyright © 2021, The Authors. All rights reserved.

关键词： Silicon carbide

Electron Transfer Enhanced by a Minimal Energetic Driving Force at the Organic-Semiconductor Interface

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Angewandte Chemie 2024年第37期136卷

作者： Hiroto Iwasaki Keisuke Fujimoto Koki Banno Qing-jun Shui Yutaka Majima Masaki Takahashi Seiichiro Izawa Laboratory for Materials and Structures Tokyo Institute of Technology 4259 Nagatsuta-cho Midori-ku Yokohama Kanagawa 226-8503 Japan Applied Chemistry Program Graduate School of Advanced Science and Engineering Hiroshima University 1-4-1 Kagamiyama Higashi-Hiroshima Hiroshima 739-8527 Japan Department of Applied Chemistry Faculty of Engineering Shizuoka University 3-5-1 Johoku Chuo-ku Hamamatsu Shizuoka 432-8561 Japan Precursory Research for Embryonic Science and Technology (PRESTO) Japan Science and Technology Agency (JST) 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan

The energetic driving force for electron transfer must be minimized to realize efficient optoelectronic devices including organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs). Exploring the dynamics of a charge-transfer (CT) state at an interface leads to a comprehension of the relationship between energetics, electron-transfer efficiency, and device performance. Here, we investigate the electron transfer from the CT state to the triplet excited state (T 1 ) in upconversion OLEDs with 45 material combinations. By analyzing the CT emission and the singlet excited-state emission from triplet–triplet annihilation via the dark T 1 , their energetics and electron-transfer efficiencies are extracted. We demonstrate that the CT→T 1 electron transfer is enhanced by the stronger CT interaction and a minimal energetic driving force (<0.1 eV), which is explained using the Marcus theory with a small reorganization energy of <0.1 eV. Through our analysis, a novel donor–acceptor combination for the OLED is developed and shows an efficient blue emission with an extremely low turn-on voltage of 1.57 V. This work provides a solution to control interfacial CT states for efficient optoelectronic devices without energy loss.

关键词： electron transfer Marcus theory organic optoelectronic devices organic light-emitting diodes organic photovoltaics