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19th International Conference on Engineering and Product Design Education, E and PDE 2017

作者： Da Silva Bertolaccini, Guilherme Vasquez, Melissa Marin Bianchi, Ana Carolina Sandes, Frode Eika Paschoarelli, Luis Carlos Medola, Fausto Orsi Graduate Programme in Design UNESP - Univ. Estadual Paulista Bauru Brazil Department of Computer Science Faculty of Technology Art and Design Oslo Norway Akershus University College of Applied Sciences Norway

ISBN: (纸本)9781904670841

The research in the field of ergonomics can contribute to the design process of Assistive Technologies using objective and subjective data measurements. The auxiliary crutches are assistive devices commonly used in the process of rehabilitation after lower-extremity injuries. However, for many subjects, walking with crutches in not an easy and comfortable task, as the loads on the upper limbs are substantial and expose the users to potentially harmful long-term effects. In this way, the objective of this study was, first, to report the evaluation of the user-crutch interface by using an objective measurement of the subjects’ muscular activity and exertion perception, and to discuss how objective data measured from the subjects can contribute for the design of the interface. Eleven able-bodied subjects participated. The test protocol consisted of 3 trials of walking with crutches, each one with a different hand diameter, namely 20 mm, 32 mm and 40 mm. Surface electromyography of forearms muscles was collected, and perceived exertion was measured using the Borg’s Scale. The mean of maximum EMG values showed that the highest values activity happened in the extensor digitorum muscle using the largest handles. However, the smallest handles increase electromyography activity in the flexor digitorum superficialis muscle. Statistically significant difference was found between the smaller and the larger handle diameter. The analysis of exertion perception did not show statistical difference in any of the situations investigated. Handle diameter was shown to be a factor affecting the biomechanics of the walking with crutches. In addition, ergonomic evaluation can provide objective measurements that, ultimately, May be applied in the improvement of user-product interface.

关键词： Electromyography

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Considering discrepancy when calibrating a mechanistic electrophysiology model

arXiv

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arXiv 2020年

作者： Lei, Chon Lok Ghosh, Sanmitra Whittaker, Dominic G. Aboelkassem, Yasser Beattie, Kylie A. Cantwell, Chris D. Delhaas, Tammo Houston, Charles Novaes, Gustavo Montes Panfilov, Alexander V. Pathmanathan, Pras Riabiz, Marina Weber dos Santos, Rodrigo Worden, Keith Mirams, Gary R. Wilkinson, Richard D. Computational Biology & Health Informatics Dept. of Computer Science University of Oxford United Kingdom MRC Biostatistics Unit University of Cambridge United Kingdom Centre for Mathematical Medicine & Biology School of Mathematical Sciences University of Nottingham United Kingdom Department of Bioengineering University of California San Diego United States Systems Modeling and Translational Biology GlaxoSmithKline R&D Stevenage United Kingdom ElectroCardioMaths Programme Centre for Cardiac Engineering Imperial College London United Kingdom CARIM School for Cardiovascular Diseases Maastricht University Netherlands Graduate Program in Computational Modeling Universidade Federal de Juiz de Fora Brazil Department of Physics and Astronomy Ghent University Belgium Laboratory of Computational Biology and Medicine Ural Federal University Ekaterinburg Russia U.S. Food and Drug Administration Center for Devices and Radiological Health Office of Science and Engineering Laboratories United States Department of Biomedical Engineering King’s College London Alan Turing Institute United Kingdom Dynamics Research Group Department of Mechanical Engineering University of Sheffield United Kingdom School of Mathematics and Statistics University of Sheffield United Kingdom

Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions. The field of cardiac simulation has begun to explore and adopt UQ methods to characterise uncertainty in model inputs and how that propagates through to outputs or predictions. In this perspective piece we draw attention to an important and under-addressed source of uncertainty in our predictions — that of uncertainty in the model structure or the equations themselves. The difference between imperfect models and reality is termed model discrepancy, and we are often uncertain as to the size and consequences of this discrepancy. Here we provide two examples of the consequences of discrepancy when calibrating models at the ion channel and action potential scales. Furthermore, we attempt to account for this discrepancy when calibrating and validating an ion channel model using different methods, based on modelling the discrepancy using Gaussian processes (GPs) and autoregressive-moving-average (ARMA) models, then highlight the advantages and shortcomings of each approach. Finally, suggestions and lines of enquiry for future work are provided. Copyright © 2020, The Authors. All rights reserved.

关键词： Uncertainty analysis

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Reproducible brain-wide association studies require thousands of individuals (Mar, 10.1038/s41586-022-04492-9, 2022)

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NATURE 2022年第7911期605卷 E11-E11页

作者： Marek, Scott Tervo-Clemmens, Brenden Calabro, Finnegan J. Montez, David F. Kay, Benjamin P. Hatoum, Alexander S. Donohue, Meghan Rose Foran, William Miller, Ryland L. Hendrickson, Timothy J. Malone, Stephen M. Kandala, Sridhar Feczko, Eric Miranda-Dominguez, Oscar Graham, Alice M. Earl, Eric A. Perrone, Anders J. Cordova, Michaela Doyle, Olivia Moore, Lucille A. Conan, Gregory M. Uriarte, Johnny Snider, Kathy Lynch, Benjamin J. Wilgenbusch, James C. Pengo, Thomas Tam, Angela Chen, Jianzhong Newbold, Dillan J. Zheng, Annie Seider, Nicole A. Van, Andrew N. Metoki, Athanasia Chauvin, Roselyne J. Laumann, Timothy O. Greene, Deanna J. Petersen, Steven E. Garavan, Hugh Thompson, Wesley K. Nichols, Thomas E. Yeo, B. T. Thomas Barch, Deanna M. Luna, Beatriz Fair, Damien A. Dosenbach, Nico U. F. Department of Psychiatry Washington University School of Medicine St Louis MO USA Department of Neurology Washington University School of Medicine St Louis MO USA Department of Psychological and Brain Sciences Washington University in St Louis St Louis MO USA Department of Psychiatry Massachusetts General Hospital Harvard Medical School Boston MA USA Department of Psychology University of Pittsburgh Pittsburgh PA USA Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Department of Bioengineering University of Pittsburgh Pittsburgh PA USA Department of Biomedical Engineering Washington University in St Louis St Louis MO USA Department of Radiology Washington University School of Medicine St Louis MO USA Department of Neurological Surgery Washington University School of Medicine St Louis MO USA Program in Occupational Therapy Washington University School of Medicine St Louis MO USA Department of Pediatrics Washington University School of Medicine St Louis MO USA University of Minnesota Informatics Institute University of Minnesota Minneapolis MN USA Department of Psychology University of Minnesota Minneapolis MN USA Masonic Institute for the Developing Brain University of Minnesota Medical School Minneapolis MN USA Department of Pediatrics University of Minnesota Medical School Minneapolis MN USA Department of Psychiatry Oregon Health and Science University Portland OR USA Minnesota Supercomputing Institute University of Minnesota Minneapolis MN USA Institute of Child Development University of Minnesota Medical School Minneapolis MN USA Department of Electrical and Computer Engineering National University of Singapore Singapore Singapore Centre for Sleep and Cognition National University of Singapore Singapore Singapore Centre for Translational MR Research National University of Singapore Singapore Singapore N.1 Institute for Health Institute for Digital Medicine National University of Singapore Singapore Sing

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Tungsten boride: a 2D multiple dirac semimetal for hydrogen evolution reaction

arXiv

引用

arXiv 2019年

作者： Wang, Aizhu Shen, Lei Zhao, Mingwen Wang, Junru Li, Weifeng Zhou, Weijia Feng, Yuanping Liu, Hong Institute for Advanced Interdisciplinary Research University of Jinan JinanShandong250022 China Department of Electrical and Computer Engineering Department of Physics National University of Singapore Singapore117579 Singapore Department of Mechanical Engineering Engineering Science Programme Faculty of Engineering National University of Singapore Singapore117575 Singapore School of Physics State Key Laboratory of Crystal Materials Shandong University JinanShandong250100 China Department of Physics & Centre for Advanced Two-dimensional Materials National University of Singapore Singapore117542 Singapore State Key Laboratory of Crystal Materials Shandong University JinanShandong250100 China

Here, we propose a two-dimensional (2D) tungsten boride (WB4) lattice, with the Gibbs free energy for the adsorption of atomic hydrogen (ΔGH) tending to be the ideal value (0 eV) at 3% strained state, to host a better hydrogen evolution reaction (HER) activity. Based on first-principles calculations, it is demonstrated that the multiple d-p-π and d-p-σ Dirac conjugations of WB4 lattice ensures its excellent electronic transport characteristics. Meanwhile, coupling with the d-orbitals of W, the p-orbitals of borophene subunits in WB4 lattice can modulate the d band center to get a good HER performance. Our results not only provide a versatile platform for hosting multiple Dirac semimetal states with a "sandwich" configuration, but also offer a guiding principle for discovering the relationship between intrinsic properties of the active center and the catalytic activity of metal layer from the emerging field of 2D noble-metal-free lattices. Copyright © 2019, The Authors. All rights reserved.

关键词： Calculations

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Measuring the volatility of the political agenda in public opinion and news media

arXiv

引用

arXiv 2018年

作者： Camargo, Chico Q. John, Peter Margetts, Helen Z. Hale, Scott A. Department of Computer Science The University of Exeter Exeter United Kingdom The Oxford Internet Institute University of Oxford Oxford United Kingdom King’s College London London United Kingdom Public Policy Programme The Alan Turing Institute London United Kingdom Meedan San FranciscoCA United States

Recent election surprises, regime changes, and political shocks indicate that political agendas have become more fast-moving and volatile. The ability to measure the complex dynamics of agenda change and capture the nature and extent of volatility in political systems is therefore more crucial than ever before. This study proposes a definition and operationalization of volatility that combines insights from political science, communications, information theory, and computational techniques. The proposed measures of fractionalization and agenda change encompass the shifting salience of issues in the agenda as a whole and allow the study of agendas across different domains. We evaluate these metrics and compare them to other measures such as issue-level survival rates and the Pedersen Index, which uses public-opinion poll data to measure public agendas, as well as traditional media content to measure media agendas in the UK and Germany. We show how these measures complement existing approaches and could be employed in future agenda-setting research. © 2018, CC BY.

关键词： Information theory

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Use of Conceptual Representations Based on Conceptual Spaces Theory Applied to BDI Agents

Use of Conceptual Representations Based on Conceptual Spaces...

引用

Brazilian Conference on Intelligent Systems (BRACIS)

作者： João Mário Lopes Brezolin Sandro Rama Fiorini Márcia de Borba Campos Rafael H. Bordini Postgraduate Programme in Computer Science Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre RS Brazil Postgraduate Programme in Computer Science Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre RS BR

The BDI architecture is one of the best known approaches for the development of agents situated in complex dynamic environments. Founded on the symbolic approach to AI, it is a consolidated model that builds upon substantial theoretical and practical contributions. However, there are aspects of the cognitive phenomena that require the representation of concepts to classify perceptual information in ways that have not been sufficiently explored in the BDI architecture. Taking into consideration that conceptual representations can, for example, improve object recognition processes, this paper addresses that problem, drawing from the theory of Conceptual Spaces. The paper also illustrates the viability of the proposed approach through the development of an application that aims to support visually impaired people. This application was developed using the Jason agent platform and the CSML language.

关键词： computer architecture Prototypes Databases Cognition computer science Object recognition Shape

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The pathogenicity of COVID-19 and the role of pentraxin-3: An updated review study

引用

Pathology - Research and Practice 2022年 238卷

作者： Ria Margiana Satish Kumar Sharma Bilal Irshad Khan Ameer A. Alameri Maria Jade Catalan Opulencia Ali Thaeer Hammid Thulfeqar Ahmed Hamza Sharaf Khamrakulovich Babakulov Walid Kamal Abdelbasset Zanko Hassan Jawhar Department of Anatomy Faculty of Medicine Universitas Indonesia Jakarta Indonesia Master's Programme Biomedical Sciences Faculty of Medicine Universitas Indonesia Jakarta Indonesia Andrology Program Faculty of Medicine Universitas Airlangga Surabaya Indonesia Dr. Soetomo General Academic Hospital Surabaya Indonesia Department of Pharmacology Glocal School of Pharmacy The Glocal University Saharanpur India Mbbs Rawalpindi Medical University Rawalpindi Pakistan Department of Chemistry University of Babylon Iraq College of Business Administration Ajman University Ajman United Arab Emirates Computer Engineering Techniques Department Faculty of Information Technology Imam Ja’afar Al-Sadiq University Baghdad Iraq Medical laboratory techniques department Al-Mustaqbal University College Babylon Iraq Tashkent State Dental Institute Makhtumkuli Street 103 Tashkent 100047 Uzbekistan Research scholar Department of Scientific affairs Samarkand State Medical Institute Amir Temur Street 18 Samarkand Uzbekistan Department of Health and Rehabilitation Sciences College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Al Kharj Saudi Arabia Department of Physical Therapy Kasr Al-Aini Hospital Cairo University Giza Egypt Department of Medical Laboratory Science College of Health Science Lebanese French University Kurdistan Region Iraq

In recent years, the COVID-19 pandemic has become one of the most crucial scientific issues in the world, and efforts to eradicate the disease are still ongoing. The acute inflammatory reaction associated with this disease is associated with several complications such as cytokine storm, multiple organ damage, lung fibrosis, and blood clots. PTX3, as part of the humoral innate immune systems, is one of the acute-phase proteins that perform various functions, such as modulating inflammation, repairing tissue, and recruiting immune cells. PTX3 is increased in people with SARS-CoV-2, and its level decreases with proper treatment. Therefore, it can be regarded as a suitable marker for the prognosis of the COVID-19 and evaluating the effectiveness of the treatment method applied. However, some studies have shown that PTX3 can be a double-edged sword and develop tumors by providing an immunosuppressive environment.

关键词： COVID-19 SARS-CoV-2 Pentraxin-3 Acute-phase proteins

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Real-Time Multiple Object Tracking A Study on the Importance of Speed

arXiv

引用

arXiv 2017年

作者： Murray, Samuel Master’s Programme Machine Learning National Institute of Informatics Tokyo Japan School of Computer Science and Communication

Multiple object tracking consists of detecting and identifying objects in video. In some applications, such as robotics and surveillance, it is desired that the tracking is performed in real-time. This poses a challenge in that it requires the algorithm to run as fast as the frame-rate of the video. Today’s top performing tracking methods run at only a few frames per second, and can thus not be used in real-time. Further, when determining the speed of the tracker, it is common to not include the time it takes to detect objects. We argue that this way of measuring speed is not relevant for robotics or embedded systems, where the detecting of objects is done on the same machine as the tracking. We propose that one way of running a method in real-time is to not look at every frame, but skip frames to make the video have the same frame-rate as the tracking method. However, we believe that this will lead to decreased *** this project, we implement a multiple object tracker, following the tracking-by-detection paradigm, as an extension of an existing method. It works by modelling the movement of objects by solving the filtering problem, and associating detections with predicted new locations in new frames using the Hungarian algorithm. Three different similarity measures are used, which use the location and shape of the bounding boxes. Compared to other trackers on the MOTChallenge leaderboard, our method, referred to as C++SORT, is the fastest non-anonymous submission, while also achieving decent score on other metrics. By running our model on the Okutama-Action dataset, sampled at different frame-rates, we show that the performance is greatly reduced when running the model – including detecting objects – in real-time. In most metrics, the score is reduced by 50%, but in certain cases as much as 90%. We argue that this indicates that other, slower methods could not be used for tracking in real-time, but that more research is required specifically on this. Copy

关键词： Object detection

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

引用

NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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